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World Journal of Integrated Traditional and Western Medicine 2022年第2期8卷 25-30页

作者： qiang wen-jing HAN Zu-cheng YUAN Jie WANG Ruo-lan First Clinical Medical College of Shaanxi University of Chinese Medicine Xianyang 712046China Shaanxi Provincial Hospital of Traditional Chinese Medicine Xi'an 710004China

Objective:Using data mining method to dig and sort out the prescriptions with Acorus tatarinowiiPolygala tenuifolia drug pair,and summarize the medication characteristics and compatibility of their prescriptions after preliminary ***:By searching the Dictionary of Traditional Chinese Medicine Prescriptions,a standardized database of prescriptions was established,and the properties,tastes and meridian tropism of prescriptions were classified,and the indications of prescriptions and core combinations of traditional Chinese medicines were ***:178 prescriptions were collected,of which 210 were *** of the drugs were warm in nature and sweet in taste,and mainly return to the heart and kidney *** the same confidence and different support,the core drug combination for treating brain diseases was Acorus tatarinowiiPolygala tenuifolia-Ginseng,and the core drug combination for treating asthenia was Acorus tatarinowii-Poria cocos-Rehmannia glutinosa-Polygala ***:The compatibility characteristics of the prescriptions containing Acorus Tatarinowii and Polygala tenuifolia in the Dictionary of Traditional Chinese Medicine Prescriptions are remarkable,which provides reference for scientific guidance of clinical rational drug use and basic research of prescriptions containing Acorus tatarinowii and Polygala tenuifolia.

关键词： Acorn tatarinowii Polygala tenuifolia Drug pair Medication law Dictionary of TCM Prescriptions Data mining

Effects of the extrusion parameters on microstructure,texture and room temperature mechanical properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 136-146页

作者： Chenjin Zhang Guangyu Yang Lei Xiao Zhiyong Kan jing Guo qiang Li Wanqi Jie State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China College of Chemistry and Environmental Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed *** dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical-rare-earth(RE)*** alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening *** results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.

关键词： Mg-rare earth alloys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms

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波浪漫滩边界对波生流数值计算的影响

海洋科学进展 2017年第2期35卷 176-188页

作者：汪鸿朱首贤李训强张文静聂屿解放军理工大学气象海洋学院江苏南京211101 河海大学海洋学院江苏南京211101

波浪漫滩是近岸波浪的小尺度运动,在实际海域的波生流数值计算中通常被忽略。本文基于Boussinesq方程的FUNWAVE模式,分别采用波浪漫滩边界、固壁边界、海绵边界进行Haller波浪港池物理模型实验的数值模拟,比较三种边界计算结果与实验观... 详细信息

波浪漫滩是近岸波浪的小尺度运动,在实际海域的波生流数值计算中通常被忽略。本文基于Boussinesq方程的FUNWAVE模式,分别采用波浪漫滩边界、固壁边界、海绵边界进行Haller波浪港池物理模型实验的数值模拟,比较三种边界计算结果与实验观测数据的误差,检验波浪漫滩边界对波生流数值计算的影响;然后设计了多种周期、波高的波生流数值模拟试验,分析多种波浪入射条件下波浪漫滩边界对近岸波生流数值计算的影响。结果表明,波浪漫滩对邻近区域波生流有明显影响,漫滩边界下的波生流计算结果更接近实验观测值,在近岸波生流数值模型中引入波浪漫滩边界可以提高波生流计算精度。

关键词：波浪漫滩波生流 Boussinesq方程数值模拟

Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan Ren Fei Zheng Tingwei Cao qiang Wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying Chen Yinyi Xiong Qin Zhou Ling-qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu wen-qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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Exploiting Multiple Correlations Among Urban Regions for Crowd Flow Prediction

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Journal of Computer Science & Technology 2020年第2期35卷 338-352页

作者： qiang Zhou jing-jing Gu Chao Ling wen-Bo Li Yi Zhuang Jian Wang College of Computer Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Crowd flow prediction has become a strategically important task in urban computing,which is the prerequisite for traffic management,urban planning and public ***,due to variousness of crowd flows,multiple hidden correlations among urban regions affect the ***,crowd flows are also influenced by the distribution of Points-of-Interests(POIs),transitional functional zones,environmental climate,and different time slots of the dynamic urban ***,we exploit multiple correlations between urban regions by considering the mentioned factors comprehensively rather than the geographical distance and propose multi-graph convolution gated recurrent units(MGCGRU)for capturing these multiple spatial *** adapting to the dynamic mobile data,we leverage multiple spatial correlations and the temporal dependency to build an urban flow prediction framework that uses only a little recent data as the input but can mine rich internal ***,the framework can mitigate the influence of the instability of data distributions in highly dynamic environments for *** experimental results on two real-world datasets in Shanghai show that our model is superior to state-of-the-art methods for crowd flow prediction.

关键词： crowd flow prediction multi-graph convolutional network multiple correlations mining

Synthesis of Sulfur/Selenium-containing Polyester with Recyclability and Controllable Hydrophilicity and Glass Transition Temperature

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Chinese Journal of Polymer Science 2023年第12期41卷 1836-1845,I0004,I0005页

作者： wen-jing Li Xiang-qiang Pan Jian Zhu Zheng-Biao Zhang Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Department of Polymer Science and EngineeringCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

We present a ring-opening polymerization of bridged cyclic lactone utilizing alcohol as the initiator and organic base as the *** γ-butyrolactone monomers(PhSGBL and PhSeGBL)were synthesized efficiently from commercially available 3-cyclohexene-1-carboxylic *** to the ring strain of the bridged structure,ring-opening polymerization of this type of γ-butyrolactone derivative was successfully carried out under mild conditions,e.g.,using ethylene glycol as the initiator and a commercial catalyst[1,5,7-triazabicyclo[4.4.0 dec-5-ene(TBD)]]as the catalyst at 30℃.The obtained polymer could be degraded to its monomer for recycling in the presence of ZnCl_(2) as a *** and PhSeGBL could also be copolymerized with ε-caprolactone to tune the glass transition ***,the hydrophilicity of the obtained sulfur-containing polymers could be adjusted by selectively oxidizing the thioether side group to sulfone/sulfoxide,which offered a way to tune the hydrophilicity of *** the other hand,the obtained selenium-containing compound could be degraded in the presence of m-CPBA(3-chloroperbenzoic acid),which offered potential application in sustained drug release.

关键词： Ring-opening polymerization Polyester Closed-loop recycling Selective oxidation

Reactions and crystal structures of heterodinuclear complexes R_3Sn-M(CO)_5(M = Mn,Re) with some nitrogen ligands

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Chinese Chemical Letters 2009年第4期20卷 465-468页

作者： Yong qiang Ma Ning Yin wen jing Peng jing Li Department of Applied Chemistry China Agriculture University Beijing 100193 China State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 China

Some reactions of R3SnM（CO）5 （M = Mn, Re） with CH3CN or pyridine were investigated to give complexes R3SnMn（CO）3LL＇ or R3SnMn（CO）4L by a facile mild method. X-ray diffractions analyses show that, in contrast ... 详细信息

关键词： Reactions Heterodinuclear complexes X-ray structure

Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： qiang Liu Xiang Li Shen Du Ming Gao Yanbin Yin Jiongming Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity