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Feasibility of ^(99m)Tc-TRODAT-1 Micro-SPECT imaging of dopamine transporter in animal retinas

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Nuclear Science and Techniques 2008年第2期19卷 105-108页

作者： ZHAO Juan qi yujin DAI qiusheng ZHANG Xuezhu QU Xiaomei HUANG Jia LIU Xingdang Department of Nuclear Medicine Huashan Hospital of Fudan University Shanghai 200040 China Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China Eye and ENT Hospital of Fudan University Shanghai 200031 China

In this paper,^(99m)Tc-TRODAT-1 Micro-SPECT (single-photon emission computed tomography) was used for imaging dopamine transporter (DAT) in retinas and to investigate the changes of DAT in retinas of guinea pigs with form deprivation myopia.Pigmented guinea pigs aged 3 weeks were derided into form deprivation myopia (FDM) group (n=6) and normal control group (n=6).The test group wore translucent goggles randomly for 4 weeks, and both groups underwent biometric measurement (refraction and axial length) before and after the experiment. Micro-SPECT retinas imaging was performed at the 4^(th) week after injection of ^(99m)Tc-TRODAT-1.The retinas were clearly resolved in the images.The ratio of ^(99m)Tc-TRODAT-1 uptake in the myopic retinas (11.55±2.80) was 3.64±1.40 lower than that in the control eye (15.20±1.98),and 2.35±1.05 lower than that in the fellow eyes (13.90±2.04).The results showed that ^(99m)Tc-TRODAT-1 Micro-SPECT eye imaging can be used to trace the distribution and changes of DAT in retina,and DAT in the myopic retinas were lower than that in the normal control eyes and fellow eyes.Micro-SPECT may provide a new approach for further studies on the role of dopamine system in the experimental myopia.

关键词：诊断学近视多巴胺能核磁共振

Nanographene oxide labeling with (188)~Re

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Nuclear Science and Techniques 2011年第2期22卷 99-104页

作者： ZHANG Xiaoyong LI Jing ZHU Ying qi yujin ZHU Zhiyong LI Wenxin HUANG qing Laboratory of Physical Biology Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China Graduate School of Chinese Academy of Sciences Beijing 100049 China

Nanographene oxide (NGO) is currently being explored for various biomedical applications.However,little information is known about its biological behaviors in vitro and in vivo.For further studying its pharmacokinetics and related biological behaviors in living systems,an effective and convenient tracing method is particularly demanded.In this work,NGO was labeled with radionuclide 188Re (188Re-NGO).To obtain high labeling yield and purity,a number of labeling conditions,including concentration of SnCl2 and ascorbic acid,reaction time and temperature,and pH were optimized,and stability of the 188Re-NGO in vitro and in vivo was evaluated.The results showed that NGO could be effectively labeled with high yield.The purified 188Re-NGO showed high stability in vitro and in vivo.A pretest of NGO biodistribution with single photon emission computed tomography showed that the 188Re-NGO was rapidly taken by organs such as lungs,liver,and spleen.The biodistribution of 188Re-NGO differs significantly from the free radionuclide,indicating that the labeling procedure is highly suitable for investigating its biological behavior in living systems.

关键词：氧化物标签非政府组织铼计算机断层扫描生物学行为放射性核素生物医学应用

司美格鲁肽联合二甲双胍对老年2型糖尿病患者血糖水平的影响

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糖尿病新世界 2024年第4期27卷 107-110页

作者：段琦吴玉巾孙晓茹泉州市第一医院福建泉州362000

目的分析老年2型糖尿病(Type 2 Diabetes Mellitus,T2DM)患者治疗中在二甲双胍基础上加入司美格鲁肽对血糖水平的影响。方法选取泉州市第一医院于2023年1—10月收治的96例老年T2DM患者作为研究对象,采用掷硬币法分为参照组(n=48,单纯应... 详细信息

目的分析老年2型糖尿病(Type 2 Diabetes Mellitus,T2DM)患者治疗中在二甲双胍基础上加入司美格鲁肽对血糖水平的影响。方法选取泉州市第一医院于2023年1—10月收治的96例老年T2DM患者作为研究对象,采用掷硬币法分为参照组(n=48,单纯应用二甲双胍)、观察组(n=48,二甲双胍基础上联合司美格鲁肽),比较两组血糖水平、炎性因子水平、不良反应发生率。结果与治疗前比较,治疗90 d后两组血糖水平均有所降低,且观察组低于参照组,差异有统计学意义(P均0.05)。观察组治疗总有效率(95.83%)高于参照组,差异有统计学意义(χ^(2)=5.031,P<0.05)。结论老年T2DM患者治疗中在二甲双胍基础上加入司美格鲁肽,可改善患者血糖水平、炎性因子水平,提高临床治疗效果,安全性较高。

关键词： 2型糖尿病二甲双胍司美格鲁肽血糖水平炎性因子

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硅胶载体的制备及在聚烯烃催化剂领域中的应用

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材料导报 2024年第1期38卷 194-204页

作者：张玉金杨琦张瑞高宇新拜永孝兰州大学材料与能源学院软物质与先进功能材料研究所兰州730000 中国石油天然气股份有限公司大庆化工研究中心黑龙江大庆163714

催化剂及催化技术的发展是聚烯烃产业技术进步的核心。硅胶作为聚烯烃催化剂常用的载体材料,在催化剂的合成及聚烯烃树脂的制备领域发挥着重要的作用。近年来,关于硅胶负载聚烯烃催化剂的研究已陆续发表。本文综述了硅胶载体的结构、制... 详细信息

催化剂及催化技术的发展是聚烯烃产业技术进步的核心。硅胶作为聚烯烃催化剂常用的载体材料,在催化剂的合成及聚烯烃树脂的制备领域发挥着重要的作用。近年来,关于硅胶负载聚烯烃催化剂的研究已陆续发表。本文综述了硅胶载体的结构、制备方法以及硅胶载体与聚烯烃催化剂(Ziegler-Natta催化剂、茂金属催化剂、后过渡金属催化剂及铬基催化剂)负载化的研究进展,并介绍了催化剂的制备机理、优点及应用。

关键词：硅胶催化剂载体聚烯烃

洗心汤对胰岛素抵抗的阿尔茨海默病小鼠PI3K/AKT/GSK-3β通路的影响

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中华中医药杂志 2024年第3期39卷 1488-1492页

作者：周源王郁金屈杰王楠陈连吉武姗姗张琪第五永长陕西中医药大学咸阳712046 陕西省中医体质与疾病防治研究重点实验室咸阳712046 陕西省中医脑病学重点实验室咸阳712046

目的:探究洗心汤对胰岛素抵抗(IR)的阿尔茨海默病(AD)小鼠模型中PI3K/AKT/GSK-3β通路的影响,阐明其缓解AD中IR及AD症状的分子机制。方法:通过高脂喂养APP/PS1小鼠并腹腔注射低浓度链脲佐菌素(STZ)构建AD-IR小鼠模型,然后给予洗心汤灌... 详细信息

目的:探究洗心汤对胰岛素抵抗(IR)的阿尔茨海默病(AD)小鼠模型中PI3K/AKT/GSK-3β通路的影响,阐明其缓解AD中IR及AD症状的分子机制。方法:通过高脂喂养APP/PS1小鼠并腹腔注射低浓度链脲佐菌素(STZ)构建AD-IR小鼠模型,然后给予洗心汤灌胃治疗。Morris水迷宫检测小鼠的学习记忆能力,血糖仪检测小鼠空腹血糖水平,ELISA检测小鼠空腹胰岛素水平,试剂盒检测ROS、MDA、GSH-Px、SOD,蛋白质印迹检测小鼠脑组织中相关蛋白的表达水平。结果:AD-IR组小鼠较对照组逃避潜伏期显著增加(P<0.05),目标平台象限滞留时间与穿越平台次数均显著减少(P<0.05),空腹血糖、血清空腹胰岛素、胰岛素抵抗值升高(P<0.05),脑组织中ROS和MDA升高(P<0.05),SOD和GSH-Px降低(P<0.05),GLUT4、p-PI3K、p-AKT、p-GSK-3β、Bcl-2蛋白降低(P<0.01),IRS1pS307、IRS1pS612、IRS1pS636、Aβ42、p-Tau、Bax、cleaved caspase-3蛋白升高(P<0.01)。经洗心汤治疗后,上述指标均显著改善(P<0.05,P<0.01)。结论:洗心汤能够激活AD-IR小鼠PI3K/AKT/GSK-3β通路,缓解小鼠脑组织中的IR,减轻AD症状及其诱导的损伤。

关键词：洗心汤阿尔茨海默病胰岛素抵抗 PI3K/AKT/GSK-3β通路

Triton-Triton Correlation and Emission Times in Intermediate Energy Nucleus-Nucleus Collisions

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Chinese Physics Letters 1995年第9期12卷 521-523页

作者： HE Zhiyong DUAN Limin LI Zuyu JIN Genming LUO qingzheng WU Heyu ZHANG Baoguo WEN Wanxin qi yujin DANG Binrong DAI Guangxi Institute of Modern Physics Academia SinicaLanzhou 730000

Triton-triton correlation functions have been measured for^(40)Ar+^(197)Au collisions at E/A=25 MeV.The anticorrelations at small relative momenta are observed and become more pronounced with the increasing total energy of two coincident tritons.Comparison with the three-body trajectory calculations indicates that the average emission times lie between 100 and 300fm/c for tritons.

关键词： Collisions coincide Triton

低结晶度B-Co_(3)O_(4)纳米颗粒电催化硝酸盐还原合成氨

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华南师范大学学报（自然科学版） 2024年第1期56卷 36-43页

作者：何景婷祁贵生杨琨纪财利贾裕胜郭豫晋张蓉蓉李宁王雅宁曾中宇樊小龙中北大学化学工程与技术学院/化工过程强化山西省重点实验室太原030051 太原工业学院理学系太原030008

采用简单的沉淀-煅烧工艺合成了B-Co_(3)O_(4)Nano-particles(NPs),研究了B-Co_(3)O_(4)NPs电催化硝酸盐还原合成氨(NitrRR)的性能。研究发现:在含0.1 mol/L NaNO_(3)的NaOH(1 mol/L)溶液中进行电催化反应,B-Co_(3)O_(4)NPs具有较高的电催化活性。当电压在-0.8 V(vs.RHE)时,获得20 mg/(h·cm^(2))的NH_(3)产率和94%的法拉效应(FE)。当电压在-0.6 V(vs.RHE)时,获得17.2 mg/(h·cm^(2))的NH_(3)产率和95%的FE。电极材料B-Co_(3)O_(4)NPs优异的电化学性能得益于B-Co_(3)O_(4)NPs中的B—O键在电催化过程中能有效抑制析氢反应。较低的结晶度和特殊的多孔结构有效促进了B-Co_(3)O_(4)NPs对NO_(3)^(-)的吸附性和还原活性,也促进了电子的传输与转移过程。

关键词： B-Co_(3)O_(4)NPs 电催化硝酸盐合成氨

Particle－particle　Correlation　and　Emission　Time　for　^（40）Ar＋^（197）Au　Collisions　at　25MeV／u

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IMP & HIRFL Annual Report 1994年 8-9页

作者： He Zhiyong Duan Limin Li Zuyu Jin Genming Luo qingzheng Wu Heyu Zhang Baoguo Wen Wanxin qi yujin Dang Bingrong and Dai Guangxi

Ｐａｒｔｉｃｌｅ－ｐａｒｔｉｃｌｅＣｏｒｒｅｌａｔｉｏｎａｎｄＥｍｉｓｓｉｏｎＴｉｍｅｆｏｒ^（４０）Ａｒ＋^（１９７）ＡｕＣｏｌｌｉｓｉｏｎｓａｔ２５ＭｅＶ／ｕ￥ＨｅＺｈｉｙｏｎｇ；ＤｕａｎＬｉｍｉｎ... 详细信息

Ｐａｒｔｉｃｌｅ－ｐａｒｔｉｃｌｅＣｏｒｒｅｌａｔｉｏｎａｎｄＥｍｉｓｓｉｏｎＴｉｍｅｆｏｒ^（４０）Ａｒ＋^（１９７）ＡｕＣｏｌｌｉｓｉｏｎｓａｔ２５ＭｅＶ／ｕ￥ＨｅＺｈｉｙｏｎｇ；ＤｕａｎＬｉｍｉｎ；ＬｉＺｕｙｕ；ＪｉｎＧｅｎｍｉｎ...

关键词： Correlation Au Collisions Ar Emission MeV Particle Time and at

The Characterization, Authentication, and Gene Expression Pattern of the MdCER Family in Malus domestica

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Horticultural Plant Journal 2019年第1期5卷 1-9页

作者： Chenhui qi Han Jiang Xianyan Zhao Ke Mao Haitao Liu Yuanyuan Li yujin Hao State Key Laboratory of Crop Biology National Research Center for Apple Engineering and Technology Shandong Agricultural University Northwest A&F University Shandong Yihui Detection Technology Co.Ltd.

Plant cuticular wax is an important determinant factor of fruit quality. Cuticular wax can protect the fruit from UV radiation, drought, and disease and increase the storage period of fruit. In many species, CER gene is associated with wax and can affect plant response to stress, but no characterization of CER gene and its family has been reported in apples. In this study, we identified 10 MdCER genes in Malus domestica based on the sequences of 10 CER genes in Arabidopsis thaliana. Three-dimensional structures were then defined, and root-mean-square deviation(RMSD)scoring matrixes were used to evaluate the matches. These 10 genes were divided into three classes using phylogenetic methods; namely,class I, II, and III. The predicted MdCER genes were distributed across 7 out of 17 chromosomes with different densities. Furthermore, the gene structures and motif compositions of the MdCER genes were analyzed. The quantitative real-time PCR results indicated that MdCER family genes were mainly expressed in the leaves and stems and rarely in the roots. Most of the MdCER members responded to salicylic acid and polyethylene glycol treatment, indicating that the MdCER family is associated with disease resistance(biotic) and abiotic stress.

关键词： apple wax MdCER gene family expression