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吸烟对老年腰椎间盘突出经皮脊柱内镜术后康复的影响

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中国老年保健医学 2024年第1期22卷 58-62页

作者：杜先龙于洋乔雪春黄天佑张鑫泮云浩锦州医科大学附属第一医院 121000 锦州医科大学朝阳市中心医院研究生培养基地 122000

目的研究吸烟对老年腰椎间盘突出患者行经皮脊柱内镜下腰椎间盘摘除术(PELD)术后康复的影响。方法回顾性分析2020年9月至2022年9月于锦州医科大学附属第一医院骨脊柱科行PELD治疗的老年患者98例,根据患者是否吸烟,分为吸烟组57例和对照... 详细信息

目的研究吸烟对老年腰椎间盘突出患者行经皮脊柱内镜下腰椎间盘摘除术(PELD)术后康复的影响。方法回顾性分析2020年9月至2022年9月于锦州医科大学附属第一医院骨脊柱科行PELD治疗的老年患者98例,根据患者是否吸烟,分为吸烟组57例和对照组41例。对两组患者的年龄、性别、体质量指数(BMI)、病程、手术节段、手术时间、手术入路、住院时间、围手术期并发症、术后12个月椎间隙高度和术后12个月内腰椎间盘突出复发情况及临床疗效进行比较分析。结果吸烟组与对照组的术前基本资料及围手术期治疗情况比较差异均无统计学意义(P>0.05)。吸烟组与对照组的复发率比较差异无统计学意义(P>0.05),但是吸烟组复发率(7.02%)远高于对照组(2.44%)。术后12个月时,对照组椎间隙高度为(9.19±1.25)mm,显著高于吸烟组的(8.69±0.67)mm,差异有统计学意义(P0.05),术后12个月对照组上述各项评分均优于吸烟组,差异有统计学意义(P<0.05)。结论吸烟可影响腰椎间盘突出症患者行PELD术后疗效康复的效果,为了获得更好的术后疗效,患者术后应戒烟。

关键词：经皮脊柱内镜腰椎间盘摘除术腰椎间盘突出吸烟

The SlWRKY57-SlVQ21/SlVQ16 module regulates salt stress in tomato

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Journal of Integrative Plant Biology 2023年第11期65卷 2437-2455页

作者： Jilin Ma Chonghua Li Lulu Sun xuechun Ma Hui qiao Wenchao Zhao Rui Yang Susheng Song Shaohui Wang Huang Huang Plant Science and Technology College Beijing University of AgricultureBeijing 102206China Beijing Key Laboratory for Agricultural Application and New Technique Beijing University of AgricultureBeijing 102206China College of Life Sciences Capital Normal UniversityBeijing 100048China

Salt stress is a major abiotic stress which severely hinders crop ***,the regulatory network controlling tomato resistance to salt remains ***,we found that the tomato WRKY transcription factor WRKY57 acted as a negative regulator in salt stress response by directly attenuating the transcription of salt-responsive genes(Sl RD29B and Sl DREB2)and an ion homeostasis gene(Sl SOS1).We further identified two VQ-motif containing proteins Sl VQ16 and Sl VQ21as Sl WRKY57-interacting *** VQ16 positively,while Sl VQ21 negatively modulated tomato resistance to salt *** VQ16 and Sl VQ21 competitively interacted with Sl WRKY57 and antagonistically regulated the transcriptional repression activity of Sl ***,the Sl WRKY57-Sl VQ21/Sl VQ16 module was involved in the pathway of phytohormone jasmonates(JAs)by interacting with JA repressors JA-ZIM domain(JAZ)*** results provide new insights into how the Sl WRKY57-Sl VQ21/Sl VQ16 module finely tunes tomato salt tolerance.

关键词： jasmonates salt stress tomato VQ protein WRKY transcription factor

p53 deficiency-induced Smad1 upregulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers

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Journal of Molecular Cell Biology 2015年第2期7卷 105-118页

作者： Xinsen Ruan qiao Zuo Hao Jia Jenny Chau Jinlin Lin Junping Ao xuechun Xia Huijuan Liu Samy LHabib Chuangang Fu Baojie Li Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai 200240China Department of Colorectal Surgery Changhai HospitalSecond Military Medical UniversityShanghai 200433China Institute of Molecular and Cell Biology Proteos61 Biopolis DriveSingapore 138673Singapore State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRenji HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 200032China Department of Cellular and Structural Biology University of Texas Health Science Center at San AntonioSan AntonioTX 78229USA

The DNA damage response helps to maintain genome integrity,suppress tumorigenesis,and mediate the effects of radiotherapy and *** previous studies have shown that Smad1 is upregulated and activated by Atm in DNA damage response,which can further bind to p53 and promote p53 *** report another aspect of the interplay between p53 and *** of rectal tumor against paired paraneoplastic specimens and analysis of>500 colorectal tumors revealed that Smad1 was upregulated in tumor samples,which was attributable to p53 *** MEFs as a model,we found that knockdown of the elevated Smad1 in p532/2 MEFs promoted cell proliferation,E1A/Ras-induced cell transformation,and *** studies suggest that elevated Smad1 and momentary activation inhibit cell proliferation by upregulating p57Kip2 and enhancing Atm–Chk2 ***,elevated Smad1 appears to have a negative effect on chemotherapy,as colorectal tumors,primary cancer cells,and cell lines with Smad1 knockdown all showed an increase in chemosensitivity,which could be attributable to elevated *** findings underscore the significance of Smad1–p53 interaction in tumor suppression and reveal an unexpected role for Smad1 in chemoresistance of colorectal cancers.

关键词： Smad1 p53 p57Kip2 chemoresistance colorectal cancer

Suppression of amplitude modulation induced by polarization mode dispersion using a multi-degree-of-freedom fiber filter

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High Power Laser Science and Engineering 2018年第4期6卷 5-15页

作者： Rao Li Youen Jiang Zhi qiao Canhong Huang Wei Fan xuechun Li Zunqi Lin National Laboratory on High Power Laser and Physics Shanghai 201800China Key Laboratory of High Power Laser and Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

Polarization mode dispersion(PMD) in fibers for high-power lasers can induce significant frequency modulation to amplitude modulation(FM-to-AM) conversion. However, existing techniques are not sufficiently flexible to achieve efficient compensation for such FM-to-AM conversion. By analyzing the nonuniform transmission spectrum caused by PMD, we found that the large-scale envelope of the transmission spectrum has more serious impacts on the amount of AM. In order to suppress the PMD-induced FM-to-AM conversion, we propose a novel tunable spectral filter with multiple degrees of freedom based on a half-wave plate, a nematic liquid crystal, and an axis-rotated polarizationmaintaining fiber. Peak wavelength, free spectral range(FSR), and modulation depth of the filter are decoupled and can be controlled independently, which is verified through both simulations and experiments. The filter is utilized to compensate for the PMD-induced FM-to-AM conversion in the front end of a high-power laser facility. The results indicate that, for a pulse with phase-modulation frequency of 22.82 GHz, the FM-to-AM conversion could be reduced from 18% to 3.2% within a short time and maintained below 6.5% for 3 h. The proposed filter is also promising for other applications that require flexible spectral control such as high-speed channel selection in optical communication networks.

关键词： advanced laser technology and applications design fiber laser and applications high-power laser laser facility laser facility and engineering laser systems modeling optimization

Progress of the injection laser system of SG-Ⅱ

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High Power Laser Science and Engineering 2018年第2期6卷 154-180页

作者： Wei Fan Youen Jiang Jiangfeng Wang Xiaochao Wang Dajie Huang Xinghua Lu Hui Wei Guoyang Li Xue Pan Zhi qiao Chao Wang He Cheng Peng Zhang Wenfa Huang Zhuli Xiao Shengjia Zhang xuechun Li Jianqiang Zhu Zunqi Lin National Laboratory on High Power Laser and Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China

A high power laser system was used to drive the ignition of inertial confinement fusion(ICF), of which the high energy,the uniform focal spot, the accurate laser waveform, and the synchronization between the laser beams are key *** accomplish this, global laser characteristics control should be assured, which was the main purpose of the injection laser system. In this paper, the key technological progress involved in the improvement of the performance of the injection laser of SG-II is reported, including frequency domain control, time domain control, near-field spatial shaping, preamplifier technology, and the optical parametric chirped pulse amplification pump source.

关键词： amplifier injection laser pulse shaping spatial shaping synchronization

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加气混凝土在外墙自保温体系中的应用分析

新型建筑材料 2009年第2期36卷 36-39页

作者：田学春董孟能陈乔重庆市建筑节能中心重庆400015 解放军后勤工程学院建筑工程系重庆400041

在当前建筑外墙保温技术中,自保温技术受到越来越大的关注,尤其是关于加气混凝土外墙自保温体系的应用和研究。结合夏热冬冷地区重庆的实际应用情况,具体分析了加气混凝土自保温体系常用构造及热桥处理方式、配套砂浆等一些常见问题,并... 详细信息

在当前建筑外墙保温技术中,自保温技术受到越来越大的关注,尤其是关于加气混凝土外墙自保温体系的应用和研究。结合夏热冬冷地区重庆的实际应用情况,具体分析了加气混凝土自保温体系常用构造及热桥处理方式、配套砂浆等一些常见问题,并针对施工提出了一些注意事项。

关键词：加气混凝土外墙自保温节能热桥砂浆

纤维素酶改性油莎豆粕可溶性膳食纤维结构与功能研究

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中国食品学报 2024年第7期24卷 241-251页

作者：周龙珠王朋董双王静丁雪纯杨娜王金荣乔汉桢甘利平河南工业大学生物工程学院郑州450001 中国农业科学院北京畜牧兽医研究所畜禽营养与饲养全国重点实验室北京100193 中国农业大学动物科学技术学院北京100193

以油莎豆粕为原料,通过复合酶法(α-淀粉酶、糖化酶和胰蛋白酶)提取油莎豆粕可溶性膳食纤维(SDF),采用纤维素酶对SDF进行酶解改性,优化纤维素酶酶解条件(酶添加量、酶解温度、酶解时间和酶解pH值),并比较改性前、后SDF含量、理化性质、... 详细信息

以油莎豆粕为原料,通过复合酶法(α-淀粉酶、糖化酶和胰蛋白酶)提取油莎豆粕可溶性膳食纤维(SDF),采用纤维素酶对SDF进行酶解改性,优化纤维素酶酶解条件(酶添加量、酶解温度、酶解时间和酶解pH值),并比较改性前、后SDF含量、理化性质、结构特性和抗氧化能力。结果表明,纤维素酶改性的最佳工艺条件是:pH值为6.5,酶解温度40℃,酶添加量0.9%,酶解时间2.5 h,SDF含量由3.55%增至10.86%。通过观察超微结构发现,改性使纤维结构改变,衍射峰强度减弱,改善了其结构特性,同时微观结构特性也得到改善。此外,纤维素酶改性使油莎豆粕SDF的持水力、膨胀性和持油力较改性前分别提高了54.58%,43.73%,38.40%;SDF质量浓度在0.5~5 mg/mL范围,改性后SDF对1,1-二苯基苦基苯肼(DPPH)自由基、2,2’-连氮-二(3-乙基苯并噻唑啉-6-磺酸),ABTS自由基和羟基自由基(·OH)的清除力显著提高,最高时分别达到42.87%,44.05%,41.46%,还原Fe^(3+)的能力在5 mg/mL时提高了1.25倍。本研究为进一步提升油莎豆粕的开发价值及其在食品和制药工业等方面应用提供参考。

关键词：油莎豆粕可溶性膳食纤维结构特性理化性质抗氧化能力

牙龈卟啉单胞菌脂多糖对巨噬细胞中铁死亡相关因子表达水平的影响

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吉林大学学报（医学版） 2022年第5期48卷 1148-1155页

作者：杜雪纯李保胜乔树伟欧燕珍李珍孟维艳吉林大学口腔医院口腔种植科吉林长春130021

目的:探讨牙龈卟啉单胞菌脂多糖(P.g-LPS)对巨噬细胞中铁死亡相关因子表达水平的影响,阐明铁死亡相关因子在牙周炎发病机制中的作用。方法:培养小鼠单核/巨噬细胞系RAW264.7细胞,分为实验组和对照组,实验组加入10 mg·L^(-1) P.g-LPS分... 详细信息

目的:探讨牙龈卟啉单胞菌脂多糖(P.g-LPS)对巨噬细胞中铁死亡相关因子表达水平的影响,阐明铁死亡相关因子在牙周炎发病机制中的作用。方法:培养小鼠单核/巨噬细胞系RAW264.7细胞,分为实验组和对照组,实验组加入10 mg·L^(-1) P.g-LPS分别处理6、12和24 h,对照组不做任何处理。采用实时荧光定量PCR(RT-qPCR)法检测2组RAW264.7细胞中长链酯酰辅酶A合成酶4(ACSL4)、谷胱甘肽过氧化物酶4(GPX4)和转铁蛋白受体1(TfR1)mRNA表达水平,2',7'-二氯荧光素二乙酸酯(DCFH-DA)荧光探针法检测2组RAW264.7细胞中活性氧(ROS)水平,硫代巴比妥酸(TBA)法检测2组RAW264.7细胞中丙二醛(MDA)水平,亚铁离子荧光探针(FeRhonox-1)法检测2组RAW264.7细胞中亚铁离子(Fe^(2+))水平,Westernblotting法检测2组RAW264.7细胞中ACSL4、GPX4和TfR1蛋白表达水平。结果:与对照组比较,处理6、12和24 h后,实验组RAW264.7细胞中GPX4 mRNA表达水平降低(P<0.05),处理12和24 h后ACSL4和TfR1 mRNA表达水平升高(P<0.05);处理12和24 h后,实验组RAW264.7细胞中ACSL4和TfR1蛋白表达水平升高(P<0.05),GPX4蛋白表达水平降低(P<0.05)。与对照组比较,实验组RAW264.7细胞中ROS、MDA和Fe^(2+)水平升高(P<0.05),且随时间增加呈上升趋势。结论:P.g-LPS诱导下RAW264.7细胞中铁死亡相关因子ACSL4和TfR1表达水平升高,而GPX4表达水平降低,并且呈时间依赖性,提示上述铁死亡相关因子的变化可能与牙周炎发病机制有关。

关键词：巨噬细胞牙龈卟啉单胞菌脂多糖铁死亡活性氧

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地诺前列酮阴道栓剂联合地西泮在足月初产妇引产中的效果观察

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武汉大学学报（医学版） 2024年第5期45卷 589-593页

作者：乔媛黄凤华李家福吴雪春陈慧君武汉大学中南医院产科湖北武汉430071

目的:探讨地诺前列酮阴道栓剂联合地西泮静脉推注用于低宫颈成熟度的足月初产妇无痛引产的临床效果及安全性。方法:采用信封法随机抽取100例拟阴道试产的初孕妇(Bishop评分<3分),分为观察组和对照组,观察组入组47例,对照组入组44例;观... 详细信息

目的:探讨地诺前列酮阴道栓剂联合地西泮静脉推注用于低宫颈成熟度的足月初产妇无痛引产的临床效果及安全性。方法:采用信封法随机抽取100例拟阴道试产的初孕妇(Bishop评分<3分),分为观察组和对照组,观察组入组47例,对照组入组44例;观察组地诺前列酮阴道栓剂取出后缓慢静脉推注地西泮10 mg,2 h后根据宫缩情况采用缩宫素引产;对照组取药后根据宫缩情况直接采用缩宫素引产。两组均在宫口开大3 cm采用硬脊膜穿破硬膜外阻滞麻醉进行分娩镇痛,比较两组产妇第1产程和总产程的时间、阴道分娩率、产后出血及新生儿窒息率。结果:观察组第一产程和总产程时间分布明显短于对照组,差异有统计学意义(P=0.004);观察组阴道分娩率(74.5%)明显高于对照组阴道分娩率(54.5%),差异有统计学意义(P=0.047);同时,两组新生儿窒息率差异无统计学意义(P=1.000)。结论:应用地诺前列酮阴道栓剂联合地西泮有助于缩短足月初产妇的产程,且对孕妇和新生儿无不良影响。

关键词：地诺前列酮阴道栓剂地西泮足月妊娠初产妇引产