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Quantificational indexes for design and evaluation of copper staves for blast furnaces

Journal of University of Science and Technology Beijing 2008年第1期15卷 10-16页

作者： Liang qian Susen cheng Hongbo Zhao School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China Continuous Casting Technology Engineering Co. Ltd. MCC Group Beijing 100081 China

The quantificational and normative design is the precondition of improving the design of copper staves for blast furnaces. Based on a 3-dimensional temperature field calculation model, from the view point of heat transfer and long campaigns note with the core of forming accretion, the forming-accretion-ability （FAA） and the rib hot surface maximum temperature difference （ATmax） as quantificational indexes to direct and evaluate the design of copper staves for blast furnaces were presented. The application of the two indexes in design essentially embodies the new long campaigns in the stage of design. With the application of the two indexes, good results can be obtained. Firstly, it was suggested that the rib height of a copper stave can be reduced to 15 mm, which is a new method and theory for the reduction of copper staves. Secondly, the influence of insert on FAA and ATmax, is decided by the volume of insert. According to this, the principle of design for the hot surface geometry of copper staves was put forward that the ratio of the rib hot surface to the copper stave hot surface （abbreviated as the ratio of rib to stave） must be maintained in the range of 45% to 55%; for the present copper stave with a 35-40 mm thick rib, the ratio of rib to stave in the range of 50% to 55% can optimize the design of copper staves; for the copper stave with a smaller rib thickness, for example 15 ram, the ratio of rib to stave in the range of 45% to 50% can optimize the design of copper staves. It can be summarized that the thicker the rib thickness, the larger is the ratio of rib to stave. 2008 University of Science and Technology Beijing. All rights reserved.

关键词： blast furnace (BF) copper stave quantificational index forming-accretion-ability

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Design and simulation of fault diagnosis based on NUIO/LMI for satellite attitude control systems

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Journal of Systems Engineering and Electronics 2012年第4期23卷 581-587页

作者： Yuehua cheng qian Hou Bin Jiang College of Automation Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 R R. China Academy of Frontier Science Nanjing University of Aeronautics and Astronautics Nanjing 210016 P. R. China

This paper presents a scheme of fault diagnosis for flexible satellites during orbit maneuver. The main contribution of the paper is related to the design of the nonlinear input observer which can avoid false alarm arising from the disturbance from orbit control force. The effects of orbit control force on the fault diagnosis system for satellite attitude control systems, including the disturbing torque caused by the misalignments and the model uncertainty caused by the fuel consumed, are discussed, where standard Lu- enberger observer cannot work well. Then the nonlinear unknown input observer is proposed to decouple faults from disturbance, Besides, a linear matrix inequality approach is adopted to reduce the effect of nonlinear part and model uncertainties on the observer. The numerical and semi-physical simulation demonstrates the effectiveness of the proposed observer for the fault diagnosis system of the satellite during orbit maneuver.

关键词： orbit control flexible satellite attitude control system,nonlinear unknown input observer (NUIO) fault diagnosis.

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Nomogram to predict the risk of endoscopic removal failure with forceps/baskets for treating submandibular stones

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World Journal of Clinical Cases 2022年第9期10卷 2710-2720页

作者： Yun Huang Pei-Sheng Liang Yao-cheng Yang Wei-xin Cai qian Tao Department of Oral and Maxillofacial Surgery Hospital of StomatologyGuanghua School of StomatologySun Yat-Sen UniversityGuangzhou 510055Guangdong ProvinceChina Department of Oral and Maxillofacial Surgery Guangdong Provincial Key Laboratory of StomatologyGuangzhou 510055Guangdong ProvinceChina

BACKGROUND Endoscopic removal with forceps/baskets is favored in treating submandibular stones due to its minimal ***,recent studies have found that endoscopic removal failure(ERF)is not unusual,and stones in such cases still need to be removed with other surgical *** the risk of ERF can be predicted preoperatively,it could be helpful for surgeons when choosing the appropriate *** To develop a predictive nomogram for the risk of ERF when treating submandibular stones based on their preoperative clinical *** A total of 180 patients with 211 submandibular stones treated from January 2012 to December 2020 were included in the current *** on the preoperative clinical features of the stones,independent risk factors for ERF were identified by logistic regression *** stones were then randomly divided into training and testing sets.A nomogram was constructed to predict the risk of ERF using the training set and then validated using both *** predictive performance of the nomogram was assessed by calibration curves and the concordance index(Cindex).RESULTS Three independent predictors,location(P=0.040),transverse diameter(P<0.001)and longitudinal diameter(P<0.001)measured on the cone beam computed tomography(CBCT)images of the submandibular stones,were identified and included in the predictive *** curves of the nomogram showed good agreement between the predicted and observed probabilities in both *** C-index in the training set was 0.917(95%CI,0.875-0.959)and that in the testing set was 0.925(95%CI,0.862-0.989).CONCLUSION A nomogram based on the location,transverse and longitudinal diameters on CBCT images of submandibular stones showed satisfactory efficacy in predicting the risk of ERF preoperatively when treating submandibular stones.

关键词： Endoscopic removal failure Submandibular stones Cone beam computed tomography Location Diameter Nomogram

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Securing Cloud Data Using a Pirate Scheme

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Chinese Journal of Electronics 2017年第6期26卷 1289-1296页

作者： cheng Hongbing qian Manyun YU Shui College of Computer Science Zhejiang University of Technology State Key Laboratory for Novel Software Technology Nanjing University School of Information Technology Deakin University

Inspired by the approach of smart pirates dealing with their treasures, the paper proposed a scheme to protect the data security and privacy in cloud computing. In the proposed scheme, cloud data will be divided into some sequenced or logical blocks. These data blocks will be distributed among cloud storage service *** of protecting the data themselves, the proposed scheme protects the mapping of the data elements on each provider. Comprehensive analysis and simulation are designed to verify the proposed scheme, the results show that it is secure for cloud data, and the real implementation on Amazon S3 also indicates that the proposed scheme is feasible and efficient for the cloud data storage.

关键词： Cloud computing Data security Pirate Storage

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Study of station and attitude maneuver of submergence rescue vehicle

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Journal of Marine Science and Application 2007年第1期6卷 15-20页

作者： ZHENG Ke-wei BIAN xin-qian SHI Xiao-cheng College of Automation Harbin Engineering University Harbin 150001 China

It is an important control process to operate motion of an submergence rescue vehicle(SRV). Seeing that the motion of the submergence rescue vehicle is special, it is necessary to employ non-linear predictive control system. For this reason, continuous dynamic performance of the system, the logical components and the operative restraints are expressed as the non-linear equations of state with the inequality restraints, and the model principle of hybrid system is introduced. The conclusion shows that it comes true to exactly control position and attitude of the SRV by means of non-linear model predictive control. The test in a model basin has also proved that the above methods are efficient.

关键词： naval gun lock-breechblock cam artillery cartridge extractor

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Reversing the mitochondrial stress-induced exhaustion of CD8^(+)T cells for improving cancer immunotherapy

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Cellular & Molecular Immunology 2021年第7期18卷 1634-1637页

作者： cheng qian Xuetao Cao National Key Laboratory of Medical Immunology Institute of ImmunologySecond Military Medical UniversityShanghaiChina Laboratory of Immunity and Inflammation College of Life SciencesNankai UniversityTianjinChina

Antigen-specific CD8+T cells that infiltrate tumor tissue have been considered the primary cytotoxic lymphocytes that exert antitumor effects,building a foundation for current immunotherapies against ***,in the face of continuous antigenic stimulation during chronic infections and cancer,T-cell differentiation leads to a state of incapacitation called T-cell exhaustion,which is a critical barrier to successful T-cell immunotherapy of *** explosive growth of malignant tumor cells accompanied by a dysfunctional vascular system and metabolite competition leads to a stressful tumor microenvironment characterized by low-oxygen tension,acidic interstitial pH,and insufficient *** evidence for the contribution of the tumor microenvironment to the metabolic reprogramming of exhausted CD8+T cells has been increasing,but the response of intratumoral T cells to metabolic stress signals is still not fully *** of a study by Scharping et al.,1 together with other recent evidence,have highlighted that the tumor microenvironment can influence the mitochondrial stress of T cells and drive the trajectory of T-cell differentiation toward *** findings add new perspectives on and insights into the molecular initiators of T-cell exhaustion and the combination of strategies that should be utilized to improve the efficacy of immunotherapy,and these perspectives are discussed in this review.

关键词： immunotherapy cancer stimulation

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Spine maturation and pruning during development: Cadherin/Catenin complexes come to help

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Science China(Life Sciences) 2015年第9期58卷 929-930页

作者： qian cheng LI YuLong State Key Laboratory of Membrane Biology Peking University School of Life Sciences PKU-IDG/Mc Govern Institute for Brain Researchand Peking-Tsinghua Center for Life Sciences School of Life Sciences PTN Joint Graduate Program Tsinghua University

Structural and functional alterations of synaptic connections underlay experience-dependent neuronal plasticity and are crucial for many brain functions, including learning and memory. Their defects, on the other hand, have been asso- ciated with neurological disorders such as autism. Although the molecular mechanism underlying long-term functional alterations of synaptic connections, including LTP and LTD, are becoming increasingly clear, the molecular mechanism for structural plasticity, such as spine pruning, remains largely unknown, especially in vivo.

关键词：蛋白复合物钙粘蛋白开发过程修剪神经可塑性成熟脊柱神经系统疾病

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Zinc-based metal-organic frameworks as efficient carriers for anticancer drug to reduce toxicity and increase efficacy

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Rare Metals 2024年第10期43卷 5152-5163页

作者： Dong-Wei Ma Jing-Sheng Lu Xiang-xin Cao Yan-Wei cheng Gang Wang Zi-qian Zhang Bo-cheng Chen Ning Lin Qing Chen College of Pharmacy Guangxi Scientific Research Center of Traditional Chinese MedicineGuangxi University of Chinese MedicineNanning 530200China Guangxi Zhuang Yao Medicine Center of Engineering and Technology Nanning 530200China

The rational design of a specific co-drug delivery platform that can address the unavoidable resistance,toxic side effects and low targeting efficiency of traditional cancer treatments is of great ***,Zn-based MOF-zeolitic imidazole framework-90(ZIF-90)was selected as the drug delivery carrier,with the cancer therapeutic drug mercaptopurine(6-MP)and glucose oxidase(GOD)as the drug models,hyaluronic acid(HA)was used for protection and targeted delivery,which designed and fabricated an intelligent drug delivery platform(6-MP@ZIF-90@GOD@HA).This platform aims to reduce the toxic side effects of 6-MP and enhance its efficacy while improving the targeting ability of GOD,thereby further enhancing the treatment ***,results from both in vitro and in vivo experiments demonstrate that the targeted synergistic chemo/reactive oxygen species(ROS)-mediated/starvation therapy inhibited the cancer cell growth while reducing the chemotherapy toxicity,which provides new possibilities for the development of more precise and effective treatment strategies.

关键词： Metal-organic framework Cancer treatment Combination therapy Drug delivery Reduced toxicity

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The potential of domestic production and imports of oil and gas in China:an energy return on investment perspective

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Petroleum Science 2016年第4期13卷 788-804页

作者： Zhao-Yang Kong Xiu-cheng Dong qian Shao xin Wan Da-Lin Tang Gui-Xian Liu School of Business Administration China University of Petroleum(Beijing)Beijing 102249China School of Business Tianjin University of Finance and EconomicsTianjin 300222China Tangshan Iron and Steel Group Co. LtdTangshan 261000China China Petroleum Enterprise Association Beijing 100724China

Concerns about China’s energy security have escalated because of the country’s high dependency on oil and gas imports, so it is necessary to calculate the availability of domestic oil and gas resources and China’s ability to obtain foreign energy through trade. In this work,the calculation was done by using the energy return on investment（EROI） method. The results showed that the EROIstnd（i.e., standard EROI） of China’s oil and gas extraction decreased from approximately 17.3：1 in 1986 to 8.4：1 in 2003, but it increased to 12.2：1 in 2013. From a company-level perspective, the EROIstnddiffered for different companies and was in the range of（8–12）：1. The EROI2,d（EROI considering energy outputs after processed and direct energy inputs） for different companies was in the range of（3–7）：1. The EROI of imported oil（EROIIO）declined from 14.8：1 in 1998 to approximately 4.8：1 in 2014, and the EROI of imported natural gas（EROIING）declined from 16.7：1 in 2009 to 8.6：1 in 2014. In 2015, the EROIIO and EROIING showed a slight increase due to decreasing import prices. In general, this paper suggests that from a net energy perspective, it has become more difficult for China to obtain oil and gas from both domestic production and imports. China is experiencing an EROI decline, which demonstrates the risk in the use of unsustainable fossil resources.

关键词： EROI Oil and gas extraction Imported oil Imported natural gas China

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Two novel rhodamine-perylenediimide fluorescent probes:Synthesis, photophysical properties, and cell imaging

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Chinese Chemical Letters 2016年第6期27卷 879-886页

作者： Huan-Ren cheng Ying qian School of Chemistry and Chemical Engineering Southeast University

In this study, two novel dual-switch fluorescent chemosensors based on rhodamine-peryleneiimide have been designed and synthesized. The dual-switching behaviors of the sensors were based on the structural transformations of rhodamine and an intramolecular photoinduced electron transfer（PET）process from rhodamine to perylenediimide. These probes exhibited excellent sensitivity to protons with enhanced fluorescence emission from 500 nm to 580 nm. The fluorescence changes of probes were reversible within a wide range of p H values from 2.0 to 11.0. Moreover, the sensors exhibited high selectivity, short response time, and long lifetime toward protons. The possible mechanism was investigated by the DFT calculation and-1H NMR. According to the experiment of confocal laser scanning microscopy, these probes could be used to detect the acidic p H variations in living *** the Fundamental Research Funds for the National Natural Science Foundation of China （No. 61178057） and for the Central Universities （No. CXLX12_0085）. The characteristic data of compounds were in the Supplementary information.

关键词： Perylenediimide Rhodamine Photoinduced electron transfer Dual-switch

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