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FOREST LANDSCAPE PATTERN DYNAMICS OF LUONINGCOUNTY IN HENAN PROVINCE AND ITS DRIVING FORCES

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Chinese Geographical Science 2003年第3期13卷 247-253页

作者： DING Sheng-yan, qian le-xiang, CAO Xin-xiang, LI Shuang, LI Hao-min(College of Environment & Planning, Henan University, Kaifeng 475001, P. R. China) College of Environment & Planning Henan University Kaifeng P. R. China

With the help of ARC/INFOR and ERDAS software, based on the information from forest resources distribution maps and TM images, four indices were chosen to analyze spatial pattern changes of forest landscape of Luoning County, Henan Province from 1983 to 1999. The results showed that: 1) The number and total area of patches were rapidly increased with time changes. The fragmentation degree of the landscape was increasing greatly. 2) The area of some forest patch types, especially shrub forest, economic forest, Populus spp. forest, Quercus spp. forest, sparse forest, deserted grassland etc. had been greatly changed. 3) The fragemation degree of each forest patch type became greater from 1983 to 1999. 4) The transition probabilities of deserted forest, economic forest, Pi-nus tabulaeformis forest, Populus spp. forest exceed 85%,Robinia pseuoacacia forest, deserted grassland, 65% and Quercus spp. forest, non-forest, shrub forest had smaller ones, which were 26.5%, 29.1% and 45.3%, respectively. The main transition trends of various patches were non-forest and Quercus spp. forest. During the course of transition, the types that 50% of area was remained were Quercus spp. forest, non-forest and shrub forest. According to above analyses, the main driving forces, such as the management policies, market economy factors and influences of human activities etc. were brought out.

关键词： forest landscape pattern driving forces luoning county

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China Life Sciences 2025年第1期68卷 204-218页

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi Dong Bangxiang Xie qian Hao xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

关键词： p53 NRF2 SLC7A11 WEE1 AZD1775 ferroptosis nucleolar stress

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豫西山地生态经济综合区划——以洛宁县为例

经济地理 2006年第6期26卷 926-930页

作者：肖燕钱乐祥聊城大学环境与规划学院中国山东聊城252000 广州大学地理科学学院中国广东广州510006

将传统区划研究方法和现代GIS技术结合,以网格作为区划的基本单元,采用“自下而上”的区划方法,以地处豫西山地的典型地区洛宁县为例,对复杂的自然生态要素与人类活动的时空变化及相互作用运用GIS分析手段进行分析和表达。根据不同区域... 详细信息

将传统区划研究方法和现代GIS技术结合,以网格作为区划的基本单元,采用“自下而上”的区划方法,以地处豫西山地的典型地区洛宁县为例,对复杂的自然生态要素与人类活动的时空变化及相互作用运用GIS分析手段进行分析和表达。根据不同区域所表现出来的对生态变化与人类经济社会活动变化的承载力差异,进行小尺度的县域生态经济综合区划。将洛宁县划分为四个生态经济区。通过对各生态经济区特征的分析,旨在协调日益激化的人地矛盾,探索生态经济的发展方向、途径和对策,为豫西山地中尺度生态经济系统的可持续发展研究提供经验和样本。

关键词：生态经济综合区划 GIS 豫西山地洛宁县

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土地利用和土地覆被变化模型方法综述

河南大学学报（自然科学版） 2005年第1期35卷 52-57页

作者：王丽钱乐祥河南大学环境与规划学院河南开封475001

对土地利用 /土地覆被变化模型的发展趋势、模型构成和模型分类作了系统的介绍,并将当前广泛使用的模型从变化的程度、变化的方向和变化的空间形式分析等角度加以分析,最后指出了土地利用 /土地覆被变化模型存在的问题,提出了相应的建议.

关键词：土地利用/土地覆被变化模型方法:土地利用动态变化变化的程度变化的方向变化的空间形式

SPOT5遥感影像融合算法比较研究——以开封地区影像图为例

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河南大学学报（自然科学版） 2008年第1期38卷 54-58,64页

作者：泮雪芹钱乐祥临沂师范学院环境与旅游学院山东临沂276005 广州大学地理科学学院广州510006

分别对遥感影像的5种融合方法进行了对比分析,明确了各融合方法相对原始影像光谱的扭曲程度,比较得出了在光谱特征上扭曲较小的融合方法.同时进一步对比分析了光谱扭曲程度较小的融合影像在图像分类识别上的精度.

关键词： SPOT5 遥感影像融合比较研究开封

Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng le Wang Wenwu Zhang Gang Li Xing Cheng Peiqiang Su Yong Wan xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

基于陆地卫星TM/ETM+改进的温湿指数及其对不透水表面的响应

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地理与地理信息科学 2013年第2期29卷 112-115页

作者：李仕峰钱乐祥王瑾广州大学地理科学学院广东广州510006

该文基于Landsat TM/ETM+影像,获取大尺度区域的温湿指数,并评估温湿指数对不透水表面的响应。利用地表温度代替气温、归一化水汽指数代替相对湿度,对传统的温湿指数计算公式进行改进,并计算了珠江三角洲核心区域的温湿指数。运用空间... 详细信息

该文基于Landsat TM/ETM+影像,获取大尺度区域的温湿指数,并评估温湿指数对不透水表面的响应。利用地表温度代替气温、归一化水汽指数代替相对湿度,对传统的温湿指数计算公式进行改进,并计算了珠江三角洲核心区域的温湿指数。运用空间剖面和归一化方法,分析了温湿指数的时空演变,发现城市范围内的温湿指数要比郊区的高,初夏和秋季的温湿指数城乡间波动要比初冬的大,且温湿指数呈逐年升高趋势。进一步分析温湿指数与归一化裸露指数的关系,发现二者存在明显正相关(相关系数分别为0.41、0.45和0.35,显著性水平为0.01)。表明不透水表面的增加导致温湿指数升高,从而加剧了夏秋季城区范围内人们对热的不舒适感,提高了冬季人们对热的舒适感。

关键词：陆地卫星TM ETM+ 温湿指数改进不透水表面

Direct Photolithography of WO_(x)Nanoparticles for High‑Resolution Non‑Emissive Displays

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Nano-Micro letters 2025年第3期17卷 297-309页

作者： Chang Gu Guojian Yang Wenxuan Wang Aiyan Shi Wenjuan Fang lei qian Xiaofei Hu Ting Zhang Chaoyu xiang Yu‑Mo Zhang Laboratory of Optoelectronic Information Technology and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201People’s Republic of China Hangzhou Bay Laboratory of Advanced Nano‑Optoelectronic Materials and Devices Qianwan Institute of CNITECHNingbo 315336People’s Republic of China Smart Materials for Architecture Research Lab Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100People’s Republic of China University of Science and Technology of China Hefei 230026People’s Republic of China State Key Lab of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012People’s Republic of China

High-resolution non-emissive displays based on electrochromic tungsten oxides(WOx)are crucial for future near-eye virtual/augmented reality interactions,given their impressive attributes such as high environmental stability,ideal outdoor readability,and low energy ***,the limited intrinsic structure of inorganic materials has presented a significant challenge in achieving precise patterning/pixelation at the micron ***,we successfully developed the direct photolithography for WOx nanoparticles based on in situ photo-induced ligand *** strategy enabled us to achieve ultra-high resolution efficiently(line widthlectrochromic materials).Additionally,the resulting device exhibited impressive electrochromic performance,such as fast response(3600 cycles),as well as promising applications in electronic logos,pixelated displays,flexible electronics,*** success and advancements presented here are expected to inspire and accelerate research and development(R&D)in high-resolution non-emissive displays and other ultra-fine micro-electronics.

关键词： Electrochromic Direct photolithography WOx nanoparticles In situ photo-induced ligand exchange High-resolution displays

城市热岛研究中地表温度与植被丰度的耦合关系

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广州大学学报（自然科学版） 2006年第5期5卷 62-68,F0003页

作者：钱乐祥广州大学地理科学学院广东广州510006

城市热岛遥感研究传统上应用归一化植被指数(Norm alized D ifference Vegetation Index,NDVI)作为植被丰度(vegetation abundance)的指示,并用于耦合地表温度与植被之间的关系.文章探讨了运用光谱混合模型获得的植被比例(vegetation fr... 详细信息

城市热岛遥感研究传统上应用归一化植被指数(Norm alized D ifference Vegetation Index,NDVI)作为植被丰度(vegetation abundance)的指示,并用于耦合地表温度与植被之间的关系.文章探讨了运用光谱混合模型获得的植被比例(vegetation fraction)作为植被丰度指标的一种选择,以2000年9月14日获得的122/44景ETM+截取的广州市海珠区作为验证影像,运用最小二乘法将变换的影像分解成三个分维影像,即绿色植被、非渗透性表面和水体.结合最大似然分类和决策树算法的混合分类处理,将比例影像进行土地覆盖分类.结果表明,地表温度与分解的植被比例的负相关关系比地表温度与NDVI的负相关关系要高出几分.由此说明,地表温度结构的空间变异无疑与归一化植被指数和植被比例相关,不同土地覆盖类型的热辐射与植被动态的相互影响导致地表温度在光谱辐射率和结构上的变化,这些变化在别的影像中也有表现,这是城市热岛空间格局形成的原因.

关键词：地表温度植被丰度城市热岛光谱混合分析