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A clinical trial of combined use of rosiglitazone and 5-aminosalicylate for ulcerative colitis

World Journal of Gastroenterology 2008年第1期14卷 114-119页

作者： Hong-liang liang qin Ouyang Department of Gastroen-terology West China Hospital Sichuan University Chengdu610041 Sichuan Province China

AIM: To investigate the therapeutic effects of the combined use of rosiglitazone and aminosalicylate on mild or moderately active ulcerative colitis (UC).METHODS: According to the national guideline for diagnosis and treatment of inflammatory bowel disease (IBD) in China, patients with mild or moderately active UC in our hospital were selected from July to November, 2004. Patients with infectious colitis, amoebiasis, or cardiac, renal or hepatic failure and those who had received corticosteroid or immunosuppressant treatment within the last month were excluded. Following a quasi-randomization principle, patients were allocated alternatively into the treatment group (TG) with rosiglitazone 4 mg/d plus 5-ASA 2 g/d daily or the control group (CG) with 5-ASA 2 g/d alone, respectively, for 4 wk. Clinical changes were evaluated by Mayo scoring system and histological changes by Truelove-Richards' grading system at initial and final point of ***: Forty-two patients completed the trial, 21 each in TG and CG. The Mayo scores in TG at initial and final points were 5.87 (range: 4.29-7.43) and 1.86 (range: 1.03-2.69) and those in CG were 6.05 (range: 4.97-7.13) and 2.57 (range: 1.92-3.22) respectively. The decrements of Mayo scores were 4.01 in TG and 3.48 in CG, with a remission rate of 71.4% in TG and 57.1% in CG, respectively. Along with the improvement of disease activity index (DAI), the histological grade improvement was more significant in TG than in CG (P < 0.05).CONCLUSION: Combined treatment with rosiglitazone and 5-ASA achieved better therapeutic effect than 5-ASA alone without any side effects. Rosiglitazone can alleviate colonic inflammation which hopefully becomes a novel agent for UC treatment.

关键词： Peroxisome proliferators-activated receptor γ Rosiglitazone Ulcerative colitis

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The In-cell iR Compensation Using a Four-electrode System

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Chinese Chemical Letters 2006年第5期17卷 703-706页

作者： Xiang qin LIN liang Dong FENG University of Science and Technology of China Hefei 230026

A novel idea of in-cell iR compensation was proposed by using a four-electrode electrochemical system, which was consisted of two working electrodes, one reference electrode （RE） and one auxiliary electrode （AE）. One of the two working electrodes was called the auxiliary working electrode （AWE）, which was directly connected to the ground. Another working electrode was used as a regular working electrode （WE） for electrochemical testing. The reference electrode was set in a frit close to the AWE for potential sampling. The other electrodes, WE, RE and AE, were connected to a conventional potentiostat of three-electrode system for electrochemical measurements. A linear narrow electrochemical cell was designed for setting AE at one end and AWE with RE at another end, and setting WE in between AE and AWE. In this way, a positive feedback potential was generated at the working electrode from the solution resistance and the current flow in the solution. An formal iR compensation over 100%, as high as 500%, had been achieved without potential oscillation. The electrochemical cell design, the principle of the in-cell iR compensation, and the preliminary voltammetric characterization by using the redox reaction of ferrocyanide anions were reported.

关键词： In-cell iR compensation four-electrode system cell design cyclic voltammetry.

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Synthesis and Crystal Structure of an Acetate Radical Bridged Dinuclear Copper(Ⅱ) Complex

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Chinese Journal of Structural Chemistry 2007年第3期26卷 347-351页

作者： DU Qiao-Yun MA liang qin Jian-Hua Department of Chemistry Luoyang Normal University Luoyang 471022 China

A new acetate radical bridged dinuclear copper（ Ⅱ ） complex [（C8H9NO2）2- Cu2（CH3COO）4] has been synthesized by the reaction of Cu（OAc）2 with pyridine-3-ethyl formate and further characterized by X-ray single-crystal diffraction. Crystal data for the title compound： triclinic system, space group Pí, with a = 8.1654（14）, b = 9.7010（16）, c = 9.9005（17） A, α = 83.266（2）, β = 78.887（2）, γ = 72.881（2）°, V= 733.9（2） A^3, Mr = 665.58, Z = 1, Dc = 1.506 g/cm^3, F（000） = 342,μ = 1.510 mm^-1, the final R = 0.0392 and wR = 0.1005. According to the structural determination, each unit of the title compound is composed of two Cu（ Ⅱ ） atoms, two pyridine-3-ethyl formate molecules and four acetate ions. Each Cu（Ⅱ） coordinates to oxygen atoms of acetate and nitrogen atoms of pyridine- 3-ethyl formate ligand to give a six-coordinate distorted octahedral geometry. It is worth mentioning that strong Cu-Cu bond can be observed in the title compound.

关键词： pyridine-3-carboxylic acetate radical bridge Cu( Ⅱ ) crystal structure

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In Silico Screening of Potential Chinese Herbal Medicine Against COVID-19 by Targeting SARS-CoV-2 3CLpro and Angiotensin Converting Enzyme Ⅱ Using Molecular Docking

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Chinese Journal of Integrative Medicine 2020年第7期26卷 527-532页

作者： GAO liang-qin XU Jing CHEN Shao-dong Department of Traditional Chinese Medicine Xiamen University HospitalXiamen UniversityXiamenFujian Provinee(361005)China College of Ocean and Earth Sciences Xiamen UniversityXiamenFujian Provinee(361102)China Department of Traditional Chinese Medicine School of MedicineXiamen UniversityXiamenFujian Provinee(361002)China

Objective:To seek potential Chinese herbal medicine(CHM)for the treatment of coronavirus disease 2019(COVID-19)through the molecular docking of the medicine with SARS-CoV-23 CL hydrolytic enzyme and the angiotensin converting enzymeⅡ(ACE2)as receptors,using computer virtual screening technique,so as to provide a basis for combination ***:The molecular docking of CHM with the SARS-Cov-23 CL hydrolase and the ACE2 converting enzyme,which were taken as the targets,was achieved by the Autodock Vina *** CHM monomers acting on 3 CLpro and ACE2 receptors were retrieved from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,the active ingredients were selected,and the key CHMs and compounds were *** on the perspective of network pharmacology,the chemical-target network was constructed,and the functional enrichment analysis of gene ontology and the pathway enrichment analysis of Kyoto encyclopedia of genes and genomes were carried out by DAVID to speculate about the mechanism of action of the core drug ***:There are6 small molecule compounds that have the optimal binding energy with the two target *** 238 potential anti-COVID-19 herbs screened in total,16 kinds of CHM containing the most active ingredients,and5 candidate anti-COVID-19 herbs that had been used in high frequency,as well as a core drug pair,namely,Forsythiae Fructus-Lonicerae Japonicae Flos were ***:The core drug pair of Forsythiae Fructus-Lonicerae Japonicae Flos containing multiple components and targets is easy to combine with 3 CLpro and ACE2,and exerts an anti-COVID-19 pneumonia effect through multi-component and multi-target,and plays the role of anti-COVID-19 pneumonia in multi-pathway.

关键词： molecular docking COVID-19 SARS-CoV-23CL hydrolytic enzyme angiotensin converting enzymeⅡ Chinese medicine

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MORPHOLOGY AND MECHANICAL PROPERTIES OF POLYPROPYLENE WITH in situ FORMED POLYAMIDE-6 FIBRILS

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Chinese Journal of Polymer Science 2007年第6期25卷 599-607页

作者： Dong liang qin Zhang Rong-ni Du Qiang Fu Colloge of Polymer Science and Materials Sichuan University State Key Laboratory of Polymer Materials Engineering Chengdu 610065 China

in situ Fibril formation of polyamide-6 （PA6） in isotropic polypropylene （iPP） was first fabricated using a slit die extrusion and hot stretching process. Then the prepared materials were subjected to injection molding in the temperature range higher than the melting temperature of iPP but lower than that of PA6. The obtained injection-molded samples were characterized via scanning electron microscopy （SEM）, differential scanning calorimetry （DSC） and two-dimensional wide- angle X-ray scattering （2D-WAXS）. Mechanical properties were also investigated. The SEM result shows that the optimum fibril formation could be only achieved in the range of 20 wt% to 30 wt% of PA6 content for the studied system. The fibril morphology changes along the sample thickness in the injection-molded bars. The fibril morphology in the skin layer was better than that in the core layer. 2D-WAXS results showed that the orientation of PP decreased with the increase of PA6 content, which indicated that the orientation of PP was confined by PA6 fibrils. Combined consideration of mechanical properties and morphology indicates that only PP/PA6 composites with 20 wt% of PA6 content show better properties because of the better fibril morphology and PP chain orientation.

关键词： in situ Fibril Morphology Property PA6 PP.

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High order compact schemes for gradient approximation

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Science China Mathematics 2010年第7期53卷 1899-1914页

作者： Huang Yunqing liang qin Yi NianYu Xiangtan Univ Sch Math & Computat Sci Hunan Key Lab Computat & Simulat Sci & Engn Xiangtan 411105 Peoples R China Peking Univ Sch Math Sci Beijing 100871 Peoples R China

In this paper, we propose three gradient recovery schemes of higher order for the linear interpolation. The first one is a weighted averaging method based on the gradients of the linear interpolation on the uniform mesh, the second is a geometric averaging method constructed from the gradients of two cubic interpolation on macro element, and the last one is a local least square method on the nodal patch with cubic polynomials. We prove that these schemes can approximate the gradient of the exact solution on the symmetry points with fourth order. In particular, for the uniform mesh, we show that these three schemes are the same on the considered points. The last scheme is more robust in general meshes. Consequently, we obtain the superconvergence results of the recovered gradient by using the aforementioned results and the supercloseness between the finite element solution and the linear interpolation of the exact solution. Finally, we provide several numerical experiments to illustrate the theoretical results.

关键词： superconvergence gradient recovery compact scheme

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Divergence-Free Virtual Element Method for the Stokes Equations with Damping on Polygonal Meshes

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Numerical Mathematics(Theory,Methods and Applications) 2024年第1期17卷 210-242页

作者： Yu Xiong Yanping Chen Jianwei Zhou qin liang School of Mathematics and Computational Science Hunan Key Laboratory for Computation and Simulation in Science and EngineeringXiangtan UniversityXiangtan 411105P.R.China School of Mathematics and Statistics Linyi University Linyi 276005P.R.China School of Mathematical Sciences South China Normal UniversityGuangzhou 510631P.R.China

In this paper,we construct,analyze,and numerically validate a family of divergence-free virtual elements for Stokes equations with nonlinear damping on polygonal *** virtual element method is H1-conforming and exact *** virtue of these properties and the topological degree argument,we rigorously prove the well-posedness of the proposed discrete *** con-vergence analysis is carried out,which imply that the error estimate for the velocity in energy norm does not explicitly depend on the *** experiments on various polygonal meshes validate the accuracy of the theoretical analysis and the asymptotic pressure robustness of the proposed scheme.

关键词： Optimal error estimates divergence-free virtual element nonlinear damping term.

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A Home-made Simple Set-up for Measurement of Electrochemical Surface Tension Spectrum on a Mercury Drop Electrode

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Chinese Chemical Letters 2006年第4期17卷 493-495页

作者： Xiang qin LIN liang Dong FENG Hao ZHANG University of Science and Technology of China Hefei 230026

A setup for recording surface tension curves at a mercury drop during potential scanning is designed based on photo-sensitive detection system. Surface tension spectrum at Hg drop can be recorded by voltam0metdc study. A Yb（Ⅲ）-NO2 catalytic reduction system was used for characterization. The simple, sensitive technique can be expected to provide fresh information on molecular interactions at electrode surfaces.

关键词： Surface tension electrochemistry mercury drop measurement.

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The prognostic impact of traditional Chinese medicine monomers on tumor-associated macrophages in non-small cell lung cancer

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Chinese Journal of Natural Medicines 2019年第10期17卷 729-737页

作者： WAN liang-qin TAN Yan JIANG Miao HUA Qian School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 100029China Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100029China

Non-small cell lung cancer(NSCLC) accounts for 80%-85% of all lung malignancies and good diagnosis and prognosis of NSCLC are critical to the increase of its survival rate. Tumor-associated macrophages(TAM) abundantly present in numerous cancer types, and the role of TAMs in tumor biology and their prognostic value in cancer become major topics of interest. After various stimulations in the tumor microenvironment, TAMs develop into a M1(tumor-inhibitory) phenotype or M2(tumor-promoting) phenotype. Recent studies show that traditional Chinese medicine(TCM) monomers have markedly inhibitory actions for NSCLC through M1/M2 modulation. Due to the TCM monomers mainly covered five categories, i.e. terpenoids, flavonoids, polysaccharides, natural polyphenols, and alkaloids. Thus, we will discuss the regulation of TCM monomers on TAM involve in these five parts in this review. In addition, the potential role of TAMs as therapeutic targets will be discussed.

关键词： Lung cancer Tumor microenvironment Tumor-associated macrophages Traditional Chinese medicine (TCM) monomer Immunotherapy

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Frontal Crash Analysis of a Fully Detailed Car Model Based on Finite Element Method

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上海交通大学学报 2004年第Z2期38卷 136-141页

作者： Han Shan-Ling Zhu Ping Lin Zhong-qin Shi Yu-liang School of Mechanical and Power Energy Engineering Shanghai Jiaotong University Shanghai200030 China School of Mechanical and Power Energy Engineering Shanghai Jiaotong University Shanghai200030 China School of Mechanical and Power Energy Engineering Shanghai Jiaotong University Shanghai200030 China School of Mechanical and Power Energy Engineering Shanghai Jiaotong University Shanghai200030 China

This paper sets up a highly detailed finite element model of a car for frontal crashworthiness applications, and then explains the characteristics of it. The geometry model is preprocessed by Hypermesh software. The finite element method solver program selected for the simulation is LS-DYNA. After the crash simulation is carefully analyzed, the frontal crash experiment is aimed to validate the finite element model. The simulation results are basically in agreement with the experimental results. The validation of the finite element model is crucial for the further research in optimization of the automotive structure or lightweighting of the vehicle.

关键词： finite element method frontal crash LS-DYNA

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