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Application of three-dimensional speckle tracking technique in measuring left ventricular myocardial function in patients with diabetes

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World Journal of Diabetes 2024年第4期15卷 783-792页

作者： Zheng Li ying qian Chun-Yun Fan Yong Huang Department of Ultrasound The People’s Hospital of DanyangDanyang Hospital of Nantong UniversityDanyang 212300Jiangsu ProvinceChina Department of Endocrinology The People’s Hospital of DanyangDanyang Hospital of Nantong UniversityDanyang 212300Jiangsu ProvinceChina

BACKGROUND Diabetic cardiomyopathy is considered as a chronic complication of diabetes mellitus(DM).Therefore,early detection of left ventricular systolic function(LVSF)damage in DM is *** To explore the use of the three-dimensional speckle tracking technique(3D-STI)for measuring LVSF in DM patients via *** The electronic databases were retrieved from the initial accessible time to 29 April *** current study involved 9 studies,including 970 *** carried out this meta-analysis to estimate myocardial function in DM compared with controls according to myocardial strain attained by *** Night articles including 970 subjects were *** significant difference was detected in the left ventricular ejection fraction between the control and the diabetic group(P>0.05),while differences in global longitudinal strain,global circumferential strain,global radial strain,and global area strain were markedly different between the controls and DM patients(all P<0.05).CONCLUSION The 3D-STI could be applied to accurately measure early LVSF damage in patients with DM.

关键词： Diabetes mellitus Left ventricular systolic dysfunction Three-dimensional speckle tracking echocardiography Meta analysis

Engineering a high-barrier d-f single-molecule magnet centered with hexagonal bipyramidal Dy(Ⅲ) unit

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Science China Chemistry 2024年第10期67卷 3291-3298页

作者： Wei Deng Chan-ying Yao Yan-Cong Chen ying-qian Zhou Shan-Nan Du Jun-Liang Liu Ming-Liang Tong Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education School of ChemistryInstitute of Green Chemistry and Molecular EngineeringGuangdong Basic Research Center of Excellence for Functional Molecular EngineeringSun Yat-sen University

In the pursuit of high-performance single-molecule magnets（SMMs）,incorporating intramolecular magnetic coupling emerges as a pivotal *** these,d-f SMMs have garnered significant attention due to their remarkable versatility,which lies in their ability to tune coordination environments and facilely substitute metal ***,achieving performance-centric d-f SMMs through the synergistic interplay between highly anisotropic f ions and d-f magnetic interactions remains a formidable *** mononuclear hexagonal bipyramidal(D6h) DyⅢSMMs have been successfully isolated,the exploration of d-f SMMs featuring D6h-lanthanide metal centers remains uncharted *** this study,we employed planar bipodal ligands in conjunction with “staple-like” axial phenoxide ligands to synthesize the first hexagonal bipyramidal d-f ***,this compound exhibits alternating-current magnetic susceptibilities peaking up to 68 K with an energy barrier surpassing 1,200 K,thus establishing a new benchmark within the heterometallic d-f SMM landscape inclusive of complexes with diamagnetic d metals and paramagnetic f ***,the ferromagnetic interaction at the d-f sites engenders oscillating relaxation times contingent on the magnetic field—a characteristic distinct from mononuclear *** findings shed light on a deliberate design approach for d-f SMMs,emphasizing the cooperative utilization of high-barrier lanthanide modules alongside d ions through magnetic *** synergy significantly enhances and diversifies the magnetic dynamics of these intriguing molecular systems.

关键词： single-molecule magnets magnetic coupling crystal engineering hexagonal bipyramid energy barrier

Identification of anti-gastric cancer effects and molecular mechanisms of resveratrol: From network pharmacology and bioinformatics to experimental validation

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 493-513页

作者： ying-qian Ma Ming Zhang Zhen-Hua Sun Hong-Yue Tang ying Wang Jiang-Xue Liu Zhan-Xue Zhang Chao Wang Department of Oncology Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina School of Graduate Studies Hebei Medical UniversityShijiazhuang 050017Hebei ProvinceChina Clinical Medical Research Center Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina Department of Gastrointestinal Surgery Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Gastric cancer(GC)is one of the most aggressive malignancies with limited therapeutic options and a poor ***,a non-flavonoid poly-phenolic compound found in a variety of Chinese medicinal materials,has shown excellent anti-GC ***,its exact mechanisms of action in GC have not been *** To identify the effects of resveratrol on GC progression and explore the related molecular *** Action targets of resveratrol and GC-related targets were screened from public *** overlapping targets between the two were confirmed using a Venn diagram,and a“Resveratrol-Target-GC”network was constructed using Cyto-scape software version *** protein-protein interaction(PPI)network was constructed using STRING database and core targets were identified by PPI network *** Database for Annotation,Visualization and Integrated A total of 378 resveratrol action targets and 2154 GC disease targets were obtained from public databases,and 181 intersection targets between the two were screened by Venn *** top 20 core targets were identified by PPI network analysis of the overlapping *** function analysis mainly involved protein binding,identical protein binding,cytoplasm,nucleus,negative regulation of apoptotic process and response to xenobiotic *** enrichment analysis suggested that the involved signaling pathways mainly included PI3K-AKT signaling pathway,MAPK signaling pathway,IL-17 signaling pathway,TNF signaling pathway,ErbB signaling pathway,*** murine osteosarcoma viral oncogene homolog(FOS)and matrix metallopeptidase 9(MMP9)were selected by differential expression analysis,and they were closely associated with immune *** docking results showed that resveratrol docked well with these two *** treatment arrested the cell cycle at the S phase,induced apoptosis,and weakened viability,migration and invasion in a dose-dependent ***,re

关键词： Resveratrol Gastric cancer Network pharmacology Bioinformatics Molecular docking

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3875-3886页

作者： Lu Zhang Yan-Ping Chen Min Ji Le-qian ying Chun-Chun Huang Jing-Yi Zhou Lin Liu Department of Oncology Zhongda HospitalMedical School of Southeast UniversityNanjing 210009Jiangsu ProvinceChina

BACKGROUND Inflammation-related markers including neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),monocyte-to-lymphocyte ratio(MLR),systemic immune-inflammation index(SII),systemic inflammation response index(SIRI)and prognostic nutritional index(PNI)could reflect tumor immune microenvironment and predict prognosis of ***,it had not been explored in alpha-fetoprotein(AFP)producing gastric cancer(GC).AIM To determine the predictive value of inflammation-related peripheral blood markers including as NLR,PLR,MLR,SII,SIRI and PNI in the prognosis of AFPproducing GC(AFPGC).Besides,this study would also compare the differences in tumor immune microenvironment,clinical characteristics and prognosis between AFPGC and AFP-GC patients to improve the understanding of this *** 573 patients enrolled were retrospectively *** were divided into AFP+group(AFP≥20 ng/mL)and AFP-group(AFP<20 ng/mL),comparing the levels of NLR/PLR/MLR/SII/SIRI/PNI and *** AFP+group,the impact of NLR/PLR/MLR/SII/SIRI/PNI and their dynamic changes on prognosis were further *** Compared with AFP-patients,AFP+patients had higher NLR/PLR/MLR/SII/-SIRI and lower PNI levels and poorer overall survival(OS).In the AFP+group,mortality was significantly lower in the lower NLR/PLR/MLR/SII/SIRI group and higher PNI ***,the dynamic increase(NLR/PLR/MLR/SII/-SIRI)or decrease(PNI)was associated with the rise of mortality within 1 year of *** Compared with AFP-patients,the level of inflammation-related peripheral blood markers significantly increased in AFP+patients,which was correlated with OS of AFP+***,the gradual increase of SII and SIRI was associated with the risk of death within one year in AFP+*** should be considered as a separate type and distinguished from AFP-GC because of the difference in tumor immune *** requires basic experiments and large clinical samples in the f

关键词： Alpha-fetoprotein producing gastric cancer Inflammatory indicator Prognosis Dynamic changes Tumor immune microenvironment

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“强粥”考

语言研究 2024年第1期44卷 109-112页

作者：钱群英浙江中医药大学基础医学院杭州310053

六朝佛教戒律中出现的“强粥”指的是干粘的稠粥、厚粥。明清文献中的“强粥”有二义:一是强迫自己喝粥,意为努力进食,以维持生命;二是用于书信,劝勉他人进食,意为保重身体。《汉语大词典》未见收录,可补辞书之失。

关键词：强粥释义厚粥《汉语大词典》

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特征分离和非阴影信息引导的阴影去除网络

通信学报 2024年第5期45卷 178-190页

作者：黄颖房少杰程彬姜茂钱鹰重庆邮电大学软件工程学院重庆400065 重庆邮电大学计算机科学与技术学院重庆400065

为了解决现有阴影去除方法中存在的性能瓶颈以及去除结果产生的色差问题,构建了一个特征分离和非阴影信息引导的阴影去除网络(FSNIG-ShadowNet)。在分离和重建阶段,利用自重建监督将阴影图像分离成直射光和环境光两部分,对光照类型和反... 详细信息

为了解决现有阴影去除方法中存在的性能瓶颈以及去除结果产生的色差问题,构建了一个特征分离和非阴影信息引导的阴影去除网络(FSNIG-ShadowNet)。在分离和重建阶段,利用自重建监督将阴影图像分离成直射光和环境光两部分,对光照类型和反射率进行特征解耦分离,设计解码器对分离的特征进行重新耦合以获得无阴影图像。在细化阶段,该网络关注阴影和非阴影的邻接区域,设计局部区域自适应归一化模块将局部非阴影区域颜色先验传递至阴影区域以减少两区域间的色差。实验结果表明,所提FSNIG-ShadowNet与其他优秀的方法相比取得了较有竞争力的结果。

关键词：阴影去除特征分离自重建颜色先验

合理使用阴道镜检查,提高评估子宫颈癌前病变的准确性

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中国实用妇科与产科杂志 2024年第1期40卷 26-28页

作者：钱德英广东省人民医院妇产科广东广州510080

阴道镜是一门易学难精的技术,阴道镜医生需要获得专业培训,掌握阴道镜检查适应证,规范阴道镜检查操作过程,避免各种可能失误,才能保证阴道镜检查的准确性。

关键词：阴道镜检查规范准确性

益气养阴法治疗早期2型糖尿病肾病的临床效果及对血清β2-MG的影响

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医药论坛杂志 2024年第2期45卷 207-210,215页

作者：钱莹开封市中医院糖尿病肾病科河南开封475000

目的探讨早期2型糖尿病肾病患者采取益气养阴疗法治疗的疗效及对血清β2微球蛋白(β2-MG)及相关指标的影响。方法选取开封市中医院糖尿病肾病科收治的早期2型糖尿病肾病患者66例进行研究,根据随机的方式将选取的患者分成对比组和治疗组... 详细信息

目的探讨早期2型糖尿病肾病患者采取益气养阴疗法治疗的疗效及对血清β2微球蛋白(β2-MG)及相关指标的影响。方法选取开封市中医院糖尿病肾病科收治的早期2型糖尿病肾病患者66例进行研究,根据随机的方式将选取的患者分成对比组和治疗组,每组33例患者,对比组患者采取基础治疗+金水宝片治疗,治疗组患者采取基础治疗+益气养阴法治疗,比较两组的治疗效果、中医各证候积分、血清β2-MG指标、尿微量蛋白指标等。结果①治疗组的治疗有效率96.97%,高于对比组的75.76%(P0.05),治疗后两组各证候积分均下降,且治疗组的各证候积分明显小于对比组(P0.05),治疗后均明显下降,且治疗组β2-MG水平(2.40±0.29)mg/L,低于对比组的(3.30±0.50)mg/L(P0.05),治疗后均明显下降,且治疗组UARE水平(46.76±26.77)μg/min,低于对比组的(80.49±23.79)μg/min(P<0.05)。结论早期2型糖尿病肾病患者实施益气养阴法治疗后,患者的中医各证候积分明显降低,其血清β2-MG指标、尿微量蛋白指标也均有明显改善,治疗效果十分显著,值得临床推广。

关键词：益气养阴法金水宝片治疗效果证候积分基础治疗

落叶松枯梢病生防菌的筛选、鉴定及其生物学特性

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林业科学研究 2024年第4期37卷 182-192页

作者：钱莹莹邓勋王铮宋小双梁军中国林业科学研究院森林生态环境与保护研究所北京100091 东北林业大学林学院黑龙江哈尔滨150040 黑龙江省森林保护研究所黑龙江哈尔滨150081 黑龙江省森林草原火灾及病虫害防控重点实验室黑龙江哈尔滨150081

[目的]为获得落叶松枯梢病的生防菌。[方法]通过对峙实验和发酵液复筛,筛选获得对落叶松枯梢病菌(Neofusicoccum laricinum)具有较强抑制效果的菌株,对筛选得到的菌株进行鉴定,并对其生物学特性展开研究。[结果]筛选得到1株对落叶松枯... 详细信息

[目的]为获得落叶松枯梢病的生防菌。[方法]通过对峙实验和发酵液复筛,筛选获得对落叶松枯梢病菌(Neofusicoccum laricinum)具有较强抑制效果的菌株,对筛选得到的菌株进行鉴定,并对其生物学特性展开研究。[结果]筛选得到1株对落叶松枯梢病病原菌有显著拮抗作用的土壤真菌T2,结合形态学以及分子生物学鉴定为钩状木霉(Trichoderma hamatum)。其平板对峙抑菌率达到74.16%,发酵液的抑菌率达到91.29%。发酵液对多种植物病原真菌均具有较强的抑菌作用,对松球壳孢菌、金黄壳囊孢菌、杨灰星叶点霉和立枯丝核菌表现出强抑制作用,抑菌率均为92.00%,对拟枝孢镰刀菌和杨生褐盘二孢菌的抑菌效果较好,分别为79.67%和62.67%。T2能利用多种碳氮源、有广泛的酸碱度适应能力及较高的致死温度。[结论]通过筛选得到的钩状木霉T2对落叶松枯梢病病原菌的拮抗作用显著,抑菌谱广,环境适应力强。本研究可为落叶松枯梢病的防治提供理论研究和基础。

关键词：落叶松 Neofusicoccum laricinum 生物防治钩状木霉