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Chemokine-like factor 1 (CKLF1) is expressed in myocardial ischemia injury in vivo and in vitro

BIOCELL 2024年第6期48卷 981-990页

作者： JULING FENG HAODONG CHEN YANGBO LIU qidi ai YANTAO YANG LEI ZHAO SHIFENG CHU NaiHONG CHEN School of Pharmacy Department of PharmacyHunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction PiecesHunan University of Chinese MedicineChangsha410208China Department of Pharmacology State Key Laboratory of Bioactive Substances and Functions of Natural MedicinesInstitute of Materia Medica&Neuroscience CenterChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100050China Department of Diagnostics Research Lab of Translational Medicine Hengyang Medical CollegeUniversity of South ChinaHengyang421001China Department of Gastrointestinal Surgery The First Affiliated HospitalHengyang Medical CollegeUniversity of South ChinaHengyang421001China

Introduction:Chemokine-like factor 1(CKLF1)is a chemokine that is overexpressed in several *** previousﬁndings revealed a signiﬁcant increase in CKLF1 expression in the ischemic brain,suggesting its potential as a therapeutic target for ischemic ***:In this study,we examined the expression dynamics of CKLF1 in both in vivo and in vitro models of ischemic cardiac *** infarction(MI)was induced in vivo by ligation of the left anterior descending artery(LAD)of the rat *** levels of CKLF1,Creatine Kinase MB Isoenzyme(CK-MB),and Lactate dehydrogenase(LDH)in the serum were detected using Enzyme-linked immunosorbent assay(ELISA).The expression of CKLF1 in the infarcted area was detected by immunohistochemistry,immunoﬂuorescence,quantitative PCR(qPCR),and Western blotting(WB).H9C2 and AC16 cardiomyocytes cultured in vitro were subjected to oxygen and glucose deprivation(OGD).LDH was used to detect cell damage,and CKLF1 expression was detected by qPCR and ***:CKLF1 mRNA and protein expression were signiﬁcantly increased in h9c2 cells at 1.5 h and in AC16 cells at 4 h after *** serum CK-MB in rats increased signiﬁcantly on theﬁrst day after infarction,while the LDH concentration increased signiﬁcantly on the third day after ***1 blood levels signiﬁcantly increased on theﬁrst day following MI in ***1 expression notably increased in the infarct area on days 1,3,and 7 *** MI tissue,CKLF1 colocalizes with cardiomyocytes,macrophages,and ***:CKLF1 was substantially expressed during myocardial ischemia injury both in vivo and in vitro and was colocalized with macrophages and neutrophils,indicating that CKLF1 is expected to be a biomarker and a drug target for the treatment of myocardial infarction.

关键词： Chemokine-like factor 1 Overexpression Myocardial infarction

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Morphological and molecular evidence for natural hybridization between Sorbus pohuashanensis and S. discolor (Rosaceae)

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Journal of Forestry Research 2024年第4期35卷 189-201页

作者： Yuxia Wu Xuedan Yu Wei Tang Wenhua Yang qidi Fu Yongqi Zheng Chuanhong Zhang State Key Laboratory of Tree Genetics and Breeding Research Institute of ForestryChinese Academy of ForestryBeijing 100091People’s Republic of China Beijing Waiyan Online Digital Technology Co. LtdBeijing 100081People’s Republic of China Huabanlv Nature Enlightenment Education Technology Co. LtdBeijing 100010People’s Republic of China

In overlapping distribution areas of Sorbus pohuashanensis and *** in North China(Mount Tuoliang,Mount Xiling and Mount Baihua),Sorbus indi-viduals were found with pink fruit,which have never been recorded for the flora of *** morphological characters combined with four chloroplast DNA markers and internal transcribed spacer(ITS)were used to analyze the origin of the Sorbus individuals with pink fruits and their relationship to *** and ***,SDA and one-way(taxon)ANOVA of morphological characters provided convincing evidence of the hybrid ori-gin of Sorbus individuals with pink fruits based on a novel morphological character and many intermediate *** analysis based on four cpDNA markers showed that either *** or *** were maternal parents of Sorbus individuals with pink ***-ence of the position of Sorbus individuals with pink fruits between cpDNA and ITS in cluster trees supported by DNA sequence comparative analysis,implying former hybridiza-tion events between *** and ***-tiple hybridization events between *** and *** might have contributed to the generation of Sorbus individuals with pink *** study has provided insights into hybridization between species of the same genus in sympatric areas,which is of great significance for the study of interspecific hybridization.

关键词： Hybridization ITS Chloroplast DNA Morphological characters Sorbus

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Specific *** valorem taxation and social welfare in mixed duopoly with foreign ownership

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Economic and Political Studies 2024年第2期12卷 207-219页

作者： Ming Sun Leonard F.S.Wang qidi Zhang School of Economics and Management Chang’an UniversityXi’anChina Wenlan School of Business Zhongnan University of Economics and LawWuhanChina

In this paper,we set up a mixed duopoly competition model between state-owned and private firms in order to compare specific and ad valorem *** that the total output under specific and ad valorem taxation remains unchanged,we find that if the public firm is completely privatised,the output of the private firm under the two tax schemes will be the *** the public firm is not completely privatised,the output of the the private firm under specific taxation will be greater than that under ad valorem *** the private firm is a pure local one,the social benefits will be the same under the two tax ***,if the private firm is a joint venture that involves domestic and foreign entities,social welfare under ad valorem taxation will be greater than that under specific taxation.

关键词： Specific taxation ad valorem taxation mixed duopoly imperfect competition privatisation foreign ownership

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Progress on immuno-microenvironment and immune-related therapies in patients with pseudomyxoma peritonei

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Cancer Biology & Medicine 2024年第7期21卷 586-605页

作者： qidi Zhao Tian Wei Ru Ma Yubin Fu Rui Yang Yandong Su Yang Yu Bing Li Yan Li School of Clinical Medicine Tsinghua UniversityBeijing 100084China Department of Surgical Oncology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Department of Peritoneal Cancer Surgery Bejing Shijitan HospitalCapital Medical UniversityBejing 100038China

Pseudomyxoma peritonei(PMP) is an indolent malignant syndrome. The standard treatment for PMP is cytoreductive surgery combined with intraperitoneal hyperthermic chemotherapy(CRS + HIPEC). However, the high recurrence rate and latent clinical symptoms and signs are major obstacles to further improving clinical outcomes. Moreover, patients in advanced stages receive little benefit from CRS + HIPEC due to widespread intraperitoneal metastases. Another challenge in PMP treatment involves the progressive sclerosis of PMP cell-secreted mucus, which is often increased due to activating mutations in the gene coding for guanine nucleotide-binding protein alpha subunit(GNAS). Consequently, the development of other PMP therapies is urgently needed. Several immune-related therapies have shown promise, including the use of bacterium-derived non-specific immunogenic agents, radioimmunotherapeutic agents, and tumor cell-derived neoantigens, but a well-recognized immunotherapy has not been established. In this review the roles of GNAS mutations in the promotion of mucin secretion and disease development are discussed. In addition, the immunologic features of the PMP microenvironment and immune-associated treatments are discussed to summarize the current understanding of key features of the disease and to facilitate the development of immunotherapies.

关键词： Pseudomyxoma peritonei tumor immuno-microenvironment immune-related therapy mucin 2 GNAS mutation

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基于双路细节关注网络的遥感影像建筑物提取

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武汉大学学报（信息科学版） 2024年第3期49卷 376-388页

作者：张卓尔潘俊舒奇迪武汉大学测绘遥感信息工程国家重点实验室湖北武汉430079

房屋等建筑物的分布情况是衡量地区发展的重要指标,利用遥感影像实现建筑物的自动高精度提取在指导城乡规划和市镇建设等方面具有重要意义。已有方法大多忽略了像素数较少的小面积建筑和边缘等细节信息的处理,针对此问题,提出了一种双... 详细信息

房屋等建筑物的分布情况是衡量地区发展的重要指标,利用遥感影像实现建筑物的自动高精度提取在指导城乡规划和市镇建设等方面具有重要意义。已有方法大多忽略了像素数较少的小面积建筑和边缘等细节信息的处理,针对此问题,提出了一种双路细节关注网络,将语义特征与细节关注特征双路并行优化,进一步提高了遥感影像中建筑物的提取精度。所提方法首先使用双路特征提取模块获取语义特征与细节关注特征,并在解码过程中进行双向优化,增强语义特征细节的同时提高细节关注特征的连续性与类别准确性,然后对二者进行融合,结合细节关注损失的监督,实现建筑物的高精度提取。在WHU建筑物数据集、ISPRS Vaihingen数据集与某地区国产高分数据集上,将所提方法与多种主流方法进行了对比验证,所提方法的F1分数和交并比均高于对比方法,且提取的建筑物完整性更好,小面积建筑漏检、误检率更低。

关键词：遥感影像建筑物提取全卷积神经网络深度学习特征优化

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我国基础货币投放机制的变迁、问题与建议——兼论央行购买国债的政策意图

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当代经济管理 2024年第9期46卷 87-96页

作者：张启迪中央财经大学国际金融研究中心北京100081

近期,市场对于中国人民银行在二级市场买卖国债的讨论逐渐增多。中国人民银行购买国债的核心政策意图在于基础货币投放,而非量化宽松。自1984年中国人民银行专门履行中央银行职能以来,基础货币投放机制发生了重要变迁。文章对基础货币... 详细信息

近期,市场对于中国人民银行在二级市场买卖国债的讨论逐渐增多。中国人民银行购买国债的核心政策意图在于基础货币投放,而非量化宽松。自1984年中国人民银行专门履行中央银行职能以来,基础货币投放机制发生了重要变迁。文章对基础货币投放机制进行了全面梳理,并对各种投放渠道的优缺点进行了深入分析。当前,基础货币投放机制正面临新变革。一方面,外汇占款已停止增长,降准空间愈发有限;另一方面,传统货币政策工具和新型货币政策工具均存在不足。政策建议方面,一是未来应将购买国债作为基础货币投放的主要渠道,二是购买国债应坚持独立性和纪律性,三是合理使用各种基础货币投放渠道,四是增持黄金可作为基础货币投放渠道的补充。

关键词：基础货币货币供应量外汇占款存款准备金中期借贷便利

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脑缺血中Bcl-2对自噬与凋亡的双重调控机制

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中药新药与临床药理 2020年第3期31卷 368-374页

作者：胡耀梅刘应蛟艾启迪阳松威罗林明罗飘刘芳陈乃宏湖南中医药大学药学院湖南长沙410208 中国医学科学院北京协和医学院药物研究所北京100050

脑缺血是一种高死亡率、高致残率的神经退行性疾病。脑缺血发病时,自噬与凋亡是缺血半暗带区神经元的主要死亡方式,减轻缺血半暗带区脑组织损伤和改善神经元症状是治疗脑缺血的重要措施。B淋巴细胞瘤-2基因(B-cell lymphoma-2,Bcl-2)不... 详细信息

脑缺血是一种高死亡率、高致残率的神经退行性疾病。脑缺血发病时,自噬与凋亡是缺血半暗带区神经元的主要死亡方式,减轻缺血半暗带区脑组织损伤和改善神经元症状是治疗脑缺血的重要措施。B淋巴细胞瘤-2基因(B-cell lymphoma-2,Bcl-2)不但是最经典的抗凋亡基因,而且与细胞的自噬通路密切相关。Bcl-2可以双重调控自噬与凋亡的信号通路,从而影响脑缺血后神经元的存活。该文分析了脑缺血与细胞自噬及凋亡的关系,并综述了Bcl-2介导的自噬与凋亡对脑缺血的作用及其双重调控机制,以期为中医药防治脑缺血研究提供新的靶点以及理论依据。

关键词：脑缺血 B淋巴细胞瘤-2基因自噬凋亡

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基于功率分离接收机方案的低复杂度信号检测算法

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通信学报 2024年第4期45卷 84-94页

作者：王艳艳李启迪唐小虎西南交通大学信息科学与技术学院四川成都611756 通号城市轨道交通技术有限公司北京100070

为了解决基于分离接收机架构下的移动通信系统中信号检测复杂度较高的问题,提出一种低复杂度的信号检测算法。首先,考虑天线噪声、后级处理噪声和功率分离因子的影响,设计分离接收机架构,并基于三维接收信号建立简化的二维接收信号模型... 详细信息

为了解决基于分离接收机架构下的移动通信系统中信号检测复杂度较高的问题,提出一种低复杂度的信号检测算法。首先,考虑天线噪声、后级处理噪声和功率分离因子的影响,设计分离接收机架构,并基于三维接收信号建立简化的二维接收信号模型。然后,在变换坐标系下表征二维接收信号的联合概率密度函数,进而提出基于最小距离的低复杂度的信号检测算法。最后,分析分离接收机方案相对于传统相干接收机的联合处理增益。理论分析表明,相比于传统的基于三维接收信号的检测算法,所提信号检测算法具有较低的计算复杂度。仿真结果表明,在一定的功率分离因子下,低复杂度信号检测所获得的近似误符号率(SER)与最优的SER性能接近,且分离接收机架构下的SER性能优于传统的相干接收机方案。

关键词：分离接收机信号检测相干接收机功率分配

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Epidemiology and genetic characterization of tet(X4)-positive Klebsiella pneumoniae and Klebsiella quasipneumoniae isolated from raw meat in Chengdu City, China

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Biosafety and Health 2024年第2期6卷 116-124页

作者： Weishuai Zhai Yiqing Wang Honghu Sun Bo Fu qidi Zhang Congming Wu Jianzhong Shen Dejun Liu Yang Wang National Key Laboratory of Veterinary Public Health and Safety College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China Technology Innovation Center for Food Safety Surveillance and Detection Sanya InstituteChina Agricultural University Sanya 572025China Irradiation Preservation Key Laboratory of Sichuan ProvinceChengdu Institute of Food InspectionChengdu 611135China Collge of Veterlnary Medicine Qingdao Agricultural UniversityQingdao 266109China

The rapid spread of mobile tigecycline resistance presents a significant public health threat,particularly with the increasing prevalence of tet(X4)-positive Enterobacterales across various *** study aimed to inves-tigate the epidemic features and transmission dynamics of tet(X4)-positive Klebsiella pneumoniae(***-niae)through the analysis of 206 raw meats,including pork(n=182),beef(n=16),duck(n=5),and chicken(n=3).These samples were collected from schools,markets,and restaurants in Chengdu City,China.A total of 25 isolates were obtained from 13 administrative *** isolates exhibited resistance to tetracycline,tigecycline,ampicillin,chloramphenicol,and *** half of the isolates also demon-strated resistance to streptomycin(80%),sulfamethoxazole/trimethoprim(72%),ciprofloxacin(64%),and ampicillin/sulbactam(56%).Among these strains,14 distinct sequence types(STs)were identified,revealing evidence of inter-regional clonal spread,notably among 9 *** *** analysis revealed the presence of two *** ST5 closely resembling hypervirulent *** from ***,12 isolates were capable of transferring tigecycline resistance to Escherichia coli *** plasmid analysis showed that the tet(X4)-harboring plasmids in *** could be classified into four types,primarily belonging to the IncFIA(HI1)/HI1A/HI1B hybrid plasmid(n=16)and IncFII plasmid(n=7),which significantly contributed to the cross-species dissemination of tet(X4).In summary,this study highlights the prevalence of MDR tet(X4)-positive *** in Chengdu,driven predominantly by clonal expansion and plasmid-mediated horizontal gene *** findings emphasize the importance of contin-uous surveillance of tet(X4)-positive *** in raw meat and the implementation of effective measures to control their spread.

关键词： tet(X4) Tigecycline K.pneumoniae Clonal spread Horizontal transfer

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直驱风电场并网对直流输电引起的火电机组轴系扭振影响机理分析

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电工技术学报 2024年第7期39卷 1971-1984页

作者：高本锋董涵枭卢亚军钟启迪河北省分布式储能与微网重点实验室(华北电力大学) 保定071003 国网经济技术研究院有限公司北京102209

火电机组与电网换相换流器高压直流输电(LCC-HVDC)间的次同步交互作用会引发火电机组轴系扭振(SSTI),而直驱风电场(DDWF)接入LCC-HVDC送端对SSTI阻尼特性的影响与机理尚未明确,相关研究有待开展。针对上述问题,该文基于DDWF与火电打捆经... 详细信息

火电机组与电网换相换流器高压直流输电(LCC-HVDC)间的次同步交互作用会引发火电机组轴系扭振(SSTI),而直驱风电场(DDWF)接入LCC-HVDC送端对SSTI阻尼特性的影响与机理尚未明确,相关研究有待开展。针对上述问题,该文基于DDWF与火电打捆经LCCHVDC送出系统,采用模块化建模法建立了小信号模型,使用特征值法分析了DDWF的接入与参数变化对LCC-HVDC引起的火电机组SSTI阻尼的影响;同时,针对特征值分析结果进行了机理分析。研究结果表明,DDWF会与火电机组共同承担LCC-HVDC的功率波动,削弱火电机组与LCC-HVDC间的次同步交互作用,从而增大SSTI阻尼,降低SSTI风险;当DDWF的容量增大、风速提升时,SSTI阻尼增大;当DDWF与LCC-HVDC整流站间电气距离增大时,SSTI阻尼降低;当LCC-HVDC整流侧由定电流控制转为定功率控制,或逆变侧由定电压控制转为定关断角控制时,SSTI阻尼降低。基于PSCAD/EMTDC平台进行了时域仿真,验证了特征值分析与机理分析的正确性。

关键词：电网换相换流器高压直流输电直驱风电场特征值分析轴系扭振风火打捆

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