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Advances in epidural labor analgesia:Effectiveness and treatment strategies of butorphanol

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World Journal of Clinical Cases 2024年第34期12卷 6669-6673页

作者： Wan-qiu Yu Zhao-qiong Zhu Fu-Shan Tang Department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyi 563003Guizhou ProvinceChina Early Clinical Research Ward Affiliated Hospital of Zunyi Medical UniversityZunyi 563003Guizhou ProvinceChina Department of Clinical Pharmacy Key Laboratory of Basic Pharmacology of Guizhou Province and School of PharmacyZunyi Medical UniversityZunyi 563006Guizhou ProvinceChina

In this editorial,we provide a critical review of the article by Tang et al published in the World J Clin Cases,focusing on the utilization of butorphanol for epidural analgesia during *** discussion encompasses recent research developments in epidural labor analgesia,specifically highlighting the current status of clinical applications of butorphanol and associated treatment *** analgesia is widely acknowledged as the primary method for pain management during labor,offering effective and prolonged pain relief while allowing mothers to remain alert and actively participate in the delivery *** the various drugs utilized for epidural labor analgesia,butorphanol has received increasing attention due to its potential efficacy and distinctive pharmacological *** a synthetic opioid analgesic,butorphanol exhibits both agonistic and antagonistic activity on opioid receptors,striking a balance between analgesia and minimizing side ***,the safety and efficacy of butorphanol in epidural labor analgesia remains *** certain studies have reported positive outcomes with butorphanol,including effective pain relief and a reduced incidence of side effects,others have raised concerns about its safety and efficacy compared to traditional opioids or alternative *** addition,the optimal dosing strategy and regimen of butorphanol as an adjuvant in epidural labor analgesia still need to be *** comprehensive synthesis and analysis of existing literature,we aim to evaluate the current evidence regarding the use of butorphanol for epidural labor analgesia,delineate areas of consensus and controversy,and propose future avenues for research and clinical practice in this domain.

关键词： Butorphanol Epidural analgesia Labor analgesia Opioids Pain management

Development of LAG-3/FGL1 blocking peptide and combination with radiotherapy for cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1150-1165页

作者： Yuzhen qian Yixuan Sun Peishang Shi Xiuman Zhou qiongqiong Zhang Qingyu Dong Shengzhe Jin Lu qiu Xiaoshuang Niu Xiaowen Zhou Wenshan Zhao Yahong Wu Wenjie Zhai Yanfeng Gao School of Life Sciences Zhengzhou UniversityZhengzhou 450001China School of Pharmaceutical Sciences(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China International Joint Laboratory for Protein and Peptide Drugs of Henan Province Zhengzhou UniversityZhengzhou 450001China

Aside from antibodies,peptides show great potential as immune checkpoint inhibitors(ICIs)due to several advantages,such as better tumor penetration and lower ***-activation gene 3(LAG-3)is an immune checkpoint which can induce T cell dysfunction through interaction with its soluble ligand fibrinogen like protein-1(FGL1).Here,we found that LAG-3 expression was higher than programmed cell death protein 1(PD-1)in multiple human cancers by TCGA databases,and successfully identified a LAG-3 binding peptide LFP-6 by phage display bio-panning,which specifically blocks the interaction of LAG-3/FGL1 but not LAG-3/***,D-amino acids were introduced to substitute the N-and C-terminus of LFP-6 to obtain the proteolysis-resistant peptide LFP-D1,which restores T cell function in vitro and inhibits tumor growth in ***,a bispecific peptide LFOP targeting both PD-1/PD-L1 and LAG-3/FGL1 was designed by conjugating LFP-D1 with PD-1/PD-L1blocking peptide OPBP-1(8-12),which activates T cell with enhanced proliferation and IFN-γ *** importantly,LFOP combined with radiotherapy significantly improve the T cell infiltration in tumor and elevate systemic antitumor immune *** conclusion,we developed a novel peptide blocking LAG-3/FGL1 which can restore T cell function,and the bispecific peptide synergizes with radiotherapy to further enhance the antitumor immune response.

关键词： LAG-3 FGL1 PD-1 PD-L1 Peptide Immune checkpoint Radiotherapy Cancer immunotherapy

Filterless narrowband photodetectors enabled by controllable band modulation through ion migration: The case of halide perovskites

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InfoMat 2024年第1期6卷 123-138页

作者： Yu Li Shanshan Yu Junjie Yang Kai Zhang Mingyu Hu Weitao qiu Fumin Guo Wei qian Sean Reinecke Tao Chen Makhsud I.Saidaminov Jian Wang Shihe Yang Guangdong Provincial Key Lab of Nano-Micro Materials Research School of Chemical Biology and BiotechnologyShenzhen Graduate SchoolPeking UniversityShenzhenGuangdongthe People's Republic of China Shenzhen Bay Laboratory Institute of Biomedical EngineeringShenzhenGuangdongthe People's Republic of China School of Advanced Materials Shenzhen Graduate SchoolPeking UniversityShenzhenGuangdongthe People's Republic of China Department of Chemistry The University of Hong KongHong Kong SARthe People's Republic of China Hefei National Laboratory for Physical Sciences at Microscale CAS Key Laboratory of Materials for Energy ConversionDepartment of Materials Science and EngineeringSchool of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefeiAnhuithe People's Republic of China College of Materials and Energy South China Agricultural UniversityGuangzhouGuangdongthe People's Republic of China Department of Chemistry University of VictoriaVictoriaBritish ColumbiaCanada

Narrowband photodetectors conventionally rely on optical structure design orbandpass filters to achieve the narrowband regime. Recently, a strategy forfilterless narrowband photoresponse based on the charge collection narrowing(CCN) mechanism was reported. However, the CCN strategy requires an electrically and optically “thick” photoactive layer, which poses challenges in controlling the narrowband photoresponse. Here we propose a novel strategy forconstructing narrowband photodetectors by leveraging the inherent ion migration in perovskites, which we term “band modulation narrowing” (BMN). Bymanipulating the ion migration with external stimuli such as illumination,temperature, and bias voltage, we can regulate in situ the energy-band structure of perovskite photodetectors (PPDs) and hence their spectral *** the Fermi energy levels obtained by the Kelvin probe force microscopy, the internal potential profiles from solar cell capacitance simulator simulation, and the anion accumulation revealed by the transient ion-drifttechnique, we discover two critical mechanisms behind our BMN strategy: theextension of an optically active but electronically dead region proximal to the top electrode and the down-bending energy bands near the electron transportlayer. Our findings offer a case for harnessing the often-annoying ionmigration for developing advanced narrowband PPDs.

关键词： band structure ion migration narrowband detection perovskite spatial distribution of charge carriers

Bat-derived oligopeptide LE6 inhibits the contact-kinin pathway and harbors anti-thromboinflammation and stroke potential

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Zoological Research 2024年第5期45卷 1001-1012页

作者： Li-Na Cha Juan Yang Jin-Ai Gao Xin Lu Xiao-Long Chang Rebecca Caroline Thuku Qi Liu qiu-Min Lu Dong-Sheng Li Ren Lai Ming-qian Fang Engineering Laboratory of Peptides of Chinese Academy of Sciences Key Laboratory of Bioactive Peptides of Yunnan ProvinceKIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesNational Resource Center for Non-Human PrimatesNational Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Key Laboratory of Genetic Evolution&Animal ModelsSino-African Joint Research Centerand New Cornerstone Science LaboratoryKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China School of Molecular Medicine Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouZhejiang 310024China First Affiliated Hospital of Kunming Medical University KunmingYunnan 650032China

Thrombosis and inflammation are primary contributors to the onset and progression of ischemic *** contact-kinin pathway,initiated by plasma kallikrein(PK)and activated factor XII(FXIIa),functions bidirectionally with the coagulation and inflammation cascades,providing a novel target for therapeutic drug development in ischemic *** this study,we identified a bat-derived oligopeptide from Myotis myotis(Borkhausen,1797),designated LE6(Leu-Ser-Glu-Glu-Pro-Glu,702 Da),with considerable potential in stroke therapy due to its effects on the contact kinin ***,LE6 demonstrated significant inhibitory effects on PK and FXIIa,with inhibition constants of 43.97μmol/L and 6.37μmol/L,*** vitro analyses revealed that LE6 prolonged plasma recalcification time and activated partial thromboplastin *** murine models,LE6 effectively inhibited carrageenan-induced mouse tail thrombosis,FeCl3-induced carotid artery thrombosis,and photochemically induced intracerebral ***,LE6 significantly decreased inflammation and stroke injury in transient middle cerebral artery occlusion ***,the low toxicity,hemolytic activity,and bleeding risk of LE6,along with its synthetic simplicity,underscore its clinical *** conclusion,as an inhibitor of FXIIa and PK,LE6 offers potential therapeutic benefits in stroke treatment by mitigating inflammation and preventing thrombus formation.

关键词： PK FXIIa Anti-thromboinflammation Ischemic stroke therapies Oligopeptide

干旱胁迫对转基因(P_(SAG12)-ipt)非洲菊光合作用的影响

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园艺学报 2007年第1期34卷 157-162页

作者：赖齐贤包志毅朱祝军毛碧增钱琼秋何勇浙江大学园艺系浙江大学生物技术研究所杭州310029

采用转基因(PSAG12-ipt)非洲菊为材料,研究干旱胁迫对叶绿素荧光和光合作用的影响。结果发现,随着干旱胁迫加剧,PSⅡ电子传递量子效率(ΦPSⅡ)、开放的PSⅡ反应中心捕获激发能效率(Fv’/Fm’)、光化学猝灭系数(qP)、表观光合电子传递速... 详细信息

采用转基因(PSAG12-ipt)非洲菊为材料,研究干旱胁迫对叶绿素荧光和光合作用的影响。结果发现,随着干旱胁迫加剧,PSⅡ电子传递量子效率(ΦPSⅡ)、开放的PSⅡ反应中心捕获激发能效率(Fv’/Fm’)、光化学猝灭系数(qP)、表观光合电子传递速率(ETR)都表现出降低的趋势,光化学反应的能量(P)在叶片所吸收的光能中所占的比例也逐渐减少,净光合速率(Pn)、气孔导度(Gs)也出现同样下降的趋势。随着干旱胁迫的解除,ΦPSⅡ、Fv’/Fm’、qP、ETR、Pn、Gs都显著上升,缓慢恢复。转基因植株与非转基因对照相比,叶绿素荧光参数和光合作用参数的变化幅度较小,在干旱胁迫下各项参数下降较慢,干旱胁迫结束后各项参数恢复较快。在干旱胁迫和恢复过程中,P在光能分配中所占的比例,转基因植株大于对照。反应中心由非光化学反应耗散的能量(E)在干旱胁迫过程和恢复过程中没有明显的变化。

关键词：非洲菊干旱胁迫光合作用叶绿素荧光

高压氧对大鼠脑缺血区线粒体氧自由基影响的实验研究

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浙江大学学报（医学版） 2008年第5期37卷 437-443页

作者：楼敏王季华钱琼秋闻树群丁美萍浙江大学医学院附属第二医院神经内科浙江杭州310009 浙江大学园艺系浙江杭州310029

目的:研究高压氧(HBO)对大鼠脑缺血区线粒体氧自由基及抗自由基酶的影响。方法:参照改良的Koizumi方法,在激光多普勒血流仪监测局部脑血流的条件下,建立线栓法大鼠局灶性脑缺血模型,缺血90min后再灌注,缺血后3h高压氧治疗(3个标准大气压... 详细信息

目的:研究高压氧(HBO)对大鼠脑缺血区线粒体氧自由基及抗自由基酶的影响。方法:参照改良的Koizumi方法,在激光多普勒血流仪监测局部脑血流的条件下,建立线栓法大鼠局灶性脑缺血模型,缺血90min后再灌注,缺血后3h高压氧治疗(3个标准大气压,1h),缺血后24h分别取缺血核心区和半暗区脑组织,差速离心提取线粒体,进行超氧阴离子自由基(O2.)生成速率、H2O2含量、丙二醛(MDA)含量测定,以及线粒体超氧化歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)和还原型谷胱甘肽(GSH)含量测定。结果:脑缺血再灌注24h后缺血半暗区和核心区线粒体的H2O2、O2.、MDA的含量较正常对照组明显增加,而SOD、GSH-PX活性以及GSH的含量较正常对照组明显下降(P<0.05)。经HBO治疗后,缺血半暗区线粒体O2.含量增加(P<0.05),SOD活性提高(P<0.05),而MDA含量减少(P<0.05);缺血核心区线粒体O2.含量增加(P<0.05),SOD活性提高(P<0.05),但MDA含量不变。HBO治疗对脑缺血区的H2O2、GSH-PX和GSH作用无影响。结论:在脑缺血时间窗内,HBO治疗能增加脑缺血区线粒体自由基生成,提高线粒体抗自由基酶活性;能抑制脑缺血半暗区线粒体的脂质过氧化损伤,但对核心区作用不明显。提示线粒体的功能状态在HBO治疗后的自由基反应中起重要作用。

关键词：高压氧脑缺血/治疗脑缺血/病理学线粒体活性氧/代谢再灌注损伤/病理学再灌注损伤/治疗疾病模型动物

Design and discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1283-1301页

作者： qian Zhao Jiale Dong Han Liu Hui Chen Huan Yu Shuyin Ye Shuangjin Yu Yu Li Longhui qiu Nazi Song Hongjiao Xu Qi Liu Zhiteng Luo Yuyi Li Rui Wang Guodong Chen Xianxing Jiang School of Pharmaceutical Sciences Guangdong Provincial Key Laboratory of Chiral Molecule and Drug DiscoverySun Yat-sen UniversityGuangzhou 510006China Organ Transplant Center the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510006China Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510006China Shenzhen Turier Biotech.Co. Ltd.Shenzhen 518118China School of Life Sciences Key Laboratory of Preclinical Study for New Drugs of Gansu ProvinceSchool of Basic Medical Sciences&Research Unit of Peptide ScienceChinese Academy of Medical SciencesLanzhou UniversityLanzhou 730000China

The role of co-agonists of glucagon-like peptide-1 receptor(GLP-1R)and glucagon receptor(GCGR)in chronic kidney disease(CKD)remains *** we found that GLP-1R and GCGR expression levels were lower in the kidneys of mice with CKD compared to healthy mice and were correlated with disease ***,GLP-1R or GCGR knockdown aggravated the progression of kidney injury in both diabetic db/db mice and non-diabetic mice undergoing unilateral ureteral obstruction(UUO).Based on the importance of GLP-1R and GCGR in CKD,we reported a novel monomeric peptide,1907-B,with dual-agonism on both GLP-1R and *** data confirmed that 1907-B had a longer half-life than long-acting semaglutide in rats or cynomolgus monkeys(~2-3 fold)and exhibited better therapeutic contribution to CKD than best-in-class monoagonists,semaglutide,or glucagon,in db/db mice and UUO *** lock-of-function models,including selective pharmacological activation and genetic knockdown,confirmed that 1907-B’s effects on ameliorating diabetic nephropathy in db/db mice,as well as inhibiting kidney fibrosis in UUO mice,were mediated through GLP-1 and glucagon *** findings highlight that 1907-B,a novel GLP-1R and GCGR co-agonist,exerts multifactorial improvement in kidney injuries and is an effective and promising therapeutic option for CKD treatment.

关键词： GLP-1 receptor Glucagon receptor Chronic kidney disease Diabetic nephropathy Kidney fibrosis Dual-agonism

Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis

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World Journal of Gastroenterology 2024年第15期30卷 2143-2154页

作者： Sen Li qian-Jun Ren Can-Hao Xie Yang Cui Li-Tao Xu Yi-Dan Wang Su Li Xing-qiu Liang Bin Wen Ming-Kun Liang Xiao-Fang Zhao Department of Basic Science Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina Department of Science and Technology Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina Traditional Chinese Medicine Specialty Office Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina

BACKGROUND Liver fibrosis is a compensatory response during the tissue repair process in chronic liver injury,and finally leads to liver cirrhosis or even hepatocellular *** pathogenesis of hepatic fibrosis is associated with the progressive accumulation of activated hepatic stellate cells(HSCs),which can transdiffer-entiate into myofibroblasts to produce an excess of the extracellular matrix(ECM).Myofibroblasts are the main source of the excessive ECM responsible for hepatic ***,activated hepatic stellate cells(aHSCs),the principal ECM producing cells in the injured liver,are a promising therapeutic target for the treatment of hepatic *** To explore the effect of taurine on aHSC proliferation and the mechanisms *** Human HSCs(LX-2)were randomly divided into five groups:Normal control group,platelet-derived growth factor-BB(PDGF-BB)(20 ng/mL)treated group,mmol/L,respectively)with PDGF-BB(20 ng/mL)treated *** Counting Kit-8 method was performed to evaluate the effect of taurine on the viability of ***-linked immunosorbent assay was used to estimate the effect of taurine on the levels of reactive oxygen species(ROS),malondialdehyde,glutathione,and iron *** electron microscopy was applied to observe the effect of taurine on the autophagosomes and ferroptosis features in *** real-time polymerase chain reaction and Western blot analysis were performed to detect the effect of taurine on the expression ofα-SMA,Collagen I,Fibronectin 1,LC3B,ATG5,Beclin 1,PTGS2,SLC7A11,and *** Taurine promoted the death of aHSCs and reduced the deposition of the *** with taurine could alleviate autophagy in HSCs to inhibit their activation,by decreasing autophagosome formation,downregulating LC3B and Beclin 1 protein expression,and upregulating p62 protein ***,treatment with taurine triggered ferroptosis and ferritinophagy to eliminate aHSCs characterized b

关键词： Hepatic stellate cells Autophagy Ferroptosis Molecular docking Taurine

外源硅和辅酶Q10对盐胁迫下黄瓜根系线粒体的保护作用

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中国农业科学 2006年第6期39卷 1208-1214页

作者：钱琼秋宰文姗何勇王永传朱祝军浙江大学园艺系/农业部园艺植物生长发育与生物技术重点开放实验室浙江大学园艺系/农业部园艺植物生长发育与生物技术重点开放实验室杭州310029 浙江省温州市农业科学研究院蔬菜研究所温州325014

目的探明外源Si和辅酶Q10(CoQ10)对NaCl胁迫下黄瓜(CucumissativusL.)幼苗根系离体线粒体膜生物物理特性和呼吸功能的保护作用。方法试验设置3个处理:CK;加50mmol.L-1NaCl;加1.0mmol.L-1K2SiO3+50mmol.L-1NaCl。处理10d后取各处理植株根系提取线粒体,在离体线粒体中加入10mmol.L-1CoQ10。结果Si能显著降低盐胁迫下黄瓜线粒体的H2O2含量,抑制线粒体的脂质过氧化,增加线粒体膜的流动性和膜电位(ΔΦM),降低膜的肿胀度,使线粒体呼吸控制比(RCR)和氧化磷酸化效率(P/O)显著升高,提高线粒体的呼吸速率。CoQ10也有降低线粒体膜膨胀度,增加线粒体膜流动性和膜电位的作用,同时可以降低线粒体的H2O2和MDA含量,缓解盐胁迫的伤害作用。结论外源Si和CoQ10能有效缓解盐胁迫对黄瓜根系线粒体膜的损伤,增强线粒体抗膜脂质过氧化能力和膜完整性,提高线粒体的呼吸作用。

关键词：黄瓜辅酶Q10 硅线粒体盐胁迫