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Polysaccharide of Alocasia cucullata Exerts Antitumor Effect by Regulating Bcl-2, Caspase-3 and ERK1/2 Expressions during Long-Time Administration

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Chinese Journal of Integrative Medicine 2024年第1期30卷 52-61页

作者： ZHOU qi-chun xiaO Shi-lin LIN Ru-kun LI Chan CHEN zhi-jie CHEN Yi-fei LUO Chao-hua MO zhi-xian LIN Ying-bo School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou(510515)China Clinical and Basic Research Team of TCM Prevention and Treatment of Non-Small Cell Lung Cancer the Second Clinical College of Guangzhou University of Chinese MedicineGuangzhou(510120)China Department of Chinese Medicine Zhujiang Hospital Affiliated to Southern Medical UniversityGuangzhou(510282)China Department of Pharmacy Jiangmen Central HospitalJiangmen(529000)China

Objective: To study the in vitro and in vivo antitumor effects of the polysaccharide of Alocasia cucullata(PAC) and the underlying mechanism. Methods: B16F10 and 4T1 cells were cultured with PAC of 40 μg/m L, and PAC was withdrawn after 40 days of administration. The cell viability was detected by cell counting kit-8. The expression of Bcl-2 and Caspase-3 proteins were detected by Western blot and the expressions of ERK1/2 mRNA were detected by quantitative real-time polymerase chain reaction(qRT-PCR). A mouse melanoma model was established to study the effect of PAC during long-time administration. Mice were divided into 3 treatment groups: control group treated with normal saline, positive control group(LNT group) treated with lentinan at 100 mg/(kg·d), and PAC group treated with PAC at 120 mg/(kg·d). The pathological changes of tumor tissues were observed by hematoxylin-eosin staining. The cell apoptosis of tumor tissues was detected by TUNEL staining. Bcl-2 and Caspase-3 protein expressions were detected by immunohistochemistry, and the expressions of ERK1/2, JNK1 and p38 mRNA were detected by qRT-PCR. Results: In vitro, no strong inhibitory effects of PAC were found in various tumor cells after 48 or 72 h of administration. Interestingly however, after 40 days of cultivation under PAC, an inhibitory effect on B16F10 cells was found. Correspondingly, the long-time administration of PAC led to downregulation of Bcl-2 protein(P <0.05), up-regulation of Caspase-3 protein(P<0.05) and ERK1 mRNA(P<0.05) in B16F10 cells. The above results were verified by in vivo experiments. In addition, viability of B16F10 cells under long-time administration culture in vitro decreased after drug withdrawal, and similar results were also observed in 4T1 cells. Conclusions: Long-time administration of PAC can significantly inhibit viability and promote apoptosis of tumor cells, and had obvious antitumor effect in tumor-bearing mice.

关键词： polysaccharide of Alocasia cucullata tumor cells Bcl-2 Caspase-3 ERK1/2 Chinese medicine

BGP4+测试系统中微型TCP/IPv6的设计与实现

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计算机应用研究 2005年第9期22卷 250-252,255页

作者：夏启志谢高岗中国科学院计算技术研究所北京100080

在很多情况下,一个实现了基本功能的微型TCP/IP是理想的。在介绍BGP4+一致性测试系统的基础上,设计了用于BGP4+测试系统的微型TCP/IPv6。该微型TCP/IPv6实现了基本的IPv6包的处理,能够进行TCP连接的建立、维护和释放,实现了窗口和重传... 详细信息

在很多情况下,一个实现了基本功能的微型TCP/IP是理想的。在介绍BGP4+一致性测试系统的基础上,设计了用于BGP4+测试系统的微型TCP/IPv6。该微型TCP/IPv6实现了基本的IPv6包的处理,能够进行TCP连接的建立、维护和释放,实现了窗口和重传等可靠传输机制。该微型TCP/IPv6有紧凑、高效的特点,可用于系统资源较少的嵌入式系统进行网络通信。

关键词：微型TCP 测试系统 BGP4

Marker Ki-67 is a potential biomarker for the diagnosis and prognosis of prostate cancer based on two cohorts

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World Journal of Clinical Cases 2024年第1期12卷 32-41页

作者： Zhen Song qi Zhou Jiang-Lei Zhang Jun Ouyang zhi-Yu Zhang Department of Urology Taixing People’s HospitalTaizhou 225400Jiangsu ProvinceChina Department of Urology The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Reproductive Medicine Center The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Prostate cancer(PCa)is a widespread malignancy,predominantly affecting elderly males,and current methods for diagnosis and treatment of this disease continue to fall *** marker Ki-67(MKI67)has been previously demonstrated to correlate with the proliferation and metastasis of various cancer cells,including those of ***,verifying the association between MKI67 and the diagnosis and prognosis of PCa,using bioinformatics databases and clinical data analysis,carries significant clinical *** To explore the diagnostic and prognostic efficacy of antigens identified by MKI67 expression in *** For cohort 1,the efficacy of MKI67 diagnosis was evaluated using data from The Cancer Genome Atlas(TCGA)and Genotype-Tissue Expression(GTEx)*** cohort 2,the diagnostic and prognostic power of MKI67 expression was further validated using data from 271 patients with clinical *** In cohort 1,MKI67 expression was correlated with prostate-specific antigen(PSA),Gleason Score,T stage,and N *** receiver operating characteristic(ROC)curve showed a strong diagnostic ability,and the Kaplan-Meier method demonstrated that MKI67 expression was negatively associated with the progression-free interval(PFI).The time-ROC curve displayed a weak prognostic capability for MKI67 expression in *** cohort 2,MKI67 expression was significantly related to the Gleason Score,T stage,and N stage;however,it was negatively associated with the *** time-ROC curve revealed the stronger prognostic capability of MKI67 in patients with *** COX regression analysis was performed to select risk factors,including PSA level,N stage,and MKI67 expression.A nomogram was established to predict the 3-year *** MKI67 expression was positively associated with the Gleason Score,T stage,and N stage and showed a strong diagnostic and prognostic ability in PCa.

关键词： Marker Ki-67 Prostate cancer Biomarker Diagnosis Prognosis

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无结构P2P网络搜索方法及其改进

计算机应用研究 2005年第9期22卷 256-260页

作者：夏启志谢高岗中国科学院计算技术研究所北京100080

对等(P2P)计算是未来网络中的关键技术,对等网络是实现下一代互联网的重要组成部分。如何高效地搜索P2P网络上的资源是P2P网络实现的最为关键的问题。在讲述对等网络的基本搜索方法的基础上,分析了许多改进的搜索方法,包括基于转发的改... 详细信息

对等(P2P)计算是未来网络中的关键技术,对等网络是实现下一代互联网的重要组成部分。如何高效地搜索P2P网络上的资源是P2P网络实现的最为关键的问题。在讲述对等网络的基本搜索方法的基础上,分析了许多改进的搜索方法,包括基于转发的改进方法、基于缓存的改进方法和基于覆盖网拓扑优化的改进方法。

关键词：对等计算无结构P2P网络搜索方法

Manipulating guest-responsive spin transition to achieve switchable fluorescence in a Hofmann-type framework

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Science China Chemistry 2024年第10期67卷 3339-3346页

作者： Xue-Ru Wu Shu-qi Wu zhi-Kun Liu Ming-Xing Chen Jun Tao Osamu Sato Hui-Zhong Kou Engineering Research Center of Advanced Rare Earth Materials(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing 100084China Institute for Materials Chemistry and Engineering&IRCCS Kyushu University744 MotookaNishi-kuFukuoka 819-0395Japan Key Laboratory of Cluster Science of Ministry of Education School of Chemistry and Chemical EngineeringLiangxiang CampusBeijing Institute of TechnologyBeijing 102488China Analytical Instrumentation Center College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

The change of fluorescence emission manipulated by spin state transition attracts considerable attention owing to its potential applications in magneto-optical switching ***,we report two two-dimensional(2D)Hofmann-type spin crossover(SCO)metal-organic frameworks(MOFs)[Fe^(Ⅱ)(PNI)_(2){Ag^(Ⅰ)(CN)_(2)}_(2)]·CHCl_(3)(3Ag·CHCl_(3))and[FeⅡ(PNI)_(2){AuⅠ(CN)_(2)}_(2)]·CHCl_(3)(3Au·CHCl_(3))based on the fluorescent ligand N-(4-pyridylmethyl)-1,8-naphthalimide(PNI).Both complexes exhibit interesting SCO behaviors switched by guest solvent molecules,namely three-step transitions for the solvated complexes and complete onestep hysteretic SCO for the desolvated ones,verified by temperature-dependent magnetic susceptibility measurements,Mossbauer spectra,structural analyses,and differential scanning calorimetry ***,temperature-dependent fluorescence spectra exhibit double peaks(monomer and excimer emission)with both emission peaks change consistent with the change in SCO properties during the solvent molecule *** this study,we integrated guest-responsive SCO behavior into MOFs to manipulate the multistability of spin state and fluorescence switching,providing a rational strategy for the development of stimuli-responsive multifunctional materials.

关键词： spin crossover fluorescence multifunctional materials metal-organic frameworks Hofmann-type

Acoustic radiation force on a cylindrical composite particle with an elastic thin shell and an internal eccentric liquid column in a plane ultrasonic wave field

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Chinese Physics B 2024年第9期33卷 423-431页

作者： Rui-qi Pan zhi-Wei Du Cheng-Hui Wang Jing Hu Run-Yang Mo Institute of Shaanxi Key Laboratory of Ultrasonics Shaanxi Normal UniversityXi’an 710119China

A model with three-layer structure is introduced to explore the acoustic radiation force(ARF)on composite particles with an elastic thin *** acoustic scattering of cylinder and the thin-shell theorem,the ARF expression was derived,and the longitudinal and transverse components of the force and axial torque for an eccentric liquid-filled composite particle was *** was found that many factors,such as medium properties,acoustic parameters,eccentricity,and radius ratio of the inner liquid column,affect the acoustic scattering field of the particle,which in turn changes the forces and *** acoustic response varies with the particle structures,so the resonance peaks of the force function and torque shift with the eccentricity and radii ratio of *** acoustic response of the particle is enhanced and exhibits higher force values due to the presence of the elastic thin shell and the coupling effect with the eccentricity of the internal liquid *** decrease of the inner liquid density may suppress the high-order resonance peaks,and internal fluid column has less effects on the change in force on composite particle at ka>3,while limited differences exist at kaxial torque on particles due to geometric asymmetry is closely related to ka and the *** distribution of positive and negative force and torque along the axis ka exhibits that composite particle can be manipulated or separated by *** theoretical analysis can provide support for the acoustic manipulation,sorting,and targeting of inhomogeneous particles.

关键词： acoustic radiation force acoustic scattering of cylinders elastic shell composite particles

Recent Progress of Earth Observation Satellites in China

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空间科学学报 2024年第4期44卷 731-740页

作者： HUANG Shusong qi Wenping ZHANG Shuai xia Tian WANG Jingqiao ZENG Yong China Centre for Resources Satellite Data and Application Beijing 100094

Currently,China has 32 Earth observation satellites in *** satellites can provide various data such as optical,multispectral,infrared,and *** spatial resolution of China Earth observation satellites ranges from low to medium to *** satellites possess the capability to observe across multiple spectral bands,under all weather conditions,and at all *** data of China Earth observation satellites has been widely used in fields such as natural resource detection,environmental monitoring and protection,disaster prevention and reduction,urban planning and mapping,agricultural and forestry surveys,land survey and geological prospecting,and ocean forecasting,achieving huge social *** article introduces the recent progress of Earth observation satellites in China since 2022,especially the satellite operation,data archiving,data distribution and data coverage.

关键词： China Earth Observation Satellites Satellite operation Data archiving Data distribution Data coverage

Coupling ideality of standing-wave supermode microresonators

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Photonics Research 2024年第8期12卷 1610-1618页

作者： MIN WANG YUECHEN LEI zhi-GANG HU CHENGHAO LAO YUANLEI WANG XIN ZHOU JINCHENG LI qi-FAN YANG BEI-BEI LI Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China School of Physics Beihang UniversityBeijing 100191China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Songshan Lake Materials Laboratory Dongguan 523808China

Standing-wave supermode microresonators that are created through the strong coupling between counter-propagating modes have emerged as versatile platforms for sensing and nonlinear *** example,these microresonators have shown potential in nanoparticle sizing and counting,as well as enhancing the single-photon optomechanical coupling rate of stimulated Brillouin ***,it has been observed that the relation between the mode linewidth and on-resonance transmission of the split supermodes differs obviously from that of the non-split *** behavior is typically quantified by the coupling ideality(I),which remains inadequately explored for the standing-wave *** this study,we theoretically and experimentally investigate the coupling ideality of standing-wave supermodes in a commonly employed configuration involving a Si O2microresonator side-coupled to a tapered *** findings demonstrate that,even with a single-mode tapered fiber,the coupling ideality of the standing-wave supermodes is limited to 0.5,due to the strong backscattering-induced energy loss into the counter-propagating direction,resulting in an additional equivalent parasitic *** achieving a coupling ideality of 0.5 presents challenges for reaching over-coupled regimes,it offers a convenient approach for adjusting the total linewidth of the modes while maintaining critically-coupled conditions.

关键词： ideality mode wave

Photo-Responsive Carbon Capture over Metalloporphyrin-C_(60) Metal-Organic Frameworks via Charge-Transfer

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Research 2024年第3期2023卷 233-241页

作者： Shi-Chao qi Zhen Sun zhi-Hui Yang Yun-Jie Zhao Jia-Xin Li xiao-qin Liu Lin-Bing Sun State Key Laboratory of Materials-Oriented Chemical Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China.

Great efforts have been devoted to the study of photo-responsive adsorption,but its current methodology largely depends on the well-defined photochromic units and their photo-driven molecular ***,a methodology to fabricate nondeforming photo-responsive sorbents is successfully *** C_(60)-fullerene doping in metalloporphyrin metal-organic frameworks(PCN-M,M=Fe,Co,or Ni)and intensively interacting with the metalloporphyrin sites,effective charge-transfer can be achieved over the metalloporphyrin-C_(60) architectures once excited by the light at 350 to 780 *** electron density distribution and the resultant adsorption activity are thus changed by excited states,which are also stable enough to meet the timescale of microscopic adsorption *** charge-transfer over Co(II)-porphyrin-C_(60) is proved to be more efficient than the Fe(II)-and Ni(II)-porphyrin-C_(60) sites,as well as than all the metalloporphyrin sites,so the CO_(2) adsorption capacity(CAC;at 0°C and 1 bar)over the C_(60)-doped PCN-Co can be largely improved from 2.05 mmol g^(−1) in the darkness to 2.69 mmol g−1 with light,increased by 31%,in contrast to photo-irresponsive CAC over all C_(60)-undoped PCN-M sorbents and only the photo-loss CAC over C_(60).

关键词： porphyrin adsorption excited