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Increased excitatory amino acid transporter 2 levels in basolateral amygdala astrocytes mediate chronic stress–induced anxiety-like behavior

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Neural Regeneration Research 2025年第6期20卷 1721-1734页

作者： Xirong Xu Shoumin Xuan Shuai Chen Dan Liu qian Xiao jie Tu Shenzhen Key Laboratory of Neuroimmunomodulation for Neurological Diseases Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina CAS Key Laboratory of Brain Connectome and Manipulation Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Brain Connectome and Behavior the Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina University of Chinese of Academy of Sciences BeijingChina Faculty of Life and Health Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

The conventional perception of astrocytes as mere supportive cells within the brain has recently been called into question by empirical evidence, which has revealed their active involvement in regulating brain function and encoding behaviors associated with ***, astrocytes in the basolateral amygdala have been found to play a role in the modulation of anxiety-like behaviors triggered by chronic stress. Nevertheless, the precise molecular mechanisms by which basolateral amygdala astrocytes regulate chronic stress–induced anxiety-like behaviors remain to be fully elucidated. In this study, we found that in a mouse model of anxiety triggered by unpredictable chronic mild stress, the expression of excitatory amino acid transporter 2 was upregulated in the basolateral amygdala. Interestingly, our findings indicate that the targeted knockdown of excitatory amino acid transporter 2 specifically within the basolateral amygdala astrocytes was able to rescue the anxiety-like behavior in mice subjected to stress. Furthermore, we found that the overexpression of excitatory amino acid transporter 2 in the basolateral amygdala, whether achieved through intracranial administration of excitatory amino acid transporter 2agonists or through injection of excitatory amino acid transporter 2-overexpressing viruses with GfaABC1D promoters, evoked anxiety-like behavior in mice. Our single-nucleus RNA sequencing analysis further confirmed that chronic stress induced an upregulation of excitatory amino acid transporter 2 specifically in astrocytes in the basolateral amygdala. Moreover, through in vivo calcium signal recordings, we found that the frequency of calcium activity in the basolateral amygdala of mice subjected to chronic stress was higher compared with normal *** knocking down the expression of excitatory amino acid transporter 2 in the basolateral amygdala, the frequency of calcium activity was not significantly increased, and anxiety-like behavior was ob

关键词： anxiety astrocytes basolateral amygdala behavior dihydrokainic acid excitatory amino acid transporter 2 fiber photometry glutamate LDN-212320 transporter

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Computer-assisted three-dimensional individualized extreme liver resection for hepatoblastoma in proximity to the major liver vasculature

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1066-1077页

作者： Wen-Li Xiu jie Liu Jing-Li Zhang Jing-Miao Wang Xue-Feng Wang Fei-Fei Wang jie Mi Xi-Wei Hao NanXia qian Dong Department of Pediatric Surgery The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Pediatric Surgery Yijishan Hospital of Wannan Medical CollegeWuhu 241000Anhui ProvinceChina Shandong Provincial Key Laboratory of Digital Medicine and Computer-assisted Surgery Shandong College Collaborative Innovation Center of Digital Medicine Clinical Treatment and Nutrition HealthQingdao UniversityQingdao 266003Shandong ProvinceChina

BACKGROUND The management of hepatoblastoma(HB)becomes challenging when the tumor remains in close proximity to the major liver vasculature(PMV)even after a full course of neoadjuvant chemotherapy(NAC).In such cases,extreme liver resection can be considered a potential *** To explore whether computer-assisted three-dimensional individualized extreme liver resection is safe and feasible for children with HB who still have PMV after a full course of *** We retrospectively collected data from children with HB who underwent surgical resection at our center from June 2013 to June *** then analyzed the detailed clinical and three-dimensional characteristics of children with HB who still had PMV after a full course of *** Sixty-seven children diagnosed with HB underwent surgical *** age at diagnosis was 21.4±18.8 months,and 40 boys and 27 girls were ***-nine(88.1%)patients had a single tumor,39(58.2%)of which was located in the right lobe of the liver.A total of 47 patients(70.1%)had PRE-TEXT III or ***-nine patients(58.2%)underwent delayed *** a full course of NAC,16 patients still had close PMV(within 1 cm in two patients,touching in 11 patients,compressing in four patients,and showing tumor thrombus in three patients).There were 6 patients of tumors in the middle lobe of the liver,and four of those patients exhibited liver anatomy *** 16 children underwent extreme liver resection after comprehensive preoperative *** procedures were performed according to the preoperative plan,and the operations were successfully ***,the 3-year event-free survival of 67 children with HB is 88%.Among the 16 children who underwent extreme liver resection,three experienced recurrence,and one died due to multiple *** Extreme liver resection for HB that is still in close PMV after a full course of NAC is both safe and *** approach not only reduces th

关键词： Children Hepatoblastoma Surgery Three-dimensional Computer-assisted

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Arabidopsis replication factor C4（AtRFC4） is critical for DNA replication during the mitotic cell cycle

Arabidopsis replication factor C4（AtRFC4） is critical for ...

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中国植物学会第十六次全国会员代表大会暨85周年学术年会

作者： jie qian Yueyue Chen Ying Hu Yingtian Deng Yang Liu Gang Li Wenxuan Zou jie Zhao State Key Laboratory of Hybrid Rice College of Life SciencesWuhan University

Replication factor C（RFC） is a conserved eukaryotic complex consisting of RFC1/2/3/4/*** plays important roles in DNA replication and the cell cycle in yeast and fruit ***,it is not very clear how RFC subunits function in higher plants,except for the Arabidopsis（At） subunits AtRFC1 and *** this study,we investigated the functions of AtRFC4 and found that loss of function of AtRFC4 led to an early sporophyte lethality that initiated as early as the elongated zygote stage,all defective embryos arrested at the two-to four-cell embryo proper stage,and the endosperm possessed six to eight free *** of rfc4-1/+ with AtRFC4 expression driven through the embryo-specific DD45 pro and ABI3 pro or the endosperm-specific FIS2 pro could not completely restore the defective embryo or endosperm,whereas a combination of these three promoters in rfc4-1/+ enabled the aborted ovules to develop into viable *** suggests that AtRFC4 functions simultaneously in endosperm and embryo and that the proliferation of endosperm is critical for embryo *** of DNA content in rfc4-1/+ verified that DNA replication was disrupted in endosperm and embryo,resulting in blocked ***,we observed a decreased proportion of late S-phase and M-phase cells in the rfc4-1/–FIS2;DD45;ABI3 pro::AtRFC4 seedlings,suggesting that incomplete DNA replication triggered cell cycle arrest in cells of the root apical ***,we conclude that AtRFC4 is a crucial gene for DNA replication.

关键词： Arabidopsis thaliana replication factor C4 embryo endosperm DNA replication cell cycle

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Mesenchymal stem cells-extracellular vesicles alleviate pulmonary fibrosis by regulating immunomodulators

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World Journal of Stem Cells 2024年第6期16卷 670-689页

作者： Ying Gao Mei-Fang Liu Yang Li Xi Liu Yu-jie Cao qian-Fa Long Jun Yu Jian-Ying Li Department of Respiratory and Critical Care Medicine Shaanxi Provincial Rehabilitation HospitalXi’an 710000Shaanxi ProvinceChina Department of Respiratory and Critical Care Medicine Second Affiliated Hospital of Ningxia Medical University(The First People’s Hospital of Yinchuan)Yinchuan 750001Ningxia Hui Autonomous RegionChina School of Clinical Medicine Xi’an Medical UniversityXi’an 710021Shaanxi ProvinceChina Department of Respiratory and Critical Care Medicine Xi’an Central HospitalXi’an 710000Shaanxi ProvinceChina Department of Neurosurgery Xi’an Central HospitalXi’an 710000Shaanxi ProvinceChina Department of Emergency Xi’an Central HospitalXi’an 710000Shaanxi ProvinceChina

BACKGROUND Pulmonary fibrosis(PF)is a chronic interstitial lung disease characterized by fibroblast proliferation and extracellular matrix formation,causing structural damage and lung *** cell therapy and mesenchymal stem cells-extracellular vesicles(MSC-EVs)offer new hope for PF *** To investigate the therapeutic potential of MSC-EVs in alleviating fibrosis,oxidative stress,and immune inflammation in A549 cells and bleomycin(BLM)-induced mouse *** The effect of MSC-EVs on A549 cells was assessed by fibrosis markers[collagen I andα-smooth muscle actin(α-SMA),oxidative stress regulators[nuclear factor E2-related factor 2(Nrf2)and heme oxygenase-1(HO-1),and inflammatory regu-lators[nuclear factor-kappaB(NF-κB)p65,interleukin(IL)-1β,and IL-2].Similarly,they were assessed in the lungs of mice where PF was induced by BLM after MSC-EV ***-EVs ion PF mice were detected by pathological staining and western ***-cell RNA sequencing was performed to investigate the effects of the MSC-EVs on gene expression profiles of macrophages after modeling in *** Transforming growth factor(TGF)-β1 enhanced fibrosis in A549 cells,significantly increasing collagen I andα-SMA ***,treatment with MSC-EVs demonstrated a remarkable alleviation of these ***,the expression of oxidative stress regulators,such as Nrf2 and HO-1,along with inflammatory regulators,including NF-κB p65 and IL-1β,were mitigated by MSC-EV ***,in a parallel manner,MSC-EVs exhibited a downregulatory impact on collagen deposition,oxidative stress injuries,and inflammatory-related cytokines in the lungs of mice with ***,the mRNA sequencing results suggested that BLM may induce PF in mice by upregulating pulmonary collagen fiber deposition and triggering an immune inflammatory *** findings collectively highlight the potential therapeutic efficacy of MSC-EVs in ameliorating fibrotic processes,oxidative stres

关键词： Mesenchymal stem cells Extracellular vesicles Pulmonary fibrosis Oxidative stress response Epithelial-mesenchymal transition

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Efficacy and safety of perioperative therapy for locally resectable gastric cancer:A network meta-analysis of randomized clinical trials

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1046-1058页

作者： Zi-Yu Kuang qian-Hui Sun Lu-Chang Cao Xin-Yi Ma Jia-Xi Wang Ke-Xin Liu jie Li Graduate College Beijing University of Traditional Chinese MedicineBeijing 100029China Oncology Department Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China

BACKGROUND Gastric cancer(GC)is the fifth most commonly diagnosed malignancy worldwide,with over 1 million new cases per year,and the third leading cause of cancer-related *** To determine the optimal perioperative treatment regimen for patients with locally resectable *** A comprehensive literature search was conducted,focusing on phase II/III randomized controlled trials(RCTs)assessing perioperative chemotherapy and chemoradiotherapy in treating locally resectable *** R0 resection rate,overall survival(OS),disease-free survival(DFS),and incidence of grade 3 or higher nonsurgical severe adverse events(SAEs)associated with various perioperative regimens were analyzed.A Bayesian network meta-analysis was performed to compare treatment regimens and rank their *** Thirty RCTs involving 8346 patients were included in this *** XELOX plus neoadjuvant radiotherapy and neoadjuvant CF were found to significantly improve the R0 resection rate compared with surgery alone,and the former had the highest probability of being the most effective option in this *** plus adjuvant FLOT was associated with the highest probability of being the best regimen for improving *** to limited data,no definitive ranking could be determined for *** nonsurgical SAEs,FLO has emerged as the safest treatment *** This study provides valuable insights for clinicians when selecting perioperative treatment regimens for patients with locally resectable *** studies are required to validate these findings.

关键词： Gastric cancer Perioperative treatment Network meta-analysis Efficacy and safety

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Boswellic acids: a review on its pharmacological properties, molecular mechanism and bioavailability

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Traditional Medicine Research 2024年第10期9卷 64-74页

作者： Na Cui Ming-jie Li Yi-Wen Wang qian Meng Ya-Jun Shi Yi Ding Department of Pharmacy 3201 HospitalHanzhong 723000China Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’an 710032China School of Pharmacy Shaanxi University of Traditional Chinese medicineXianyang 712046China

Boswellic acids is a general term for a series of pentacyclic triterpenoid compounds that are isolated from the oleogin resin of the Boswellia genus and serve as the main active *** exhibits a wide range of biological activities,such as anti-inflammatory,anti-cancer,antibacterial,antiviral,hepatoprotective,neuroprotective,anti-diabetic,and anti-thrombotic *** a result,it has gained significant recognition among practitioners of traditional Chinese and Indian *** biological effects may be associated with multiple molecular targets and signal transduction ***,the poor pharmacokinetic properties of the substance lead to lower bioavailability,which affects its *** address this issue,scientists have proposed a number of strategies,such as solid dispersions,phytosome®technologies,and novel drug delivery *** article aims to provide a comprehensive overview for boswellic acids on the phytochemistry,molecular mechanisms,potential therapeutic applications,and strategies to improve bioavailability.

关键词： boswellic acids molecular mechanism pharmacological properties bioavailability

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长沙市粮食生产“四高”技术集成与示范

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湖南农业科学 2024年第9期 34-40,48页

作者：王少希罗冬生钱艳杰李诚胡明勇刘苏易展平姚艳红王冲勇长沙市农业技术推广中心湖南长沙410003

2023年继2022年的长沙市粮食生产“四高”试验示范,开展双季稻品种选配和“培地扩容、激光平田,因地选种、依茬搭配,机械密植、变量施肥,生防优先、梯级控害”技术集成示范。结果表明,双季稻品种最适搭配为:欣荣优123+隆晶优1212、中安7... 详细信息

2023年继2022年的长沙市粮食生产“四高”试验示范,开展双季稻品种选配和“培地扩容、激光平田,因地选种、依茬搭配,机械密植、变量施肥,生防优先、梯级控害”技术集成示范。结果表明,双季稻品种最适搭配为:欣荣优123+隆晶优1212、中安7号+泰优398、陵两优268+泰优398、陵两优268(浏阳)+Y两优911、湘早籼32号(宁乡)+Y两优911;千亩核心示范片、万亩综合试验区和十万亩辐射带动区周年平均产量分别达19478.3、18066.4和15077.4 kg/hm^(2),较非示范区双季稻周年产量分别增产51.8%、40.8%和17.5%;千亩核心示范片、万亩综合试验区年纯收入分别为20630.68元/hm^(2)、19437.78元/hm^(2),较非示范区分别增收87.7%、76.8%。

关键词：粮食生产品种选配 “四高”技术示范双季稻

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Perspective of Calcium Imaging Technology Applied to Acupuncture Research

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Chinese Journal of Integrative Medicine 2024年第1期30卷 3-9页

作者： LI Sha LIU Yun ZHANG Nan LI Wang XU Wen-jie XU Yi-qian CHEN Yi-yuan CUI Xiang ZHU Bing GAO Xin-yan Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing(100700)China

Acupuncture, a therapeutic treatment defined as the insertion of needles into the body at specific points(ie, acupoints), has growing in popularity world-wide to treat various diseases effectively, especially acute and chronic pain. In parallel, interest in the physiological mechanisms underlying acupuncture analgesia, particularly the neural mechanisms have been increasing. Over the past decades, our understanding of how the central nervous system and peripheral nervous system process signals induced by acupuncture has developed rapidly by using electrophysiological methods. However, with the development of neuroscience, electrophysiology is being challenged by calcium imaging in view field, neuron population and visualization in vivo. Owing to the outstanding spatial resolution, the novel imaging approaches provide opportunities to enrich our knowledge about the neurophysiological mechanisms of acupuncture analgesia at subcellular, cellular, and circuit levels in combination with new labeling, genetic and circuit tracing techniques. Therefore, this review will introduce the principle and the method of calcium imaging applied to acupuncture research. We will also review the current findings in pain research using calcium imaging from in vitro to in vivo experiments and discuss the potential methodological considerations in studying acupuncture analgesia.

关键词： acupuncture research calcium imaging optical imaging nervous system

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二维相关跳频序列偶唯一性和理论界

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北京邮电大学学报 2018年第1期41卷 31-36页

作者：许成谦赵雅洁燕山大学信息科学与工程学院秦皇岛066004 燕山大学河北省信息传输与信号处理重点实验室秦皇岛066004

针对传统跳频序列偶只包含时延变量的一维汉明相关函数的问题,在相关函数中加入频移因素,提出了跳频序列偶的时频二维移位汉明相关函数的概念.证明了二维相关跳频序列偶的唯一性,保证了这类信号在实际应用中的唯一接收.导出了由二维相... 详细信息

针对传统跳频序列偶只包含时延变量的一维汉明相关函数的问题,在相关函数中加入频移因素,提出了跳频序列偶的时频二维移位汉明相关函数的概念.证明了二维相关跳频序列偶的唯一性,保证了这类信号在实际应用中的唯一接收.导出了由二维相关跳频序列偶的汉明相关函数、序列偶个数、频隙个数和序列长度构成的理论界,对于构造满足理论界的二维相关跳频序列偶具有重要意义.

关键词：跳频序列偶二维汉明相关函数唯一性理论界

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Investigating the mechanisms of isochorismate synthase:An approach to improve salicylic acid synthesis and increase resistance to Fusarium head blight in wheat

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The Crop Journal 2024年第4期12卷 1054-1063页

作者： Ya-Zhou Zhang jie Man Dan Xu Lan Wen Yinghui Li Mei Deng qian-Tao Jiang qiang Xu Guo-Yue Chen Yu-Ming Wei State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130SichuanChina Triticeae Research Institute Sichuan Agricultural UniversityChengdu 611130SichuanChina

Salicylic acid(SA),a vital endogenous hormone,plays a crucial role in plant growth and the response to abiotic and biotic *** synthase(ICS)and phenylalanine ammonia lyase(PAL)are critical rate-limiting enzymes for SA *** head blight(FHB)seriously threatens the safety of wheat production,but increasing the content of SA can enhance FHB ***,the pathway of SA synthesis and regulation in wheat remains *** this study,three wheat ICS(TaICSA,TaICSB,and TaICSD)were identified,and their functions were validated in vitro for isomerizing chorismate to *** mutation of one or two homoeoalleles of TaICSA,TaICSB,and TaICSD in the wheat variety‘Cadenza’reduced SA levels under ultraviolet treatment and Fusarium graminearum infection,further enhancing sensitivity to *** of TaICSA can significantly enhance SA levels and resistance to *** further study SA synthesis pathways in wheat and avoid interference with pathogenicity related genes,the leaves of wild-type Cadenza and different TaICS mutant lines were subjected to ultraviolet treatment for transcriptomic *** results showed that 37 PALs might be involved in endogenous SA synthesis,and 82 WRKY and MYB family transcription factors may regulate the expression of ICS and *** results were further confirmed by *** conclusion,this study expands our knowledge of SA biosynthesis and identifies TaICSA,as well as several additional candidate genes that encode transcription factors for regulating endogenous SA levels,as part of an efficient strategy for enhancing FHB resistance in wheat.

关键词： Salicylic acid Chorismate Isochorismate RNA-seq Phenylalamine ammonia lyase

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