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Structures and ion transport mechanisms of plant high-affinity potassium transporters

Molecular Plant 2024年第3期17卷 409-422页

作者： Jiangqin Wang Yanping Luo Fan Ye Zhong Jie Ding Shao Jian Zheng shuai qiao Yong Wang Jiangtao Guo Wei Yang Nannan Su international Institutes of Medicine the Fourth Affiliated HospitalZhejang University School of MedicineYiwuZhejiang 322000China Department of Biophysics and Department of Neurology of the Fourth Affiliated Hospital Zhejiang University School of MedicineHangzhouZhejang 310058China State Key Laboratory of Plant Environmental Resilience College of Life SciencesZhejang UniversityHangzhouZhejang 310058China College of Life Sciences Zhejiang UniversityHangzhouZhejiang 310058China NHC and CAMS Key Laboratory of Medical Neurobiology MOE Frontier Science Center for Brain Science and Brain-machine IntegrationSchool of Brain Science and Brain MedicineZhejiang UniversityHangzhouZhejiang 310058China Nanhu Brain-computer Interface Institute Hangzhou.Zheiang 311100.China

Plant high-affinity K^(+) transporters(HKTs)mediate Na^(+) and K^(+) uptake,maintain Na^(+)/K^(+) homeostasis,and therefore play crucial roles in plant salt tolerance.In this study,we present cryoelectron microscopy structures of HKTs from two classes,classI HKT1;1 from Arabidopsis thaliana(AtHKT1;1)and class II HKT2;1 from Triticum aestivum(TaHKT2;1),in both Na^(+) -and K^(+) -bound states at 2.6-to 3.0-A resolutions.BothAtHKT1;1and TaHKT2;1function ashomodimers.Each HKT subunit consists of four tan-dem domain units(D1-D4)with a repeated K^(+) -channel-like M-P-M topology.In each subunit,D1-D4 assemble into an ion conduction pore with a pseudo-four-fold symmetry.Although both TaHKT2;1and AtHKT1;1 have only one putative Na^(+) ion bound in the selectivity filter with a similar coordination pattern,the two HKTs display different K^(+) binding modes in the filter.TaHKT2;1 has three K^(+) ions bound in the selec-tivity filter,but AtHKT1;1 has only two K^(+) ions bound in the filter,which has a narrowed external entrance due to the presence of a Ser residue in the first filter motif.These structures,along with compu-tational,mutational,and electrophysiological analyses,enable us to pinpoint key residues that are critical for the ion selectivity of HKTs.The findings provide new insights into the ion selectivity and ion transport mechanisms of plant HKTs and improve our understanding about how HKTs mediate plant salt tolerance and enhance crop growth.

关键词： HKTs structure ion selectivity mechanism salt tolerance

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Refractive index sensing based on a twisted nano-kirigami metasurface

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Photonics Research 2024年第2期12卷 218-225页

作者： SHUQI qiao XIAOCHEN ZHANG QINGHUA LIANG YANG WANG CHANG-YIN JI XIAOWEI LI LAN JIANG shuai FENG HONGLIAN GUO JIAFANG LI School of Science Minzu University of ChinaBeijing 100081China Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(Ministry of Education) Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic Systemsand School of PhysicsBeijing Institute of TechnologyBeijing 100081China Laser Micro/Nano Fabrication Laboratory School of Mechanical EngineeringBeijing Institute of TechnologyBeijing 100081China

Plasmonic sensing technology has attracted considerable attention for high sensitivity due to the ability to effectively localize and manipulate light.In this study,we demonstrate a refractive index(RI)sensing scheme based on open-loop twisted meta-molecule arrays using the versatile nano-kirigami principle.RI sensing has the features of a small footprint,flexible control,and simple preparation.By engineering the morphology of meta-molecules or the RI of the ambient medium,the chiral surface lattice resonances can be significantly enhanced,and the wavelength,intensity,and sign of circular dichroism(CD)can be flexibly tailored.Utilizing the relation between the wavelength of the CD peak and the RI of the superstrate,the RI sensor achieves a sensitivity of 1133 nm/RIU.Additionally,we analyze these chiroptical responses by performing electromagnetic multipolar decomposition and electric field distributions.Our study may serve as an ideal platform for applications of RI measurement and provide new insights into the manipulation of chiral light–matter interactions.

关键词： twisted chiral index

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Global epidemiology of mental disorder in atrial fibrillation between 1998-2021:A systematic review and meta-analysis

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World Journal of Psychiatry 2024年第1期14卷 179-193页

作者： shuai Zhang Na Zhang Liu Liu Wang Zheng Zi-Lin Ma Si-Yu qiao Ying-Li Zhao Yi-Hong Wei Gang Wu Qiu-Ting Yu Bing Deng Lin Shen Department of Cardiology LongHua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

BACKGROUND As the burden of mental disorders among patients with atrial fibrillation(AF)increases,researchers are beginning to pay close attention to the risk and prevalence of these comorbidities.Although studies have independently analyzed the risk of comorbidity with depression and anxiety in patients with AF,no study has systematically focused on the global epidemiology of these two mental disorders.AIM To explore the prevalence of depression and anxiety in patients with AF.METHODS Five databases were searched from their date of establishment until January 2023.Observational studies reporting the comorbidity of AF with depression and anxiety,were included in this study.Basic information,such as the first author/publication year,study year,study type,and prevalence of depression and anxiety,were extracted.STATA SE 15.1 was used to analyze the data.Subgroup,meta-regression,and sensitivity analyses were performed to estimate study heterogeneity.RESULTS After a thorough search,26 studies were identified and included in this metaanalysis.The prevalence rates of depression and anxiety in adults with AF were 24.3%and 14.5%,respectively.Among adult males with AF,the prevalence was 11.7%and 8.7%,respectively,whereas in females it was 19.8%and 10.1%,respectively.In older adults with AF,the prevalence rates of depression and anxiety were 40.3%and 33.6%,respectively.The highest regional prevalence of depression and anxiety was observed in European(30.2%)and North American(19.8%)patients with AF.CONCLUSION In this study,we found that the prevalence of depression and anxiety among patients with AF varies with sex,region,and evaluation scales,suggesting the need for psychological interventions for patients with AF in clinical practice.

关键词： Atrial fibrillation Depression Anxiety Prevalence

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A contradictory phenomenon of thicken pericardium and cardiac compression without inferior vena cava dilation:sign of IVC escape

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Journal of Geriatric Cardiology 2024年第5期21卷 583-587页

作者： Tie-Nan CHEN Shuang ZHAO shuai qiao Yong-Yong HAN Qing LIU Chang-Le LIU Guang-Ping LI Tong LIU Hua-Ying FU Department of Cardiovascular Surgery Second Hospital of Tianjin Medical UniversityTianjinChina Department of Cardiology Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular DiseaseTianjin Institute of Cardi-ologyThe Second Hospital of Tianjin Medical UniversityTianjinChina Department of Oncology Second Hospital of Tianjin Medical UniversityTianjinPeople's Republic of China

A 77-year-old female presented with shortness of breath and tightness of chest was admitted.Her past medical history included hypertension and she has been taking nifedipine regularly.Two years before,she was diagnosed with pericardial effusion(Figure 1)and had pericardiocentesis drainage.On physical examination,her blood pressure was 151/100 mm-Hg and her pulse rate was 91 beats/min.

关键词： admitted cardiac thick

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Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain

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Science China(Life Sciences) 2024年第1期67卷 67-82页

作者： Chun-Kui Zhang Pan Wang Yuan-Yuan Ji Jian-shuai Zhao Jun-Xiang Gu Xian-Xia Yan Hong-Wei Fan Ming-Ming Zhang Yu qiao Xiao-Die Liu Bao-Juan Li Ming-Hui Wang Hai-Long Dong Hao-Hong Li Peng-Cheng Huang Yun-Qing Li Wu-Gang Hou Jin-Lian Li Tao Chen Department of Anatomy and K.K.Leung Brain Research Centre Fourth Military Medical UniversityXi’an 710032China Beijing Institute of Basic Medical Sciences Beijing 100850China Key Laboratory of Ministry of Public Health for Forensic Science Xi’an Jiaotong UniversityXi’an 710061China Department of Anesthesiology Xijing HospitalFourth Military Medical UniversityXi’an 710032China Department of Neurosurgery the Second Affiliated Hospital of Xian Jiaotong UniversityXi’an 710004China School of Biomedical Engineering Fourth Military Medical UniversityXi’an 710032China Affiliated Mental Health Centre and Hangzhou Seventh People’s Hospital Zhejiang University School of MedicineHangzhou 310013China The MOE Frontier Research Center of Brain&Brain-machine Integration Zhejiang University School of Brain Science and Brain MedicineHangzhou 310058China Department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Anatomy School of MedicineNorthwest UniversityXi’an 710069China

Chronic pain often develops severe mood changes such as depression.However,how chronic pain leads to depression remains elusive and the mechanisms determining individuals’responses to depression are largely unexplored.Here we found that depression-like behaviors could only be observed in 67.9%of mice with chronic neuropathic pain,leaving 32.1%of mice with depression resilience.We determined that the spike discharges of the ventral tegmental area(VTA)-projecting lateral habenula(LHb)glutamatergic(Glu)neurons were sequentially increased in sham,resilient and susceptible mice,which consequently inhibited VTA dopaminergic(DA)neurons through a LHbGlu-VTAGABA-VTADA circuit.Furthermore,the LHbGlu-VTADA excitatory inputs were dampened via GABAB receptors in a pre-synaptic manner.Regulation of LHb-VTA pathway largely affected the development of depressive symptoms caused by chronic pain.Our study thus identifies a pivotal role of the LHb-VTA pathway in coupling chronic pain with depression and highlights the activity-dependent contribution of LHbGlu-to-VTADA inhibition in depressive behavioral regulation.

关键词： chronic pain depression lateral habenula ventral tegmental area dopamine susceptibility

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一种基于图神经网络的社会化推荐算法

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东北大学学报（自然科学版） 2024年第1期45卷 10-17页

作者：吕艳霞郝帅乔广通邢烨东北大学秦皇岛分校计算机与通信工程学院河北秦皇岛066004

现有的社会化推荐算法大多着眼于用户购买或点击等单一的交互行为,并未同时考虑收藏、浏览等多种不同的交互行为.而且当前的社会化推荐算法重点只关注推荐的准确性,忽略了推荐结果的可解释性.针对以上问题,提出了一种基于图神经网络的... 详细信息

现有的社会化推荐算法大多着眼于用户购买或点击等单一的交互行为,并未同时考虑收藏、浏览等多种不同的交互行为.而且当前的社会化推荐算法重点只关注推荐的准确性,忽略了推荐结果的可解释性.针对以上问题,提出了一种基于图神经网络的社会化推荐算法SRGN,将用户的社交关系和物品间客观存在的语义联系以特定的方式注入到算法架构中,并且利用消息传递的方式实现交互的多行为联合编码,从而提升推荐的准确性.此外,设计了可解释模块为推荐结果提供推荐的理由.在两个真实数据集上与其他8种算法进行对比实验,结果表明提出的算法在推荐性能和用户友好性上具有明显的优势.

关键词：推荐系统社会化推荐图神经网络可解释推荐个性化推荐

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Stratigraphic framework and sedimentary evolution during the Cryogenian-Ediacaran transition in northeastern Sichuan Basin,South China

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Petroleum Science 2024年第2期21卷 823-835页

作者： Yi Zhang Hong-Wei Kuang Yong-Qing Liu Qiang Shi Dong-Ge Wang Ke-Ning Qi Yu-Chong Wang Da-Wei qiao Xiao-shuai Chen Li-Zhi Wu Meng Tian Long Chen Yi Wei Liao-Yuan Song Jian Li Zi-Gang Wu Yun-Qian Liu Xuan-Chun Liu An-Qing Chen Zhi-Wei Liao Institute of Geology Chinese Academy of Geological SciencesBeijing100037China State Key Laboratory of Coal Mine Disaster Dynamics and Control School of Resources and Safety EngineeringChongqing UniversityChongqing400044China No.205 Geological Team Chongqing Bureau of Geology and Minerals ExplorationChongqing401121China Chongqing Institute of Geological Survey Chongqing401122China Key Laboratory of Deep-time Geography and Environment Reconstruction and Applications of Ministry of Natural Resources Chengdu University of TechnologyChengdu610059SichuanChina

The northeastern Sichuan area in the northern Yangtze margin has unique Ediacaran geological records,especially the Doushantuo Formation(DST),and become a hot research area in recent years.However,the Cryogenian-Ediacaran(C-E)boundary has not been precisely identified,which restricts the in-depth study of geological information during this crucial transitional period and is unfavorable for a systematic and complete understanding of the Yangtze Block and even the global paleogeographic pattern.This study conducted stratigraphy,sedimentology,and chronostratigraphy to establish the stratigraphic framework and sedimentary evolution of the C-E transition strata in northeastern Sichuan.The results showed that the Ediacaran sediments,without the cap dolomite,unconformably overlaid the Cryogenian sediments in the studied area.The Member II of the DST,characterized by 50-160 m of red-green sandstone(approximately equivalent to the original Chengkou“Guanyinya Formation”),directly overlaid the Cryogenian sediments and displayed a 623±2.3 Ma maximum depositional age from the detrital zircon U-Pb dating.Regional stratigraphic correlations indicate that the C-E transition strata in northeastern Sichuan had a consistent lithological association and sedimentary sequence characteristics but differed from the Three Gorges.Typically,the upper Nantuo massive glacial diamictites transition to the icebergs rafted lonestone-bearing mudstones at the top,then change upward to DST barrier coast sandstones.The proposed DST of the northeastern Sichuan Basin was divided into three lithostratigraphic members without the regional Member I cap dolomite:(i)Member II purple-red,gray-green sandstone strata,(ii)MemberⅢblack mudstone strata,and(iii)Member IV P-Mn bearing strata.During the C-E transition,the study area experienced(i)the global deglaciation stage in the terminal Marinoan glaciation and(ii)the filling-leveling up stage with clastic rocks in the early Ediacaran.Overall,the early Ediacaran of northeastern Sichuan succeeded the paleogeogr

关键词： Marinoan glaciation Doushantuo formation Cap dolomite Deglacial and coastal deposits Detrital zircon U-Pb dating

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时序数据库关键技术综述

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计算机研究与发展 2024年第3期61卷 614-638页

作者：刘帅乔颖罗雄飞赵怡婧王宏安中国科学院大学计算机科学与技术学院北京100049 人机交互北京市重点实验室(中国科学院软件研究所) 北京100190

随着工业物联网(industrial Internet of things,IIoT)的不断发展,越来越多的设备和传感器开始连接到网络中,产生了大量的时间序列数据(简称“时序数据”),时序数据爆炸式的增长给数据库管理系统带来了新的挑战:持续高吞吐量数据摄取、... 详细信息

随着工业物联网(industrial Internet of things,IIoT)的不断发展,越来越多的设备和传感器开始连接到网络中,产生了大量的时间序列数据(简称“时序数据”),时序数据爆炸式的增长给数据库管理系统带来了新的挑战:持续高吞吐量数据摄取、低延迟多维度数据查询、高性能时间序列索引以及低成本数据存储.近年来时序数据库技术已经成为一个研究热点,一些学者对时序数据库技术进行了深入的研究,同时出现了一些专门用于管理时序数据的时序数据库,并且已经被应用在多个领域,成为工业物联网中不可缺少的关键组成.现有的时序数据库相关综述侧重于时序数据库的功能和性能比较,以及在特定领域中对时序数据库的选择建议,缺少对时序数据库持久化存储、查询、计算和索引等关键技术的研究,同时这些综述工作出现的时间较早,缺少对现代时序数据库关键技术的研究.对学术界时序数据存储研究和工业界时序数据库进行了全面的调查和研究,凝练了时序数据库的4类关键技术:1)时间序列索引优化技术;2)内存数据组织技术;3)高吞吐量数据摄取和低延迟数据查询技术;4)海量历史数据低成本存储技术.同时分析总结了时序数据库评测基准.最后,展望了时序数据库关键技术在未来的发展方向.

关键词：工业物联网时序数据时序数据库时序数据压缩时序数据存储

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基于摩擦系数变化的隧道口冰雪环境下路面防滑技术研究

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公路 2024年第3期69卷 385-392页

作者：乔建刚张帅泽王傑河北工业大学土木与交通学院天津市300401

为提高山区高速公路冰雪环境下隧道口行车安全和预防交通事故,探究山区高速隧道路段特殊天气和交通环境导致路面摩擦系数在不同天气条件和隧道口不同区段的变化,通过不同工况下路面摩擦系数室内试验,分析各工况下路面摩擦系数的变化规... 详细信息

为提高山区高速公路冰雪环境下隧道口行车安全和预防交通事故,探究山区高速隧道路段特殊天气和交通环境导致路面摩擦系数在不同天气条件和隧道口不同区段的变化,通过不同工况下路面摩擦系数室内试验,分析各工况下路面摩擦系数的变化规律。根据路面温度和路面环境相对湿度与路面模型系数的相互关系,构建摩擦系数~路面温湿度关系模型,对冰雪环境下不同天气的路面摩擦系数进行预测。研究结果表明:对试验测得不同工况下摩擦系数与所建立的模型计算得到的摩擦系数进行对比,3种路面状况下平均误差分别为9.99%、7.81%和9.88%,总体平均误差小于10%,吻合较好。根据预测结果,确定对于冰雪环境下隧道口路面防滑技术设置区段为距洞口-200 m~+60 m,即将向隧道纵深内部延伸60 m的距离,防滑措施技术建议在设置区段铺筑相变沥青混凝土。

关键词：山区高速公路路面摩擦系数冰雪环境隧道口关系模型

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Seasonal Variations of Mesospheric Densities Observed by Rayleigh Lidar at Golmud,Qinghai

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空间科学学报 2020年第2期40卷 207-214页

作者： DAI Yaru PAN Weilin qiao shuai HU Xiong YAN Zhaoai BAN Chao Near-space Environment Laboratory National Space Science CenterChinese Academy of SciencesBeijing 100190 Key Laboratory of Middle Atmosphere and Global Environment Observation Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029 University of Chinese Academy of Sciences Beijing 100049 Zhongneng Power-Tech Development Company of Limited Beijing 100034

From Aug.2013 to Oct.2015,a Rayleigh lidar has been used to study the middle atmosphere at Golmud(36.25°N,94.54°E),Qinghai,located in the northeastern part of the Tibetan Plateau.Mesospheric density profiles from 50 to 90 km were retrieved based on 205 nights of lidar observation,with a total of 1616hours of operation.We compared our lidar density measurements with SABER observations onboard TIMED satellite and MSIS-00 model data.The results showed that the annual mean density measured by lidar agreed well with SABER data,but both were lower than that of MSIS-00.All datasets exhibited dominant annual oscillation in the mesosphere.From 63 to 85 km,the annual amplitude of lidar density is larger than those of SABER and MSIS-00.PDD(Percentage of Density Difference)was calculated to investigate the mesospheric density climatology.The largest density variations of lidar,MSIS-00,and SABER occurred at around 72 km.Both lidar and SABER PDD reached their maximum in May,about one month earlier than the MSIS-00;while the minimum PDD appeared in late December for all datasets.

关键词： Lidar SABER MSIS model Mesospheric density Seasonal variations

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