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Succinylation modification:a potential therapeutic target in stroke

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Neural Regeneration Research 2024年第4期19卷 781-787页

作者： Jie Lian Wenwu Liu qin Hu Xiaohua Zhang Department of Neurosurgery Ren Ji HospitalShanghai Jiao Tong University School of Medicine Department of Diving and Hyperbaric Medicine Naval Medical CenterNaval Medical University

Stroke is a leading cause of mortality and disability *** cell death triggered by the compromised supply of blood oxygen and glucose is one of the major pathophysiology of strokeinduced brain *** mitochondrial energy metabolism is observed minutes after stroke and is closely associated with the progression of ***,a new type of posttranslational modification,known as lysine succinylation,has been recognized to play a significant role in mitochondrial energy metabolism after ***,the role of succinylation modification in cell metabolism after stroke and its regulation are not well *** aimed to review the effects of succinylation on energy metabolism,reactive oxygen species generation,and neuroinflammation,as well as Sirtuin 5 mediated desuccinylation after *** also highlight the potential of targeting succinylation/desuccinylation as a promising strategy for the treatment of *** succinylation level is dynamically regulated by the nonenzymatic or enzymatic transfer of a succinyl group to a protein on lysine residues and the removal of succinyl catalyzed by *** evidence has suggested that succinylation can regulate the metabolic pathway through modulating the activity or stability of metabolic ***,especially Sirtuin 5,are characterized for their desuccinylation activity and have been recognized as a critical regulator of metabolism through desuccinylating numerous metabolic *** between succinylation and desuccinylation has been implicated in the pathophysiology of *** agents that enhance the activity of Sirtuin 5 have been employed to promote desuccinylation and improve mitochondrial metabolism,and neuroprotective effects of these agents have been observed in experimental stroke ***,their therapeutic efficacy in stroke patients should be validated.

关键词： mitochondria metabolism neuroprotection sirtuin 5 stroke succinylation modification

The biosynthesis of alarm pheromone in the wheat aphid Rhopalosiphum padi is regulated by hormones via fatty acid metabolism

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Journal of Integrative Agriculture 2024年第7期23卷 2346-2361页

作者： Chengxian Sun Yaoguo qin Julian Chen Zhengxi Li Department of Entomology/Ministry of Agriculture Key Laboratory for Monitoring and Environment-friendly Control of Crop Pests College of Plant ProtectionChina Agricultural UniversityBeijing 100193China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China

Aphids are major insect pests in agriculture and forestry *** attacks by natural enemies,many aphids release an alarm pheromone to protect their *** most aphids,the main component of the aphid alarm pheromone(AAP)is the sesquiterpene hydrocarbon(E)-β-farnesene(EβF).However,the mechanisms behind its biosynthesis and regulation remain poorly *** this study,we used the bird cherry–oat aphid Rhopalosiphum padi,which is an important wheat aphid,to investigate the regulatory mechanisms of EβF *** results showed that EβF biosynthesis occurs during the mature embryo period and the molting period of the 1st-and 2nd-instar *** provide the prerequisite material for EβF production and *** on transcriptome sequencing,RNAi analysis,hormone treatments,and quantitative measurements,we found that the biosynthesis of EβF utilizes acetyl coenzyme A produced from fatty acid degradation,which can be suppressed by juvenile hormone but it is promoted by 20-hydroxyecdysone through the modulation of fatty acid *** is the first systemic study on the modulation of EβF production in *** results of our study provide insights into the molecular regulatory mechanisms of AAP biosynthesis,as well as valuable information for designing potential aphid control strategies.

关键词： (E)-β-farnesene critical period for biosynthesis fatty acid metabolism juvenile hormone 20-hydroxyecdysone

Reproductive biology of Hemitripterus villosus in the Bohai Strait,China

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Journal of Oceanology and Limnology 2024年第3期42卷 881-892页

作者： Ping SUN Song qin Zhengyi LIU Longchuan ZHUANG Key Laboratory of Coastal Biology and Biological Resource Utilization Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China University of Chinese Academy of Sciences Beijing 100049China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China

To understand the reproductive biology of Hemitripterus villosus in the Bohai Strait,and fill the key knowledge gap in verifying reproductive seasonality and documenting gonadotropin dependent reproductive cycle of this species,a year-round detail study was conducted for the first *** total,263 individuals were randomly sampled off the coasts of the Bohai *** show that and the overall female-to-male ratio(1.35:1)did not differ significantly from the 1:1 sex *** length and weight relationship for females and males were regressed,depicting an isometric growth for both *** reproductive phases of the complete gonadotropin dependent reproductive cycle in both sexes were *** monthly variations in the gonadosomatic and hepatosomatic indexes for both sexes further indicated that this species spawns a single batch of eggs per year and the peak spawning period is from October to *** average diameter of eggs ranged from 2.10 to 3.57 *** length at first sexual maturity was 224.87 mm for females and 241.26 mm for *** positive relationships between absolute fecundity and fish size,and also gonadal weight were *** from the Bohai Strait exhibited smaller body size,smaller egg diameter,lower gonadosomatic index,lower absolute fecundity,and higher population extinction risk than the other populations’studied *** findings contribute to understanding the status of this isolated westernmost population,and we emphasize that more efficient protection measures for the species and control measures are urgently required to improve the coastal environment in the Bohai Strait.

关键词： Hemitripterus villosus Bohai Strait fecundity length at first maturity reproductive seasonality

Transient state analysis of a rub-impact rotor system during maneuvering flight

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Chinese Journal of Aeronautics 2024年第7期37卷 236-251页

作者： Jun WANG Yunfei LIU Zhaoye qin Liang MA Fulei CHU Beijing Key Laboratory of Health Monitoring and Self-Recovery for High-End Machinery Equipment Beijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China College of Aeronautical Engineering Civil Aviation University of ChinaTianjin 300300China

Maneuvering flight substantially affects the dynamic behavior of rotors;particularly,such flight may cause rubbing between a rotor and stator,which is one of the most serious damages in aircraft *** this paper,a nonlinear dynamic model for describing the dynamic characteristics of a rub-impact rotor system during maneuvering flight is established based on the Lagrange ***,numerical simulations employing the Newmark method are performed,delving into the detailed discussion of the influence of parameters such as rotational speed and maneuvering flight on the transient and steady-state responses of the rotor *** effect mechanism of maneuver load and its coupling with rub impact is *** results show that the impact response induced by maneuvering flight is more obvious in the subcritical state than in the supercritical *** additional stiffness and damping are also induced;in particular,the additional damping has a coupling ***,the rub impact imposes an additional constraint on the rotor system,thereby weakening the influence of the maneuver load and becoming the major factor that determines the dynamic behavior of the rotor system at high speeds.

关键词： Maneuvering flight Rub impact Rotor system Dynamic response Impact response

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On Depolymerization

CCS Chemistry 2024年第2期6卷 297-312页

作者： Bo qin Xi Zhang College of Chemistry and Chemical Engineering Hunan UniversityChangsha 410082 Department of Chemistry Tsinghua UniversityBeijing 100084

Polymers have become an essential part of modern life and the global economy on account of their costeffectiveness and versatile ***,most postconsumer polymer wastes are unrecycled,leading to environmental pollution and resource ***,as an efficient chemical recycling approach,holds great promise in establishing a circular polymer *** this review,we attempt to highlight recent and significant advancements in depolymerization *** key research topics are discussed:(1)depolymerization of commodity polymers to produce reusable monomers and high-value chemicals;(2)depolymerization of intrinsically depolymerizable *** is anticipated that this review will reflect the present status and future trends of this rapidly evolving realm of depolymerization.

关键词： depolymerization chemical recycling sustainable polymers circular polymer economy catalysis dynamic covalent chemistry

Path Tracking Controller Design of Automated Parking Systems via NMPC with an Instructible Solution

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 353-367页

作者： Liang Chen Zhaobo qin Manjiang Hu Yougang Bian Xiaoyan Peng State Key Laboratory of Advanced Design and Manufacturing Technology for Vehicle College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China Wuxi Intelligent Control Research Institute of Hunan University Wuxi 214115China

Parking difficulties have become a social issue that people have to *** parking system is practicable for quick par operations without a driver which can also greatly reduces the probability of parking *** paper proposes a Lyapunov-based nonlinear model predictive controller embedding an instructable solution which is generated by the modified rear-wheel feedback method(RF-LNMPC)in order to improve the overall path tracking accuracy in parking ***,A discrete-time RF-LNMPC considering the position and attitude of the parking vehicle is proposed to increase the success rate of automated parking ***,the RF-LNMPC problem with a multi-objective cost function is solved by the Interior-Point Optimization,of which the iterative initial values are described as the instructable solutions calculated by combining modified rear-wheel feedback to improve the performance of local optimal ***,the details on the computation of the terminal constraint and terminal cost for the linear time-varying case is *** closed-loop stability is verified via Lyapunov techniques by considering the terminal constraint and terminal cost ***,the proposed RF-LNMPC is implemented on a selfdriving Lincoln MKZ platform and the experiment results have shown improved performance in parallel and vertical parking *** Monte Carlo analysis also demonstrates good stability and repeatability of the proposed method which can be applied in practical use in the near future.

关键词： Automated parking Path tracking controller Nonlinear model predictive control Monte Carlo analysis

Chain Extender-induced Hydrogen Bonding Organization Determines the Morphology and Properties of Thermoplastic Polycarbonate Polyurethane

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Chinese Journal of Polymer Science 2024年第1期42卷 87-96,I0009页

作者： Yi-Lang qin Ping Zhu Chen-Xi Ouyang Xia Dong Fuwai Hospital Chinese Academyof Medical Sciences&Peking Union Medical College/National Center for Cardiovascular DiseasesBejing 100037China CASKey Laboratoryof Engineering Plastics CAS Research/Education Centerfor Excellence in Molecular SciencesInstitute ofChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Thermoplastic polycarbonate polyurethanes(PCUs) are multiblock copolymers that have been applied for medical devices for long time. Aliphatic diols are common chain extenders(CE) involved in the composition of the hard segments of PCU. However, limited knowledge was discovered about how the chemical structure of CE affects the hydrogen bonding organization within PCUs and their mechanical *** investigate this problem, a group of PCUs were synthesized respectively by extending the polymer chain with 1,4-butanediol(BDO),aminoethanol(MEA), ethanediol(EO) as three kinds of chain extenders. Tiny differences in the CE chemical structure results in remarkable variations in phase separation, condensed morphologies, thermal and mechanical properties, which are characterized by Fourier transform infrared spectrometer, atomic force microscopy, small-angle X-ray scattering, differential scanning calorimetry, and tensile tests. The microstructural evolution during unilateral deformation and the different mechanism induced by the different CEs was probed and unveil by in situ wide-and small-angle X-ray diffraction. Symmetry of CE can improve the organization of the hydrogen bonding. The coherence strength of the urethane/urea group also plays a key role by comparing the two PCUs with ethanediol and aminoethanol.

关键词： Thermoplastic polycarbonate polyurethane Chain extender Hydrogen bonding Mechanical properties

MOF-derived porous graphitic carbon with optimized plateau capacity and rate capability for high performance lithium-ion capacitors

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 395-404页

作者： Ge Chu Chaohui Wang Zhewei Yang Lin qin Xin Fan College of Materials Science&Engineering Guilin University of TechnologyGuilin 541004China Institute of Energy Innovation College of Materials Science and EngineeringTaiyuan University of TechnologyTaiyuan 030024China

The development of anode materials with high rate capability and long charge-discharge plateau is the key to improve per-formance of lithium-ion capacitors(LICs).Herein,the porous graphitic carbon(PGC-1300)derived from a new triply interpenetrated co-balt metal-organic framework(Co-MOF)was prepared through the facile and robust carbonization at 1300°C and washing by HCl *** as-prepared PGC-1300 featured an optimized graphitization degree and porous framework,which not only contributes to high plateau capacity(105.0 mAh·g^(−1)below 0.2 V at 0.05 A·g^(−1)),but also supplies more convenient pathways for ions and increases the rate capability(128.5 mAh·g^(−1)at 3.2 A·g^(−1)).According to the kinetics analyses,it can be found that diffusion regulated surface induced capa-citive process and Li-ions intercalation process are coexisted for lithium-ion ***,LIC PGC-1300//AC constructed with pre-lithiated PGC-1300 anode and activated carbon(AC)cathode exhibited an increased energy density of 102.8 Wh·kg^(−1),a power dens-ity of 6017.1 W·kg^(−1),together with the excellent cyclic stability(91.6%retention after 10000 cycles at 1.0 A·g^(−1)).

关键词： metal-organic framework porous graphitic carbon optimized plateau capacity kinetic analysis lithium-ion capacitor

Geochemical characteristics,generation,and evolution mechanism of coalbed methane in the south-western Ordos Basin,China

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Frontiers of Earth Science 2024年第2期18卷 296-311页

作者： Yabing LIN Yong qin Dongmin MA Shengquan WANG College of Geology and Environment Xi’an University of Science and TechnologyXi’an 710054China Key Laboratory of Coalbed Methane Resource and Reservoir Formation Process(the Ministry of Education) China University of Mining and TechnologyXuzhou 221008China Shaanxi Provincial Key Laboratory of Geological Support for Coal Green Exploitation Xi’an 710054China

The south-western Ordos Basin is rich in low-middle rank coalbed methane(CBM)resources;while the geochemical characteristics and genetic mechanism of CBM are not ***,according to geological and geochemical test data from gas and coal seam water from CBM wells in Bingchang,Jiaoxun,Huangling,Yonglong,and Longdong minging areas,we systematically studied the geochemical characteristics,generation,and evolution mechanism of CBM in Jurassic Yan’an Formation in the south-western Ordos *** results show that the CH4 content of whole gas is in the range of 42.01%-94.72%.The distribution ranges of theδ^(13)C-CH_(4)value is−87.2‰to−32.5‰,indicating diverse sources of thermogenic gas and biogenic *** microbial methane is mainly generated by a CO_(2)reduction pathway,with certain methyl-type fermentation ***δ^(13)C-CH_(4)has a positive correlation with burial depth,indicating the obvious fractionation of *** relationship between the genetic types and burial depth of the CBM reservoir indicates that the favorable depth of secondary biogenic gas is less than 660 *** Late Cretaceous Yanshanian Movement led to the uplift of the Ordos Basin,and a large amount of thermogenic gas escaped from the edge of the *** the Paleogene Period,the coal reservoir in the basin margin has received recharge from atmospheric precipitation,which is favorable for the formation of secondary biogenic *** deep area,generally under 1000 m,mainly contains residual thermogenic *** intermediate transition zone is mixed *** by the tectonic background,the genetic types of CBM in different mining areas are controlled by the coupling of burial depth,coal rank,and hydrogeological *** Binchang mining area contains biogenic gas,and the development of CBM has achieved initial success,indicating that similar blocks with biogenic gas formation conditions is key to the efficient development of *** research results provide a scientific basis for

关键词： coalbed methane stable isotopes geochemistry generation and evolution mechanism Ordos Basin