检索结果-南通市图书馆

Synergistic effects of the entomopathogenic fungus Isaria javanica and low doses of dinotefuran on the efficient control of the rice pest Sogatella furcifera

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2024年第2期23卷 621-638页

作者： Tingting Zhou qian zhao Chengzhou Li Lu Ye Yanfang Li Nemat OKeyhani Zhen Huang Department of Entomology College of Plant ProtectionSouth China Agricultural UniversityGuangzhou 510642China Guangdong Provincial Key Laboratory of High Technology for Plant Protection Plant Protection Research InstituteGuangdong Academy of Agricultural SciencesGuangzhou 510642China Department of Microbiology and Cell Science Institute of Food and Agricultural SciencesUniversity of FloridaFL 32611USA

The rice planthopper,Sogatella furcifera,is a piercing-sucking insect pest of rice,Oryza sativa.It is responsible for significant crop yield losses,and has developed moderate to high resistance to several commonly used chemical insecticides.We investigated the effects of the insect fungal pathogen Isaria javanica,alone and in combination with the chemical insecticide dinotefuran,on S.furcifera under both laboratory and field conditions.Our results show that I.javanica displays high infection efficiency and mortality for different stages of S.furcifera,reducing adult survival,female oviposition and ovary development.Laboratory bioassays showed that the combined use of I.javanica with a low dose(4-16 mg L^(-1))of dinotefuran resulted in higher mortality in S.furcifera than the use of I.javanica or dinotefuran alone.The combined treatment also had more significant effects on several host enzymes,including superoxide dismutase,catalase,peroxidase,and prophenol oxidase activities.In field trials,I.javanica effectively suppressed populations of rice planthoppers to low levels(22-64%of the level in untreated plots).Additional field experiments showed synergistic effects,i.e.,enhanced efficiency,for the control of S.furcifera populations using the combination of a low dose of I.javanica(1×10^(4) conidia mL^(-1))and a low dose of dinotefuran(~4.8-19.2%of normal field use levels),with control effects of>90%and a population level under 50 insects per 100 hills at 3-14 days post-treatment.Our findings indicate that the entomogenous fungus I.javanica offers an attractive biological control addition as part of the integrated pest management(IPM)practices for the control of rice plant pests.

关键词： Isaria javanica Sogatella furcifera entomopathogenic fungus white planthopper rice synergistic effect on pest control

Reconfigurable and orthogonal stiffness-structure patterning of dynamically crosslinked amphigels

在线全文

学校读者我要写书评

暂无评论

SmartMat 2024年第2期5卷 145-155页

作者： Chen Yang Weizhong Zheng Chujun Ni Ye Li Di Chen Tao Xie qian zhao State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhouChina Ningbo Innovation Center Zhejiang UniversityNingboChina School of Chemical Engineering East China University of Science and TechnologyShanghaiChina

Patterning diversified properties and surface structure of polymer materials are of great importance toward their potential in biology,optics,and electronics.However,achieving both the patternability of stiffness and microstructure in a reconfigurable manner remains challenging.Here,we prepare amphigels crosslinked by dynamic disulfide bonds,which can be reversibly swollen by immiscible water or liquid paraffin.In the paraffingel form,the materials exhibited a high modulus of 130 MPa due to densified hydrogen bonds.Whereas swollen by water,the modulus fell over two orders of magnitude owing to the destruction of the hydrogen bonds.Via regionalized swelling of the solvents,well-controlled and rewritable soft/stiff mechanical patterns can be created.On the other hand,the dynamic exchange of the disulfide crosslinking enables mechanophoto patterning to fabricate sophisticated macrogeometries and microstructures.The reconfigurable stiffness-structure patterning can be manipulated orthogonally,which will create more application opportunities beyond conventional hydrogels and organogels.

关键词： amphigels dynamic crosslinking hydrogels organogels surface patterning

Soybean(Glycine max)rhizosphere organic phosphorus recycling relies on acid phosphatase activity and specific phosphorusmineralizing-related bacteria in phosphate deficient acidic soils

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2024年第5期23卷 1685-1702页

作者： qianqian Chen qian zhao Baoxing Xie Xing Lu Qi Guo Guoxuan Liu Ming Zhou Jihui Tian Weiguo Lu Kang Chen Jiang Tian Cuiyue Liang Root Biology Center State Key Laboratory for Conservation and Utilization of Subtropical Agro-BioresourcesCollege of Natural Resources and EnvironmentSouth China Agricultural UniversityGuangzhou 510642China College of Natural Resources and Environment South China Agricultural UniversityGuangzhou 510642China Henan Academy of Crops Molecular Breeding Henan Academy of Agricultural SciencesZhengzhou 450002China

Bacteria play critical roles in regulating soil phosphorus(P) cycling. The effects of interactions between crops and soil P-availability on bacterial communities and the feedback regulation of soil P cycling by the bacterial community modifications are poorly understood. Here, six soybean(Glycine max) genotypes with differences in P efficiency were cultivated in acidic soils with long-term sufficient or deficient P-fertilizer treatments. The acid phosphatase(AcP) activities, organic-P concentrations and associated bacterial community compositions were determined in bulk and rhizosphere soils. The results showed that both soybean plant P content and the soil AcP activity were negatively correlated with soil organic-P concentration in P-deficient acidic soils. Soil P-availability affected the ɑ-diversity of bacteria in both bulk and rhizosphere soils. However, soybean had a stronger effect on the bacterial community composition, as reflected by the similar biomarker bacteria in the rhizosphere soils in both P-treatments. The relative abundance of biomarker bacteria Proteobacteria was strongly correlated with soil organic-P concentration and AcP activity in low-P treatments. Further high-throughput sequencing of the phoC gene revealed an obvious shift in Proteobacteria groups between bulk soils and rhizosphere soils, which was emphasized by the higher relative abundances of Cupriavidus and Klebsiella, and lower relative abundance of Xanthomonas in rhizosphere soils. Among them, Cupriavidus was the dominant phoC bacterial genus, and it was negatively correlated with the soil organic-P concentration. These findings suggest that soybean growth relies on organic-P mineralization in P-deficient acidic soils, which might be partially achieved by recruiting specific phoCharboring bacteria, such as Cupriavidus.

关键词： organic phosphorus acid phosphatase soybean bacterial community phoC-harboring bacteria rhizosphere

Design and discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第3期14卷 1283-1301页

作者： qian zhao Jiale Dong Han Liu Hui Chen Huan Yu Shuyin Ye Shuangjin Yu Yu Li Longhui Qiu Nazi Song Hongjiao Xu Qi Liu Zhiteng Luo Yuyi Li Rui Wang Guodong Chen Xianxing Jiang School of Pharmaceutical Sciences Guangdong Provincial Key Laboratory of Chiral Molecule and Drug DiscoverySun Yat-sen UniversityGuangzhou 510006China Organ Transplant Center the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510006China Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510006China Shenzhen Turier Biotech.Co. Ltd.Shenzhen 518118China School of Life Sciences Key Laboratory of Preclinical Study for New Drugs of Gansu ProvinceSchool of Basic Medical Sciences&Research Unit of Peptide ScienceChinese Academy of Medical SciencesLanzhou UniversityLanzhou 730000China

The role of co-agonists of glucagon-like peptide-1 receptor(GLP-1R)and glucagon receptor(GCGR)in chronic kidney disease(CKD)remains unclear.Herein we found that GLP-1R and GCGR expression levels were lower in the kidneys of mice with CKD compared to healthy mice and were correlated with disease severity.Interestingly,GLP-1R or GCGR knockdown aggravated the progression of kidney injury in both diabetic db/db mice and non-diabetic mice undergoing unilateral ureteral obstruction(UUO).Based on the importance of GLP-1R and GCGR in CKD,we reported a novel monomeric peptide,1907-B,with dual-agonism on both GLP-1R and GCGR.The data confirmed that 1907-B had a longer half-life than long-acting semaglutide in rats or cynomolgus monkeys(~2-3 fold)and exhibited better therapeutic contribution to CKD than best-in-class monoagonists,semaglutide,or glucagon,in db/db mice and UUO mice.Various lock-of-function models,including selective pharmacological activation and genetic knockdown,confirmed that 1907-B’s effects on ameliorating diabetic nephropathy in db/db mice,as well as inhibiting kidney fibrosis in UUO mice,were mediated through GLP-1 and glucagon signaling.These findings highlight that 1907-B,a novel GLP-1R and GCGR co-agonist,exerts multifactorial improvement in kidney injuries and is an effective and promising therapeutic option for CKD treatment.

关键词： GLP-1 receptor Glucagon receptor Chronic kidney disease Diabetic nephropathy Kidney fibrosis Dual-agonism

Advantageous properties of halide perovskite quantum dots towards energy-efficient sustainable applications

在线全文

学校读者我要写书评

暂无评论

Green Energy & Environment 2024年第6期9卷 949-965页

作者： qian zhao Shuo Wang Young-Hoon Kim Shekhar Mondal Qingqing Miao Simiao Li Danya Liu Miao Wang Yaxin Zhai Jianbo Gao Abhijit Hazarika Guo-Ran Li School of Materials Science and Engineering Nankai UniversityTianjin300350China Department of Energy Engineering Hanyang UniversitySeoul04763Republic of Korea Polymers and Functional Materials Division CSIR-Indian Institute of Chemical TechnologyUppal RoadTarnakHyderabad500007India Institute of Process Engineering Chinese Academy of SciencesBeijing100190China Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of PhysicsHunan Normal UniversityChangshHunan410081China Department of Chemistry Brock University1812 Sir Isaac WaySt CatharinesOntarioCanada

As lead halide perovskite(LHP)semiconductors have shown tremendous promise in many application fields,and particularly made strong impact in the solar photovoltaic area,low dimensional quantum dot forms of these perovskites are showing the potential to make distinct marks in the fields of electronics,optoelectronics and photonics.The so-called perovskite quantum dots(PQDs)not only possess the most important features of LHP materials,i.e.,the unusual high defect tolerance,but also demonstrate clear quantum size effects,along with exhibiting desirable optoelectronic properties such as near perfect photoluminescent quantum yield,multiple exciton generation and slow hot-carrier cooling.Here,we review the advantageous properties of these nanoscale perovskites and survey the prospects for diverse applications which include lightemitting devices,solar cells,photocatalysts,lasers,detectors and memristors,emphasizing the distinct superiorities as well as the challenges.

关键词： Perovskite quantum dot Light-emitting Detector Laser Solar cell

CRL2^(APPBP2)-mediated TSPYL2 degradation counteracts human mesenchymal stem cell senescence

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第3期67卷 460-474页

作者： Daoyuan Huang qian zhao Kuan Yang Jinghui Lei Ying Jing Hongyu Li Chen Zhang Shuai Ma Shuhui Sun Yusheng Cai Guibin Wang Jing Qu Weiqi Zhang Si Wang Guang-Hui Liu Advanced Innovation Centerfor Human Brain Protection National Clinical Research Centerfor Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational MedicineCenter International Centerfor Aging and CancerBejing Municipal GeriatricMedical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Beijing Institute for Stem Cell and Regenerative Medicine Beijing100101China CAS Key Laboratory of Genomic and Precision Medicine Bejing Institute of Genomics and China National Center for BioinformationChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration CASBeijing 100101China The Fifth People's Hospital of Chongqing Chongqing 400062China Sino-Danish Cllege University of Chinese Academy of SciencesBeijing101408China National Laboratory of Biomacromolecules CAS Center for Excelence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing100101China State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China

Cullin-RING E3 ubiquitin ligases(CRLs),the largest family of multi-subunit E3 ubiquitin ligases in eukaryotic cells,represent core cellular machinery for executing protein degradation and maintaining proteostasis.Here,we asked what roles Cullin proteins play in human mesenchymal stem cell(hMSC)homeostasis and senescence.To this end,we conducted a comparative aging phenotype analysis by individually knocking down Cullin members in three senescence models:replicative senescent hMSCs,Hutchinson-Gilford Progeria Syndrome hMSCs,and Werner syndrome hMSCs.Among all family members,we found that CUL2 deficiency rendered hMSCs the most susceptible to senescence.To investigate CUL2-specific underlying mechanisms,we then applied CRISPR/Cas9-mediated gene editing technology to generate CUL2-deficient human embryonic stem cells(hESCs).When we differentiated these into h MSCs,we found that CUL2 deletion markedly accelerates hMSC senescence.Importantly,we identified that CUL2 targets and promotes ubiquitin proteasome-mediated degradation of TSPYL2(a known negative regulator of proliferation)through the substrate receptor protein APPBP2,which in turn downregulates one of the canonical aging marker-P21^(waf1/cip1),and thereby delays senescence.Our work provides important insights into how CRL2^(APPBP2)-mediated TSPYL2 degradation counteracts hMSC senescence,providing a molecular basis for directing intervention strategies against aging and aging-related diseases.

关键词： Cullins stem cell senescence aging proteostasis ubiquitination APPBP2 TSPYL2

A high-performance lithium anode based on N-doped composite graphene

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第3期43卷 1030-1036页

作者： Can Jiao Hao-Bo Sun Li Zhang Shang-qian zhao Guo-Yao Pang Chun-Rong zhao Shi-Gang Lu General Research Institute for Nonferrous Metals Beijing100088China China Automotive Battery Research Institute Co.Ltd Beijing101407China

Lithium(Li)metal is the most promising electrode for next-gene ration rechargeable batteries.In order to push the commercialization of the lithium metal batteries,a kind of nitrogen(N)-doped composite graphene(NCG)adopted as the Li plating host was prepared to regulate Li metal nucleation and suppress dendrite growth.Furthermore,a new kind of sandwich-type composite lithium metal(STCL)electrode was developed to improve its application.The STCL electrode can be used as convenient as a piece of Li foil but no dendrite growth.In a symmetric battery,the STCL electrode cycled for more than 4500 h with the overpotential of less than 40 mV.And due to the creative design,the STCL promises the Li-S battery with a prolonged cycling lifespan.

关键词： Lithium metal anode Lithiophilic N-doped composite graphene Sandwich-type composite lithium metal electrode

Recombinant adeno-associated virus 8-mediated inhibition of microRNA let-7a ameliorates sclerosing cholangitis in a clinically relevant mouse model

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第5期30卷 471-484页

作者： Hui Hua qian-qian zhao Miriam Nkesichi Kalagbor Guo-Zhi Yu Man Liu Zheng-Rui Bian Bei-Bei Zhang qian Yu Yin-Hai Xu Ren-Xian Tang Kui-Yang Zheng Chao Yan Jiangsu Key Laboratory of Immunity and Metabolism Department of Pathogenic Biology and ImmunologyNational Demonstration Center for Experimental Basic Medical Science EducationLaboratory of Infection and ImmunityXuzhou Medical UniversityXuzhou 221004Jiangsu ProvinceChina Department of Laboratory Medicine The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221002Jiangsu ProvinceChina

BACKGROUND Primary sclerosing cholangitis(PSC)is characterized by chronic inflammation and it predisposes to cholangiocarcinoma due to lack of effective treatment options.Recombinant adeno-associated virus(rAAV)provides a promising platform for gene therapy on such kinds of diseases.A microRNA(miRNA)let-7a has been reported to be associated with the progress of PSC but the potential therapeutic implication of inhibition of let-7a on PSC has not been evaluated.AIM To investigate the therapeutic effects of inhibition of a miRNA let-7a transferred by recombinant adeno-associated virus 8(rAAV8)on a xenobiotic-induced mouse model of sclerosing cholangitis.METHODS A xenobiotic-induced mouse model of sclerosing cholangitis was induced by 0.1% 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine(DDC)feeding for 2 wk or 6 wk.A single dose of rAAV8-mediated anti-let-7a-5p sponges or scramble control was injected in vivo into mice onset of DDC feeding.Upon sacrifice,the liver and the serum were collected from each mouse.The hepatobiliary injuries,hepatic inflammation and fibrosis were evaluated.The targets of let-7a-5p and downstream molecule NF-κB were detected using Western blot.RESULTS rAAV8-mediated anti-let-7a-5p sponges can depress the expression of let-7a-5p in mice after DDC feeding for 2 wk or 6 wk.The reduced expression of let-7a-5p can alleviate hepato-biliary injuries indicated by serum markers,and prevent the proliferation of cholangiocytes and biliary fibrosis.Furthermore,inhibition of let-7a mediated by rAAV8 can increase the expression of potential target molecules such as suppressor of cytokine signaling 1 and Dectin1,which consequently inhibit of NF-κB-mediated hepatic inflammation.CONCLUSION Our study demonstrates that a rAAV8 vector designed for liver-specific inhibition of let-7a-5p can potently ameliorate symptoms in a xenobiotic-induced mouse model of sclerosing cholangitis,which provides a possible clinical translation of PSC of human.

关键词： Primary sclerosing cholangitis Recombinant adeno-associated virus 8 Let-7a-5p Therapeutic effects Inflammation

Effective norfloxacin elimination via photo-Fenton process over the MIL-101(Fe)-NH_(2)immobilized onα-Al_(2)O_(3)sheet

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2022年第11期33卷 4828-4833页

作者： qian zhao Chong-Chen Wang Peng Wang Beijing Key Laboratory of Functional Materials for Building Structure and Environment Remediation/Beijing Energy Conservation&Sustainable Urban and Rural Development Provincial and Ministry Co-construction Collaboration Innovation Center School of Environment and Energy EngineeringBeijing University of Civil Engineering and ArchitectureBeijing 100044China

MIL-101(Fe)-NH_(2)@Al_(2)O_(3)(MA)catalysts were successfully synthesized by reactive seeding(RS)method onα-Al_(2)O_(3)substrate,which demonstrated excellent photo-Fenton degradation performance toward fluoroquinolone antibiotics(i.e.,norfloxacin,ciprofloxacin,and enrofloxacin).The structure and morphology of the obtained MA were characterized by transmission electron microscopy(TEM),high-resolution transmission electron microscopy(HRTEM),atomic force microscope(AFM).The as-prepared MA could accomplish>90%of norfloxacin degradation efficiency for 10 cycles’photo-Fenton processes,owing to its excellent chemical and water stability.In addition,the effects of operational factors including H_(2)O_(2)concentration,foreign ions,and pH on the photo-Fenton degradation of norfloxacin over MA were clarified.The ESR spectra further document that^(•)O_(2)^(−),1O_(2)and•OH radicals are prominent in the decomposition process of antibiotic molecules.Finally,the plausible photo-Fenton norfloxacin degradation mechanisms were proposed and verified.

关键词： MIL-101(Fe)-NH_(2)@Al_(2)O_(3)(MA) Photo-Fenton NOR Mechanism Real solar