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基于循证医学证据规范高眼压症的诊疗

中华医学杂志 2024年第24期104卷 2195-2199页

作者：乔春艳王思宇首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科研究所北京市眼科学与视觉科学重点实验室北京

高眼压症是指眼压升高但未引起青光眼性视神经改变或视野损伤的一种状态, 在40岁以上人群中的患病率高达4%～10%。美国高眼压症治疗研究(OHTS)指出, 高眼压症患者的原发性开角型青光眼(POAG)发病率逐年上升, 因此有必要对其进行长期随... 详细信息

高眼压症是指眼压升高但未引起青光眼性视神经改变或视野损伤的一种状态, 在40岁以上人群中的患病率高达4%～10%。美国高眼压症治疗研究(OHTS)指出, 高眼压症患者的原发性开角型青光眼(POAG)发病率逐年上升, 因此有必要对其进行长期随访。本文详述了高眼压症进展为POAG的五大基本危险因素, 包括年龄、眼压、垂直杯盘比、视野模式标准差和中央角膜厚度, 并介绍了其他潜在危险因素, 如眼压的长期波动、双眼眼压及视野的不对称性、视盘的结构内表型及视盘出血。根据危险因素可预测高眼压症进展为POAG的风险, 不同风险的患者开始治疗的时机和随访时间间隔不同, 风险大者应更早开始预防性治疗, 且随访间隔时间较短。药物治疗和选择性激光小梁成形术(SLT)均可作为高眼压症的初始治疗方式。结合循证医学研究证据和个体化评估治疗, 可更有效地提高高眼压症的临床诊疗水平。

关键词：高眼压青光眼, 开角型循证医学

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Leptolaimus holovachovi sp. nov. (Nematoda) from Shenzhen Mangrove Nature Reserve, Shenzhen, South China

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Journal of Oceanology and Limnology 2020年第6期38卷 1907-1913页

作者： qiao chunyan JIA Susu HUANG Yong College of Life Sciences Liaocheng UniversityLiaocheng 252059China Key Laboratory for Ecological Conservation and Biodiversity of Institution of Higher Learning of Shandong Province Liaocheng 252059China

A new free-living marine nematode species of the genus Leptolaimus belonging to the family Leptolaimidae was collected from intertidal sediments of the Shenzhen Mangrove Nature Reserve,Shenzhen,South China,and it is described here as Leptolaimus holovachovi *** new species is characterized by body length 734-896μm in males and 822-941μm in females;papilliform cephalic sensilla;circular amphideal fovea;males with 7-14 anterior midventral alveoli in the pharyngeal region,4-5 midventral tubular precloacal supplements and 4-6 alveolar precloacal supplements;spicules slender,slightly arcuate,proximally cephalated and distally ***-like gubernaculum without *** new species differs from other congener species of the genus by the unique feature of having anterior midventral alveoli in the pharyngeal region.

关键词： new species free-living marine nematode taxonomy South China Sea

车网互动背景下小区电动汽车充放电商业模式研究

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电气应用 2024年第6期43卷 24-30页

作者：尹宏源龚成尧乔春彦国网浙江省电力有限公司杭州供电公司浙江杭州310016 杭州市新能源汽车服务有限公司浙江杭州310012 国网浙江电动汽车服务有限公司浙江杭州310013

主要研究了车网互动背景下,从充电设施负荷聚合商视角考虑,对小区内电动汽车充放电开展调控,实现配电网安全运行、负荷聚合商收益和客户出行需求多方共赢。首先,分析了小区各类用电负荷特性及车网互动技术原理;其次,建立了小区电动汽车... 详细信息

主要研究了车网互动背景下,从充电设施负荷聚合商视角考虑,对小区内电动汽车充放电开展调控,实现配电网安全运行、负荷聚合商收益和客户出行需求多方共赢。首先,分析了小区各类用电负荷特性及车网互动技术原理;其次,建立了小区电动汽车充放电优化双层模型,以小区等效负荷曲线的峰谷差最小为外层优化的目标函数,求解确定电动汽车作用下的负荷曲线最小峰谷差及各时段电动汽车总充放电功率安排,以负荷聚合商收益最大为内层优化的目标函数,结合外层优化得到的总充放电功率安排为约束具体求解;最后,采用设定算例对所提充放电策略进行了验证,仿真结果表明所提策略可以明显降低小区负荷峰谷差,并帮助负荷聚合商建立可持续发展的商业模式。

关键词：电动汽车车网互动居住区负荷聚合商

A Polysaccharide-based Hydrogel and PLGA Microspheres for Sustained P24 Peptide Delivery: An In vitro and In vivo Study Based on Osteogenic Capability

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Chemical Research in Chinese Universities 2019年第5期35卷 908-915页

作者： CAI Qing qiao chunyan NING Jun DING Xinxin WANG Haoyang ZHOU Yanmin Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling School of StomotologyJilin UniversityChangchun 130021P.R.China The First Hospital of Jilin University Changchun 130021P.R.China

A bone morphogenetic protein-2(BMP-2) derived synthetic oligopeptide, S [PO4]KIPKASSVPTELSAISTLYLDDD(P24), has shown great potential for facilitating bone regeneration. However, P24 cannot be directly used onto bone defects, while a continuous sustained delivery of P24 may lead to a better formation of bone tissue. Based on this issue, we have developed a sustained delivery system incorporating P24-loaded poly(lactide-co-glycolide)(PLGA) microspheres and nano-hydroxyapatite(n-HA) into the composite hydrogel. The P24-contained compound material was characterized with NMR, FTIR and SEM to demonstrate the fomiation of compound structure containing P24, PLGA and n-HA. A continuous drug release of P24 was observed for over 60 d that evidently enhanced the efficiency in promoting the proliferation of MC3T3-E1 cells and the secrete of alkaline phosphatase(ALP) in vitro. Moreover, the osteoinduction eflect of the hydrogel system with P24 peptide niicrospheres was demonstrated in vivo and manifested by the result of immunohistochemistry. This novel injectable composite hydrogel is expected to be applied to improving the bone defect treatment in bone tissue engineering.

关键词： BMP-2 derived peptide Hydrogel PLGA microsphere Osteogenesis Tissue engineering

Efficacy of a Nutritional Cream Intervention to Treat Depression in Rescuers:A Randomized Controlled Trial

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Biomedical and Environmental Sciences 2024年第7期37卷 754-761页

作者： qiao Wang Hengyu Luan chunyan Li Rufang Gong Qiongxuan Li Jiayi Deng Xiaoyong Sai Department of Statistics and Epidemiology The Graduate School of the Chinese PLA General HospitalBeijing 100853China Comprehensive Internal Medicine Western Medical Branch of PLA General HospitalBeijing 100144China Department of Respiratory The First Medical Center of PLA General HospitalBeijing 100853China Department of Pharmacy Intravenous Admixture Services(PIVAS) The First Medical Center of PLA General HospitalBeijing 100853China

Objective To explore the effectiveness of a nutritional intervention in rescuers who screened positive for *** A randomized controlled trial design was *** June to August,2022,4,460 rescuers were screened using the Self-Rating Depression Scale(SDS),and 1,615 positive cases were ***-one volunteers were recruited and randomly divided into a nutritional intervention group and a control *** intervention group received health education and nutritional intervention(a compound paste therapy primarily composed of red roses and Seville orange flowers),while the control group received psychological *** scores were assessed before and after the *** There was a statistically significant decline in SDS scores in the nutritional intervention group after the intervention(P<0.05).Furthermore,the SDS scores of the intervention group were significantly lower than those of the control group,both before and after the intervention(P<0.05).No severe adverse reactions were observed during safety *** The nutritional intervention effectively reduced the depression scores in *** nutritional intervention is recommended for rescuers who initially screen positive for depression.

关键词： Nutritional intervention Rescuers Depression Randomized controlled trial

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先天性青光眼的手术治疗进展

中华眼科杂志 2014年第8期50卷 626-629页

作者：苗森乔春艳首都医科大学附属北京安贞医院眼科 100029 首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科学与视觉科学重点实验室

先天性青光眼是一类严重影响儿童视功能的疾病.与成人青光眼不同,药物治疗仅能作为辅助治疗方法,抗青光眼手术作为其主要有效治疗方法应尽早实施.先天性青光眼的手术方式较多,近年来随着技术的不断发展,小梁切开仪的临床应用、360.小梁... 详细信息

先天性青光眼是一类严重影响儿童视功能的疾病.与成人青光眼不同,药物治疗仅能作为辅助治疗方法,抗青光眼手术作为其主要有效治疗方法应尽早实施.先天性青光眼的手术方式较多,近年来随着技术的不断发展,小梁切开仪的临床应用、360.小梁缝线切开术等创新的手术方式逐渐被应用于先天性青光眼的治疗,并取得了较好的疗效.同时,随着内镜技术在眼内的应用逐渐成熟,内镜辅助下进行的前房角切开术及睫状体光凝术,突破了传统手术方式的限制,扩大了经典手术方式的适用范围.本文主要对先天性青光眼的不同手术方式及最新进展进行综述.

关键词：青光眼内窥镜检查小梁切除术青光眼引流植入物激光凝固术

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真实世界研究中眼科病例注册登记研究现状

中华眼科杂志 2023年第2期59卷 150-154页

作者：张烁乔春艳首都医科大学附属北京同仁医院北京同仁眼科中心、北京市眼科研究所、北京市眼科学与视觉科学重点实验室北京100730

近年出现的一种新的研究理念,即真实世界研究(RWS)主要依靠注册登记研究(registration study)及大数据管理,对实际临床诊疗实践或健康体检中的真实效果、风险等进行评价。本文比较了RWS与随机对照试验的差异,并总结了目前国内外医疗领域... 详细信息

近年出现的一种新的研究理念,即真实世界研究(RWS)主要依靠注册登记研究(registration study)及大数据管理,对实际临床诊疗实践或健康体检中的真实效果、风险等进行评价。本文比较了RWS与随机对照试验的差异,并总结了目前国内外医疗领域RWS中注册登记研究的现状,尤其近年眼科学领域病例注册登记研究的应用进展,以期在未来临床工作中,能够有更多的医疗机构和医师依托病例注册登记系统进行随访,开展多中心、大样本RWS。

关键词：实用性临床试验(主题) 眼科学眼疾病登记数据管理

A visible-light-assisted Pd/TiO_(2)gas sensor with carbon nanotubes electrodes for trace formaldehyde detection

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Rare Metals 2024年第1期43卷 257-266页

作者： Can Liu qiao-qiao Zou Bin Liu Yong Zhang School of Physics and Optoelectronics Xiangtan UniversityXiangtan 411105China Hunan Institute of Advanced Sensing and Information Technology Xiangtan UniversityXiangtan 411105China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105China

Owing to the ppb-level detection standard toward the toxic and harmful gas,the detection of trace gases has become an important subject in the field of indoor environment ***,the traditional resistive gas sensors hardly meet the requirement due to the weak signal generated by trace gas molecules that are difficult to ***,a visible-light-assisted Pd/TiO_(2)gas sensor is proposed to endow the effective detection of trace formaldehyde(HCHO)gas without heating *** from the enhanced photocatalytic properties of TiO_(2)by Pd decoration,the visible-light-assisted Pd/TiO_(2)gas sensor can detect the HCHO gas as low as80×10^(–9)at room *** successful preparation of nanoscale TiO_(2)sensing layer is facilitated by the ultrathin carbon nanotube interdigital electrode in the gas sensor,which avoids the discontinuity of the sensing layer caused by the excessive thickness of the traditional metal *** addition,the whole preparation process of the Pd/TiO_(2)gas sensor with carbon nanotube electrodes is compatible with mainstream CMOS fabrication technology,which is expected to realize the batch fabrication and micro-integrated application of gas *** is expected that our work can provide a new strategy for the batch preparation of high-performance trace HCHO gas sensors and their future applications in portable electronic devices such as smartphones.

关键词： Visible-light-assisted gas sensor Pd/TiO_(2) Trace HCHO detection Carbon nanotubes electrodes

原发性闭角型青光眼相关解剖结构遗传度的研究进展

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中华眼科杂志 2018年第11期54卷 864-867页

作者：杨晓晗乔春艳首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科学与视觉科学重点实验室100730

青光眼是全球首位不可逆性致盲眼病,原发性闭角型青光眼(PACG)则是青光眼的常见类型之一.研究表明PACG的发病与多种因素相关,其中包括眼解剖因素和遗传易感性.与PACG发病相关的解剖结构,如前房深度、晶状体的相对位置及厚度、房角状态... 详细信息

青光眼是全球首位不可逆性致盲眼病,原发性闭角型青光眼(PACG)则是青光眼的常见类型之一.研究表明PACG的发病与多种因素相关,其中包括眼解剖因素和遗传易感性.与PACG发病相关的解剖结构,如前房深度、晶状体的相对位置及厚度、房角状态、眼轴长度等均具有遗传倾向,而遗传度正是量化遗传倾向的指标,因此遗传度研究为解释疾病的遗传易感性以及理解疾病的发病机制提供了重要线索.本文针对与PACG有关的解剖结构遗传度研究进行综述,以期为临床研究提供参考.(中华眼科杂志.20i8.54:864-867)。

关键词：青光眼闭角型前房晶体轴长度眼疾病遗传易感性