检索结果-南通市图书馆

Insufficient MIRO1 contributes to declined oocyte quality during reproductive aging

在线全文

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年

作者： Zhen-Nan Pan Hao-Lin Zhang Kun-Huan Zhang Jia-qian Ju Jing-Cai Liu Shao-Chen Sun College of Animal Science and Technology Nanjing Agricultural University Reproductive Medicine Centre The Affiliated Yantai Yuhuangding Hospital of Qingdao University

Mitochondrial Rho-GTPase 1 (MIRO1) is an outer mitochondrial membrane protein which regulates mitochondrial transport and mitophagy in mitosis. In present study, we reported the crucial roles of MIRO1 in mammalian oocyte meiosis and its potential relationship with aging. We found that MIRO1 expressed in mouse and porcine oocytes, and its expression decreased in aged mice. MIRO1 deficiency caused the failure of meiotic resumption and polar body extrusion in both mouse and porcine oocytes, which could be rescued by exogenous MIRO1supplementation. Mass spectrometry data indicated that MIRO1 associated with several cytoskeleton and cell cycle-related proteins, and MIRO1 regulated motor protein Dynein for microtubule-organizing centers (MTOCs) dynamics at germinal vesicle (GV) stage, which determined meiotic resumption. Furthermore, we found that MIRO1 regulated Aurora A and kinesin family member 11 (KIF11) for meiotic spindle assembly in oocytes. Besides, MIRO1 associated with several mitochondria-related proteins dynamic-related protein 1 (DRP1),Parkin and lysosomal-associated membrane protein 2 (LAMP2) for mitochondrial dynamics and mitophagy during oocyte meiosis. Taken together, our results suggested that MIRO1 played pivotal roles in meiotic resumption, spindle assembly and mitochondrial function in mouse and porcine oocytes, and its insufficiency might contribute to the oocyte maturation defects during aging.

关键词：

Fault-tolerant FADS system development for a hypersonic vehicle via neural network algorithms

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Theoretical & Applied Mechanics Letters 2023年第5期13卷 357-366页

作者： qian wan Minjie Zhang Guang Zuo Tianbo Xie LandSpace Technology Corporation Ltd.H1 Zhonghang Intl Plaza 13 Ronghua South RoadBeijing 100176China Department of Aerospace and Mechanical Engineering University of Southern CaliforniaLos AngelesCA 90089-1189USA

Hypersonic vehicles suffer from extreme aerodynamic heating during flights, especially around the area of leading edge due to its small curvature. Therefore, flush air data sensing(FADS) system has been developed to perform accurate measurement of the air data parameters. In the present study, the method to develop the FADS algorithms with fail-operational capability for a sharp-nosed hypersonic vehicle is provided. To be specific, the FADS system implemented with 16 airframe-integrated pressure ports is used as a case study. Numerical simulations of different freestream conditions have been conducted to generate the database for the FADS targeting in 2 ≤ Ma ≤ 5 and 0 km ≤ H ≤ 30 km. Four groups of neural network algorithms have been developed based on four different pressure port configurations, and the accuracy has been validated by 280 groups of simulations. Particularly, the algorithms based on the 16-port configuration show an excellent ability to serve as the main solver of the FADS, where 99. 5% of the angle-of-attack estimations are within the error band ±0. 2°. The accuracy of the algorithms is discussed in terms of port configuration. Furthermore, diagnosis of the system health is present in the paper. A fault-tolerant FADS system architecture has been designed, which is capable of continuously sensing the air data in the case that multi-port failure occurs, with a reduction in the system accuracy.

关键词： FADS System Hypersonic vehicle Neural network Numerical simulation Fault detection Redundancy management

Enteromorpha prolifera polysaccharide-Fe(Ⅲ) complex promotes intestinal development as a new iron supplement

在线全文

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年第1期 219-231页

作者： Yingying Feng Yuying Wu Jialu wang Zhenglin dong qian Yu Shuangshuang Xia Chunxue Liu Haihua wang Xin Wu Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences CAS Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of Sciences ANYOU Biotechnology Group Co.Ltd Qingdao Seawin Biotech Group Co. LTD

Iron is a crucial micronutrient, and its deficiency can have detrimental effects on the health of infants. Dietary polysaccharide-iron(Ⅲ) complexes(PICs) are promising for addressing iron deficiency due to their minimal adverse reactions and high iron absorption rate. This study aimed to investigate the effects of dietary Enteromorpha prolifera polysaccharide-Fe(Ⅲ) complex(EP-Fe) on newborns, using 3-day weaned piglets as the iron-deficiency model. Results showed that EP-Fe improved iron levels and promoted intestinal development in piglets. Transcriptome sequencing revealed that EP-Fe increased the survival of intestinal epithelial cells under hypoxia by upregulating the expression of genes that promote the development of the vascular system. Additionally, EP-Fe enhanced the mucosal barrier functions by inhibiting myosin light chain kinase(MLCK)/phosphorylated myosin light chain(p-MLC) signaling pathway to increase the expression of intestinal tight junction proteins. Furthermore, the 16S r RNA gene sequencing of gut microbiota showed that EP-Fe promoted the enrichment of Bacteroides＿fragilis and other gut microbes that can metabolize carbohydrates. In conclusion, EP-Fe is an effective iron supplement for newborns, and it can be developed as a comprehensive nutritional supplement.

关键词：

Risk assessment of water security in Haihe River Basin during drought periods based on D-S evidence theory

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Water Science and Engineering 2014年第2期7卷 119-132页

作者： qian-jin dong Xia LIU State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University Hubei Provincial Collaborative Innovation Center for Water Resources Security Wuhan University School of Geography and Planning Sun Yat-sen University

The weights of the drought risk index （DRI）, which linearly combines the reliability, resiliency, and vulnerability, are difficult to obtain due to complexities in water security during drought periods. Therefore, drought entropy was used to determine the weights of the three critical indices. Conventional simulation results regarding the risk load of water security during drought periods were often regarded as precise. However, neither the simulation process nor the DRI gives any consideration to uncertainties in drought events. Therefore, the Dempster-Shafer （D-S） evidence theory and the evidential reasoning algorithm were introduced, and the DRI values were calculated with consideration of uncertainties of the three indices. The drought entropy and evidential reasoning algorithm were used in a case study of the Haihe River Basin to assess water security risks during drought periods. The results of the new DRI values in two scenarios were compared and analyzed. It is shown that the values of the DRI in the D-S evidence algorithm increase slightly from the original results of Zhang et al. （2005）, and the results of risk assessment of water security during drought periods are reasonable according to the situation in the study area. This study can serve as a reference for further practical application and planning in the Haihe River Basin, and other relevant or similar studies.

关键词： risk assessment " water security " drought periods " entropy " D-S evidence theory "evidential reasoning algorithm " Haihe River Basin

Target localization based on cross-view matching between UAV and satellite

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2022年第9期35卷 333-341页

作者： Kan REN Lei DING Minjie wan Guohua GU qian CHEN Jiangsu Key Laboratory of Spectral Imaging and Intelligent Sense Nanjing University of Science and TechnologyNanjing 210094China

Matching remote sensing images taken by an unmanned aerial vehicle(UAV) with satellite remote sensing images with geolocation information. Thus, the specific geographic location of the target object captured by the UAV is determined. Its main challenge is the considerable differences in the visual content of remote sensing images acquired by satellites and UAVs, such as dramatic changes in viewpoint, unknown orientations, etc. Much of the previous work has focused on image matching of homologous data. To overcome the difficulties caused by the difference between these two data modes and maintain robustness in visual positioning, a quality-aware template matching method based on scale-adaptive deep convolutional features is proposed by deeply mining their common features. The template size feature map and the reference image feature map are first obtained. The two feature maps obtained are used to measure the similarity. Finally, a heat map representing the probability of matching is generated to determine the best match in the reference image. The method is applied to the latest UAV-based geolocation dataset(University-1652 dataset) and the real-scene campus data we collected with UAVs. The experimental results demonstrate the effectiveness and superiority of the method.

关键词： Cross-view image matching Satellite Target localization Template matching Unmanned Aerial Vehicle(UAV)

DYNAMICS OF THE ZONAL ASYMMETRIC STRUCTURE OF ARCTIC OSCILLATION

在线全文

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2004年第5期16卷 533-536页

作者： wanGXiu-hong YUWei-dong LUOTi-qian SchoolofEnergyandPowerEngineering JiangsuUniversityZhenjiang212013China KeyLaboratoryofMarineScienceandNumericalmodeling TheFirstInstituteofOceanographyStateOceanicAdministrationQingdao266061China

The Arctic Oscillation (AO), though basically is a zonal symmetricphenomenon, also shows zonal asymmetric variation. The dynamics of this zonal variation isconsidered here from the point of view of the planetary propagation on the earth sphere. Based onthe linear barotropic vorticity e-quation, the planetary wave ray path is calculated in the winterJanuary. It shows that NAO( North Atlantic Oscillation), AO and North Pacific could be linkedthrough the planetary wave propagation, which acts as the atmospheric bridge. The zonal symmetricand asymmetric structures both have association with these Rossby wave activities.

关键词： planetary wave arctic oscillation (AO) zonal asymmetric structure

Contribution of phenylpropanoid metabolism to plant development and plant–environment interactions

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2021年第1期63卷 180-209页

作者： Nai-qian dong Hong-Xuan Lin National Key Laboratory of Plant Molecular Genetics CAS Centre for Excellence in Molecular Plant Sciences and Collaborative Innovation Center of Genetics and DevelopmentShanghai Institute of Plant Physiology and Ecologythe Chinese Academy of SciencesShanghai 200032China University of the Chinese Academy of Sciences Beijing 100049China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China

Phenylpropanoid metabolism is one of the most important metabolisms in plants, yielding more than 8,000 metabolites contributing to plant development and plant-environment *** metabolism materialized during the evolution of early freshwater algae that were initiating terrestrialization and land plants have evolved multiple branches of this pathway, which give rise to metabolites including lignin, flavonoids, lignans, phenylpropanoid esters, hydroxycinnamic acid amides, and *** studies have revealed that many factors participate in the regulation of phenylpropanoid metabolism, and modulate phenylpropanoid homeostasis when plants undergo successive developmental processes and are subjected to stressful environments. In this review, we summarize recent progress on elucidating the contribution of phenylpropanoid metabolism to the coordination of plant development and plant–environment interaction, and metabolic flux redirection among diverse metabolic routes. In addition, our review focuses on the regulation of phenylpropanoid metabolism at the transcriptional, post-transcriptional, post-translational,and epigenetic levels, and in response to phytohormones and biotic and abiotic stresses.

关键词： flavonoids lignin metabolic flux phenylpropanoid secondary metabolites

Molecule‑Level Multiscale Design of Nonflammable Gel Polymer Electrolyte to Build Stable SEI/CEI for Lithium Metal Battery

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第1期17卷 404-423页

作者： Qiqi Sun Zelong Gong Tao Zhang Jiafeng Li Xianli Zhu Ruixiao Zhu Lingxu wang Leyuan Ma Xuehui Li Miaofa Yuan Zhiwei Zhang Luyuan Zhang Zhao qian Longwei Yin Rajeev Ahuja Chengxiang wang Key Laboratory for Liquid‑Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061People’s Republic of China Condensed Matter Theory Department of Physics and AstronomyUppsala UniversityUppsala 75120Sweden

The risk of flammability is an unavoidable issue for gel polymer electrolytes(GPEs).Usually,flameretardant solvents are necessary to be used,but most of them would react with anode/cathode easily and cause serious interfacial instability,which is a big challenge for design and application of nonflammable ***,a nonflammable GPE(SGPE)is developed by in situ polymerizing trifluoroethyl methacrylate(TFMA)monomers with flame-retardant triethyl phosphate(TEP)solvents and LiTFSI–LiDFOB dual lithium *** is strongly anchored to PTFMA matrix via polarity interaction between-P=O and-CH_(2)CF_(3).It reduces free TEP molecules,which obviously mitigates interfacial reactions,and enhances flame-retardant performance of TEP *** TEP molecules are also inhibited in solvation of Li^(+),leading to anion-dominated solvation sheath,which creates inorganic-rich solid electrolyte interface/cathode electrolyte interface *** coordination structure changes Li^(+)transport from sluggish vehicular to fast structural transport,raising ionic conductivity to 1.03 mS cm^(-1) and transfer number to 0.41 at 30℃.The Li|SGPE|Li cell presents highly reversible Li stripping/plating performance for over 1000 h at 0.1 mA cm^(−2),and 4.2 V LiCoO_(2)|SGPE|Li battery delivers high average specific capacity>120 mAh g^(−1) over 200 *** study paves a new way to make nonflammable GPE that is compatible with Li metal anode.

关键词： Anchoring effect Nonflammable gel electrolyte In situ cross-linked Electrode-electrolyte interface Li metal battery

AOL4PS:A Large-scale Data Set for Personalized Search

在线全文

学校读者我要写书评

暂无评论

Data Intelligence 2021年第4期3卷 548-567页

作者： qian Guo Wei Chen Huaiyu wan School of Computer and Information Technology Beijing Jiaotong UniversityBeijing 100044China Beijing Key Laboratory of Traflc Data Analysis and Mining Beijing 100044China

Personalized search is a promising way to improve the quality of Websearch,and it has attracted much attention from both academic and industrial *** of the current related research is based on commercial search engine data,which can not be released publicly for such reasons as privacy protection and information *** leads to a serious lack of accessible public data sets in this *** few publicly available data sets have not become widely used in academia because of the complexity of the processing process required to study personalized search *** lack of data sets together with the difficulties of data processing has brought obstacles to fair comparison and evaluation of personalized search *** this paper,we constructed a large-scale data set AOL4 PS to evaluate personalized search methods,collected and processed from AOL query *** present the complete and detailed data processing and construction ***,to address the challenges of processing time and storage space demands brought by massive data volumes,we optimized the process of data set construction and proposed an improved BM25 *** are performed on AOL4 PS with some classic and state-of-the-art personalized search methods,and the experiment results demonstrate that AOL4 PS can measure the effect of personalized search models.

关键词： Personalized search Text data processing Data set construction