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数值仿真方法在轮胎结构优化设计中的应用

轮胎工业 2008年第10期28卷 594-600页

作者：高明乔玲玲冯希金丁海峰三角轮胎股份有限公司山东威海264200

以8.25R20规格全钢载重子午线轮胎为例介绍数值仿真技术在轮胎结构优化设计中的应用,重点研究胎圈设计曲线对轮胎力学性能的影响。采用非线性有限元软件ABAQUS模拟分析3种胎圈曲线设计方案的轮胎从安装轮辋到充气、加载以及驱动状态下... 详细信息

以8.25R20规格全钢载重子午线轮胎为例介绍数值仿真技术在轮胎结构优化设计中的应用,重点研究胎圈设计曲线对轮胎力学性能的影响。采用非线性有限元软件ABAQUS模拟分析3种胎圈曲线设计方案的轮胎从安装轮辋到充气、加载以及驱动状态下的受力情况,并优选出优化方案试制8.25R20规格全钢载重子午线轮胎进行成品试验。结果表明,采用优选方案生产的轮胎耐久性能提高约30%。

关键词：全钢载重子午线轮胎有限元结构优化非线性

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang Jian Wu Hui Hong Wei Quan Xinyu qiao Chun Cui Chenmeng qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

Structural engineering of high-entropy alloys for advanced electrocatalytic reactions

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Tungsten 2025年第1期7卷 1-31页

作者： qiao Xie Ying-Jie Yu Hai-Jun Zhang Ya-Ping Deng Wen Lei The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and Technology Department of Chemical Engineering Waterloo Institute for Sustainable Energy Waterloo Institute for Nanotechnology University of Waterloo

High-entropy alloys(HEAs) have emerged as promising candidates to replace traditional precious metal catalysts,owing to their unique chemical and physical *** review commences by revisiting the fundamental concepts of HEAs,including their synthesis methods and structural control strategies in *** underscores the critical role of meticulously manipulating both macroscopic and microscopic structures of the HEAs to optimize their catalytic performance.A deep understanding of the structure-activity relationship in HEAs across various configurations is pivotal in developing more effective *** review methodically encapsulates the research progress of structural control strategies for HEAs in achieving efficient energy conversion,with the aim of gaining a better understanding of the relationship between structure and *** review concludes by summarizing the current achievements and challenges,and suggestions for potential future directions of HEAs in the fields of energy conversion and environmental purification.

关键词： Electrocatalytic Energy conversion High-entropy alloys Structural modulation

低分子肝素联合华法林治疗慢性阻塞性肺疾病临床疗效观察

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实用医院临床杂志 2017年第2期14卷 101-103页

作者：杜辛歌王迎难吴巧玲李培凌湖北省宜昌市第一人民医院&三峡大学人民医院呼吸与危重症医学科湖北宜昌443000

目的探讨低分子肝素联合华法林治疗慢性阻塞性肺疾病((chronic obstructive pulmonary disease,COPD)的临床疗效。方法选取我院收治的86例COPD患者,按随机数字表法分为观察组和对照组各43例。对照组在常规治疗基础上采用低分子肝素皮下... 详细信息

目的探讨低分子肝素联合华法林治疗慢性阻塞性肺疾病((chronic obstructive pulmonary disease,COPD)的临床疗效。方法选取我院收治的86例COPD患者,按随机数字表法分为观察组和对照组各43例。对照组在常规治疗基础上采用低分子肝素皮下注射,1次/天,6~7天为一个疗程;观察组在对照组基础上再口服华法林治疗。结果治疗后观察组总有效率、第一秒用力呼吸容积/用力肺活量(FEV1/FVC)及FEV1%pred比值明显高于对照组;呼吸困难指数评分及呼吸困难改善时间明显低于对照组(P<0.05)。结论低分子肝素联合华法林治疗COPD疗效显著,能显著改善患者肺功能和呼吸困难情况,缩短呼吸困难时间。

关键词：低分子肝素华法林慢性阻塞性肺疾病肺功能

Impact of Bubbles on Mechanical Performances in a Borosilicate Glass

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 25-29页

作者： LI Chengxing LI Dongfeng MA Shilong qiao Ang ZHENG Qingshuang China Helicopter Research and Development Institute Jingdezhen 333001China State Key Laboratory of Silicate Materials for Ar-chitectures Wuhan University of TechnologyWuhan 430070China

To analyze the impact of bubbles on the mechanical behavior of glasses,by controlling the refining time,we prepared three borosilicate glasses with the same composition and different *** the analysis software integrated within the optical microscope,the diameter and number of the bubbles on the surface of three borosilicate glasses were *** the hardness and crack initiation resistance(CR),we built the relationship between the porosity and the mechanical performance of these borosilicate glasses.

关键词： bubbles oxide glass hardness creak initiation resistance

Co/Co_(7)Fe_(3)heterostructures with controllable alloying degree on carbon spheres as bifunctional electrocatalyst forrechargeable zinc-air batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 476-487页

作者： Junkang Chen Yongyue Zhuang Yanxin qiao Yu Zhang Aihua Yuan Hu Zhou School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Exploring efficient and nonprecious metal electrocatalysts of oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)is crucial for developing rechargeable zinc-air batteries(ZABs).Herein,an alloying-degree control strategy was employed to fabricate nitrogen-doped carbon sphere(NCS)decorated with dual-phase Co/Co_(7)Fe_(3)heterojunctions(CoFe@NCS).The phase composition of materials has been adjusted by controlling the alloying *** optimal CoFe_(0.08)@NCS electrocatalyst displays a half-wave potential of 0.80 V for ORR and an overpotential of 283 mV at 10 mA·cm^(-2)for OER in an alkaline *** intriguing bifunctional electrocatalytic activity and durability is attributed to the hierarchically porous structure and interfacial electron coupling of highly-active Co_(7)Fe_(3)alloy and metallic Co *** the CoFe_(0.08)@NCS material is used as air-cathode catalyst of rechargeable liquid-state zinc-air battery(ZAB),the device shows a high peak power-density(157 mW·cm^(-2))and maintains a stable voltage gap over 150 h,outperforming those of the benchmark(Pt/C+RuO_(2))-based *** particular,the as-fabricated solid-state flexible ZAB delivers a reliable compatibility under different bending *** work provides a promising strategy to develop metal/alloy-based electrocatalysts for the application in renewable energy conversion technologies.

关键词： bifunctional electrocatalysts oxygen reduction reaction oxygen evolution reaction zinc-air battery metal/alloy carbon sphere

Hp感染与胃癌及胃癌前病变组织MUC2、MUC5AC、MUC6、CD10表达的关系

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中华医院感染学杂志 2022年第5期32卷 721-725页

作者：杨玉霞马丽莉高燕白菊芳郑有花乔玲玲张学成青海省人民医院消化内科青海西宁810000 青海省人民医院病理科青海西宁810000

目的探究幽门螺杆菌(Hp)感染与胃癌及胃癌前病变组织黏蛋白(MUC)2、MUC5AC、MUC6、CD10表达的关系。方法选择2018年6月-2020年6月青海省人民医院收治的209例胃癌患者(胃癌组)和184例胃癌癌前病变患者(胃癌前病变组),采用快速尿素酶试... 详细信息

目的探究幽门螺杆菌(Hp)感染与胃癌及胃癌前病变组织黏蛋白(MUC)2、MUC5AC、MUC6、CD10表达的关系。方法选择2018年6月-2020年6月青海省人民医院收治的209例胃癌患者(胃癌组)和184例胃癌癌前病变患者(胃癌前病变组),采用快速尿素酶试验(RUT)和改良 Giemsa染色法检测 Hp感染情况,收集胃病变组织标本,采用免疫组化法检测 MUC2、MUC5AC、MUC6、CD10蛋白表达情况,比较两组 Hp感染阳性率及MUC2、MUC5AC、MUC6、CD10蛋白表达水平,并分析 MUC2、MUC5AC、MUC6、CD10表达与 Hp感染的关系。结果胃癌组 Hp感染阳性率为69.38%(145/209),高于胃癌前病变组的54.35%(100/184)(P<0.05);免疫组化结果显示,胃癌组 MUC2、CD10表达阳性率高于胃癌前病变组(P<0.05),MUC5AC、MUC6表达阳性率低于胃癌前病变组(P<0.05);Hp感染阳性胃癌前病变及胃癌病灶组织中 MUC2、CD10表达阳性率高于 Hp感染阴性(P<0.05),Hp感染阳性胃癌前病变及胃癌病灶组织中 MUC5AC、MUC6表达阳性率低于 Hp感染阴性(P<0.05)。结论 Hp感染可促进胃癌 MUC2、CD10表达和抑制 MUC5AC、MUC6表达,MUC2、CD10上调表达与MUC5AC、MUC6下调表达以及 Hp感染均为胃癌发生和发展的重要因素。

关键词：幽门螺杆菌胃癌胃癌前病变组织黏蛋白2 黏蛋白5AC 黏蛋白6 CD10

手术室路径化护理联合多模式疼痛护理对子宫肌瘤手术效果及疼痛程度的影响

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罕少疾病杂志 2025年第1期32卷 179-181页

作者：尚小巧张玲玲陈晶南阳市第二人民医院妇科河南南阳473000

目的探究手术室路径化护理联合多模式疼痛护理对子宫肌瘤手术效果及疼痛程度的影响。方法选取2019年7月至2024年7月期间于本院接受手术治疗的子宫肌瘤患者110例,按护理方案分为两组,对照组(n=60)患者接受常规护理,观察组(n=50)患者接... 详细信息

目的探究手术室路径化护理联合多模式疼痛护理对子宫肌瘤手术效果及疼痛程度的影响。方法选取2019年7月至2024年7月期间于本院接受手术治疗的子宫肌瘤患者110例,按护理方案分为两组,对照组(n=60)患者接受常规护理,观察组(n=50)患者接受手术室路径化护理联合多模式疼痛护理。比较两组患者的围术期手术指标、疼痛程度、负性情绪、舒适度以及并发症发生情况。结果干预前,两组SAS、SDS及GCQ评分差异均不显著(P>0.05)。干预后,观察组排气时间、排便时间、下床时间、住院时间、术后各时间点的VAS评分、SAS评分、SDS评分、并发症总发生率均显著低于对照组(P<0.05);GCQ评分显著高于对照组(P<0.05)。结论在接受手术治疗的子宫肌瘤患者中,实施手术室路径化护理联合多模式疼痛护理,可有效改善患者的疼痛程度及负性情绪,显著提高患者的舒适度,明显减少并发症的发生,利于患者术后恢复。

关键词：手术室路.径化护理多模式疼痛护理子宫肌瘤手术效果疼痛程度

Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration

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Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： Ronglin Han Lanxin Luo Caiyan Wei Yaru qiao Jiming Xie Xianchao Pan Juan Xing Department of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina Department of Medicinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamide polydimethylsiloxane stiffness