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基于Web of Science数据库的前列腺癌根治术后尿失禁相关研究的可视化分析

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实用临床医药杂志 2024年第10期28卷 17-23页

作者：张银陈慧张小青李萍钱丽萍庄君龙南京大学医学院附属鼓楼医院泌尿外科江苏南京210008

目的使用文献计量学方法分析前列腺癌根治术后尿失禁相关文献,了解该领域的研究现状及发展趋势。方法检索Web of Science核心合集数据库中2013年1月1日-2023年3月25日的前列腺癌根治术后尿失禁相关文献,使用VOS viewer和CiteSpace软... 详细信息

目的使用文献计量学方法分析前列腺癌根治术后尿失禁相关文献,了解该领域的研究现状及发展趋势。方法检索Web of Science核心合集数据库中2013年1月1日-2023年3月25日的前列腺癌根治术后尿失禁相关文献,使用VOS viewer和CiteSpace软件进行年发文量、国家、机构、作者、来源期刊及关键词的可视化分析。结果共检索到相关文献1 212篇,年发文量整体呈上升趋势。美国发文量居第1位,其次为德国和意大利,其中美国与其他国家合作较多;发文量排名前10的机构大部分来自美国,高贡献机构以纪念斯隆-凯特琳癌症中心、美国加州大学旧金山分校为主;发文量最多的作者是MATTHEW R,作者间形成了多个稳定的合作团队;该领域主要期刊有Journal of Urology、European Urology等;研究热点多集中在前列腺根治术后尿失禁的影响因素、评估诊断、治疗方法与结局指标的关系等;研究趋势为尿失禁康复、生物反馈、局部治疗、机器人辅助前列腺根治与患者报告结局。结论前列腺癌根治术后尿失禁越来越受到学者关注,但中国相较于发达国家发文总量较少,学术影响力和学者间交流薄弱,今后可加强国际科研交流合作,借鉴国外相关研究成果,促进中国前列腺癌根治术后尿失禁相关研究的发展。

关键词：前列腺根治术尿失禁可视化分析研究热点文献计量学聚类分析

Seasonal Distribution of Observed Colored Dissolved Organic Matter(CDOM)in the Eastern Indian Ocean

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Journal of Ocean University of China 2023年第4期22卷 886-896页

作者： CAI xiaoqing MENG Jie YUAN Chao LIU Rongjie HOU Erhu BI Dayong LI Yaoru qian Chengcheng ZHONG Shan Shandong Key Laboratory of Marine Ecological Environment and Disaster Prevention and Mitigation Qingdao 266061China North China Sea Marine Forecasting Center Ministry of Natural ResourcesQingdao 266061China National Ocean Technology Center Ministry of Natural ResourcesTianjin 300112China The First Institute of Oceanography Ministry of Natural ResourcesQingdao 266061China North China Sea Environmental Monitoring Center Ministry of Natural ResourcesQingdao 266033China

Colored dissolved organic matter(CDOM)is a crucial constituent that affects the optical absorption properties of *** to the relatively limited measured data on the spatial distribution characteristics of CDOM in the tropical eastern Indian Ocean,this study analyzes the optical absorption characteristics of CDOM in the southeast Indian Ocean using the data collected during four seasons from 2013 to *** work also systematically describes the seasonal horizontal and vertical distribution characteristics of CDOM in this area and conducts a preliminary analysis of the relevant factors affecting CDOM absorption characteristics in this *** indicate that the CDOM ag(440)during summer was remarkably lower than that in the coastal waters of Europe and coastal waters of China but slightly higher than that in the western and southeast *** spatial distribution of surface CDOM shows remarkable seasonal differences,and the spatial distribution characteristics of CDOM in the 5°S,92°E region differ between spring/summer and autumn/*** values of ag(400)and ag(440)are weak/strong at a surface/subsurface level of 100 m,with differences found between summer and *** correlation of CDOM with temperature,salinity,and chlorophyll-a concentration is relatively low,indicating that CDOM is an independent driving mechanism influenced by phytoplankton degradation,photobleaching,and water mixing.

关键词： colored dissolved organic matter tropical eastern Indian Ocean distribution characteristics influencing factors

全程与阶段性非充分灌溉条件下水稻的生长及部分生理反应

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土壤学报 2004年第4期41卷 641-644页

作者：钱晓晴沈其荣王娟娟周明耀柏彦超杨建昌南京农业大学资源与环境科学学院南京210095 扬州大学农学院江苏扬州225009 扬州大学水利与建筑工程学院江苏扬州225009

有关水分胁迫改变水稻生长形态、组织结构与生理代谢方面的研究已有不少报道,但试验结果间颇有差异[1-9].在以往水分胁迫的植物效应研究中,往往只讨论水分胁迫处理本身对试验结果的影响,较少涉及处理前水稻生长环境的影响.至今尚未见有... 详细信息

有关水分胁迫改变水稻生长形态、组织结构与生理代谢方面的研究已有不少报道,但试验结果间颇有差异[1-9].在以往水分胁迫的植物效应研究中,往往只讨论水分胁迫处理本身对试验结果的影响,较少涉及处理前水稻生长环境的影响.至今尚未见有作物对全程和阶段性非充分灌溉反应差异的试验报道.本研究拟通过作物体对水分胁迫较为敏感的叶片水分含量、叶绿素含量和丙二醛(MDA)含量、根系活力、叶片气孔阻抗和光合速率等指标进行测定,探讨抽穗后(即阶段性)与全程非充分灌溉影响水稻产量形成的差异及其生理机制,为发展水稻节水栽培技术提供理论依据.……

关键词：非充分灌溉水稻生长组织结构生理代谢水分胁迫

Chronic Hepatitis B Infection with Low Level Viremia Correlates with the Progression of the Liver Disease

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Journal of Clinical and Translational Hepatology 2021年第6期9卷 850-859页

作者： qian Zhang Hong Peng xiaoqing Liu Huimin Wang Jinjie Du Xinhua Luo Hong Ren Peng Hu Department of Infectious Diseases Institute for Viral HepatitisThe Key Laboratory of Molecular Biology for Infectious DiseasesChinese Ministry of EducationThe Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Infectious Diseases Guizhou Provincial People’s HospitalGuiyangGuizhouChina

Background and Aims:Currently,insufficient clinical data are available to address whether low-level viremia(LLV)observed during antiviral treatment will adversely affect the clinical outcome or whether treatment strategies should be altered if LLV *** study compared the clinical out-comes of patients with a maintained virological response(MVR)and patients who experienced LLV and their treatment ***:A retrospective cohort of 674 patients with chronic hepatitis B virus(HBV)infection who received antiviral treatment for more than 12 months was analyzed for the development of end-stage liver disease and treatment strategies during the follow-up ***-stage liver disease included decompensated liver cirrhosis and hepatocellular carcinoma(HCC).Results:During a median 42-month follow-up,end-stage liver disease developed more frequently in patients who experienced LLV than in those who experienced MVR(7.73%and 15.85%vs.0.77%and 5.52%at 5 and 10 years,respectively;p=0.000).The trend was consistent after propensity score *** the high-risk group of four HCC risk models,LLV patients had a higher risk of HCC development(p<0.05).By Cox proportional hazard model analysis,LLV was an independent risk factor for end-stage liver disease and HCC(hazard ratio[HR]=6.280,confidence interval[CI]=2.081-18.951,p=0.001;HR=5.108,CI=1.392-18.737,respectively;p=0.014).Patients achieved a lower rate of end-stage liver disease by adjusting treatment compared to continuing the original treatment once LLV occurred(p<0.05).Conclusions:LLV is an independent risk factor for end-stage liver disease and HCC,and treatment adjustments can be considered.

关键词： Low-level viremia Chronic hepatitis B End-stage liver disease Hepatocellular carcinoma Treatment strategies

Perilipin 2在小鼠肝脏CGI-58特异性敲除所致肝脏微泡型脂肪变性中的作用

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陆军军医大学学报 2024年第15期46卷 1701-1712页

作者：张艺馨李杰万小勤蒋孝清陈江慧邓芳李旻典张倩包鑫余张志辉陆军军医大学(第三军医大学)第一附属医院心血管内科代谢生物钟与心血管疾病中心重庆400038 陆军军医大学(第三军医大学)第一附属医院老年心脑血管疾病教育部重点实验室重庆400038 重庆医科大学基础医学院重庆400016 陆军军医大学(第三军医大学)高原军事医学系病理生理学教研室重庆400038 陆军军医大学(第三军医大学)第一附属医院全科医学科重庆400038

目的探究Perilipin 2(Plin2)在肝脏CGI-58特异性敲除所致脂肪肝的作用,并比较Plin2和Plin3在脂滴生成和脂质蓄积的作用效能。方法将20只7周龄CGI-58^(Flox/Flox)小鼠(雄鼠10只,雌鼠10只)根据性别采用完全随机分组法分为对照组(NC组,n=5... 详细信息

目的探究Perilipin 2(Plin2)在肝脏CGI-58特异性敲除所致脂肪肝的作用,并比较Plin2和Plin3在脂滴生成和脂质蓄积的作用效能。方法将20只7周龄CGI-58^(Flox/Flox)小鼠(雄鼠10只,雌鼠10只)根据性别采用完全随机分组法分为对照组(NC组,n=5,注射靶向肝脏实现过表达Cre蛋白及对照Micro-RNA的腺相关病毒)和实验组(Mi-KD组,n=5,注射靶向肝脏实现过表达Cre蛋白及靶向Plin2的Micro-RNA的腺相关病毒),记录小鼠体质量变化,检测小鼠代谢相关表型和肝脏病理学的差异,RT-qPCR检测小鼠肝脏脂质代谢和胆固醇代谢相关基因的改变;以AML-12小鼠肝细胞作为细胞模型,构建SiRNA实现AML-12细胞Plin2/Plin3敲低,Bodipy染色和酶比色法检测对比正常培养和OA诱导下Plin2/Plin3敲低后AML-12细胞脂滴生成和脂质蓄积。结果Mi-KD小鼠肝脏中的PLIN2蛋白水平降低了99%以上;Mi-KD缓解了CGI-58特异性敲除雌鼠的肝肿大(P=0.0195)和肝细胞损伤(P=0.0004),降低了组织学NAS评分(P=0.0002)和肝脏甘油三酯含量(P=0.0166),显著改善了肝脏CGI-58特异性敲除所致的肝脏微泡型脂肪变性;敲低Plin2使AML-12细胞内甘油三酯含量呈下降趋势,敲低Plin3显著降低AML-12细胞内甘油三酯含量(P=0.0014);在OA诱导下,Plin2/Plin3敲低均显著降低OA诱导的AML-12细胞内甘油三酯的蓄积(P<0.05)。结论肝脏Plin2在CGI-58敲除所致的微泡型脂肪变性的发展过程中至关重要,Plin2和Plin3均参与肝细胞脂滴生成与脂质蓄积,且Plin3的作用强于Plin2。

关键词：肝脏微泡型脂肪变性围脂滴包被蛋白2 比较鉴定基因-58 钱林-多尔夫曼综合征脂滴

保护性睡眠干预应用于新生儿高胆红素血症中的疗效

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国际护理学杂志 2024年第18期43卷 3278-3282页

作者：钱亚湖赵丽高小青顾晓华龚丹无锡市妇幼保健院无锡214000

目的探讨保护性睡眠干预应用于新生儿高胆红素血症中的临床疗效。方法选取2020年4月至2021年4月无锡市妇幼保健院收治的高胆红素血症新生儿130例, 将其随机分为对照组和观察组, 各65例。对照组给予常规干预, 观察组给予保护性睡眠干预,... 详细信息

目的探讨保护性睡眠干预应用于新生儿高胆红素血症中的临床疗效。方法选取2020年4月至2021年4月无锡市妇幼保健院收治的高胆红素血症新生儿130例, 将其随机分为对照组和观察组, 各65例。对照组给予常规干预, 观察组给予保护性睡眠干预, 比较两组临床症状情况、胆红素水平、不良事件发生率以及临床疗效。结果观察组干预后临床症状情况优于对照组(P<0.05);观察组干预后胆红素水平低于对照组(P<0.05);观察组干预后不良事件发生率低于对照组(P<0.05);观察组干预后临床疗效高于对照组(P<0.05)。结论将保护性睡眠干预应用于高胆红素血症患儿中, 可有效改善其临床症状, 控制胆红素水平, 减少不良事件的发生, 并且显著改善患儿的临床疗效。

关键词：保护性睡眠干预新生儿高胆红素血症胆红素

Characteristics of brainstem auditory evoked potential of neonates with mild or moderate hyperbilirubinemia

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Neural Regeneration Research 2007年第11期2卷 660-664页

作者： xiaoqing Guo Xiuhong Pu Tao An qian Li Meng Qiu Qiong Wu Yanlan Tan Department of Pediatrics the 309 Clinical Division General Hospital of Chinese PLA Beijing 100091 China

BACKGROUND： Brainstem auditory evoked potential （BAEP） has been widely used to evaluate the functional integrity and development of injured auditory system and brain, especially to objectively evaluate the function of auditory system and brain stem of very young babies, such as neonates and sick babies. OBJECTIVE： To observe the changes of BAEP of neonates with hyperbilirubinemia, and to investigate the relationship of bilirubin concentration and BAEP. DESIGN： An observation experiment. SETTING： Department of Pediatrics, the 309 Clinical Division, General Hospital of Chinese PLA. PARTICIPANTS： Fifty-eight neonates with mild or moderate hyperbilirubinemia exhibiting jaundice within 24 hours after born, who received the treatment in the Department of Pediatrics, the 309 Clinical Division, General Hospital of Chinese PLA between January 2004 and May 2007, were recruited in this study. The involved neonates, 31 boys and 27 girls, had gestational age of 37 to 46 weeks. They had no history of birth asphyxia, and were scored 8 to 10 points when born. Written informed consents of examination and treatment were obtained from the guardians of the neonates. This study was approved by the Hospital Ethics Committee. According to serum total bilirubin value, the neonates were assigned into 3 groups： low-concentration bilirubin group （n =16）, moderate-concentration bilirubin group （n =27） and high-concentration bilirubin group （n =15）. According to mean daily bilirubin increase, the subjects were sub-assigned into bilirubin rapid increase group （n =39） and bilirubin slow increase group （n = 19）. METHODS： After admission, all the neonates received drug treatment. Meanwhile, their 116 ears were examined with a myoelectricity evoked potential equipment （KEYPOINT） in latency, wave duration, amplitude and wave shape differentiation of each wave of BAEP. BAEP abnormal type was observed and abnormal rate of BAEP was calculated. MAIN OUTCOME MEASURES： ①Abnormal rate and abnorm

关键词： hyperbilirubinemia brainstem auditory evoked potential neonates

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设施农田土壤氮污染现状及修复技术

现代农业科技 2023年第11期 176-180,185页

作者：李慧曹逸凡 Waleed Awadelkareem Husain Mohammed Mohammed Dawood Yahya Haroun 王桂良余彬彬钱晓晴扬州大学江苏扬州225009 扬州瑞华环境与生物工程研究所有限公司江苏扬州225127 扬州大学土壤健康研究所江苏扬州225009

我国部分地区设施农田土壤污染问题突出。其中,化肥的使用尤其是氮肥的过量施用给农田土壤造成了较为严重的污染,还间接导致设施农田土壤次生盐渍化、酸化、养分失调等危害。本文概述了土壤修复技术在改良设施农田土壤方面的应用,包括... 详细信息

我国部分地区设施农田土壤污染问题突出。其中,化肥的使用尤其是氮肥的过量施用给农田土壤造成了较为严重的污染,还间接导致设施农田土壤次生盐渍化、酸化、养分失调等危害。本文概述了土壤修复技术在改良设施农田土壤方面的应用,包括物理方法、化学方法和生物方法,分析了设施农田氮污染修复存在的问题,并提出防治设施农田土壤污染的对策,针对设施农田氮污染修复技术研究中尚待解决的科学问题及未来发展方向进行了展望,为我国设施农田氮污染研究和修复技术创新提供参考,从而推动土壤环境修复和粮食安全生产。

关键词：设施农田土壤氮污染修复技术

Epigenetic and transcriptional activation of the secretory kinase FAM20C as an oncogene in glioma

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Journal of Genetics and Genomics 2023年第6期50卷 422-433页

作者： Bo Gong Yi Liang qian Zhang Huan Li Jialing Xiao Liang Wang Han Chen Wenjie Yang xiaoqing Wang Yi Wang Zongze He Department of Health Management Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China The Key Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Department of Neurology Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Department of Neurosurgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Department of Pathology Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Department of Critical Care Medicine Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan610072China

Gliomas are the most prevalent and aggressive malignancies of the nervous *** bioinformatic studies have revealed the crucial role of the secretory pathway kinase FAM20C in the prediction of glioma invasion and ***,little is known about the pathogenesis of FAM20C in the regulation of ***,we construct the full-length transcriptome atlas in paired gliomas and observe that 22 genes are upregulated by full-length transcriptome and differential APA *** of ATAC-seq data reveals that both FAM20C and NPTN are the hub genes with chromatin openness and differential ***,in vitro and in vivo studies suggest that FAM20C stimulates the proliferation and metastasis of glioma ***,NPTN,a novel cancer suppressor gene,counteracts the function of FAM20C by inhibiting both the proliferation and migration of *** blockade of FAM20C by neutralizing antibodies results in the regression of xenograft ***,MAX,BRD4,MYC,and REST are found to be the potential trans-active factors for the regulation of *** together,our results uncover the oncogenic role of FAM20C in glioma and shed new light on the treatment of glioma by abolishing FAM20C.

关键词： Glioma Alternativepolyadenylation sites FAM20C Trans-activefactors