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On Chevalley Restriction Theorem for Semi-reductive Algebraic Groups and Its Applications

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Acta Mathematica Sinica,English Series 2022年第8期38卷 1421-1435页

作者： Ke OU bin shu Yu Feng YAO School of Statistics and Mathematics Yunnan University of Finance and EconomicsKunming 650221P.R.China School of Mathematical Sciences East China Normal UniversityShanghai 200241P.R.China Department of Mathematics Shanghai Maritime UniversityShanghai 201306P.R.China

An algebraic group is called semi-reductive if it is a semi-direct product of a reductive subgroup and the unipotent radical.Such a semi-reductive algebraic group naturally arises and also plays a key role in the study of modular representations of non-classical finite-dimensional simple Lie algebras in positive characteristic,and some other cases.Let G be a connected semi-reductive algebraic group over an algebraically closed field F and g=Lie(G).It turns out that G has many same properties as reductive groups,such as the Bruhat decomposition.In this note,we obtain an analogue of classical Chevalley restriction theorem for g,which says that the G-invariant ring F[g]~G is a polynomial ring if g satisfies a certain“positivity”condition suited for lots of cases we are interested in.As applications,we further investigate the nilpotent cones and resolutions of singularities for semi-reductive Lie algebras.

关键词： Semi-reductive algebraic groups semi-reductive Lie algebras Chevalley restriction theorem nilpotent cone Steinberg map Springer resolution

Clinical and Angiographic Predictors of Major Side Branch Occlusion after Main Vessel Stenting in Coronary Bifurcation Lesions

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Chinese Medical Journal 2015年第11期128卷 1471-1478页

作者： Dong Zhang Bo Xu Dong Yin Yi-Ping Li Yuan He Shi-Jie You shu-bin qiao Yong-Jian Wu Hong-bing Yan Yue-Jin Yang Run-Lin Gao Ke-Fei Dou Department of Cardiology State Key Laboratory of Cardiovascular Disease Cardiovascular Institute Fuwai Hospital and National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background： Major side branch （SB） occlusion is one of the most serious complications during percutaneous coronary intervention （PCI） for bifurcation lesions. We aimed to characterize the incidence and predictors of major SB occlusion during coronary bifurcation intervention. Methods： We selected consecutive patients undergoing PCI （using one stent or provisional two stent strategy） for bifurcation lesions with major SB. All clinical characteristics, coronary angiography findings, PCI procedural factors and quantitative coronary angiographic analysis data were collected. Multivariate logistic regression analysis was performed to identify independent predictors of SB occlusion. SB occlusion after main vessel （MV） stenting was defined as no blood flow or any thrombolysis in myocardial infarction （TIMI） flow grade decrease in SB after MV stenting. Results： Among all 652 bifurcation lesions, 32 （4.91%） SBs occluded. No blood flow occurred in 18 lesions and TIMI flow grade decreasing occurred in 14 lesions. In multivariate analysis, diameter ratio between MV/SB （odds ratio [OR]： 7.71,95% confidence interval [C/]： 1.53-38.85, P = 0.01）, bifurcation angle （OR： 1.03, 95% CI： 1.02-1.05, P 〈 0.01）, diameter stenosis of SB before MV stenting （OR： 1.05, 95% CI： 1.03-1.07, P〈 0.01）, TIMI flow grade of SB before MV stenting （OR： 3.59, 95% CI： 1.48-8.72, P〈 0.01） and left ventricular eject fraction （LVEF）（OR： 1.06, 95% Cl： 1.02-1.11, P 〈 0.01） were independent predictors of SB occlusion. Conclusions： Among clinical and angiographic findings, diameter ratio between MV/SB, bifurcation angle, diameter stenosis of SB before MV stenting, TIMI flow grade of SB before MV stenting and LVEF were predictive of major SB occlusion after MV stenting.

关键词： Coronary Bifurcation Lesions Major Side Branch Occlusion Percutaneous Coronary Intervention

Impact of myocardial perfusion imaging on in-hospital coronary angiography and revascularization of patients with suspected coronary artery disease

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Chinese Medical Journal 2011年第11期124卷 1603-1609页

作者： HAN Ping-ping TIAN Yue-qin FANG Wei YANG Min-fu ZHANG Xiao-li SHEN Rui SUN Xiao-xin qiao shu-bin YANG Yue-jin HE Zuo-xiang Depamnent of Nuclear Medicine (Han PP Tian YQ Fang W YangMF Zhang XL Shen R Sun XX and He ZX) Department ofCardiology (Qiao SB and Yang YJ) Fuwai Hospital andCardiovascular Institute Chinese Academy of Medical Sciences &Peking Union Medical College Beijing 100037 China

Background Noninvasive cardiac imaging is now central to the diagnosis and management of patients with moderate probability for coronary artery disease. The aim of this study was to assess the impact of stress myocardial perfusion single photon emission computerized tomography （SPECT） on in-hospital coronary angiography and revascularization for such patients. Methods Between January 2005 and June 2007, 1053 consecutive in-hospital patients （423 women,

关键词： stress single photon emission computerized tomography coronary angiography revascularization hospitalization

定喘汤联合布地奈德福莫特罗治疗咳嗽变异性哮喘疗效及对外周血细胞间黏附分子-1、嗜酸细胞活化趋化因子的影响

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世界中西医结合杂志 2020年第1期15卷 107-110页

作者：赵小鹏乔树斌北京市丰台中西医结合医院呼吸与危重症医学科

目的定喘汤联合布地奈德福莫特罗治疗咳嗽变异性哮喘疗效及对外周血细胞间黏附分子-1(Intercellular Adhesion Molecule1,ICAM-1)、嗜酸细胞活化趋化因子(Eotaxin)的影响。方法将2014年11月~2017年11月于我院就诊的80例咳嗽变异性哮喘患... 详细信息

目的定喘汤联合布地奈德福莫特罗治疗咳嗽变异性哮喘疗效及对外周血细胞间黏附分子-1(Intercellular Adhesion Molecule1,ICAM-1)、嗜酸细胞活化趋化因子(Eotaxin)的影响。方法将2014年11月~2017年11月于我院就诊的80例咳嗽变异性哮喘患者,按照随机数字分组法分为两组,观察组与对照组各40例,其中对照组患者予以布地奈德福莫特罗治疗,观察组则采用定喘汤联合布地奈德福莫特罗进行治疗。治疗8周后,比较两组临床疗效、肺功能指标(FEV1、FEV1/FVC、PEF)及血清ICAM-1、Eotaxin水平,不良反应发生情况的差异。结果与对照组(临床总有效率为60.0%)相比,观察组疗效显著(临床总有效率为90.0%),且差异具有统计学意义(P<0.05);治疗后观察组患者FEV1/FVC、FEV1、PEF值均明显高于对照组,且差异具有统计学意义(P<0.05);治疗后,观察组患者ICAM-1以及Eotaxin水平明显低于对照组,且差异具有统计学意义(P<0.05);两组患者均未发生严重不良反应。结论定喘汤联合布地奈德福莫特罗能够显著改善咳嗽变异性哮喘患者的肺部功能,通过下调体内ICAM-1、Eotaxin水平,降低患者炎症反应,提高治疗效果。

关键词：定喘汤布地奈德福莫特罗咳嗽变异性哮喘 ICAM-1 Eotaxin

The prognostic value of collateral circulation in coronary chronic total occlusion underwent percutaneous coronary intervention

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Journal of Geriatric Cardiology 2024年第2期21卷 232-241页

作者： Xiao-Ying HU Wei-Xian YANG Chang-Dong GUAN Li-Hua XIE Ke-Fei DOU Yong-Jian WU Jin-Qing YUAN Jie QIAN Yue-Jin YANG shu-bin qiao Lei SONG Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina National Clinical Research Center for Cardiovascular Diseases BeijingChina Catheterization Laboratories Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

BACKGROUND The prognostic value of coronary collateral circulation(CC)in patients undergoing chronic total occlusion(CTO)percutaneous coronary intervention(PCI)is underdetermined.The purpose of the study was to assess the prognostic value of current two CC grading systems and their association with long-term outcomes in patients with CTO underwent PCI.METHODS We consecutively enrolled patients with single-vessel CTO underwent PCI between January 2010 and December2013.All patients were categorized into well-developed or poor-developed collaterals group according to angiographic Werner's CC(grade 2 vs.grade 0–1)or Rentrop(grade 3 vs.grade 0–2)grading system.The primary endpoint was 5-year cardiac death.RESULTS Of 2452 enrolled patients,the overall technical success rate was 74.1%.Well-developed collaterals were present in686 patients(28.0%)defined by Werner's CC grade 2,and in 1145 patients(46.7%)by Rentrop grade 3.According to Werner's CC grading system,patients with well-developed collaterals had a lower rate of 5-year cardiac death compared with those with poordeveloped collaterals(1.6%vs.3.3%,P=0.02),those with suboptimal recanalization was associated with higher rate of 5-year cardiac death compared with optimal recanalization(4.7%vs.0.8%,P=0.01)and failure patients(4.7%vs.1.6%,P=0.12).However,the similar effect was not shown in Rentrop grading system.CONCLUSIONS In patients with the single-vessel CTO underwent PCI,well-developed collaterals by Werner's CC definition were associated with lower rate of 5-year cardiac death.Werner's CC grading system had a greater prognostic value than Rentrop grading system in patients with CTO underwent PCI.

关键词： coronary collateral occlusion

基于影像计算的冠状动脉功能学评价的研究进展

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中国介入心脏病学杂志 2021年第11期29卷 648-651页

作者：马越宋雷乔树宾国家心血管病中心北京协和医学院中国医学科学院阜外医院冠心病中心北京100037

在冠状动脉疾病的临床评价方面,血流储备分数因能特异性地反映出冠状动脉病变的功能学特征,被国内外指南推荐应用于指导临界病变或多支病变患者血运重建策略的制订。随着近年来冠状动脉CT、冠状动脉造影、光学相干断层成像及血管内超声... 详细信息

在冠状动脉疾病的临床评价方面,血流储备分数因能特异性地反映出冠状动脉病变的功能学特征,被国内外指南推荐应用于指导临界病变或多支病变患者血运重建策略的制订。随着近年来冠状动脉CT、冠状动脉造影、光学相干断层成像及血管内超声等冠状动脉成像技术的不断进步,在成像的基础上,经人工模拟计算得出的新型冠状动脉功能学评价手段应运而生。本文对近年来基于影像计算的冠状动脉功能学评价主要研究进展进行综述。

关键词：冠状动脉疾病血流储备分数影像计算

Validation of Predictive Value of Patterns of Nonadherence to Antiplatelet Regimen in Stented Patients Thrombotic Risk Score in Chinese Population Undergoing Percutaneous Coronary Intervention:A Prospective Observational Study

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Chinese Medical Journal 2018年第22期131卷 2699-2704页

作者： Xue-Yan Zhao Jian-Xin Li Xiao-Fang Tang Jing-Jing Xu Ying Song Lin Jiang Jue Chen Lei Song Li-Jian Gao Zhan Gao shu-bin qiao Yue-Jin Yang Run-Lin Gao Ro Xu Jin-Qing Yuan Coronary Heart Disease Center State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Epidemiology State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

Background: The patterns of nonadherence to antiplatelet regimen in stented patients(PARIS) thrombotic risk score are a novel score for predicting the risk of coronary thrombotic events(CTEs) after percutaneous coronary intervention(PCI) with drug?eluting stents.However, the prognostic value of this score has not been fully evaluated in non?Euro?American PCI populations.Methods: We performed a prospective, observational study of 10,724 patients who underwent PCI in Fuwai hospital, China and evaluated the PARIS thrombotic risk score’s predictive value of CTEs in the PCI population. The area under the receiver operating characteristic curve(AUROC) was used to assess the predictive value of the PARIS score for CTE.Results: Among 9782 patients without in?hospital events, a total of 95 CTEs occurred during the 2?year follow?up. The PARIS score was significantly higher in patients with CTEs(3.38 ± 2.04) compared with patients without events(2.53 ± 1.70, P < 0.001).According to the risk stratification of the PARIS thrombotic score, the risk of CTEs in the high?risk group was 3.14 times higher than that in the low?risk group(hazard ratio [HR], 3.14; 95% confidence interval [CI], 1.92–5.13; P < 0.001). However, the risk of CTEs in the intermediate?risk and low?risk groups was not significant(HR, 1.39; 95% CI, [0.86–2.24]; P = 0.184). The PARIS score showed prognostic value in evaluating CTEs in the overall population(AUROC, 0.621; 95% CI, 0.561–0.681), the acute coronary syndrome(ACS) population(AUROC, 0.617; 95% CI, 0.534–0.700; P = 0.003), and the non?ACS population(AUROC, 0.647; 95%CI, 0.558–0.736; P = 0.001).Conclusions: In a real?world Chinese population, the PARIS thrombotic risk score shows a modest prognostic value for CTEs in patients after PCI. This score also has a predictive value for CTEs in the ACS and non?ACS subgroup populations.

关键词： Coronary Thrombosis Percutaneous Coronary Intervention Prognosis Risk Assessment

Evaluation of the Patterns of Non-Adherence to Anti-Platelet Regimens in Stented Patients Bleeding Score for Predicting the Long-term Out-of-hospital Bleeding Risk in Chinese Patients after Percutaneous Coronary Intervention

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Chinese Medical Journal 2018年第12期131卷 1406-1411页

作者： Xue-Yan Zhao Jian-Xin Li Xiao-Fang Tang Jing-Jing Xu Ying Song Lin Jiang Jue Chen Lei Song Li-Jian Gao Zhan Gao shu-bin qiao Yue-Jin Yang Run-Lin Gao Bo Xu Jin-Qing Yuan Department of Cardiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Department of Epidemiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background： The Patterns of Non-Adherence to Anti-Platelet Regimens in Stented Patients （PARIS） bleeding score is a novel score for predicting the out-of-hospital bleeding risk after percutaneous coronary intervention （PCI）. However, whether this score has the same value in non-European and American populations is unclear. This study aimed to assess the PARIS bleeding score＇s predictive value of bleeding in patients alter PCI in the Chinese population. Methods： We perforined a prospective, observational study of 10,724 patients who underwent PCI from January to December 2013, in Fuwai Hospital, China. We defined the primary end point as major bleeding （MB） according to Bleeding Academic Research Consortium definition criteria including Type 2, 3, or 5. The predictive value of the PARIS bleeding score was assessed with the area under the receiver operating characteristic （AUROC） curve. Results： Of 9782 patients, 245 （2.50%） MB events occurred during the 2 years of follow-up. The PAP, IS bleeding score was significantly higher in the MB group than that of non-MB group （4.00 [3.00, 5.00] vs. 3.00 [2.00, 5.00], Z=3.71, P 〈 0.001 ）. According to risk stratification of the PARIS bleeding score, the bleeding risk in the intermediate- and high-risk groups was 1.50 times （hazard ratio [HR]： 1.50; 95% confidence interval [CI]： 1.160-1.950; P=0.002） and 2.27 times higher （HR： 2.27; 95% CI： 1,320-3.900： P=0.003） than that in the low-risk group. The PARIS bleeding score showed a moderate predictive value for MB in the overall population （AUROC： 0.568, 95% CI： 0.532-0.605; P 〈 0.001 ） and acute coronary syndrome （ACS） subgroup （AUROC： 0.578, 95% CI： 0.530-0.626; P = 0.001 ） and tended to be predictive in the non-ACS subgroup （AUROC： 0.556, 95% CI： 0,501 0.611; P = 0.054）.

关键词： Bleeding： Percutaneous Coronary Intervention Prognosis

急性冠脉综合征患者血浆内脏脂肪素水平及其影响因素研究

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中国循环杂志 2010年第2期25卷 104-106页

作者：刘圣文乔树宾中国医学科学院北京协和医学院心血管病研究所阜外心血管病医院冠心病诊治中心北京市100037

目的:探讨急性冠脉综合征患者血浆内脏脂肪素水平及其影响因素。方法:根据临床表现和冠状动脉造影结果分为两组:急性冠脉综合征组100例和对照组51例。收集患者一般临床资料及生化指标;测定血浆内脏脂肪素、单核细胞趋化蛋白-1(MCP-1)、... 详细信息

目的:探讨急性冠脉综合征患者血浆内脏脂肪素水平及其影响因素。方法:根据临床表现和冠状动脉造影结果分为两组:急性冠脉综合征组100例和对照组51例。收集患者一般临床资料及生化指标;测定血浆内脏脂肪素、单核细胞趋化蛋白-1(MCP-1)、白细胞介素-6、高敏C反应蛋白(hs-CRP)、空腹血糖等细胞因子水平。结果:急性冠脉综合征组血浆内脏脂肪素水平较对照组明显升高13.4(11.1,15.9)ng/mL比10.2(8.7,12.8)ng/mL,P<0.05],调整年龄、性别、高血压、糖尿病、高脂血症和吸烟等因素后,差异依然存在。多元线性回归分析表明急性冠脉综合征患者内脏脂肪素与MCP-1、白细胞介素-6、空腹血糖呈正相关,回归系数β分别为0.003、0.080和0.358。结论:急性冠脉综合征患者血浆内脏脂肪素水平显著升高,与MCP-1、白细胞介素-6和空腹血糖水平密切相关。

关键词：内脏脂肪素急性冠脉综合征