检索结果-南通市图书馆

Science China Chemistry 2024年第1期67卷 368-373页

作者： Xing-Yu Wang Pei Xu Wen-Wen Liu hao-qiang Jiang Song-Lei Zhu Dong Guo Xu Zhu Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy School of PharmacyXuzhou Medical UniversityXuzhou 22100China

Unprecedented divergent synthesis of gem-difluorovinylacetic acid and glutaric acid derivatives fromα-CF_(3)alkenes with formate as the carbonyl source was *** reaction can undergo selective mono-or triple C-F bond cleavage by simply switching the photocatalyst and hydrogen atom transfer(HAT)catalyst under visible-light-induced conditions at room *** acts as both the C1 source and the reductant through the generation of CO_(2)^(·-)species,which underwent Giese radical addition to electron-deficient alkenes to trigger the consecutive C-F bond cleavage and carboxylation process.

关键词： C-F bond activation defluorocarboxylation carbon dioxide radical anion visible light

High-resolution mid-infrared single-photon upconversion ranging

在线全文

学校读者我要写书评

暂无评论

Photonics Research 2024年第6期12卷 1294-1302页

作者： SHUHONG JIANG KUN HUANG TINGTING YU JIANAN FANG BEN SUN YAN LIANG qiang hao E.WU MING YAN HEPING ZENG State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200062China Chongqing Key Laboratory of Precision Optics Chongqing Institute of East China Normal UniversityChongqing 401121China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China School of Optical Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China Shanghai Research Center for Quantum Sciences Shanghai 201315China Guangyang Bay Laboratory Chongqing Institute for Brain and IntelligenceChongqing 400064China

Single-photon laser ranging has widespread applications in remote sensing and target ***,highly sensitive light detection and ranging(lidar)has long been restricted in the visible or near-infrared *** appealing quest is to extend the operation wavelength into the mid-infrared(MIR)region,which calls for an infrared photon-counting system at high detection sensitivity and precise temporal ***,we devise and demonstrate an MIR upconversion lidar based on nonlinear asynchronous optical ***,the infrared probe is interrogated in a nonlinear crystal by a train of pump pulses at a slightly different repetition rate,which favors temporal optical scanning at a picosecond timing resolution and a kilohertz refreshing rate ***,the cross-correlation upconversion trace is temporally stretched by a factor of 2×10^(4),which can thus be recorded by a low-bandwidth silicon *** combination with the time-correlated photon-counting technique,the achieved effective resolution is about two orders of magnitude better than the timing jitter of the detector itself,which facilitates a ranging precision of 4μm under a low detected flux of 8×10^(−5) photons per *** presented MIR time-of-flight range finder is featured with single-photon sensitivity and high positioning resolution,which would be particularly useful in infrared sensing and imaging in photon-starved scenarios.

关键词： resolution lidar repetition

A comprehensive review of meal?replacement from dining table to sickbed: beyond biomedical potentials

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： hao qiang Tianshu Xu Peng Ma Siyuan Zhang Guanhua Du Guifen qiang Tengfei Ji The School of Chemistry Cardiff University State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College and Beijing Key Laboratory of Drug Target and Screening Research State Key Laboratory Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College

The emergence of meal replacement (MR) originates from physical exercise or fitness as a substitute for one or all meals and later expands to the field of weight loss. Indeed， the main application of current meal replacement is to lose body weight， whether patients with obesity， diabetes， fatty liver， infertile or pregnant women can benefit from weight loss. In addition， MRs still exhibit more biomedical potential in preventing and treating diseases， like anti-diabetes， improving fatty liver and kidney disease， preventing cancer， conceiving and reducing pregnancy complications， and improving life quality. Indeed， there are also disadvantages to meal replacement， including causing adverse effects， although most are acceptable and tolerated. To date， various commercially-developed MRs are walking from dining table to sickbed. Therefore， a scientific understanding of the advantages and disadvantages of meal replacements is crucial for their extensive application beyond biomedical potentials.

关键词：

Effects of nutrient limitations on the sinking velocity of Thalassiosira weissflogii

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2024年第6期43卷 163-172页

作者： Jie Zhu qiang hao Wei Zhang Yingying Ma Jiangning Zeng Ocean College Zhejiang UniversityZhoushan 316000China Second Institute of Oceanography Ministry of Natural ResourcesHangzhou 310012China Key Laboratory of Marine Ecosystem Dynamics Ministry of Natural ResourcesHangzhou 310012China Zhejiang Key Laboratory of Nearshore Engineering Environment and Ecological Security Hangzhou 310012China Tianjin Key Lab of Aqua-Ecology and Aquaculture College of FisheriesTianjin Agricultural UniversityTianjin 300384China

The sinking of diatoms is critic al to the formation of oceanic biological pumps and coastal hypoxic ***,little is known about the effects of different nutrient restrictions on diatom *** this study,we measured the sinking velocity(SV) of Thalassiosira weissflogii using a new phytoplankton video observation instrument and analyzed major biochemical components under varying nutrient *** results showed that the SV of *** under different nutrient limitation conditions varied *** highest SV of(1.77±0.02) m/d was obtained under nitrate limitation,signific antly surpassing that under phosphate limitation at(0.98±0.13) m/*** the nutrient limitation was released,the SV steadily decreased to(0.32±0.03) m/d and(0.15±0.05) m/d,***;under conditions with limited nitrate and phosphate concentrations,the SV values of *** significantly positively correlated with the lipid content(P <0.001),with R~2 values of 0.86 and 0.69,*** change of the phytoplankton SV was primarily related to the intracellular compo sition,which is controlled by nutrient conditions but did not significantly correlate with transparent extracellular polymer and biosilica *** results of this study help to understand the regulation of the vertical sinking process of diatoms by nutrient restriction and provide new insights into phytoplankton dynamics and their relationship with the marine nutrient structure.

关键词： nutrient limitation Thalassiosira weissflogii sinking velocity biochemical component lipid content

Successful treatment of severe hepatic impairment in erythropoietic protoporphyria:A case report and review of literature

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第6期16卷 966-972页

作者： Tao Zeng Shu-Ru Chen hao-qiang Liu Yu-Tian Chong Xin-Hua Li Department of Infectious Diseases Key Laboratory of Liver Disease of Guangdong ProvinceThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Blood Transfusion The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina

BACKGROUND Erythropoietic protoporphyria(EPP)is a rare genetic disorder stemming from ferrochelatase gene mutations,which leads to abnormal accumulation of protoporphyrin IX primarily in erythrocytes,skin,bone marrow and *** porphyria-related severe liver damage is rare,its consequences can be severe with limited treatment *** SUMMARY This case study highlights a successful intervention for a 35-year-old male with EPP-related liver impairment,employing a combination of red blood cell(RBC)exchange and therapeutic plasma exchange(TPE).The patient experienced significant symptom relief and a decrease in bilirubin levels following multiple PE sessions and an RBC *** The findings suggest that this combined approach holds promise for managing severe hepatic impairment in EPP.

关键词： Erythropoietic protoporphyria Red blood cell exchange Plasma exchange Delta-aminolevulinic acid Ferrochelatase Case report

Application of non-mydriatic fundus photography-assisted telemedicine in diabetic retinopathy screening

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第2期15卷 251-259页

作者： Wan Zhou Xiao-Jing Yuan Jie Li Wei Wang hao-qiang Zhang Yuan-Yuan Hu Shan-Dong Ye Department of Endocrinology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Endocrinology Anhui Provincial HospitalAffiliated to Anhui Medical UniversityHefei 230001Anhui ProvinceChina

BACKGROUND Early screening and accurate staging of diabetic retinopathy(DR)can reduce blindness risk in type 2 diabetes ***’s complex pathogenesis involves many factors,making ophthalmologist screening alone insufficient for prevention and ***,endocrinologists are the first to see diabetic patients and thus should screen for retinopathy for early *** To explore the efficacy of non-mydriatic fundus photography(NMFP)-enhanced telemedicine in assessing DR and its various *** This retrospective study incorporated findings from an analysis of 93 diabetic patients,examining both NMFP-assisted telemedicine and fundus fluorescein angiography(FFA).It focused on assessing the concordance in DR detection between these two ***,receiver operating characteristic(ROC)curves were generated to determine the optimal sensitivity and specificity of NMFP-assisted telemedicine,using FFA outcomes as the standard *** In the context of DR diagnosis and staging,the kappa coefficients for NMFPassisted telemedicine and FFA were recorded at 0.775 and 0.689 respectively,indicating substantial intermethod ***,the NMFP-assisted telemedicine’s predictive accuracy for positive FFA outcomes,as denoted by the area under the ROC curve,was remarkably high at 0.955,within a confidence interval of 0.914 to 0.995 and a statistically significant P-value of less than *** predictive model exhibited a specificity of 100%,a sensitivity of 90.9%,and a Youden index of *** NMFP-assisted telemedicine represents a pragmatic,objective,and precise modality for fundus examination,particularly applicable in the context of endocrinology inpatient care and primary healthcare settings for diabetic *** implementation in these scenarios is of paramount significance,enhancing the clinical accuracy in the diagnosis and therapeutic management of *** methodology not only streamlines patient evaluation

关键词： Diabetes Diabetic retinopathy Non-mydriatic fundus photography-assisted telemedicine Fundus fluorescein angiography

Measurement of the neutron-induced total cross sections of ^(nat)Pb from 0.3 eV to 20 MeV on the Back-n at CSNS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第2期35卷 85-93页

作者： Jie-Ming Xue Song Feng Yong-hao Chen Han Yi Min Xiao Pin-Jing Cheng Xin-Xiang Li Rong Liu Yi-Wei Yang Zi-Jie Han Da-Jun Zhao hao-qiang Wang Bao-Qian Li Ji-Rong Zhao Lei-Xun Tang Wen Luo Bo Zheng School of Nuclear Science and Technology University of South ChinaHengyang 421001China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China

The neutron-induced total cross sections of natural lead have been measured in a wide energy range(0.3 eV-20 MeV)on the back-streaming white neutron beamline(Back-n)at the China Spallation Neutron *** energy was determined by the neutron total cross-section spectrometer using the time-of-flight technique.A fast multi-cell fission chamber was used as the neutron detector,and a 10-mm-thick high-purity natural lead sample was employed for the neutron transmission *** on-beam background was determined using Co,In,Ag,and Cd *** excitation function of ^(nat)Pb(n,tot)reaction below 20 MeV was calculated using the TALYS-1.96 nuclear-reaction modeling *** present results were compared with previous results,the evaluated data available in the five major evaluated nuclear data libraries(i.e.,ENDF/B-VIII.0,JEFF-3.3,JENDL-5,CENDL-3.2,and BROND-3.1),and the theoretical calculation *** agreement was found between the new results and those of previous experiments and with the theoretical curves in the corresponding *** measurement obtained the neutron total cross section of natural lead with good accuracy over a wide energy range and added experimental data in the resonance energy *** provides more reliable experimental data for nuclear engineering design and nuclear data evaluation of lead.

关键词： Neutron-induced total cross section Natural lead Time-of-flight TALYS-1.96 CSNS Back-n white neutron beamline

Effects of phosphorus limitation on sinking velocities of phytoplankton during summer in the Changjiang River Estuary

在线全文

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2024年第6期43卷 131-141页

作者： Xinchi You qiang hao Jie Zhu Wei Zhang Haiyan Jin Dewang Li Huanhong Ji Yu Ke Feng Zhou Ocean College Zhejiang UniversityZhoushan 316021China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310000China Key Laboratory of Marine Ecosystem Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China Donghai Laboratory Zhoushan 316021China East China Sea Ecological Center Ministry of Natural ResourcesShanghai 201206China Key Laboratory of Marine Ecological Monitoring and Restoration Technologies Ministry of Natural ResourcesShanghai 201206China Observation and Research Station of Yangtze River Delta Marine Ecosystems Ministry of Natural ResourcesZhoushan 316021China

The sinking of phytoplankton is critical to organic matter transportation in the ocean and it is an essential process for the formation of coastal hypoxic *** study was based on a field investigation conducted during the summer of 2022 in the Changjiang River(Yangtze River) Estuary(CJE) and its adjacent *** settling column method was employed to measure the sinking velocity(SV) of different size fractions of phytoplankton at the surface of the sea and to analyze their environmental control *** findings reveal significant spatial variation in phytoplankton SV(-0.55-2.41 m/d) within the ***-speed sinking was predominantly observed in phosphate-depleted regions beyond the CJE *** the same time,an upward trend was more commonly observed in the phosphate-rich regions near the CJE *** SV ranges for different sizefractionated phytoplankton,including micro-(>20 μm),nano-(2-20 μm),and picophytoplankton(0.7-2 μm),were-0.50-4.74 m/d,-1.04-1.59 m/d,and-1.24-1.65 m/d,*** analysis revealed a significant negative correlation between SV and dissolved inorganic phosphorus(DIP),implying that the influence of DIP contributes to *** variations in phytoplankton alkaline phosphatase activity suggested a significant increase in SV across all size fractions in the event of phosphorus *** communities with limited photo synthetic capacity(maximum photochemical efficience,Fv/Fm <0.3) were found to have higher SV than that of communities with strong capacity,suggesting a link between sinking and alterations in physiological conditions due to phosphate *** findings from the in situ phosphate enrichment experiments confirmed a marked decrease in SV following phosphate *** findings suggest that phosphorus limitation is the primary driver of elevated SV in the *** study enhances the comprehension of the potential mechanisms underlying hypoxic zone formation in the CJE,providing no

关键词： phytoplankton sinking velocity Changjiang River Estuary phosphorus limitation alkaline phosphatase

Chromosome-level genome assembly of the Asian citrus psyllid,Diaphorina citri

在线全文

学校读者我要写书评

暂无评论

Insect Science 2024年第1期31卷 13-27页

作者： Shuang Lei Shi-Jiang Yu Qi Pan Li-Li Ding Si-Chen Li Lu-Yan Cheng Shu-Qi Wang Bing-Hai Lou Jun He Cui-Yun Lei Lin Cong hao-qiang Liu Xue-Feng Wang Chun Ran Citrus Research Institute Southwest University/Chinese Academy of Agricultural SciencesNational Engineering Research Center for CitrusChongqingChina

Diaphorina citri is a global citrus *** a vector insect,it can transmit the causative agents of citrus huanglongbing,causing irreversible losses to the citrus *** acquisition of genomic information can provide a molecular genetic basis for effective control of ***,the DNBSEQ™,Oxford Nanopore Technologies,and Hi-C technologies are applied to generate a high-quality chromosome-level genome of *** genome size of *** was 523.78 Mb with a scaffold N50 of 47.05 Mb distributed on 13 chromosomes.A total of 250.64 Mb(47.85%)repeat sequences and 24048 protein-coding genes were *** resequencing of female and male individuals indicated that the sex chromosome system of *** is *** analysis demonstrated that *** and Pachypsylla venusta,which separated from their most recent common ancestor about 336.62 million years ago,were the most closely ***,we identified genes potentially involved in detoxification metabolism,pathogen transmission,and honeydew secretion for further *** high-quality genome provides an important reference for developing effective management strategies of ***.

关键词： Asian citrus psyllid chromosome-level genome comparative genomics cytochrome P450 detoxification Huanglongbing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

电池领域包含参数限定权利要求的研究

专利代理 2024年第2期 100-105页

作者：郝强国家知识产权局专利局专利审查协作天津中心天津300304

电池领域的专利申请中存在较多以参数限定的产品权利要求,并且参数的表征形式、测定方法各异,这类案件的新创性评价一直是该领域专利申请撰写和审查的难点所在。文章从多个复审和实审案例出发,从参数限定本身的类型入手,着眼于权利要求... 详细信息

电池领域的专利申请中存在较多以参数限定的产品权利要求,并且参数的表征形式、测定方法各异,这类案件的新创性评价一直是该领域专利申请撰写和审查的难点所在。文章从多个复审和实审案例出发,从参数限定本身的类型入手,着眼于权利要求中参数的不同测定方法以及参数限定的产品在说明书中给出的制备方法两个角度,针对电池领域参数限定权利要求的新颖性推定、创造性评价等方面分别进行讨论,为包含参数限定的电池领域专利申请撰写和审查提供可行的参考建议。

关键词：参数限定产品权利要求电池领域专利申请与审查