检索结果-南通市图书馆

Patient-Reported Outcomes of Postoperative NSCLC Patients with or without Staged Chinese Herb Medicine Therapy during Adjuvant Chemotherapy (NALLC 2): A Randomized, Double-Blind, Placebo-Controlled Trial

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第11期30卷 963-973页

作者： ZHANG Yi-lu JIAO Li-jing GONG Ya-bin XU Jian-fang NI Jian SHEN Xiao-yong ZHANG Jie ZHOU Di qian cheng-xin WANG Qin YAO Jia-lin YANG Wen-xiao SU Ling-zi WANG Li-yu LI Jia-qi YAO Yi-qin ZHANG Yuan-hui WANG Yi-chao CHEN Zhi-wei XU Ling Oncology Department Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Institute of Traditional Chinese Medicine Oncology Shanghai University of Traditional Chinese MedicineShanghai 201203China Oncology Department Shanghai Pulmonary HospitalShanghai Tongji UniversityShanghai 200433China Thoracic Surgery Department Huadong HospitalShanghai Fudan UniversityShanghai 200040China Thoracic Surgery Department Shanghai Cancer HospitalShanghai Fudan UniversityShanghai 200032China Oncology Department Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China

Objective:To investigate whether the combination of chemotherapy with staged Chinese herbal medicine(CHM) therapy could enhance health-related quality of life(QoL) in non-small-cell lung cancer(NSCLC)patients and prolong the time before deterioration of lung cancer symptoms,in comparison to chemotherapy ***:A prospective,double-blind,randomized,controlled trial was conducted from December 14,2017 to August 28,2020.A total of 180 patients with stage ⅠB-ⅢA NSCLC from 5 hospitals in Shanghai were randomly divided into chemotherapy combined with CHM(chemo+CHM) group(120 cases) or chemotherapy combined with placebo(chemo+placebo) group(60 cases) using stratified blocking *** European Organization for Research and Treatment of Cancer(EORTC) Quality-of-Life-Core 30 Scale(QLQ-C30) was used to evaluate the patient-reported outcomes(PROs) during postoperative adjuvant chemotherapy in patients with early-stage *** events(AEs) were assessed in the safety ***:Out of the total 180 patients,173 patients(116in the chemo+CHM group and 57 in the chemo+placebo group) were included in the PRO *** initial mean QLQ-C30 Global Health Status(GHS)/QoL scores at baseline were 57.16±1.64 and 57.67±2.25 for the two respective groups(P>0.05).Compared with baseline,the chemo+CHM group had an improvement in QLQ-C30GHS/QoL score at week 18 [least squares mean(LSM) change 17.83,95% confidence interval(CI) 14.29 to 21.38].Conversely,the chemo+placebo group had a decrease in the score(LSM change-13.67,95% CI-22.70 to-4.63).A significant between-group difference in the LSM GHS/QoL score was observed,amounting to 31.63 points(95% CI25.61 to 37.64,P<0.001).The similar trends were observed in physical functioning,fatigue and appetite *** week 18,patients in the chemo+CHM group had a higher proportion of improvement or stabilization in GHS/QoL functional and symptom scores compared to chemo+placebo group(P<0.001).The median time to deterioration

关键词： non-small-cell lung cancer adjuvant chemotherapy patient-reported outcome health-related quality of life Chinese herbal medicine

在线全文

学校读者我要写书评

暂无评论

化疗所致血小板减少的中西医治疗进展

中医肿瘤学杂志 2021年第5期3卷 57-62页

作者：钱程欣李嘉旗周迪上海中医药大学附属岳阳中西医结合医院肿瘤一科上海200437

化疗所致血小板减少症(Chemotherapy-inducedthrombocytopenia,CIT)可推迟或减缓后续抗肿瘤治疗进程,并对患者的生活质量和长期生存获益产生不利影响。早期预防CIT的发生可避免减少化疗剂量和延迟化疗进程。中医药作为我国肿瘤治疗中的... 详细信息

化疗所致血小板减少症(Chemotherapy-inducedthrombocytopenia,CIT)可推迟或减缓后续抗肿瘤治疗进程,并对患者的生活质量和长期生存获益产生不利影响。早期预防CIT的发生可避免减少化疗剂量和延迟化疗进程。中医药作为我国肿瘤治疗中的特色,可保护骨髓造血功能,有效地提升血小板水平,对于防治化疗后血小板减少症具有重要的现实意义。本文分析中西医治疗化疗后血小板减少症的不同策略,结合中医辨证对CIT的治疗现状进行综述。

关键词：肿瘤化疗相关性血小板减少症西药中医药治疗综述

在线全文

学校读者我要写书评

暂无评论

264张处方有毒中药饮片超剂量使用分析

中国医院药学杂志 2018年第8期38卷 878-881页

作者：常昕楠刘力范鲁丹王晓雯钱信成杨德超上海中医药大学附属曙光医院药剂科上海200021

目的:调查门诊中药饮片处方中有毒中药饮片超剂量使用情况,为中医临床合理用药提供参考。方法:随机抽取2016年6月至2017年5月门诊中药饮片处方,参照《中国药典》(2015年版)和《上海市中药饮片炮制规范》(2008年版)规定的中药饮片用量范... 详细信息

目的:调查门诊中药饮片处方中有毒中药饮片超剂量使用情况,为中医临床合理用药提供参考。方法:随机抽取2016年6月至2017年5月门诊中药饮片处方,参照《中国药典》(2015年版)和《上海市中药饮片炮制规范》(2008年版)规定的中药饮片用量范围,对处方中超剂量使用的有毒中药饮片的品种、剂量、各剂量使用频次和频率、超剂量程度等进行统计分析。结果:超剂量使用的有毒中药饮片共有21个品种,占某院有毒中药饮片品种数的45.65%,其中12种有两种以上超上限使用剂量;超剂量使用频率排名前五位的中药饮片品种和剂量分别是水蛭9 g、吴茱萸6 g、蒺藜15 g、仙茅12 g、天仙子9 g;超剂量使用程度排序,水蛭12 g位列第一,是剂量上限的4倍。小毒中药饮片较有毒中药饮片平均超剂量使用频率更高,但两者平均超剂量使用程度并无显著性差异(P>0.05)。活血化瘀药和平肝息风药的超剂量使用频率和程度均排名前三。结论:有毒中药饮片超剂量使用整体情况较合理。建议结合地区用药习惯,制定中药饮片尤其是有毒中药饮片的剂量范围,以保证临床用药安全、有效。

关键词：有毒中药饮片超剂量处方分析

在线全文

学校读者我要写书评

暂无评论

基于风场模拟的接触网b值动态响应分析

铁道标准设计 2017年第1期61卷 103-107页

作者：王圣昆刘明光李光泽钱学成王昕北京交通大学电气工程学院北京100044 兰州铁路局兰州730000 国网江苏省电力公司常州供电公司江苏常州213003

接触网线索受风振动会造成b值变化,为了将风荷载引起的变化量剔除,对随机风场作用下的接触网进行仿真研究。利用ANSYS软件建立全补偿简单链形悬挂接触网模型;采用谐波叠加法模拟得到随机风场;分析b值风致变化的机理,仿真完成了接触网模... 详细信息

接触网线索受风振动会造成b值变化,为了将风荷载引起的变化量剔除,对随机风场作用下的接触网进行仿真研究。利用ANSYS软件建立全补偿简单链形悬挂接触网模型;采用谐波叠加法模拟得到随机风场;分析b值风致变化的机理,仿真完成了接触网模型在不同随机风荷载作用下的动态响应分析。研究结果表明:接触网b值风致变化是线索受风偏移导致的结果,横向偏移起主要作用;脉动风场作用下接触网各跨会随机产生不同大小的补偿位移,随着风速提升补偿位移振幅相应变大且变化率呈增大趋势;对于半个锚段12跨接触网,当风速达到41m/s时,补偿位移振幅为60.61 mm,接近棘轮补偿装置断线b值变化量,说明识别断线事故时应考虑风振的影响。

关键词：电气化铁道接触网随机风场 b值风致响应

A TRUST REGION-TYPE METHOD FOR SOLVINGMONOTONE VARIATIONAL INEQUALITY

在线全文

学校读者我要写书评

暂无评论

Journal of Computational Mathematics 2000年第1期18卷 13-24页

作者： Xi-ming Liang cheng-Xian Xu Ji-xin qian Institute of Industrial Process Control National Lab of Industrial Control TechnologyZhejiang UniversityHangzhou 310027China School of Science Xi’an Jiaotong UniversityXi’an 710049China

Presents a study which proposed to introduce a trust region-type modification of Newton method for the monotone inequality problem using merit function. Concepts of monotone mapping; Proof of convergence of algorithm ... 详细信息

关键词： variational inequality problem trust region method global convergence quadratic convergence

Model test of the group piles foundation of a high-speed railway bridge in mined-out area

在线全文

学校读者我要写书评

暂无评论

Frontiers of Structural and Civil Engineering 2016年第4期10卷 488-498页

作者： xin LIANG qian-gong cheng Jiu-jiang WU Jian-ming CHEN Faculty of Geoseienees and Environmental Engineering Southwest Jiaotong University Chengdu 611756 China Faculty of Civil Engineering Guangxi University of Science and Technology Liuzhou 545006 China

The research on the mechanism of pile-soil-cap-goaf interaction and settlement of high-speed railway bridge located in mined-out area is still relatively rare. By taking the pile group of Guanshandi bridge foundation in Hefei- Fuzhou high-speed railway as the prototype, a model test is carried out. According to the similarity theory, the similar constant is derived and the similar model material is determined. Meanwhile, three types of data including the bearing behavior of piles, and the settlement law, and soil among piles are investigated. It can be found that： the influence of goaf on the bearing capacity of pile is inversely to the loading degree, the larger of loading degree, the smaller impact of goaf on the bearing capacity. There is no negative side friction can been found in pile body and the degree of downward tendency for the barycenter of side friction layout is obvious for piles in goaf. Although the bearing ratio of soil resistance under cap is relatively large, the cap effect is suggested be ignored considering the characteristic of goaf. There is a maximum critical value for the uneven settlement of pile group in goaf, and when the value is reached, the uneven settlement stop growing anymore. In addition, the formula for calculating bearing capacity and settlement of pile group in goaf based on test results, theory analysis and related standard is established.

关键词： high-speed railway mined-out areas goaf group piles foundation physical model test bearing capacity,settlement

Synergistically optimizing electrical and thermal transport properties of ntype PbSe

在线全文

学校读者我要写书评

暂无评论

Progress in Natural Science:Materials International 2018年第3期28卷 275-280页

作者： xin qian Yu Xiao cheng Chang Lei Zheng Lidong Zhao School of Materials Science and Engineering Beihang University

In this paper,we report that the thermoelectric performance of n-type Pb Se could be improved through synergistically optimizing electrical and thermal transport properties via Sb doping and Mg *** carrier concentration was firstly optimized through Sb doping,resulting in a maximum power factor of15.4μW cm-1K-2and maximum ZT of0.9 at 873 K in ***,Mg was selected for alloying in Pb sites to produce point defects,which can largely intensify the phonon scattering and lower thermal *** Mg alloying,the thermal conductivity at 300 K（873 K）was significantly suppressed from4.6 Wm-1K-1(1.5 Wm-1K-1)for Pb0.99Sb0.01Se to2.9 Wm-1K-1(1.1 Wm-1K-1)for Pb0.99Sb0.01Se-6%Mg *** combining Sb doping and Mg alloying,a maximum ZT of1.1 was achieved at 873 K for Pb0.99Sb0.01Se-6%Mg Se,and the average ZT(ZTave)was increased by 28.6%from0.42 for Pb0.99Sb0.01Se to0.54 for Pb0.99Sb0.01Se-6%Mg *** results indicate that Pb Se is a robust candidate for medium-temperature thermoelectric applications.

关键词： Thermoelectric n-type PbSe Seebeck coefficient Thermal conductivity Average ZT

A simplified method for the determination of vertically loaded pile-soil interface parameters in layered soil based on FLAC3D

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Structural and Civil Engineering 2016年第1期10卷 103-111页

作者： Jiu-jiang WU Yan LI qian-gong cheng Hua WEN xin LIAN School of Civil Engineering and Architecture Southwest University of Science and Technology Mianyang 621010 China Department of Geological Engineering Southwest Jiaotong University Chengdu 610031 China Faculty of Civil Engineering Guangxi University of Science and Technology Liuzhou 545006 China

The numerical analysis of pile-soil interaction commonly requires a lot of trial works to determine the interface parameters and the accuracy cannot be ensured normally. Considering this, this paper first conducts a sensitivity analysis to figure out the influence of interface parameters on the bearing behavior of a single pile in sand. Then, a simplified method for the determination of pile-soil interface parameters in layered soil is proposed based on the parameter studies. Finally, a filed loading test is used for the validation of the simplified method, and the calculated results agree well with the monitoring data. In general, the simplified method proposed in this paper works with higher accuracy and consumes less time compared with the traditional trial works, especially on the determinations ofinterfacial cohesive and interracial friction angle.

关键词： determination of interface parameters pile-soil interaction FLAC3D sensitivity analysis layered soil

Gastric cancer immunotherapy:A scientometric and clinical trial review

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第2期30卷 196-198页

作者： qian-cheng Du xin-Yu Wang Hua Yu Thoracic Surgery Shanghai Xuhui Central HospitalShanghai 200031China Thyroid Breast and Vascular SurgeryShanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of General Surgery Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China

This letter is intended to arouse your interest in a recent review of comprehensive scientometrics and clinical trials on immunotherapy for gastric cancer(GC).Our study reviews recent advances in immunotherapy in the field of GC and highlights its new prospects as a treatment for *** research reveals China’s leadership in this field,as well as new therapeutic strategies such as immune checkpoint inhibitors,cellular immunotherapy,and *** combined findings highlight the potential of immunotherapy to improve survival and quality of life in patients with stomach *** believe that this study will provide important guidance for the future direction of the GC treatment field.

关键词： Gastric cancer Immunotherapy Bibliometrics Comment Therapeutic strategies