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Synthesis and Crystal Structure of a Novel Ternary Ni(II) Complex with 2-Hydroxyl-1,10- phenanthroline and 2-Hydroxynicotinic Acid as ligands

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Chinese Journal of Structural Chemistry 2006年第6期25卷 747-751页

作者： WANG Jian-Ge DU qiao-Yun li Peng-Yun Department of Chemistry Luoyang Normal University Luoyang 471022 China

A novel ternary complex of [NiL1L2·2H2O]·NO3·H2O （L1 = 2-hydroxyl-1,10-phenanthroline （HOphen）, L2 = 2-hydroxynicotinic acid （H2nicO）） was synthesized, and its crystal structure was determined by X-ray diffraction and further characterized by infrared and elementary analysis. The title complex （C18H18NiN4O10, Mr = 509.07） belongs to the triclinic system, space group P1^- with a = 712490（7）, b = 11.0164（10）, c = 13.3864（13）A, α = 91.6040（10）,β= 98.8620（10）, γ= 107.1140（10）°, V= 1006.43（17）A^3, Z = 2, Dc = 1.680 g/cm^3,μ= 1.032 mm^-1, F（000） = 524, the final R = 0.0461 and wR= 0.1238. In the complex, the Ni（H） ion is six-coordinated to assume a distorted octahedral geometry, and a 3D supramolecular network comes into being via weak intermolecular interactions of X-O--.H （X = N, O）.

关键词： 2-hydroxyl-1,10-phenanthroline 2-hydroxynicotinic acid nickel complex crystal structure

Dynamics in small worlds of tree topologies of wireless sensor networks

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Journal of Systems Engineering and Electronics 2012年第3期23卷 325-334页

作者： qiao li Baihai Zhang Zhun Fan Athanasios V.Vasilakos School of Automation Beijing Institute of TechnologyBeijing 100081R R.China Department of Mechanical Engineering Technical University of Denm arkKongens Lyngby 2800Denmark Department of Computer and Telecommunications Engineering University of Western MacedoniaKozani GR 50100Greece

Tree topologies, which construct spatial graphs with large characteristic path lengths and small clustering coefficients, are ubiquitous in deployments of wireless sensor networks. Small worlds are investigated in tree-based networks. Due to link ad- ditions, characteristic path lengths reduce rapidly and clustering coefficients increase greatly. A tree abstract, Cayley tree, is con- sidered for the study of the navigation algorithm, which runs auto- matically in the small worlds of tree-based networks. In the further study, epidemics in the small worlds of tree-based wireless sen- sor networks on the large scale are studied, and the percolation threshold is calculated, at which the outbreak of the epidemic takes place. Compared with Cayley tree, there is a smaller percolation threshold suffering from the epidemic.

关键词： epidemic navigation algorithm small world tree topology.

腰椎压缩性骨折的护理干预措施及应用效果分析

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智慧健康 2024年第16期10卷 107-109,119页

作者：李心雨李乔姜婷王宏刘丹牡丹江医科大学附属红旗医院黑龙江牡丹江157000

目的探究对腰椎压缩性骨折患者进行综合护理干预的效果。方法选择2021—2022年本院收治的60例腰椎压缩性骨折患者作为研究对象。将2021年收治的30例患者纳入对照组,采取常规护理方式;将2022年收治的30例患者纳入观察组,采取综合护理方... 详细信息

目的探究对腰椎压缩性骨折患者进行综合护理干预的效果。方法选择2021—2022年本院收治的60例腰椎压缩性骨折患者作为研究对象。将2021年收治的30例患者纳入对照组,采取常规护理方式;将2022年收治的30例患者纳入观察组,采取综合护理方式。比较两组患者的心理情绪、并发症发生率、康复效果。结果护理后,观察组汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)得分较对照组更低(P<0.05);观察组并发症发生率较对照组更低(P<0.05);康复效果比较,观察组护理后椎体前缘高度较对照组更高,观察组Cobb角较对照组更低(P<0.05)。结论腰椎压缩性骨折护理中,综合护理干预可有效改善患者心理状态,减少并发症的发生,促进康复,值得推广。

关键词：腰椎压缩性骨折综合护理干预心理情绪生活质量并发症康复效果

Effects of hypothalamic paraventricular nuclei on apoptosis and proliferation of gastric mucosal cells induced by ischemia/reperfusion in rats

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World Journal of Gastroenterology 2007年第6期13卷 874-881页

作者： li li Yong-Mei Zhang Wei-li qiao lin Wang Jian-Fu Zhang Department of Pathophysiology Xuzhou Medical College 84 West Huaihai Road Xuzhou 221002 Jiangsu Province China Department of Physiology Xuzhou Medical College 84 West Huaihai Road Xuzhou 221002 Jiangsu Province China Department of Neurobiology Xuzhou Medical College 84 West Huaihai Road Xuzhou 221002 Jiangsu Province China Department of Histology and Embryology Xuzhou Medical College 84 West Huaihai Road Xuzhou 221002 Jiangsu Province China

AIM： To investigate the effects of electrical stimulation of hypothalamic paraventricular nuclei （PVN） on gastric mucosal cellular apoptosis and proliferation induced by gastric ischemia/reperfusion （I/R） injury. METHODS： For different experimental purposes, stimulating electrode plantation or electrolytic destruction of the PVN was applied, then the animals＇ GI/R injury model was established by clamping the celiac artery for 30 min and allowing reperfusing the artery for 30 rain, 1 h, 3 h or 6 h respectively. Then histological, immunohistochemistry methods were used to assess the gastric mucosal damage index, the gastric mucosal cellular apoptosis and proliferation at different times. RESULTS： The electrical stimulation of PVN significantly attenuated the GI/R injury at 30 min, i h and 3 h after reperfusion. The electrical stimulation of PVN decreased gastric mucosal apoptosis and increased gastric mucosal proliferation. The electrolytic destruction of the PVN could eliminate the protective effects of electrical stimulation of PVN on GI/R injury. These results indicated that the PVN participated in the regulation of GI/R injury as a specific area in the brain, exerting protective effects against the GI/R injury, and the protection was associated with the inhibition of cellular apoptosis and the promotion of gastric mucosal proliferation. CONCLUSION： Stimulating PVN significantly inhibits the gastric mucosal cellular apoptosis and promots gastric mucosal cellular proliferation. This may explain the protective mechanisms of electrical stimulation of PVN against GI/R injury.

关键词： Hypothalamic paraventricular nuclei Gastric ischemia/reperfusion Proliferation Apoptosis

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1例D-二聚体高于FDP的原因分析

医药论坛杂志 2024年第4期45卷 441-444,F0003页

作者：宋迪乔莹利张绮思阜外华中心血管病医院检验科郑州450000

目的报道1例由异嗜性抗体影响,导致患者血浆D-二聚体(D-dimer)高于纤维蛋白(原)降解产物(FDP)的病例,为临床诊疗提供帮助。方法主要采用更换检测系统的平行试验,多倍稀释试验,异嗜性抗体阻断剂(Heterophilic antibody blocking reagent,... 详细信息

目的报道1例由异嗜性抗体影响,导致患者血浆D-二聚体(D-dimer)高于纤维蛋白(原)降解产物(FDP)的病例,为临床诊疗提供帮助。方法主要采用更换检测系统的平行试验,多倍稀释试验,异嗜性抗体阻断剂(Heterophilic antibody blocking reagent,HBR)或二硫苏糖醇(dithiothreitol,DTT)处理的方法识别并纠正假性增高的D-二聚体。结果更换检测系统后,D-二聚体的测定结果在正常范围内;稀释试验提示D-二聚体和稀释倍数之间无线性关系,随着稀释倍数的增加,D-二聚体呈先上升后下降的趋势;HBR或DTT处理后D-二聚体分别为0.60 mg/L FEU、0.50 mg/L FEU,均显著低于初始结果。结论该病例D-二聚体高于FDP的原因为异嗜性抗体引起的D-二聚体假性增高,可通过更换检测系统、HBR或DTT处理的方法纠正。

关键词： D-二聚体纤维蛋白(原)降解产物异嗜性抗体干扰

一种改良的博来霉素诱导的肺纤维化模型造模方法

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空军军医大学学报 2024年第4期45卷 425-429页

作者：李乔王苗风田宇赵峰空军军医大学西京医院呼吸内科陕西西安710032

目的建立博来霉素诱导的小鼠肺纤维化模型,比较经气管滴注和经气管吸入两种不同给药方式的成模差异。方法选择6~8周C57BL/6雄性小鼠46只,取6只小鼠随机分为经气管滴注组和经气管吸入组,每组3只。小鼠麻醉后分别经气管滴注和吸入亚甲蓝,... 详细信息

目的建立博来霉素诱导的小鼠肺纤维化模型,比较经气管滴注和经气管吸入两种不同给药方式的成模差异。方法选择6~8周C57BL/6雄性小鼠46只,取6只小鼠随机分为经气管滴注组和经气管吸入组,每组3只。小鼠麻醉后分别经气管滴注和吸入亚甲蓝,观察小鼠双肺和胃内亚甲蓝的分布。取另40只小鼠随机分为经气管滴注+生理盐水组、经气管吸入+生理盐水组、经气管滴注+博来霉素组、经气管吸入+博来霉素组。观察各组小鼠造模后的精神状态、体质量变化和生存状况,并在第21日取肺组织用于组织学、羟脯氨酸和TGF-β、α-SMA和COL1A1等蛋白水平Western blotting检测。结果经气管滴注组,亚甲蓝不均匀且局限地分布于双肺,伴不同程度胃内残留。经气管吸入组,亚甲蓝较均匀且弥散地分布于双肺,无明显胃内残留。与两对照组相比,两模型组小鼠精神状态欠佳,体质量下降明显,死亡率升高;小鼠肺组织肺泡结构破坏严重,伴大量胶原沉积,羟脯氨酸含量显著升高(P<0.05),Western blotting显示肺组织TGF-β、α-SMA和COL1A1等蛋白的表达显著增多(P<0.05)。结论经气管吸入+博来霉素组小鼠纤维化病灶分布更加均匀,各项指标相对稳定,是建立肺纤维化模型理想的方法。

关键词：肺纤维化博来霉素经气管给药疾病模型

Dexmedetomidine mediates the mechanism of action of ferroptosis in mice with Alzheimer’s disease by regulating the mTOR-TFR1 pathway

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世界精神病学杂志 2023年第8期13卷 511-523页

作者： li qiao Gang li Hong-Xun Yuan Intensive Care Unit Peking University International HospitalBeijing 102206China

BACKGROUND Alzheimer’s disease(AD)is the most common neurodegenerative disorder,and there are currently no effective drugs to delay progression of the *** may play a vital part in AD,and is therefore receiving increasing attention by *** To investigate the effects of dexmedetomidine(Dex)on ferroptosis in AD mouse *** Hippocampal neurons(HNs)HT22 were induced by amyloidβ-protein(Aβ)and both in vitro and in vivo AD mouse models were prepared via *** cellcounting kit-8 assay and immunofluorescence technique were adopted to determine cell proliferation activity and intracellular Fe2+levels,and the TBA method and microplate method were employed for malondialdehyde and glutathione measurements,*** tissue damage was determined using hematoxylin and eosin and Nissl *** learning and memory ability in each group was assessed by the Morris water maze test,and the expression levels of mammalian target of rapamycin(mTOR)signal molecules and ferroptosis-related proteins transferrin receptor 1(TFR1),SLC7A11 and glutathione peroxidase 4 were examined by western *** Dex enhanced lipid peroxidation and iron influx in mouse HNs in both in vitro and in vivo experiments,while inhibition of the mTOR axis blocked this *** findings demonstrate that Dex can inhibit ferroptosis-induced damage in mouse HNs by activating mTOR-TFR1 signaling to regulate ferroptosis-associated proteins,thus alleviating cognitive dysfunction in AD *** Dex can activate the mTOR-TFR1 axis to inhibit ferroptosis in mouse HNs,thereby improving the learning and memory ability of mice.

关键词： Dexmedetomidine Ferroptosis Alzheimer’s disease Mammalian target of rapamycin Mice

Analysis of the extremely cold and heavy snowfall in North America in January 2015

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Atmospheric and Oceanic Science Letters 2016年第2期9卷 75-82页

作者： CUI Hong-yan qiao Fang-li First Institute of Oceanography State Oceanic Administration Key Laboratory of Marine Science and Numerical Modeling State Oceanic Administration

With global warming and declining Arctic sea ice area in autumn observed by satellites since 1979, anomalous cold snaps in recent winters have affected large parts of North America, Europe, and East Asia. In January 2015, North America suffered extremely cold and heavy snowfall events. As revealed in this paper, the NCEP reanalysis data show that the temperature decreased significantly in January 2015 in North America, including the air temperature in the troposphere and the surface air temperature. Moreover, snow cover increased obviously in January 2015 in North America, while there was a significant negative anomaly of geopotential height. The wind formed the anomalous pattern, which favored cold currents blowing to the North American continent from the polar region, and bringing plenty of water vapor. Our results suggest that the anomalous north wind and decreasing westerly jet stream, which allowed cold and moist air to easily penetrate the North American continent from the Arctic, was one of the main reasons for the extremely cold and heavysnow winter of 2015 in North America.

关键词： Snowfall cold winter atmospheric circulation geopotential height strong north wind

红外热成像评估联合经络取穴冲击波治疗腰椎间盘突出症的效果

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广东医学 2024年第6期45卷 723-727页

作者：彭丽娜陶青云张巧利台州骨伤医院治未病科浙江温岭317500 台州骨伤医院筋伤科浙江温岭317500 台州骨伤医院冲击波治疗室浙江温岭317500

目的探讨红外热成像评估经络取穴冲击波治疗腰椎间盘突出症的效果。方法前瞻性选取台州骨伤医院筋伤科收治确诊为腰椎间盘突出症患者72例,按照单双数随机选择分为对照组(采用阿是穴冲击波治疗)和治疗组(采用经络取穴冲击波治疗),每组36... 详细信息

目的探讨红外热成像评估经络取穴冲击波治疗腰椎间盘突出症的效果。方法前瞻性选取台州骨伤医院筋伤科收治确诊为腰椎间盘突出症患者72例,按照单双数随机选择分为对照组(采用阿是穴冲击波治疗)和治疗组(采用经络取穴冲击波治疗),每组36例。于两组患者术前、术后1个月和术后3个月,分别比较两组患者红外热成像热图温度均值;比较两组患者疼痛视觉模拟(VAS)评分、日本骨科协会(JOA)评分、Oswestry功能障碍指数(ODI)评分;检测并比较两组患者C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6);比较两组患者行走步态数据(步长、步速、步频、支撑相百分比);比较两组患者治疗3个月后的疗效。结果术后3个月,治疗组的红外热成像热图温度均值、VAS评分、ODI评分、CRP水平、TNF-α水平、IL-6水平和支撑相百分比均低于对照组(均P0.05)。治疗组和对照组的治疗总有效率分别为97.22%和77.78%,差异有统计学意义(P<0.05)。结论采用红外热成像联合经络取穴冲击波治疗腰椎间盘突出症可有效改善患者的临床症状,减轻疼痛和炎症反应,改善腰椎结构和功能,疗效较佳,且不良反应较小,可在临床推广应用。

关键词：腰椎间盘突出症红外热成像经络取穴冲击波治疗疗效