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Journal of Environmental Sciences 2011年第9期23卷 1452-1459页

作者： Tianran Chen Kefu Yu Shu Li Tegu Chen qi shi Key Laboratory of Marginal Sea Geology South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510301 China

Barium to calcium （Ba/Ca） ratio in corals has been considered as a useful geochemical proxy for upwelling,river flood and other oceanic ***,recent studies indicated that additional environmental or biological factors can influence the incorporation of Ba into coral *** this study,Ba/Ca ratios of two Porites corals collected from Daya Bay,northern South China Sea were ***/Ca signals in the two corals were ‘anomalous’ in comparison with Ba behaviors seen in other near-shore corals influenced by upwelling or riverine *** Ba/Ca profiles displayed similar and remarkable patterns characterized by low and randomly fluctuating background signals periodically interrupted by sharp and large synchronous peaks,clearly indicating an environmental *** analysis indicated that the Ba/Ca profiles were not correlated with previously claimed environmental factors such as precipitation,coastal upwelling,anthropogenic activities or phytoplankton blooms in other *** maxima of Ba/Ca appeared to occur in the period of Sr/Ca maxima,coinciding with the winter minimum temperatures,which suggests that the anomalous high Ba/Ca signals were related to winter-time low sea surface *** speculated that the Ba/Ca peaks in corals of the Daya Bay were most likely the results of enrichment of Ba-rich particles in their skeletons when coral polyps retracted under the stresses of anomalous winter low *** this case,Ba/Ca ratio in relatively high-latitude corals can be a potential proxy for tracing the low temperature stress.

关键词： Ba/Ca barium Porites coral cold water stress northern South China Sea

How to Extend the Bridge Density Functional Approximation to the Confined Non-hard Sphere Fluid

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Chinese Journal of Chemical Physics 2006年第4期19卷 319-324页

作者： shi-qi Zhou Key Laboratory of Green Packaging and Biological Nanotechnolog of Hunan Province and Institute of Modern Statistical Mechanics Hunan University of Technology Zhuzhou 412008 China

A theoretical method was proposed to extend a bridge density functional approximation （BDFA） for the non-uniform hard sphere fluid to the non-uniform Lennard-Jones （LJ） fluid. The DFT approach for LJ fluid is simple, quantitatively accurate in a wide range of coexistence phase and external field parameters. Especially, the DFT approach only needs a second order direct correlation function （DCF） of the coexistence bulk fluid as input, and is therefore applicable to the subcritical temperature region. The present theoretical method can be regarded as a non-uniform counterpart of the thermodynamic perturbation theory, in which it is not at the level of the free energy but at the level of the second order *** National Natural Science Foundation of China （No. 20546004） and the Natural Science Foundation of Education Department of Hunan Province （No.04C711）.

关键词： Density functional theory Bridge density functional approximation Hard sphere fluid Correlation function

HALONICKEL 2,4-DI-t-BUTYL-6-(QUINOLIN-8-YLIMINOMETHYL)PHENOLATES:SYNTHESIS,CHARACTERIZATION AND ETHYLENE REACTIVITY

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Chinese Journal of Polymer Science 2013年第5期31卷 769-777页

作者： qi-song shi Xiang Hao Carl Redshaw 孙文华 College of Materials Science and Engineering Beijing Institute of Petrochemical Technology Key Laboratory of Engineering Plastics and Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of Sciences Department of Chemistry University of Hull

A series of nickel halides bearing 2,4-di-t-butyl-6-（quinolin-8-yliminomethyl） phenolate ligands was synthesized and characterized by IR spectroscopy and elemental analysis. Molecular structures of C1 （R = H, X = Br） and C2 （R = H, X = C1） were further confirmed by single-crystal X-ray crystallographic studies, and revealed a distorted square planar geometry at nickel. Upon activation with diethylaluminum chloride （Et2AlCl）, all nickel pre-catalysts displayed good catalytic activity [up to 9.3 × 10^5 g mol-1（Ni） h-1] for ethylene oligomerization with major dimerization. In the presence of methylaluminoxane （MAO）, the nickel complex C1 was capable of ethylene polymerization under 3 MPa, and produced polyethylene products with narrow polydispersity （1.16-1.73） and molecular weights in the range of 2.6-4.95 kg/mol.

关键词： Nickel 2,4-Di-t-butyl-6-(quinolin-8-yliminomethyl)-phenolates Ethylene oligomerization Polymerization.

Microstructure and magnetic properties of sintered Nd-Fe-B magnets with Ce substitution for Nd by intergranular-alloy method

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Rare Metals 2020年第1期39卷 62-69页

作者： Jian-Xin Huang Ying Liu Jun Li Wei Zhao qi shi College of Materials Science and Engineering Sichuan UniversityChengdu610065China Key Laboratory of Advanced Special Material and Technology Ministry of EducationChengdu610065China

Aiming at the comprehensive utilization of the rare-earth resources and the preparation of the high-performance low-cost Nd-Fe-B magnets,sintered magnets with different Ce substitution amounts of 17.2 wt%,24.8 wt%and 31.8 wt%were prepared by intergranularalloy *** influence of substitution of Ce for Nd on their microstructure and magnetic properties in this work was detailedly *** results indicated that the remanence(Br)and the maximum energy product((BH)max)of the sintered magnets decreased monotonic ally with the increase in Ce ***,the obvious enhancement of coercivity(Hcj)was also observed,which was mainly due to the improvement of microstructure and the smooth,continuous grain boundary(GB).It can be found that a reasonable Ce substitution of 24.8 wt%for the sintered magnets could promote the refinement of microstructure,leading to the realization of superior magnetic *** is expected that the investigations could be beneficial to offer a feasible method for preparing the high-performance low-cost Ce-doped magnets.

关键词： Microstructure Sintered magnets Ce substitution Intergranular-alloy method

Nanochaperones Based on Hydrophobic Interaction and Coordination Inhibit Protein Misfolding and Fibrillation

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Chinese Journal of Polymer Science 2024年第11期42卷 1710-1718,I0009页

作者： Hui Wang Lin-Lin Xu Lin-qi shi Ru-Jiang Ma Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer ChemistryState Key Laboratory of Medicinal Chemical BiologyFrontiers Science Center for New Organic MatterCollege of ChemistryNankai UniversityTianjin300071China Haihe Laboratory of Sustainable Chemical Transformations Tianjin300192China

Amyloidosis is characterized by the deposition of fibrillar aggregates,with a specific peptide or protein as the primary component,in affected tissues or *** proliferation and deposition of amyloid fibrils can cause organismal dysfunction and lethal pathological outcomes associated with *** this study,a nanochaperone(nChap-NA)was developed to inhibit protein misfolding and fibrillation by simulating the function of natural molecular *** nanochaperone was prepared by self-assembly of two block copolymers PEG-b-PCL and PCL-b-P(NIPAM-co-AANTA),which had a phase-separated surface consisting of hydrophobic PNIPAM microdomains with coordinative NTA(Zn)moieties and hydrophilic PEG *** hydrophobic interaction of the PNIPAM microdomain and the coordination of NTA(Zn)synergistically work together to effectively trap the amyloid monomer and block its fibrillation *** and human islet amyloid polypeptide(hIAPP)were used as model proteins to investigate the nanochaperone's inhibition of amyloid misfolding and *** was proved that the nanochaperone could stabilize the natural conformation of the trapped insulin and hIAPP,and effectively inhibit their *** vivo study demonstrated that the nanochaperone could effectively preserve the bioactivity of insulin and reduce the cytotoxicity caused by hIAPP *** study may provide a promising strategy for the prophylactic treatment of amyloidosis.

关键词： Nanochaperone Amyloidosis Insulin hIAPP Inhibit fibrillation

Triclosan-conjugated,Lipase-responsive Polymeric Micelles for Eradication of Staphylococcal Biofilms

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Chinese Journal of Polymer Science 2024年第6期42卷 718-728页

作者： Yan-qiang Huang Yuan-Feng Li Yong Liu Lin-qi shi Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise533000China Translational Medicine Laboratory the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325035China Wenzhou Institute University of Chinese Academy of SciencesWenzhou325001China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials of Ministry of Educationand Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin300071China

Bacterial biofilms present a significant challenge in treating drug-resistant infections,necessitating the development of innovative *** this study,we introduce triclosan-conjugated,lipase-responsive polymeric micelles designed to exploit biofilm properties and serve as a responsive drug delivery *** micelles were created using an amphiphilic block polymer synthesized via ring-opening polymerization ofε-caprolactone(CL)and triclosan-containing cyclic trimethylene carbonate(MTC-Tri).Poly(ethylene glycol)(PEG-OH)acted as the macro-initiator,resulting in micelles with a PEG shell that facilitated their penetration into bacterial *** important advantage of our micelles lies in their interaction with local bacterial lipases within *** lipases triggered rapid micelle degradation,releasing triclosan in a controlled *** liberated triclosan effectively eliminated bacteria embedded in the ***,the triclosan-conjugated micelles displayed minimal toxicity to murine fibroblasts,indicating their biocompatibility and *** finding emphasizes the potential application of these micelles in combatting drug resistance observed in bacterial *** triclosan-conjugated,lipase-responsive polymeric micelles exhibit promising characteristics for addressing drug resistance in bacterial *** harnessing biofilm properties and implementing a responsive drug delivery system,we seek to provide an effective solution in the fight against drug-resistant bacteria.

关键词： Self-assembly Polymer prodrug Ring-opening polymerization Biofilm eradication Cytotoxicity

30 glitches in 18 radio pulsars

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Research in Astronomy and Astrophysics 2021年第7期21卷 1-16页

作者： Hong-Yi Liu shi-qi Zhou Yu-qi Zhang Zhong-Wen Feng Xia Zhou School of Applied Technology XiHua UniversityNanchong 637000China Physics and Space Science College China West Normal UniversityNanchong 637009China

Pulsar timing is a classic technology of detecting irregularities in pulsar *** carried out this method for 18 young radio pulsars,with long-term timing observations obtained between 2007 and 2015 using the Parkes 64-m radio *** a result,30 glitches were identified,ranging from 0.75 × 10^(-9) to 8.6 × 10^(-6) in the relative glitch sizes Δv/v,where v=1/P is the pulse *** glitches are composed of 26 new glitches and four published glitches with new exponential *** pulsars exhibit normal glitches,and six pulsars were observed to undergo a glitch event for the first *** discuss the properties and implications for neutron-star physics of these glitches,and show that they are in agreement with previous work,except that the cumulative probability distributions of the mean waiting times for PSRs J0537-6910,J1341-6220 and J1740-3015 are not in consonance with the Poisson model.

关键词： methods:data analysis stars:neutron pulsars:general

Molecular phylogeny of Anopheles hyrcanus group(Diptera:Culicidae)based on mtDNA COI

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Infectious Diseases of Poverty 2017年第1期6卷 522-531页

作者： Yuan Fang Wen-qi shi Yi Zhang National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesMinistry of Science and TechnologyKey Laboratory of Parasite and Vector BiologyMinistry of HealthShanghai 200025China

Background:The Anopheles hyrcanus group,which includes at least 25 species,is widely distributed in the Oriental and Palearctic *** group members have been incriminated as vectors of malaria and other mosquito-borne *** is difficult to identify Hyrcanus Group members by morphological ***,molecular phylogeny has been proposed as an important complementary method to traditional morphological ***:Based on the GenBank database and our original study data,we used 466 mitochondrial DNA COI sequences belonging to 18 species to reconstruct the molecular phylogeny of the Hyrcanus Group across its worldwide geographic ***:The results are as follows.1)The average conspecific K2P divergence was 0.008(range 0.002-0.017),whereas sequence divergence between congroup species averaged 0.064(range 0.026-0.108).2)The topology of COI tree of the Hyrcanus Group was generally consistent with classical morphological taxonomy in terms of species classification,but disagreed in subgroup *** the COI tree,the group was divided into at least three main *** first cluster contained ***;the second was composed of the Nigerrimus Subgroup and ***;and the third cluster was comprised of the Lesteri Subgroup and other unassociated species.3)Phylogenetic analysis of COI indicated that ancient hybridizations probably occurred among the three closely related species,***,***,and ***.4)The results supported *** as a probable synonym of ***,and it was possible that *** and *** were the same species,as evident from their extremely low interspecific genetic divergence(0.020 and 0.007,respectively)and their phylogenetic ***:In summary,we reconstructed the molecular phylogeny and analysed genetic divergence of the Hyrcanus Group using mitochondrial COI *** results suggest that in the future of malaria surveillance,we should not only pay much attent

关键词： Mosquito DNA barcoding Genetic distance Malaria

成纤维细胞生长因子受体1 抑制剂对胶原诱导关节炎模型大鼠骨破坏的影响

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中国组织工程研究 2025年第5期29卷 968-977页

作者：韩海慧孟晓辉徐博冉磊施杞肖涟波上海中医药大学上海市201203 上海中医药大学附属光华医院上海市200052 上海市中医药研究院中西医结合关节炎研究所上海市200052

背景:课题组前期的研究表明靶向成纤维细胞生长因子受体1(fibroblast growth factor receptor 1,FGFR1)可能是治疗类风湿性关节炎的有效靶点。目的:探讨FGFR1抑制剂(PD173074)对胶原诱导关节炎模型大鼠骨破坏的影响。方法:将25只雌性SD... 详细信息

背景:课题组前期的研究表明靶向成纤维细胞生长因子受体1(fibroblast growth factor receptor 1,FGFR1)可能是治疗类风湿性关节炎的有效靶点。目的:探讨FGFR1抑制剂(PD173074)对胶原诱导关节炎模型大鼠骨破坏的影响。方法:将25只雌性SD大鼠随机分为5组,正常对照组、模型组、甲氨蝶呤组、PD173074低剂量组、PD173074高剂量组。除正常对照组外,其余各组大鼠建立Ⅱ型胶原诱导关节炎模型。造模成功后正常组及模型组大鼠腹腔注射无菌PBS,甲氨蝶呤组药物注射剂量为1.04 mg/kg,PD173074低剂量组和高剂量组药物注射剂量分别为5,20 mg/kg,1次/周。给药4周后取材,观察大鼠临床症状以及关节肿胀情况,踝关节Micro-CT三维重建及分析,观察踝关节病理变化,检测关节周围血管生成情况及核因子κB受体活化因子配体的表达,检测关节滑膜中p-FGFR1、血管内皮生长因子A、抗酒石酸酸性磷酸酶的表达,观察肝、脾、肾病理变化并计算肝、脾、肾指数。结果与结论:①PD173074能够减轻模型大鼠踝关节临床症状及关节肿胀,延缓骨质丢失,改善骨结构,减轻关节滑膜侵袭以及软骨骨侵蚀,降低关节周围破骨细胞数量,抑制关节滑膜组织中的血管生成,降低核因子κB受体活化因子配体的表达,抑制FGFR1磷酸化蛋白、抗酒石酸酸性磷酸酶和血管内皮生长因子A的蛋白表达。②大鼠肝、脾、肾病理观察表明经过PD173074治疗后无明显的毒副作用。③研究证明了FGFR1抑制剂能够延缓Ⅱ型胶原诱导关节炎模型大鼠关节炎症及骨破坏的进展,并抑制血管的生成。初步验证了PD173074在Ⅱ型胶原诱导关节炎模型中的治疗作用,其可能是通过抑制FGFR1磷酸化发挥作用,为寻找类风湿性关节炎新的治疗靶点提供了方向。

关键词：类风湿关节炎 PD173074 成纤维细胞生长因子受体1 胶原诱导型关节炎动物模型骨破坏血管生成

A Practical Synthesis of (S)-(+)-2-(6-methoxyl-2-naphthyl) propionic Acid

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Chinese Chemical Letters 2002年第6期13卷 505-508页

作者： Hong Zhu MA Bo WANG qi Zhen shi DepartmentofChemistry NorthwestUniversityShaanXiKeyLaboratoryofPhysico－InorganicChemistryXi′an710068

A simplified procedure for enantioselective synthesis of (S)-(+)-2-(6-methoxyl-2- naphthyl) propionic acid ((S)-(+)-naproxen), starting from (6-methoxy-a-naphthyl) -1-propanone, with D-mannitol as auxiliary catalyzed ... 详细信息

关键词： Auxiliary D-mannitol enantioselective synthesis onepot (S)-(+)-naproxen.