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Enteromorpha prolifera polysaccharide-Fe(Ⅲ) complex promotes intestinal development as a new iron supplement

Science China(Life Sciences) 2025年第1期68卷 219-231页

作者： Yingying Feng Yuying Wu Jialu wang Zhenglin dong qian Yu Shuangshuang Xia Chunxue Liu Haihua wang Xin Wu Tianjin Institute of Industrial Biotechnology Chinese Academy of SciencesTianjin 300308China CAS Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China ANYOU Biotechnology Group Co.Ltd Taicang 215412China Qingdao Seawin Biotech Group Co. LTDQingdao 266071China

Iron is a crucial micronutrient, and its deficiency can have detrimental effects on the health of infants. Dietary polysaccharide-iron(Ⅲ) complexes(PICs) are promising for addressing iron deficiency due to their minimal adverse reactions and high iron absorption rate. This study aimed to investigate the effects of dietary Enteromorpha prolifera polysaccharide-Fe(Ⅲ) complex(EP-Fe) on newborns, using 3-day weaned piglets as the iron-deficiency model. Results showed that EP-Fe improved iron levels and promoted intestinal development in piglets. Transcriptome sequencing revealed that EP-Fe increased the survival of intestinal epithelial cells under hypoxia by upregulating the expression of genes that promote the development of the vascular system. Additionally, EP-Fe enhanced the mucosal barrier functions by inhibiting myosin light chain kinase(MLCK)/phosphorylated myosin light chain(p-MLC) signaling pathway to increase the expression of intestinal tight junction proteins. Furthermore, the 16S r RNA gene sequencing of gut microbiota showed that EP-Fe promoted the enrichment of Bacteroides_fragilis and other gut microbes that can metabolize carbohydrates. In conclusion, EP-Fe is an effective iron supplement for newborns, and it can be developed as a comprehensive nutritional supplement.

关键词： Enteromorpha prolifera polysaccharide-Fe(III)complex iron deficiency intestinal development gut microbiota weaned piglet

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Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Hai-dong qian Qiao Gao Sheng-Lan Xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

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Prediction of specific spoilage organisms in smoked chicken legs with modified atmosphere packaging at 4℃ using multivariate statistical analysis

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Food Science and Human Wellness 2025年第1期14卷 271-281页

作者： qiang wang Yubo Zhao Yumeng Sui qian Chen Zhiming dong qian Liu Baohua Kong Ligang Qin College of Food Science Northeast Agricultural UniversityHarbin 150030China College of Animal Science and Technology Northeast Agricultural UniversityHarbin 150030China

The present study monitored bacterial succession,physicochemical properties,and volatile organic compounds(VOCs)changes in smoked chicken legs with modified atmosphere packaging(MAP,60% CO_(2) and 40%N_(2))during a 25-day storage period at 4℃.After 15 days of storage,S erratia proteamaculans and Pseudomonas fragi became the predominant ***,physicochemical properties changed significantly,as evidenced by an increase in thiobarbituric acid reactive substances and b*(yellowness)value,and a decrease in hardness.A total of 65 VOCs were identified during *** between bacterial succession and quality indicators(including VOCs and physicochemical properties)allowed the identification of 26 core dominant bacteria,including ***,Psychrobacter alimentarius,Pseudomonas putida,and Pseudomonas poae,which were positively related to spoilage VOCs(e.g.,1-octen-3-ol,1-pentanol,and 3-methyl-1-butanol)and could be defined as specific spoilage organisms(SSOs).The results of this study provide a systematic approach to predict SSOs in smoked chicken legs during storage,which can also provide a basis for product safety.

关键词： Smoked chicken legs Modified atmosphere packaging Bacterial community Volatile organic compounds Specific spoilage organisms

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Global patterns of taxonomic and phylogenetic endemism in liverwort assemblages

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Plant Diversity 2025年第1期47卷 82-88页

作者： Hong qian Shenhua qian Research and Collections Center Illinois State Museum1011 East Ash StreetSpringfieldIL 62703USA Key Laboratory of the Three Gorges Reservoir Region's Eco-Environment Ministry of EducationChongqing UniversityChongqing 400045China College of Environment and Ecology Chongqing UniversityChongqing 400045China

Exploring the worldwide patterns of endemism and the processes that lead to the formation of highendemism centers is crucial in *** study examines the geographic distribution and ecological influences on the endemism of liverworts across 390 regions *** assess phylogenetic endemism and relative phylogenetic endemism in relation to eleven environmental factors,which represent current and Quaternary climate variations,as well as topographic and environmental *** with higher endemism in liverworts tend to have higher temperatures,precipitation,and environmental heterogeneity,but lower temperature seasonality and lesser impacts from Quaternary climate *** exhibiting notably high endemism are predominantly found in tropical Asia,Madagascar,eastern Australia,and the Andes,while those with notably low endemism are generally in temperate Eurasia and North America,parts of Africa,and eastern South *** of neo-endemism are mainly in southern Africa,whereas centers of paleo-endemism are in southern South America,tropical Asia,and New *** variability is a more significant predictor of phylogenetic endemism than current climate conditions,which are themselves more predictive than variables related to Quaternary climate ***,these three types of explanatory variables combined explain only about one-third of the variance in phylogenetic endemism.

关键词： Bryophyte Quaternary climate change Current climate Topographic heterogeneity Endemism

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Recent advances in exploring new blood-based biomarkers for the early diagnosis of gastric cancer

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Science China Chemistry 2025年第1期68卷 35-45页

作者： Xinyu Peng qian Ma Da Han School of Life Science Shanghai UniversityShanghai 200444China Institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acid Chemistry and NanomedicineState Key Laboratory of Oncogenes and Related GenesRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Research and Development Intellinosis Biotechnologies Co.Ltd.Shanghai 201112China

Gastric cancer(GC)is a prevalent and lethal malignancy worldwide,and the 5-year survival rate is less than 30%.The absence of distinctive symptoms often leads to late-stage diagnosis,contributing to a grim *** detection is pivotal for improving the survival rates and outcomes of GC *** diagnostic methods,including gastroscopy and histopathological examination,are restricted in the early diagnosis of *** protein biomarkers,such as carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9),and carbohydrate antigen 72-4(CA72-4),exhibit insufficient sensitivity and specificity for GC screening,which diminishes their clinical ***,novel circulating biomarkers,such as circulating tumor cells(CTCs),circulating tumor cell DNA(ct DNA),and circulating free RNA(cf RNA),have emerged as promising candidates in the burgeoning field of liquid biopsy due to their superior sensitivity and *** review focuses on the latest research on blood-based biomarkers for GC diagnosis and examines the clinical potentials and challenges associated with these emerging biomarkers.

关键词： gastric cancer early diagnosis blood

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A single-pixel elemental imaging method using neutron-induced gamma-ray activation

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Nuclear Science and Techniques 2025年第1期36卷 1-12页

作者： Can Cheng Yong-Ji Xie Xun-Rong Xia Jia-Yu Gu dong Zhao Yi-Ze Chen Ai-Yun Sun Xu-Wen Liang Wen-Bao Jia Da-qian Hei Department of Ionizing Radiation and Medical Engineering Jiangsu Institute of MetrologyNanjing 210023China Institute of Nuclear Analytical Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China China Nuclear Power Engineering Co. LtdBeijing 100840China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China

Neutron-induced gamma-ray imaging is a spectroscopic technique that uses characteristic gamma rays to infer the elemental distribution of an ***,this technique requires the use of large facilities to supply a high neutron flux and a time-consuming detection procedure involving direct collimating *** this study,a new method based on low neutron flux was proposed.A single-pixel gamma-ray detector combined with random pattern gamma-ray masks was used to measure the characteristic gamma rays emitted from the *** of the elemental distribution in the sample,comprising 30×30 pixels,were reconstructed using the maximum-likelihood expectation-maximization *** results demonstrate that the elemental imaging of the sample can be accurately determined using this *** proposed approach,which eliminates the need for high neutron flux and scanning measurements,can be used for in-field imaging applications.

关键词： Elemental imaging Neutron-induced gamma-ray activation Single-pixel imaging

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Five-user quantum virtual local area network with an AlGaAs entangled photon source

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Science China(Physics,Mechanics & Astronomy) 2025年第3期68卷 61-73页

作者： Cheng qian Hongkai Tian Xu Jing Yichen Liu Zhe Chen Huiran Luo Yuan Du Xiaodong Zheng Tangsheng Chen Yuechan Kong Hua-Lei Yin dong Jiang Bin Niu Liangliang Lu Key Laboratory of State Manipulation and Advanced Materials in Provincial Universities School of Physical Science and TechnologyNanjing Normal UniversityNanjing210023China School of Internet Anhui UniversityHefei230039China National Key Laboratory of Solid-State Microwave Devices and Circuits Nanjing Chip Valley Industrial Technology InstituteNanjing Electronic Devices InstituteNanjing210016China Research Center for Quantum Optics and Quantum Communication School of ScienceQingdao University of TechnologyQingdao266520China Department of Physics and Beijing Key Laboratory of Opto-electronic Functional Materials and Micro-nano Devices Key Laboratory of Quantum State Construction and Manipulation(Ministry of Education)Renmin University of ChinaBeijing100872China Beijing Academy of Quantum Information Sciences Beijing100193China National Engineering Research Center of Agro-Ecological Big Data Analysis and Application Anhui UniversityHefei230601China National Laboratory of Solid-State Microstructures and School of Physics Nanjing UniversityNanjing210093China Hefei National Laboratory Hefei230088China

The promotion of quantum network applications demands the scalable connection of quantum *** is preferable to set up multiple logical networks coexisting on a single physical network infrastructure to accommodate a larger number of *** we present a quantum virtual network architecture that offers this level of scalability,without being constrained to a fixed physical-layer network relying solely on passive multiplexing *** architecture can be understood as arising from the superposition of a fully connected entanglement distribution network and port-based virtual local area network,which group multiusers by access *** terms of hardware,we leverage a semiconductor chip with a high figure-of-merit modal overlap to directly generate high-quality polarization entanglement,and a streamlined polarization analysis module,which requires only one single-photon detector for each end *** experimentally perform the BBM92 QKD protocol on the five-user quantum virtual network and demonstrate voice and image encryption on a campus area *** results may provide insights into the realization of large-scale quantum networks with integrated and cost-efficient photonic architecture.

关键词： quantum network quantum entanglement distribution integrated photonics image and voice encryption

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Revolutionizing photothermal CO_(2)hydrogenation with ceria-based catalysts

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Nano Research 2025年第1期18卷 30-49页

作者： Zhaorui Zhang Xiao Han Junhong Zhang Yunyun dong Jinsheng Zhao qian Xu Ningqiang Zhang School of Chemistry and Chemical Engineering Liaocheng UniversityLiaocheng 252059China Institute for Catalysis Hokkaido UniversityN-21W-10Sapporo 001-0021Japan National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China

In the context of achieving carbon neutrality,CO_(2)catalytic conversion technologies are effective in reducing atmospheric CO_(2)concentrations while simultaneously producing renewable *** approach is seen as a viable method for constructing a new carbon cycle,thereby effectively addressing the issue of global *** CO_(2)conversion has recently emerged as a promising research focus due to its high energy utilization efficiency,superior CO_(2)conversion,excellent product selectivity,mild operating conditions,low energy consumption and minimal operating *** oxide(CeO_(2))has been widely used in photothermal catalysis due to its unique chemical properties,particularly when used as a support material with supported metals,creating distinctive interfacial sites for catalytic *** an emerging star support in photothermal CO_(2)conversion,its contributions are equally significant and should not be ***,to our knowledge,there has been no comprehensive review of CeO_(2)applications in catalytic hydrogenation of CO_(2).In this paper,we summarize and discuss CeO_(2)-based materials for photothermal CO_(2)conversion to value-added *** research particularly focuses on the synthesis methods of CeO_(2)-supported catalysts,the history of CeO_(2)in photothermal catalysis,types of photothermal catalytic reactors,unique characterization methods for the photothermal catalysts and the photothermal CO_(2)hydrogenation reactions by CeO_(2)-based *** related to further challenges and future directions for photothermal CO_(2)hydrogenation are also provided.

关键词： CO_(2)neutrality hydrogenation photothermal catalysis ceria C1 chemistry

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Comprehensive metabolic profiling of dioxin-like compounds exposure in laying hens:Implications for toxicity assessment

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Journal of Environmental Sciences 2025年第2期148卷 107-115页

作者： Xiaoxu Hu Tong Xu Yangsheng Chen qian Zhang Lijuan Tang Liping Zheng Chu wang Pu wang Shujun dong Ruiguo wang Su Zhang Qinghua Zhang Heidi Qunhui Xie Li Xu Bin Zhao State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Department of Cardiology Beijing HospitalNational Center of GerontologyBeijing 100730China School of Environment Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Hubei Key Laboratory of Industrial Fume and Dust Pollution Control School of Environment and HealthJianghan UniversityWuhan 430056China Institute of Quality Standards and Testing Technology for Agro-Products Chinese Academy of Agricultural SciencesBeijing 100081China

The evaluation of toxicity related to polychlorinated dibenzo-p-dioxins and furans(PCDD/Fs)and dioxin-like polychlorinated biphenyls(DL-PCBs)is crucial for a comprehensive risk assessment in real-world exposure *** study employed a controlled feeding experiment to investigate the metabolic effects of dioxin-like compounds(DLCs)on laying hens via feed *** enriched with two concentrations(1.17 and 5.13 pg toxic equivalents(TEQ)/g dry weight(dw))were administered over 14 days,followed by 28 days of clean *** analyses of blood samples revealed significant metabolic variations between PCDD/Fs and DL-PCBs exposed groups and controls,reflecting the induced metabolic *** changes were observed in sphingosine,palmitoleic acid,linoleate,linolenic acid,taurocholic acid,indole acrylic acid,and dibutyl phthalate levels,implying possible connections between PCDD/Fs and DL-PCBs toxic effects and energy-neuronal imbalances,along with lipid accumulation and anomalous amino acid metabolism,impacting taurine ***,we identified three differential endogenous metabolites—L-tryptophan,indole-3-acetaldehyde,and indole acrylic acid—as potential ligands for the aryl hydrocarbon receptor(AhR),suggesting their role inmediating PCDD/Fs and DL-PCBs *** comprehensive investigation provides novel insights into the metabolic alterations induced by PCDD/Fs and DL-PCBs in laying hens,thereby enhancing our ability to assess risks associated with their exposure in human populations.

关键词： Polychlorinated dibenzo-p-dioxins and furans Dioxin-like polychlorinated biphenyls Laying hens Metabolomic

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Geographic patterns and ecological causes of phylogenetic structure in mosses along an elevational gradient in the central Himalaya

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Plant Diversity 2025年第1期47卷 98-105页

作者： Hong qian Oriol Grau Research and Collections Center Illinois State Museum1011 East Ash StreetSpringfieldIL 62703USA Parc Natural de l’Alt Pirineu Llavorsí25595CataloniaSpain CREAF Centre de Recerca Ecològica i Aplicacions ForestalsBellaterra 08193CataloniaSpain

Understanding the underlying mechanisms driving species assembly along elevational gradients is of great interest in ecology and *** Himalaya is one of the world’s hotspots of biodiversity,and the elevational gradient of the central Himalaya in Nepal is one of the longest elevational gradients in the *** are important constituents of vegetation in the Himalaya,and knowledge of geographic patterns and ecological causes of phylogenetic structure of mosses along elevational gradients in the Himalaya is critical to understanding the assembly of plant diversity in general,and moss diversity in particular,in the ***,we investigate the relationships of phylogenetic structure metrics reflecting different evolutionary depths with elevation and climatic variables representing mean temperature and precipitation conditions,climate extremes,and climate seasonality for mosses distributed along an elevational gradient spanning about 5000 m in the central Himalaya,*** a given climatic variable,different metrics of phylogenetic structure show different spatial and climatic patterns,but all phylogenetic metrics standardized for species richness show that phylogenetic dispersion in moss assemblages tend to increase with increasing elevation and decreasing *** standardized effect size of mean pairwise distance of moss assemblages shows a triphasic(zig-zag)pattern,which is generally consistent with the triphasic patterns previously found in angiosperms and ferns along the same elevational *** study shows that temperature-related variables and climate seasonality variables are more important drivers of phylogenetic dispersion in mosses in Nepal,compared with precipitation-related variables and climate extreme variables,respectively.

关键词： Bryophyte Climatic gradient Nepal Niche evolution Phylogenetic diversity Phylogenetic relatedness

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