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Application of deep learning methods combined with physical background in wide field of view imaging atmospheric Cherenkov telescopes

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Nuclear Science and Techniques 2024年第4期35卷 208-220页

作者： Ao-Yan Cheng hao Cai Shi Chen Tian-Lu Chen Xiang Dong you-Liang Feng Qi Gao Quan-Bu Gou Yi-Qing Guo Hong-Bo Hu Ming-Ming Kang Hai-Jin Li Chen Liu Mao-yuan Liu Wei Liu Fang-Sheng Min chu-Cheng Pan Bing-qiang Qiao Xiang-Li qian Hui-Ying sun Yu-Chang sun Ao-Bo Wang Xu Wang Zhen Wang Guang-Guang Xin Yu-Hua Yao qiang yuan Yi Zhang School of Physics and Technology Wuhan UniversityWuhan 430072China School of Physics and Astronomy Yunnan UniversityKunming 650091China Ministry of Education The Key Laboratory of Cosmic Rays(Tibet University)Lhasa 850000China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences 19 A Yuquan RoadShijingshan DistrictBeijing 100049China College of Physics Sichuan UniversityChengdu 610064China School of Intelligent Engineering Shandong Management UniversityJinan 250357China Tsung‑Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China Suzhou Aerospace Information Research Institute Suzhou 215123China College of Physics Chongqing UniversityNo.55 Daxuecheng South RoadHigh‑tech DistrictChongqing 401331China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210008China

The High Altitude Detection of Astronomical Radiation(HADAR)experiment,which was constructed in Tibet,China,combines the wide-angle advantages of traditional EAS array detectors with the high-sensitivity advantages of focused Cherenkov *** objective is to observe transient sources such as gamma-ray bursts and the counterparts of gravitational *** study aims to utilize the latest AI technology to enhance the sensitivity of HADAR *** datasets and models with distinctive creativity were constructed by incorporating the relevant physical theories for various *** models can determine the type,energy,and direction of the incident particles after careful *** obtained a background identification accuracy of 98.6%,a relative energy reconstruction error of 10.0%,and an angular resolution of 0.22°in a test dataset at 10 *** findings demonstrate the significant potential for enhancing the precision and dependability of detector data analysis in astrophysical *** using deep learning techniques,the HADAR experiment’s observational sensitivity to the Crab Nebula has surpassed that of MAGIC and *** energies below 0.5 TeV and remains competitive with conventional narrow-field Cherenkov telescopes at higher *** addition,our experiment offers a new approach for dealing with strongly connected,scattered data.

关键词： VHE gamma-ray astronomy HADAR Deep learning Convolutional neural networks

Chlorinated Polyfluoroalkyl Ether Sulfonic Acids(Cl-PFESAs)Are Associated with Eye Diseases in Humans and Eye Toxicity in Zebrafish

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Environment & Health 2024年第6期2卷 390-400页

作者： Lu-Yin Wu Li-Xia Liang Yang Zhou Zeeshan Mohammed Zhengmin Min qian Stephen Edward McMillin Maya Tabet chu chu yuan-yuan Fan jia-Xin Zhou Jing-Wen Huang Wei-Hong Tan Guang-Hui Dong Li-Zi Lin Joint International Research Laboratory of Environment and Health Ministry of EducationGuangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk AssessmentDepartment of Occupational and Environmental HealthSchool of Public HealthSun Yat-sen UniversityGuangzhou 510080China State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment South China Institute of Environmental SciencesMinistry of Environmental ProtectionGuangzhou 510655China Department of Developmental Biology&Genetics School of Biological SciencesIndian Institute of ScienceBangalore 400060India Department of Epidemiology and Biostatistics College for Public Health&Social JusticeSaint Louis UniversitySt.LouisMissouri 63104United States School of Social Work Saint Louis UniversitySt.LouisMissouri 63103United States College of Global Population Health University of Health Sciences and Pharmacy in St.LouisSt.LouisMissouri 63110United States Guangdong Cardiovascular Institute Department of Reproductive MedicineDepartment of Obstetrics and GynecologyGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Reproductive Medicine and Genetics Center The People’s Hospital of Guangxi Zhuang Autonomous RegionNanning 530021China

Evidence from animal experiments has shown that chlorinated polyfluoroalkyl ether sulfonic acids(Cl-PFESAs)can induce vision dysfunction in ***,environmental epidemiological evidence supporting this hypothesis remains *** our case−control study,samples collected from 270 individuals(135 controls and 135 cases)from the Isomers of C8 Health Project data were analyzed for *** also repeated our analysis on zebrafish to support our findings in humans and to decipher the mechanism underlying Cl-PFESA eye *** serum levels of per-and polyfluoroalkyl substances(PFASs)and alternatives were significantly higher in the cases than in the *** serum Cl-PFESA levels were associated with greater odds of eye diseases,and the trend showed a statistically significant dose-dependent *** Shapley additive explanations(SHAP)value indicated that 8:2 Cl-PFESA was the dominant eye disease risk factor among the 13 studied *** zebrafish experiments,Cl-PFESAs induced eye toxicity in adult zebrafish by oxidative damage and cell *** to the control group,there was significantly reduced thicknesses of the inner plexiform layer(IPL),outer plexiform layer(OPL),and retinal tissue in the zebrafish exposed to *** study provides human clinical and animal experimental data,showing that exposure to PFASs increases the odds of the development of eye toxicity.

关键词： eye diseases chlorinated polyfluoroalkyl ether sulfonic acids(Cl-PFESAs) case−control study shapley additive explanations(SHAP) zebrafish experiment

Searching for^(76)Ge neutrinoless double beta decay with the CDEX-1B experiment

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Chinese Physics C 2024年第10期48卷 11-22页

作者： Bing-Tao Zhang Jun-Zheng Wang Li-Tao Yang qian Yue Ke-Jun Kang yuan-Jing Li Hai-Peng An C.Greeshma jian-Ping Chang Yun-Huan Chen jian-Ping Cheng Wen-Han Dai Zhi Deng Chang-hao Fang Xin-Ping Geng Hui Gong Qiu-Ju Guo Xu-yuan Guo Li He Sheng-Ming He Jin-Wei Hu Han-Xiong Huang Tu-Chen Huang Hai-Tao jia Xi jiang S.Karmakar hao-Bin Li jian-Min Li Jin Li qian-Yun Li Ren-Ming-Jie Li Xue-qian Li Yu-Lan Li Yi-Fan Liang Bin Liao Fong-Kay Lin Shin-Ted Lin jia-Xuan Liu Shu-Kui Liu Yan-Dong Liu Yu Liu yuan-yuan Liu Zhong-Zhi Liu hao Ma Yu-Cai Mao Qi-yuan Nie Jin-Hua Ning Hui Pan Ning-chun Qi Jie Ren Xi-Chao Ruan Ze She Manoj Kumar Singh Tian-Xi sun Chang-jian Tang Wei-you Tang Yang Tian Guang-Fu Wang Li Wang Qing Wang Yu-Feng Wang Yun-Xiang Wang Henry-Tsz-King Wong Shi-Yong Wu Yu-Cheng Wu hao-Yang Xing Rui Xu Yin Xu Tao Xue Yu-Lu Yan Nan Yi chun-Xu Yu Hai-Jun Yu jian-Feng Yue Ming Zeng Zhi Zeng Feng-Shou Zhang Lei Zhang Zhen-Hua Zhang Zhen-Yu Zhang Kang-Kang Zhao Ming-Gang Zhao Ji-Fang Zhou Zu-Ying Zhou Jing-Jun Zhou Key Laboratory of Particle and Radiation Imaging(Ministry of Education)and Department of Engineering Physics Tsinghua UniversityBeijing 100084 Department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875 College of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and Technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 Department of Physics Banaras Hindu UniversityVaranasi 221005 Department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1B,1.008 kg)in the China Jinping Underground Laboratory(CJPL)for 500.3 days to search for neutrinoless double beta(0νββ)decay of^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1989–2089 keV for this work)with a factor of 23.A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1/2)^(0ν)>1.0×10^(23)yr(90%C.L.),corresponding to the upper limits on the effective Majorana neutrino mass:<3.2–7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge

Two-dimensional materials for future information technology: status and prospects

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Science China(Information Sciences) 2024年第6期67卷 1-147页

作者： hao QIU Zhihao YU Tiange Zhao Qi ZHANG Mingsheng XU Peifeng LI Taotao LI Wenzhong BAO Yang CHAI Shula CHEN Yiqi CHEN Hui-Ming CHENG Daoxin DAI Zengfeng DI Zhuo DONG Xidong DUAN Yuhan FENG Yu FU Jingshu GUO Pengwen GUO Yue hao Jun HE Xiao HE Jingyi HU Weida HU Zehua HU Xinyue HUANG Ziyang HUANG Ali IMRAN Ziqiang KONG jia LI qian LI Weisheng LI Lei LIAO Bilu LIU Can LIU chunsen LIU Guanyu LIU Kaihui LIU Liwei LIU Sheng LIU yuan LIU Donglin LU Likuan MA Feng MIAO Zhenhua NI Jing NING Anlian PAN Tian-Ling REN haowen SHU Litao sun Yue sun Quanyang TAO Zi-Ao TIAN Dong WANG hao WANG haomin WANG jialong WANG Junyong WANG Wenhui WANG Xingjun WANG Yeliang WANG Yuwei WANG Zhenyu WANG Yao WE... School of Electronic Science and Engineering Nanjing University School of Integrated Circuits Interdisciplinary Research Center for Future Intelligent Chips (Chip-X)Nanjing University School of Integrated Circuit Science and Engineering Nanjing University of Posts and Telecommunications State Key Laboratory of Infrared Physics Shanghai Institute of Technical Physics Chinese Academy of Sciences School of Physics and Key Lab of Quantum Materials and Devices of the Ministry of Education School of Electronic Science & EngineeringSoutheast University College of Integrated Circuits State Key Laboratory of Silicon and Advanced Semiconductor MaterialsZhejiang University Suzhou Laboratory State Key Laboratory of Integrated Chips and Systems School of MicroelectronicsFudan University Shaoxin Laboratory Department of Applied Physics The Hong Kong Polytechnic University Key Laboratory for Micro-Nano Physics and Technology of Hunan Province College of Materials Science and EngineeringHunan University College of Integrated Circuits Zhejiang University Shenzhen Geim Graphene Center Shenzhen Key Laboratory of Layered Materials for Value-Added ApplicationsTsinghua-Berkeley Shenzhen Institute & Institute of Materials ResearchTsinghua Shenzhen International Graduate SchoolTsinghua University State Key Laboratory of Extreme Photonics and Instrumentation College of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZijingang CampusZhejiang University National Key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences CAS Key Laboratory of Nanophotonic Materials and Devices & Key Laboratory of Nanodevices and Applications i-LabSuzhou Institute of Nano-Tech and Nano-Bionics (SINANO)Chinese Academy of Sciences College of Chemistry and Chemical Engineering Hunan University Key Laboratory of Quantum State Construction and Manipulation (Ministry of Education) Department of PhysicsRenmin University of China School

Over the past 70 years, the semiconductor industry has undergone transformative changes,largely driven by the miniaturization of devices and the integration of innovative structures and materials. Two-dimensional(2D) materials like transition metal dichalcogenides(TMDs) and graphene are pivotal in overcoming the limitations of silicon-based technologies, offering innovative approaches in transistor design and functionality, enabling atomic-thin channel transistors and monolithic 3D integration. We review the important progress in the application of 2D materials in future information technology, focusing in particular on microelectronics and optoelectronics. We comprehensively summarize the key advancements across material production, characterization metrology, electronic devices, optoelectronic devices, and heterogeneous integration on silicon. A strategic roadmap and key challenges for the transition of 2D materials from basic research to industrial development are outlined. To facilitate such a transition, key technologies and tools dedicated to 2D materials must be developed to meet industrial standards, and the employment of AI in material growth, characterizations, and circuit design will be essential. It is time for academia to actively engage with industry to drive the next 10 years of 2D material research.

关键词： two-dimensional (2D) materials information technology production technology standardization of characterization microelectronicdevices optoelectronic devices multi-functional integration

Strong association of SLCIA1 and DPF3 gene variants with idiopathic male infertility in Han Chinese

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Asian Journal of Andrology 2017年第4期19卷 486-492页

作者： Shu-yuan Liu Chang-Jun Zhang Hai-Ying Peng hao sun Ke-Qin Lin Xiao-Qin Huang Kai Huang jia-you chu Zhao-Qing Yang Department of Medical Genetics Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming 650118 China Reproductive Medical Research Centre People's Hospital of Shiyan Shiyan 442000 China

Male infertility is a multifactorial syndrome encompassing a wide variety of disorders. In recent years, several genome-wide single-nucleotide polymorphism （SNP） association studies （GWAS） have been performed on azoospermia and/or oligozoospermia in different populations including two GWAS on nonobstructive azoospermia in China; however, the association of SNPs with idiopathic male infertility, especially asthenozoospermia and oligozoospermia, and their correlation with semen parameters are still not clear. To investigate genetic variants associated with idiopathic male infertility （asthenozoospermia, oligozoospermia, and oligoasthenozoospermia） in Chinese Han people, 20 candidate SNPs were selected from GWAS results and genotyped using the Sequenom MassARRAY assay. A total of 136 subfertile men and 456 healthy fertile men were recruited, rs6476866 in SLCIA1 （P = 1.919E-4, OR = 0.5905, 95% Ch 0.447-0.78） and rs10129954 in DPF3 （P = 0.0023, OR = 2.199, 95% Ch 1.311-3.689） were strongly associated with idiopathic male infertility. In addition, positive associations were observed between asthenozoospermia and rs215702 in LSM5 （P= 0.0016, OR = 1.479, 95% CI： 1.075-2.033） and between oligoasthenozoospermia and rs2477686 in PEXIO （P= 0.0011, OR = 2.935, 95% Ch 1.492-5.775）. In addition, six SNPs （rs215702 in LSMS, rs6476866 in SLCIA1, rs10129954 in DPF3, rs1801133 in MTHFR, rs2477686 in PEXIO, and rs10841496 in PED3A） were significantly correlated with semen quality alterations. Our results suggest that idiopathic male infertility in different ethnic groups may share the same mechanism or pathway. Cohort expansion and further mechanistic studies on the role of genetic factors that influence spermatogenesis and sperm progressive motility are suggested.

关键词： candidate SNPs Han Chinese idiopathic male infertility semen quality

Strong Correlation of Abnormal Serum and Urinary Iodine Levels with Papillary Thyroid Cancer:A Case-control Study

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Biomedical and Environmental Sciences 2020年第1期33卷 62-67页

作者： XIU Cheng HE qian Zhao Hong jian yuan Zhen Nan GUO Lun Hua WANG Feng qian YANG Xian Guang TIAN Qiu Shi sun Qi hao MIAO Su Sheng sun Ji FAN Li Jun jia Shen Shan Department of Head and Neck Oncology the Third Affiliated HospitalHarbin Medical UniversityHarbin 150030HeilongjiangChina Public Health College Shandong First Medical University&Shandong Academy of Medical SciencesTai’an 271016ShandongChina General Surgery Department People's Hospital of Chengwu CountyHeze 274200ShandongChina Public Health College Harbin Medical UniversityHarbin 150076HeilongjiangChina Center for Endemic Disease Control Chinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin 150076HeilongjiangChina

Thyroid cancer is the most common malignancy of the endocrine system,and its incidence is increasing *** China,its incidence has increased from 1.78/104 in 1988 to 10.58/104 *** cancers are mainly classified into papi... 详细信息

关键词： PTC Strong Correlation Abnormal Serum and Urinary Iodine Levels Papillary Thyroid Cancer:A Case-control Study

2000—2021年长江中游流域气候对植被和生态系统服务功能的影响分析

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环境生态学 2024年第6期6卷 99-108页

作者：孙应龙韩佳芮陈紫璇周媛延昊曹云钱永兰国家气象中心北京100081 中国气象局气象干部培训学院北京100081 江西省生态气象中心江西南昌330096 南昌国家气候观象台江西南昌330043

长江中游流域湿地湖泊众多,植被覆盖度高,在增加碳汇、水源涵养、水土保持等方面发挥着重要作用,是我国重要的生态安全屏障。本研究基于中分辨率成像光谱(MODIS)数据、风云气象卫星资料和逐月气象资料等长时间尺度的多源数据,对2000—2... 详细信息

长江中游流域湿地湖泊众多,植被覆盖度高,在增加碳汇、水源涵养、水土保持等方面发挥着重要作用,是我国重要的生态安全屏障。本研究基于中分辨率成像光谱(MODIS)数据、风云气象卫星资料和逐月气象资料等长时间尺度的多源数据,对2000—2021年长江中游流域气候条件及植被净初级生产力(NPP)、植被覆盖度、植被生态质量指数等植被生态表征指数的时空变化进行评价。同时,本研究还研究了长江中游流域2000年以来生态系统服务功能(土壤保持功能、水源涵养功能)的时空变化趋势以及气候对其影响。结果表明:2000—2021年,长江中游流域生态气候条件总体呈增加趋势,降水量平均每年增加7.3 mm,年平均气温平均每年升高0.03℃,较好的水热条件促进了植被生长,植被NPP和植被覆盖度平均每年分别增加5.1 gC/m和0.5%;区域生态系统服务功能也呈波动增加趋势,涵养水量和土壤保持量平均每年分别增加2.89 mm和4.96 t/hm^(2)。2000—2021年长江中游流域生态系统服务功能的气候影响主要体现在降水上,降水量和涵养水量、土壤保持量呈显著的正相关性,而气温相关性较差,表明降水是影响长江中游流域生态系统服务功能的重要气候影响因素。本研究揭示了2000—2021年气候变化对长江中游流域生态系统服务功能的影响,为切实保障湿地、植被生态建设,以及防灾减灾提供了气象依据。

关键词：气候条件植被生态质量生态系统服务功能

Jujuboside A ameliorates tubulointerstitial fibrosis in diabetic mice through down-regulating the YY1/TGF-β1 signaling pathway

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Chinese Journal of Natural Medicines 2022年第9期20卷 656-668页

作者： LIU Yang-Yang LI Lin JI Bei hao Shi-Long KUANG Xiao-Feng CAO Xin-Yun yuan jia-Yu jiaNG Zhen-Zhou qian Si-Tong WEI chu-Jing XU Jing YIN Xiao-Xing LU qian YANG Ting-Ting jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhou 221004China New Drug Screening Center Jiangsu Center for Pharmacodynamics Research and EvaluationChina Pharmaceutical UniversityNanjing 210009China

Diabetic nephropathy(DN)is one of the most common complications of diabetes mellitus,which is characterized in renal tubulointerstitial fibrosis(TIF).The current study was designed to investigate the protective effect of Jujuboside A(Ju A)on TIF in type 2 diabetes(T2DM)mice,and explore its underlying anti-fibrosis mechanism.A mouse T2DM model was established using high fat diet(HFD)feeding combined with intraperitoneal injection of streptozotocin(STZ).Then,diabetic mice were treated with Ju A(10,20 and 40 mg·kg^(−1)·d^(−1),i.g.)for 12 *** showed that administration of Ju A not only down-regulated fasting blood glucose(FBG)levels,but also improved hyperlipidemia and renal function in diabetic ***,the reduced ECM accumulation was observed in the renal cortex of Ju A treated diabetic mice,while the TIF progression was also attenuated by Ju A through blocking the epithelial-to-mesenchymal transition(EMT)of renal tubular epithelial cells(RTECs).Further mechanism studies showed that Ju A treatment effectively down-regulated the protein expression and subsequent nuclear translocation of Yin Yang 1(YY1)in the renal cortex of diabetic mice,and reduced the levels of transforming growth factor-β1(TGF-β1)in the serum and renal cortex of Ju A treated *** to in vitro studies,the up-regulated YY1/TGF-β1 signaling pathway was restored by Ju A in high glucose(HG)cultured HK-2 *** together,these findings demonstrated that Ju A can ameliorate the TIF of DN through down-regulating the YY1/TGF-β1 signaling pathway.

关键词： Diabetic nephropathy Jujuboside A Tubulointerstitial fibrosis Extracellular matrix YY1/TGF-β1 signaling pathway

Acute gastrointestinal injury in critically ill patients with COVID-19 in Wuhan,China

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World Journal of Gastroenterology 2020年第39期26卷 6087-6097页

作者： jia-Kui sun Ying Liu Lei Zou Wen-hao Zhang Jing-Jing Li Yu Wang Xiao-Hua Kan Jiu-Dong Chen qian-Kun Shi Shou-Tao yuan Department of Intensive Care Unit Nanjing First HospitalNanjing Medical UniversityNanjing 210006Jiangsu ProvinceChina Department of Isolation Units Tongji HospitalHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Intensive Care Unit Lishui People's HospitalNanjing 211200Jiangsu ProvinceChina

BACKGROUND The coronavirus disease 2019(COVID-19)is spreading rapidly around the *** critically ill patients have organ injury,including acute respiratory distress syndrome,acute kidney injury,cardiac injury,or liver ***,few studies on acute gastrointestinal injury(AGI)have been reported in critically ill patients with *** To investigate the prevalence and outcomes of AGI in critically ill patients with *** In this retrospective study,demographic data,laboratory parameters,AGI grades,clinical severity and outcomes were *** primary endpoints were AGI incidence and 28-d *** From February 10 to March 102020,83 critically ill patients out of 1314 patients with COVID-19 were ***-two(86.7%)patients had AGI during hospital stay,of these patients,30 had AGI gradeⅠ,35 had AGI gradeⅡ,5 had AGI gradeⅢ,and 2 had AGI gradeⅣ.The incidence of AGI gradeⅡand above was 50.6%.Forty(48.2%)patients died within 28 days of *** organ dysfunction syndrome developed in 58(69.9%)patients,and septic shock in 16(19.3%)*** with worse AGI grades had worse clinical variables,a higher incidence of septic shock and 28-d *** organ failure assessment(SOFA)scores(95%CI:1.374-2.860;P<0.001),white blood cell(WBC)counts(95%CI:1.037-1.379;P=0.014),and duration of mechanical ventilation(MV)(95%CI:1.020-1.340;P=0.025)were risk factors for the development of AGI gradeⅡand *** The incidence of AGI was 86.7%,and hospital mortality was 48.2%in critically ill patients with *** scores,WBC counts,and duration of MV were risk factors for the development of AGI gradeⅡand *** with worse AGI grades had a higher incidence of septic shock and 28-d mortality.

关键词： Gastrointestinal injury Organ dysfunction Septic shock Critically ill COVID-19