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Gut microbiota shifts in hepatitis B-related portal hypertension after transjugular intrahepatic portosystemic shunt:Mechanistic and clinical implications

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World Journal of Gastroenterology 2025年第3期31卷 134-137页

作者： qi-rong Jiang Da-Wu Zeng Department of Hepatology Hepatology Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina Department of Infectious Diseases The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350004Fujian ProvinceChina

In this article,we provide commentary on the recent article by Zhao et *** focus on the shifts in the gut microbiota of patients with hepatitis B virus(HBV)-associated cirrhosis/portal hypertension(PH)following transjugular intrahepatic portosystemic shunt(TIPS)and the implications for understanding the mechanisms,diagnosis,and *** comparing the gut microbiota composition and dynamic changes before and after TIPS in patients with and without hepatic encephalopathy,the authors found an increase in non-probiotic bacteria in those who developed hepatic encephalopathy post-TIPS,with Morganella species present only in the hepatic encephalopathy *** gut microbiota changes post-TIPS among patients without the occurrence of hepatic encephalopathy suggest potential therapeutic benefits through prophylactic microbiome ***,the specific gut microbiota alterations may hold promise to predict the risk of hepatic encephalopathy in individuals undergoing TIPS for HBVrelated *** these promising findings,future studies are needed to address limitations,including a small sample size,a relatively short evaluation period for gut microbiota alterations,the absence of data on dynamic alterations in gut microbiota post-TIPS and their correlation with blood ammonia levels,and the lack of validation in animal *** conclusion,Zhao et al's study has shed new light on the link of gut microbiota with post-TIPS hepatic encephalopathy,potentially through the intricate gut-liver axis,and has important clinical implications for improving the management of patients with HBV-related PH.

关键词： Hepatitis B virus Cirrhosis Portal hypertension Hepatic encephalopathy Transjugular intrahepatic portosystemic shunt Gut microbiota

Systematic analysis of microfauna indicator values for treatment performance in a full-scale municipalwastewater treatment plant

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Journal of Environmental Sciences 2013年第7期25卷 1379-1385页

作者： Bo Hu rong qi Min Yang State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences

The indicator values of microfauna functional groups and species for treatment performancewere systematically evaluated based on the continuous monitoring of the entire microfauna communities including both protozoa and metazoa over a period of 14 months, in two parallel full-scale municipalwastewater treatment systems in a plant in Beijing, China. A total of 57 species of ciliates, 14 species （units） of amoebae, 14 species （units） of flagellates and4 classes of small metazoawere identified,with Arcella hemisphaerica, Vorticella striata, Vorticella convallaria, Epistylis plicatilis and small flagellates （e.g. Bodo spp.） as thedominant protozoa, and rotifers as thedominant metazoa. The abundance of the sessile ciliateswas correlatedwith the removals of BOD 5 （Pearson＇s r = 0.410, p 〈 0.05） and COD Cr （r = 0.397, p 〈 0.05）while the testate amoebaewas significantly positively related to nitrification （r = 0.523, p 〈 0.01）. At the same time, some other associationswere also identified： the abundances of the large flagellates （r = 0.447, p 〈 0.01）, the metazoa （r = 0.718, p 〈 0.01） and species Aspidisca sulcata （r = 0.337, p 〈 0.05）were positively related to nitrification; the abundance of Aspidisca costatawas correlated to the TN （total nitrogen） removal （r = -0.374, p 〈 0.05 ）; the abundances of the sessile species Carchesium polypinum （r = 0.458, p 〈 0.01） and E. plicatilis （r = 0.377, p 〈 0.05）were correlatedwith the removal of suspended solids.

关键词： protozoan metazoan activated sludge treatment performance bioindicator

About 300 days Optical Quasi-periodic Oscillations in the Long-term Light Curves of the Blazar PKS 2155-304

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Research in Astronomy and Astrophysics 2022年第8期22卷 284-293页

作者： qi Zheng Xue-Guang Zhang qi-rong Yuan School of Physics and Technology Nanjing Normal UniversityNanjing 210023China

Based on the long-term light curves collected from the Catalina Sky Survey(CSS)(from 2005 to 2013)and the All-Sky Automated Survey for Supernovae(ASAS-SN)(from 2014 to 2018),optical quasi-periodic oscillations(QPOs)about 300 days can be well determined in the well-known blazar PKS 2155-304 through four different methods:the generalized Lomb-Scargle periodogram(GLSP)method,the weighted wavelet Z-transform technique,the epoch-folded method and the redfit *** GLSP determined significance level for the periodicity is higher than 99.9999%based on a false alarm *** redfit provided confidence level for the periodicity is higher than 99%in the ASAS-SN light curve,after considering the effects of red *** on continuous autoregressive process created artificial light curves,the probability of detecting fake QPOs is lower than 0.8%.The determined optical periodicity of 300 days from the CSS and ASAS-SN light curves is well consistent with the reported optical periodicity in the ***,three possible models are discussed to explain the optical QPOs in PKS 2155-304:the relativistic frame-dragging effect,the binary black hole model and the jet precession model.

关键词： (galaxies:)BL Lacertae objects:individual(PKS 2155-304) galaxies:active (galaxies:)quasars:supermassive black holes

Numerical Study on the Effect of Nerve Control on Upper Airway Collapse in Obstructive Sleep Apnea

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International Journal of Automation and computing 2016年第2期13卷 117-124页

作者： qi-Guo rong Shuang Ren qi-Hong Li Department of Mechanics and Engineering Science College of EngineeringPeking University Department of Stomatology Affiliated Hospital of Academy of Military Medical Sciences

Obstructive sleep apnea syndrome （OSAS） is a respiratory disease characterized by the upper airway collapses and reopens repeatedly during sleep. Though the nerve control plays a key role in the upper airway collapse, it has been considered in previous studies only with lumped parameter models. Based on a finite element model including airway and surrounding structures, the effect of nerve control on the upper airway collapse was studied with fluid-structure interaction method. Spring elements were used to simulate the function of the muscle group. The simulation results show that the nerve control reduces the deformation of airway successfully and avoids the risk of OSAS.

关键词： Upper airway collapse fluid-structure interaction nerve control finite element analysis biomechanics

Treatment of coke plant wastewater by SND fixed biofilm hybrid system

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Journal of Environmental Sciences 2007年第2期19卷 153-159页

作者： qi rong YANG Kun YU Zhao-xiang Department of Chemistry Tongji University Shanghai 200092 China

In this article, coke plant wastewater was treated by a simultaneous nitrifying and denitrifying （SND） fixed biofilm hybrid system. The results showed that suitable parameters of the system were important for the performance of the bio-degradation system. The chemical oxygen demand （COD） removal efficiency in this system was satisfactory, higher than 94%, and ammonia nitrogen was higher than 95%. The effluent COD concentration could meet the discharge standard, except for very few situations. The results showed that a sufficient carbon source was important for making ammonia nitrogen concentration meet the discharge standard. Then the TiN removal efficiency in this system can be brought higher than 94%. Dissolved oxygen （DO） is very important to the performance of the SND bio-degradation system, and the suitable DO is about 3.5-4.0 mg/L at the forepart of reactor. In addition, the performance of the system was almost not affected by pH value. The results show that the system is feasible to treat coke plant wastewater.

关键词： coke plant wastewater SND fixed biofilm ammonia nitrogen COD carbon source

Responses of protists with different feeding habits to the changes of activated sludge conditions:A study based on biomass data

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Journal of Environmental Sciences 2012年第12期24卷 2127-2132页

作者： Bo Hu rong qi Wei An Min Yang State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

Changes of protists, which were categorized into different functional groups primarily according to their feeding habits, in two full-scale municipal wastewater treatment systems experiencing sludge bulking were investigated over a period of 14 months. Protist biomass represented 3.7% to 5.2% of total biomass on average under normal sludge conditions, and the percentage increased significantly （p 〈 0.05） under sludge bulking conditions. The biomass of Chilodonella spp., capable of eating filamentous bacteria, tended to decrease in both systems when sludge bulking occurred, showing that the abnormal growth of filamentous bacteria did not lead to a biomass bloom of this group of protists. On the other hand, the bactivorous protists represented more than 96% of total protist biomass, and the biomass of this group, particularly the attached ciliates, increased significantly （p 〈 0.05） when sludge bulking occurred. The significant increase of the attached ciliates may have possibly facilitated the growth of filamentous bacteria through selectively preying on non-filamentous bacteria and further exacerbated sludge bulking. The redundancy analysis and correlation analysis results showed that the biomass changes of the attached ciliates were primarily related to the sludge volume index and to some extent related to five-day biochemical oxygen demand loading and hydraulic retention time.

关键词： protist biomass activated sludge feeding habit sludge bulking

Treatment of coke plant wastewater by A/O fixed biofilm system

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Science China Chemistry 2005年第5期48卷 489-496页

作者： YU Zhaoxiang qi rong YIN Yanjun Department of Chemistry Tongji University Shanghai 200092 China Department of Chemistry Tongji University Shanghai 200092 China Department of Chemistry Tongji University Shanghai 200092 China

Coke plant wastewater was treated by an anaerobic–aerobic (A/O) biofilm system. A lab-scale experiment, during which semi-soft media were packed in both the anaerobic and the aerobic reactors, was carried out. The influence parameters, such as HRT, C/N ratio, OLR, and the recycling flow rate on the performance of the system, were studied. The results showed that a sufficient carbon source was important to the performance of bio-degradation system. The COD removal rate increased from 64.15% to 83.28% by raising C/N in wastewater from 2.5 (no ex-ternal carbon source) to 5. But the effluent COD concentration was still a little higher than the discharge standard. In order to make it meet the discharge standard, a deep treatment, coagula-tion, was applied, which was proved as an effective method. Then the effluent COD concentra-tion can be brought to lower than 200 mg·L?1. The NH4-N removal rate in this system was sat-isfactory, being higher than 99%. In addition, it was almost not affected by both C/N ratio and coagulation treatment. The results show that the system is feasible to treat coke plant wastewa-ter.

关键词： coke plant wastewater, fixed biofilm, ammonia nitrogen, COD, HRT, OLR.

Comparison of bacterial community structures in two systems of a sewage treatment plant using PCR-DGGE analysis

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Journal of Environmental Sciences 2011年第12期23卷 2049-2054页

作者： Abd El-Latif Hesham rong qi Min Yang State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China Genetics Department Faculty of Agriculture Assiut University Assiut Egypt

The combination of PCR amplification of 16S rRNA genes with denaturing gradient gel electrophoresis （DGGE） analysis was used to reveal the compositions and dynamics of bacterial communities in a sewage treatment plant with two systems, i.e., an anoxic- anaerobic-aerobic system （inverted A2O） and an anaerobic-anoxic-aerobic one （conventional A2O） over a period from February to July 2009, during which both systems experienced serious sludge bulking problems. The DGGE patterns showed that there were many common bands in both systems, suggesting the high similarity of bacterial communities of the two systems. Meanwhile, the moving window correlation analysis showed that the two systems experienced different microbial community structure changes during the period, which might be related with the different situations of the occurrence and disappearance of sludge bulking, as being reflected by sludge volume index （SVI） values. Major bands of DGGE patterns of sludge samples were further sequenced. Phylogenetic affiliation indicated that the majority of the sequences obtained were affiliated with Actinobacteria, Firmicutes, Bacteroidetes/Chlorobi group and α- and β-Proteobacteria. Two sequences showed high similarities to typical filamentous bacteria Microthrix parvicella and Nostocoida limicola I, indicating that these bacterial species have been involved in the sludge bulking problems.

关键词： PCR-DGGE bacterial community activated sludge sludge bulking sewage treatment plant

Stability analysis of slope in strain-softening soils using local arc-length solution scheme

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Journal of Mountain Science 2017年第1期14卷 175-187页

作者： WANG Xiang-rong rong qi-guo SUN Shu-li WANG Hui College of Engineering Peking University Graduate School AICES RWTH Aachen University

Soils with strain-softening behavior — manifesting as a reduction of strength with increasing plastic strain — are commonly found in the natural environment. For slopes in these soils,a progressive failure mechanism can occur due to a reduction of strength with increasing strain. Finite element method based numerical approaches have been widely performed for simulating such failure mechanism,owning to their ability for tracing the formation and development of the localized shear strain. However,the reliability of the currently used approaches are often affected by poor convergence or significant mesh-dependency,and their applicability is limited by the use of complicated soil models. This paper aims to overcome these limitations by developing a finite element approach using a local arc-length controlled iterative algorithm as the solution strategy. In the proposed finite element approach,the soils are simulated with an elastoplastic constitutive model in conjunction with the Mohr-Coulomb yield function. The strain-softening behavior is represented by a piece-wise linearrelationship between the Mohr-Coulomb strength parameters and the deviatoric plastic strain. To assess the reliability of the proposed finite element approach,comparisons of the numerical solutions obtained by different finite element methods and meshes with various qualities are presented. Moreover,a landslide triggered by excavation in a real expressway construction project is analyzed by the presented finite element approach to demonstrate its applicability for practical engineering problems.

关键词： Strain-softening Progressive failure Slope stability Local arc-length scheme Numerical simulation