检索结果-南通市图书馆

Identification of SPP1 as an extracellular matrix signature for metastatic castration-resistant prostate cancer

中国药理学与毒理学杂志 2019年第10期 760-761页

作者： PANG Xiao-cong XIE Ran ZHANG Zhuo LIU qian-xin WU Shi-liang CUI Yi-min Department of Pharmacy Peking University First Hospital Department of Urology Peking University First Hospital

OBJECTIVE Resistance to androgen deprivation therapy(ADT) is the main challenge for advanced fatal prostate cancer(PCa), which can gradually develop into metastatic castration-resistant prostate cancer(m CRPC). However, the pathologic mechanisms of m CRPC are still far from clear. Given the high incidence and mortality related to m CRPC, understanding the causes and pathogenesis of this condition as well as identifying potential biomarkers are of great *** In the research reported here, we integrated several gene expression profiles from hormone sensitive prostate cancer(HSPC) and m CRPC datasets to identify differentially expressed genes(DEGs), key biological pathways, and cellular components. K-nearest neighbor,logistic regression, naive Bayes, and random forest classifiers models were established to identify key regulated genes. Furthermore, organoid models were employed to validate the results in vitro. RESULTS We found that extracellular matrix(ECM) genes were significantly enriched, and further filtered them using Pearson correlation analysis and stepwise regression to find ECM signatures to differentiate between the HSPC and m CRPC phenotypes. Six ECM signatures were input into K-nearest neighbor, logistic regression, naive Bayes, and random forest classifiers models. Random forest algorithm with the six-gene prognostic signature showed best performance, which had high sensitivity and specificity for HSPC and m CRPC classification. Among the six ECM genes, SPP1 was identified as the key hub signature for PCa metastasis and drug resistance development; we found that both protein and m RNA expression levels of SPP1 were remarkably up-regulated in m CRPC compared with HSPC in organoid models and could regulate the androgen receptor signaling pathway. CONCLUSION Therefore, SPP1 is a potential novel biomarker and therapeutic target for m CRPC. Further understanding of the role of SPP1 in m CRPC development may help to explore effectively therapeutic

关键词： SPP1 castration-resistant prostate cancer extracellular matrix metastasis organoid model

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Multiple myocardial bridges affecting left anterior descending artery and right coronary artery with hypertrophic cardiomyopathy:a case report

引用

Chinese Medical Journal 2007年第8期120卷 734-736页

作者： HU xin-ying ZHOU Da-xin qian Ju-ying ZHANG Feng PAN Cui-zhen GE Jun-bo Department of Cardiology Shanghai Institute of Cardiovascular Disease Zhongshan Hospital Fudan University Shanghai 200032 China

The prevalence of myocardial bridging in hypertrophic cardiomyopathy （HCM） is relatively higher, and it usually occurs in the middle and distal portions of the left anterior descending artery. It is rarely reported that multiple lesions of myocardial bridging affecting not only the left anterior descending artery but also right coronary artery. We reported a 56-year-old man suffering from chest discomfort on exertion. Echocardiography and ventriculography showed hypertrophy of the apex involving the anterior and lateral wall. Coronary angiograph revealed multiple myocardial bridges affecting the left anterior descending artery and the right posterior descending artery.

关键词： myocardial bridge hypertrophic cardiomyopathy left anterior descending artery right posterior descending artery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于输入输出模型的双时标分散控制方法

引用

浙江大学学报（工学版） 2008年第11期42卷 1873-1877,1884页

作者：牛健赵均钱积新浙江大学控制科学与工程学系浙江杭州310027

针对不同通道的过程动态响应速度具有显著差异的多变量系统,提出了一种基于时标分解的双时标分散控制方法.由于控制中的过程模型一般都是由实验测试方法得到的输入输出模型,该方法是以系统输入输出模型为基础,在状态空间模型的框架下对... 详细信息

针对不同通道的过程动态响应速度具有显著差异的多变量系统,提出了一种基于时标分解的双时标分散控制方法.由于控制中的过程模型一般都是由实验测试方法得到的输入输出模型,该方法是以系统输入输出模型为基础,在状态空间模型的框架下对系统进行基于奇异摄动理论的时标分解,并由分解得到的快、慢模型分别设计最优控制器.此方法实现了时标模型实际上的分离,并对2个子系统进行完全独立设计,给出了在最优二次型目标下的最优控制率.最后利用该方法仿真一个实际测得的三输入三输出的精馏塔模型,给出了设定值跟踪的仿真效果,验证了该方法的有效性.

关键词：双时标分散控制奇异摄动

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Magnetic resonance imaging： a valuable method for diagnosing chronic lumbago caused by lumbar muscle strain and monitoring healingprocess

引用

Chinese Medical Journal 2013年第13期126卷 2465-2471页

作者： OUYANG Lin JIA qian-xin XIAO Yu-hui KE Lai-shun HE Ping Department of Medical Imaging People's Liberation Army 175th Hospital Affiliated Southeast Hospital of Xiamen University Zhangzhou Fujian 363000 China

Background Magnetic resonance imaging （MRI） is the most sensitive technique for evaluating the healing process and should be performed before the patients return to their exercise routines. The aim of this research was to diagnose chronic lumbago associated with lumbar muscle strain and to monitor healing process by MRI. Methods Sixty-five symptomatic cases of chronic lumbago caused by lumbar muscle strain were collected from March 2009 to October 2011. MRI was used to examine, diagnose and monitor the healing process. The control group included 65 random cases of asymptomatic volunteers. MRI methods included routine sequences of GRE TlWl, TSE T2WI and special sequences of T2-STIR-FS, combined with DWI. We compared the MRI characteristics of symptomatic cases before and after healing and with asymptomatic controls. Results The important MRI characteristics of chronic lumbago with lumbar muscle strain included：（1） The low back muscle showed edema. （2） The low back intermuscular spaces showed edema and/or fluid. （3） The low back spaces beside the spinous process showed edema and/or fluid. （4） The low back vertebral articular process fossae or transverse process fossae showed fluid. Of these image characteristics, the intermuscular space edema provided the best diagnostic sensitivity, Se=83%, with Y1=0.63, Tr=74%. The low back muscle edema provided the best diagnostic specificity, Sp=100%, with Y1=0.66, Tr=83%. And the spaces edema beside the spinous process provided the best diangnostic accuracy, Tr=86%, with YI = 0.71, Se=80%, Sp=91%. The diagnosis accurate could be improved by combining multiple MRI characteristics. The diagnostic accuracy could achieve n=93%, with Y1=0.86, Se=100% and Sp=86% when two characteristics were combined. After rehabilitation care, the edema disappeared on the repeated MRI. Conclusions MRI may well be a useful diagnostic method for lumbago with lumbar muscle strain. Combining routine sequences with T2-STIR-FS and DWI sequences could demon

关键词： psoas muscles," sprains and strains," magnetic resonance imaging muscular-skeletal image

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

完善煤炭市场体系促进经济较快发展

引用

中国流通经济 2007年第2期21卷 4-7页

作者：欧新黔国家发展和改革委员会北京市100824

本文认为,近年来推行的煤炭订货改革有效发挥了市场配置资源的基础性作用,加快了政府职能转变,初步形成了国家宏观调控指导下供需双方企业自主衔接资源、协商定价的新机制,为保障煤炭稳定供应、促进经济平稳较快发展奠定了重要基础。200... 详细信息

本文认为,近年来推行的煤炭订货改革有效发挥了市场配置资源的基础性作用,加快了政府职能转变,初步形成了国家宏观调控指导下供需双方企业自主衔接资源、协商定价的新机制,为保障煤炭稳定供应、促进经济平稳较快发展奠定了重要基础。2007年是推进煤炭订货改革关键性的一年,为进一步推进改革,加强市场监管,规范市场行为,建立并完善统一开放、竞争有序的煤炭市场体系,煤炭订货改革要进一步引入市场机制,简化铁路运力配置框架;依法规范购销关系,企业自主签订合同;完善煤炭价格市场形成机制,供需双方协商定价;以提高运输效率为核心,优化运力配置。有关各方应认清形势,自觉适应并支持改革;把握原则要求,加快衔接进度;落实企业定价自主权,搞好价格协商;加强行业自律,规范企业行为,为建成既能实现市场主体自由交易,又有利于国家宏观调控、市场运作、规范运行、功能齐全、层次分明、方式多样、手段先进的现代煤炭市场化体系,搞好组织实施与衔接工作。

关键词：煤炭市场体系订货改革产运需衔接

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

原发性阴道癌的远期疗效及预后影响因素分析

引用

中华肿瘤杂志 2018年第3期40卷 227-231页

作者：卢倩张新辽宁省肿瘤医院妇科沈阳110042

目的探讨影响原发性阴道癌患者预后的临床相关因素。方法对1999—2014年间辽宁省肿瘤医院妇科收治的有完整病理诊断、临床随访资料的118例原发性阴道癌患者进行回顾性研究，分析患者年龄、有无子宫切除史、病理类型、国际妇产科联盟（F... 详细信息

目的探讨影响原发性阴道癌患者预后的临床相关因素。方法对1999—2014年间辽宁省肿瘤医院妇科收治的有完整病理诊断、临床随访资料的118例原发性阴道癌患者进行回顾性研究，分析患者年龄、有无子宫切除史、病理类型、国际妇产科联盟（FIGO）分期、肿瘤大小、肿瘤生长部位、治疗方式等因素对患者预后的影响。结果118例原发性阴道癌患者的中位生存时间为93个月，1、3、5、10和15年生存率分别为89.7%、68.1%、60.4%、37.3%和19.0%。单因素分析结果显示，原发性阴道癌的FIGO分期、病理类型、肿瘤大小、治疗方式、肿瘤生长区段与患者的预后有关（均P〈0.05），而患者年龄、有无子宫切除史与患者的预后无关（均P〉0.05）。Cox多因素回归分析显示，FIGO分期（P＝0.008）、肿瘤生长区段（P＝0.001）、治疗方式（P＝0.007）为影响原发性阴道癌患者预后的独立因素。结论FIGO分期、病理类型、肿瘤大小、治疗方式和肿瘤生长区段与原发性阴道癌患者的预后有关，其中FIGO分期、肿瘤生长区段和治疗方式为影响原发性阴道癌患者预后的独立因素。

关键词：阴道肿瘤肿瘤原发性预后

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

实施中小企业成长工程促进经济社会和谐发展

引用

中国行政管理 2007年第7期 6-7页

作者：欧新黔国家发展改革委

一、中小企业发展有利于和谐社会构建

关键词：企业成长经济社会和谐发展构建社会主义和谐社会工程和谐社会构建中小企业小企业发展

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

落实科学发展观推进我国现代物流业持续快速健康发展(上)

引用

中国流通经济 2005年第12期19卷 8-11页

作者：欧新黔国家发展和改革委员会北京市100824

本文认为,我国现代物流业已经由起步阶段开始迈向理性、务实、快速发展的新阶段,社会物流需求持续增长,物流企业快速成长,物流管理和服务不断创新,物流基础设施、技术装备和物流技术条件日益改善,物流信息化步伐加快等。文章提出,党中... 详细信息

本文认为,我国现代物流业已经由起步阶段开始迈向理性、务实、快速发展的新阶段,社会物流需求持续增长,物流企业快速成长,物流管理和服务不断创新,物流基础设施、技术装备和物流技术条件日益改善,物流信息化步伐加快等。文章提出,党中央和国务院领导高度重视现代物流发展,有关部门和地方政府为推进现代物流业发展做了大量卓有成效的工作,一是统筹规划,增加投入,支持和鼓励现代物流业发展;二是结合实际,出台政策,积极推进物流领域对外开放;三是搭建平台,打好基础,大力支持物流信息化建设和物流人才的培养;四是部际合作,营造环境,加快建立现代物流市场体系等。

关键词：科学发展观现代物流物流企业物流现代化

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Simulation analysis of static and dynamic characteristics of once-through steam generator in concentric annuli tube

引用

Journal of Marine Science and Application 2006年第3期5卷 36-40页

作者： ZHANG Wei BIAN xin-qian XIA Guo-qing College of Automation Harbin Engineering University Harbin 150001 China

The once-through steam generator (OTSG) in concentric annuli tube is a new type of steam generator which applies double side to transfer heat. The heat flux between the water of centric tube, outside annuli tube and that of annulus channel is assumed to be equal, and then the steam generator’s model is built by lumped parameters with moving boundary. In the basis of the built model, static and dynamic characteristics are analyzed. The static characteristics are proved by experiment results in a 19-tube once-through steam generator of Babcock & Wilcox. The characteristics that the lengths of three regions (subcooled region, nucleate boiling region, superheat region) change with power can be explained by theory analysis. The dynamic characteristics accord with the heat and hydraulics and the results of analysis according to the mechanism.

关键词： once-through steam generator dynamic characteristics simulatin calculation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The 1st August 2010 Solar storm effects on the ionosphere in the Yangtze River Delta region Based on Ground and Space GPS technology

The 1st August 2010 Solar storm effects on the ionosphere in...

引用

第四届中国卫星导航学术年会

作者： Hu Wang qian-xin Wang Ying-yan Cheng Chinese Academy of Surveying ＆ Mapping

On 1st August 2010, the entire side of the sun facing earth erupted in a frenzy of solar activity. This solar storm just like a solar tsunami, the massive multiple filaments of magnetism were released from the solar surface during the solar storm. Then these high energy particles、protons and electrons from coronal mass ejections hit against the earth’s magnetic field. These hits caused intensively geomagnetic storms and ionospheric variations. Now well established ground and space based GPS instruments can offer a unique chance for a real time monitoring of ionosphere variations and characteristics. So in this paper we investigate ionospheric behavior responded to the solar storm using Ground and Space based GPS measurements. Firstly this paper describes a method of real-time solving TEC and GPS instrumental biases using Kalman filtering, so this can be used to provide absolute amount of ionospheric TEC for real-time monitoring of ionosphere changes during the solar storm. The Yangtze River Delta regional ground based GPS network measurements are used and a real-time regional ionosphere model is created, then real-time VTEC and TEC rate are also calculated. Furthermore, in order to analyze electron density structure changes during the solar storm, electron density profiles derived from GPS measurements onboard the LEO satellite COSMIC （Constellation Observing System for Meteorology, Ionosphere, and Climate） are used. Whereas the ground based GPS measurements show horizontal distribution during the solar storm, the space based GPS measurements show a vertical distribution. Meanwhile, with consideration of the solar and geomagnetic parameter, the ionospheric anomallies with phenomenon of TEC and electron density profiles changes in the special region during the sun storm are analyzed in detail and discussed by adopting the numerical computions.

关键词： Ionosphere GPS COSMIC TEC VTEC Kalman filter GPS instrumental biases

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：