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Potential role of the protein interactome in translating TCM theory and clinical practice into modern biomedical knowledge

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Chinese Journal of Natural Medicines 2024年第5期22卷 385-386页

作者： CHEN qian fan Xiaohui Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100China

With the awarding of the 2015 Nobel Prize in Physiology or Medicine to Chinese pharmacologist Tu Youyou,and the significant contributions of traditional Chinese medicine(TCM)for coronavirus disease 2019(COVID-19),TCM has garnered increasing attention and interest *** advanced research progress has been made in the efficacy research,mechanism elucidation and target prediction of TCM in recent years[1].

关键词： Protein interactome Traditional Chinese medicine Therapeutic effectiveness

Photonic crystal-connected bidirectional micro-ring resonator array for duplex mode and wavelength channel(de)multiplexing

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Photonics Research 2024年第8期12卷 1802-1812页

作者： ZHIWEI GUAN CHAOFENG WANG CHUANGXIN XIE HAISHENG WU JUNMIN LIU HUAPENG YE dianyuan fan JIANGNAN XIAO SHUQING CHEN International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China College of Physics and Engineering Technology Minzu Normal University of XingyiXingyi 562400China College of New Materials and New Energies Shenzhen Technology UniversityShenzhen 518118China Guangdong Provincial Key Laboratory of Optical Information Materials and Technology and Institute of Electronic Paper Displays South China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou 510006China Terahertz Technology Innovation Research Institute Shanghai Key Laboratory of Modern Optical SystemTerahertz Science Cooperative Innovation CenterSchool of Optical-Electrical Computer EngineeringUniversity of Shanghai for Science and TechnologyShanghai 200093China

The progress of on-chip optical communication relies on integrated multi-dimensional mode(de)multiplexers to enhance communication capacity and establish comprehensive ***,existing multi-dimensional(de)multiplexers,involving modes and wavelengths,face limitations due to their reliance on single-directional total internal reflection and multi-level mode conversion based on directional coupling *** constraints restrict their potential for full-duplex functionality and highly integrated *** solve these problems by introducing a photonic-like crystal-connected bidirectional micro-ring resonator array(PBMRA)and apply it to duplex mode-wavelength multiplexing *** directional independence of total internal reflection and the cumulative effect of the subwavelength-scale pillar within the single-level photonic crystal enable bidirectional mode and wavelength multiplexed signals to transmit among multi-pair nodes without interference,improving on-chip integration in single-level mode *** a proof of concept,we fabricated a nine-channel bidirectional multi-dimensional(de)multiplexer,featuring three wavelengths and three TE modes,compactly housed within a footprint of 80μm×80μm,which efficiently transmits QPSK-OFDM signals at a rate of 216 Gbit/s,achieving a bit error rate lower than 10^(-4).Leveraging the co-ring transmission characteristic and the orthogonality of the mode-wavelength channel,this(de)multiplexer also enables a doubling of communication capacity using two physical transmission channels.

关键词： resonator channel mode

Mode Multiplication of Cylindrical Vector Beam Using Raytracing Control

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Chinese Physics Letters 2024年第9期41卷 40-51页

作者： Jing Wang Qingji Zeng Haisheng Wu Chuangxin Xie Huapeng Ye Ze Dong dianyuan fan Shuqing Chen Institute of Microscale Optoelectronics Shenzhen UniversityShenzhen 518060China Guangdong Provincial Key Laboratory of Optical Information Materials and Technology and Institute of Electronic Paper DisplaysSouth China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou 510006China School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China

Cylindrical vector beams(CVBs)hold significant promise in mode division multiplexing communication owing to their inherent vector mode ***,existing studies for facilitating CVB channel processing are confined to mode shift conversions due to their reliance on spin-dependent helical modulations,overlooking the pursuit of mode multiplication *** challenge lies in the multiplicative operation upon inhomogeneous vector mode manipulation,which is expected to advance versatile CVB channel switching and ***,we tackle this gap by introducing a raytracing control strategy that conformally maps the light rays of CVB from the whole annulus distribution to an annular sector *** with the multifold conformal annulus-sector mappings and polarization-insensitive phase modulations,this approach facilitates the parallel transformation of input CVB into multiple complementary components,enabling the mode multiplication conversion with protected vector *** as a demonstration,we experimentally implemented the multiplicative operation of four CVB modes with the multiplier factors of𝑁N=+2 and N=−3,achieving the converted mode purities over 94.24%and 88.37%.Subsequently,200 Gbit/s quadrature phase shift keying signals were successfully transmitted upon multiplicative switching of four CVB channels,with the bit-error-rate approaching 1×10−*** results underscore our strategy’s efficacy in CVB mode multiplication,which may open promising prospects for its advanced applications.

关键词： structure. multiplicative approaching

Grow rice under sunshine of Xizang/Tibet:promise and challenges

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Journal of Genetics and Genomics 2024年第3期51卷 265-267页

作者： Chunkun fan Xiaoming Zheng Qingbo Yuan Tao Wang qian qian Qingyun Bu fan Chen Agricultural Institute Xizang Academy of Agricultural and Animal Husbandry ScienceLasaXizang 850032China National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop SciencesChinese Academy of AgriculturalSciencesBeijing 100081China Sanya National Research Institute of Breeding in Hainan Chinese Academy of Agricultural SciencesBeijing 572000China Yazhouwan National Laboratory SanyaHainan 572704China Chengdu Institute of Biology Chinese Academy of SciencesChengduSichuan 610041China Northeast Institute of Geography and Agroecology Chinese Academy of SciencesHarbinHeilongjiang 150081China

Xizang,previously known as Tibet,is located in the southwest region of China and is the highest region of the Qinghai-Tibet Plateau(QzP),with an average altitude of over 4000 *** the development of modern agriculture,the grain productivity in Xizang has been effectively *** total annual grain production has increased from 558,700 tons in 1988 to 1044,000 tons in 2018(Xizang Statistical Year Book).

关键词： sunshine Tibet southwest

Harpoon-shaped topological photonic crystal for on-chip beam splitter

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 91-98页

作者： Zhiwei Guan Ruixue Dou Chuangxin Xie Tianyimei Zuo Liyu Huang Keyin Wen Chaofeng Wang Huapeng Ye Junmin Liu Ze Dong dianyuan fan Shuqing Chen Institute of Microscale Optoelectronics Shenzhen UniversityShenzhen 518060China College of Physics and Engineering Technology Minzu Normal University of XingyiXingyi 562400China Guangdong Provincial Key Laboratory of Optical Information Materials and Technology and Institute of Electronic Paper Displays South China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou 510006China College of New Materials and New Energies Shenzhen Technology UniversityShenzhen 518118China School of information and Electronics Beijing Institute of TechnologyBeijing 100081China

The advancement of integrated optical communication networks necessitates the deployment of on-chip beam splitters for efficient signal interconnections at network ***,the pursuit of micron-scale beam splitting with large corners and reducing the device footprint to boost connection flexibility often results in phase *** mismatches,which stem from radiation modes and backward scattering,pose significant obstacles in creating highly integrated and interference-resistant *** address this,we introduce a solution based on the topological valley-contrasting state generated by photonic crystals with opposing valley Chern numbers,manifested in a harpoon-shaped structure designed to steer the splitting *** approach enables adiabatic mode field evolution over large corners,capitalizing on the robust phase modulation capabilities and topological protection provided by the subwavelength-scale valley-contrasting *** demonstration reveals that beam splitters with large corners of 60°,90°,and 120°exhibit insertion loss fluctuations below 2.7 dB while maintaining a minimal footprint of 8.8μm×8.8μ*** a practical demonstration,these devices facilitate three-channel signal connections,successfully transmitting quadrature phase shift keying signals at 3.66 Tbit/s with bit error rates below the forward error correction threshold,demonstrating performance comparable to that in defects *** harnessing the unidirectional excitation feature,we anticipate significant enhancements in the capabilities of signal distribution and connection networks through a daisy chain configuration.

关键词： channel interconnection on-chip beam splitter topological valley-contrasting state

Characteristics of the HIV/AIDS Epidemic among People Aged≥50 Years in China during 2018–2021

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Biomedical and Environmental Sciences 2024年第4期37卷 399-405页

作者： HOU Yu Shan JIN Yi Chen CAI Chang TANG Hou Lin QIN qian qian LYU fan National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Objective This study aimed to determine the current epidemiological status of PLWHA aged≥50 years in China from 2018 to *** also aimed to recommend targeted interventions for the prevention and treatment of HIV/AIDS in elderly *** Data on newly reported cases of PLWHA,aged≥50 years in China from 2018 to 2021,were collected using the *** tests and spatial analyses were also *** Between 2018 and 2021,237,724 HIV/AIDS cases were reported among patients aged≥50 years in *** main transmission route was heterosexual transmission(91.24%).Commercial heterosexual transmission(CHC)was the primary mode of transmission among males,while non-marital non-CHC([NMNCHC];60.59%)was the prevalent route in *** proportion of patients with CHC decreased over time(Z=67.716,P<0.01),while that of patients with NMNCHC increased(Z=153.05,P<0.01).The sex ratio varied among the different modes of infection,and it peaked at 17.65 for *** spatial analysis indicated spatial clustering,and the high-high clustering areas were mainly distributed in the southwestern and central-southern *** In China,PLWHA,aged≥50 years,were predominantly infected through heterosexual *** primary modes of infection were CHC and *** were variations in the sex ratio among different age groups,infected through various sexual ***/AIDS cases exhibited spatial *** on these results,the expansion of HIV testing,treatment,and integrated behavioral interventions in high-risk populations is recommended to enhance disease detection in key regions.

关键词： HIV/AIDS Aged≥50 years China

Disposal of zinc extraction residues via iron ore sintering process:an innovative resource utilization

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Journal of Iron and Steel Research International 2024年第7期31卷 1636-1645页

作者： Chun-long fan Cheng-yi Ding Tao Yang Yun-fei Luo Yi-fan Wang qian Li Hong-ming Long School of Metallurgical Engineering Anhui University of TechnologyMa'anshan 243002AnhuiChina Zhongye Changtian International Engineering Co. Ltd.Changsha 410205HunanChina Key Laboratory of Metallurgical Emission Reduction and Resources Recycling(Ministry of Education) Anhui University of TechnologyMa'anshan 243002AnhuiChina

Zinc extraction residue,a solid waste generated from the treatment of zinc-containing dust in rotary kilns,is commonly stockpiled in steel companies for extended *** poses significant disposal challenges and environmental pollution *** far,research on the treatment of zinc extraction residues has been slow,inadequate,and *** this gap,a novel approach was proposed to effectively treat the zinc extraction residue via the iron ore sintering *** was feasible to add 1 wt.%of zinc extraction residues to the sintering raw *** more adequate mineralization reaction resulted in higher yield and tumbler indexes,despite a slight decrease in sintering *** this may result in a slight decrease in sintering speed,the more complete mineralization reaction leads to improved sintering yield and tumbler ***,the addition of zinc extraction residues reduced the CO and NO_(x) concentrations in the sintering flue ***,the iron ore sintering process provided a viable solution for resource utilization and environmentally friendly treatment of zinc extraction residues.

关键词： Zinc extraction residue Iron ore sintering Co-processing Waste utilization Gas pollutant reduction

Cell metabolism pathways involved in the pathophysiological changes of diabetic peripheral neuropathy

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Neural Regeneration Research 2024年第3期19卷 598-605页

作者： Yaowei Lv Xiangyun Yao Xiao Li Yuanming Ouyang Cunyi fan Yun qian Department of Orthopedics Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration ShanghaiChina Youth Science and Technology Innovation Studio of Shanghai Jiao Tong University School of Medicine ShanghaiChina College of Fisheries and Life Science Shanghai Ocean UniversityShanghaiChina

Diabetic peripheral neuropathy is a common complication of diabetes *** the pathophysiological metabolic mechanism impels the generation of ideal ***,existing limited treatments for diabetic peripheral neuropathy expose the urgent need for cell metabolism *** the lack of comprehensive understanding of energy metabolism changes and related signaling pathways in diabetic peripheral neuropathy,it is essential to explore energy changes and metabolic changes in diabetic peripheral neuropathy to develop suitable treatment *** review summarizes the pathophysiological mechanism of diabetic peripheral neuropathy from the perspective of cellular metabolism and the specific interventions for different metabolic pathways to develop effective treatment *** metabolic mechanisms(e.g.,polyol,hexosamine,protein kinase C pathway)are associated with diabetic peripheral neuropathy,and researchers are looking for more effective treatments through these pathways.

关键词： cell metabolism diabetic peripheral neuropathy peripheral nerve injury protein kinase C pathway reactive oxygen species.

Patent-based technological developments and surfactants application of lithium-ion batteries fire-extinguishing agent

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Journal of Energy Chemistry 2024年第1期88卷 39-63,I0002页

作者： Jianqi Zhang Tao fan Shuai Yuan Chongye Chang Kuo Wang Ziwei Song Xinming qian State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100084China Industrial Safety Research Institute China Academy of Safety Science and TechnologyBeijing 100012China Fire Engineering Department China People’s Police UniversityLangfang 065000HebeiChina

While newer,more efficient Lithium-ion batteries(LIBs)and extinguishing agents have been developed to reduce the occurrence of thermal runaway accidents,there is still a scarcity of research focused on the application of surfactants in different LIBs extinguishing agents,particularly in terms of patented *** aim of this review paper is to provide an overview of the technological progress of LIBs and LIBs extinguishing agents in terms of patents in Korea,Japan,Europe,the United States,China,*** initial part of this review paper is sort out LIBs technology development in different *** addition,to compare LIBs extinguishing agent progress and challenges of liquid,solid,combination of multiple,and *** subsequent section of this review focuses on an in-depth analysis dedicated to the efficiency and challenges faced by the surfactants corresponding design principles of LIBs extinguishing agents,such as nonionic and anionic surfactants.A total of 451,760 LIBs-related patent and 20 LIBs-fire-extinguishing agent-related patent were included in the *** extinguishing effect,cooling performance,and anti-recombustion on different agents have been *** a comprehensive comparison of these agents,this review suggests that temperature-sensitive hydrogel extinguishing agent is ideal for the effective control of LIBs *** progress and challenges of surfactants have been extensively examined,focusing on key factors such as surface activity,thermal stability,foaming properties,environmental friendliness,and electrical ***,it is crucial to emphasize that the selection of a suitable surfactant must align with the extinguishing strategy of the extinguishing agent for optimal firefighting effectiveness.

关键词： LIBs Fire-extinguishing agent Surfactants Patent