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Incidence,predictors and prognosis of acute kidney injury in acute ST-segment elevation myocardial infarction patients undergoing emergent coronary angiography/primary percutaneous coronary intervention

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Journal of Geriatric Cardiology 2023年第2期20卷 139-149页

作者： jing TAN Ying-Hua ZHANG jin SI Ke-Ling XIAO qi HUA jing LI Department of Cardiology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Geriatric Medicine Xuanwu HospitalCapital Medical UniversityNational Clinical Research Center for Geriatric DiseasesBeijingChina

BACKGROUND Acute kidney injury(AKI) after coronary angiography(CAG) and primary percutaneous coronary intervention(PPCI) is frequently observed, and often interpreted as contrast induced-AKI. This study aimed to investigate the incidence, predictors and outcomes of AKI in acute ST-segment elevation myocardial infarction(STEMI) patients undergoing emergent CAG/PPCI using the control group of STEMI patients who were not exposed to contrast agents within the first 72 *** We performed a retrospective analysis of 1670 STEMI patients. Of them, 673 patients underwent emergent CAG/PPCI, and 997 patients treated with thrombolysis or no reperfusion therapy who were not exposed to contrast material during the first 72 h. AKI was defined as an increase of serum creatinine ≥ 44.2 mmol/L or ≥ 25% from baseline within 72 h. Patents were then followed up for the occurrence of all-cause mortality for 40 months(interquartile range: 24–55 months).RESULTS After propensity score matching, 505 pairs of patients were matched. Overall, the incidence of AKI was 27.4%, and AKI rates were not significantly different in patients with and without emergent CAG/PPCI procedure(27.5% vs. 27.3%, P = 0.944). Multivariate logistic regression analysis identified that the independent predictors of AKI were female, elevated interleukin-6 level,decreased lymphocyte count, left ventricular ejection fraction < 50% and use of diuretics in patients with emergent CAG/PPCI. Patients with AKI than those without AKI experienced higher incidence of acute heart failure with Killip class Ⅲ(9.4% vs. 3.3%, P =0.005;15.2% vs. 6.8%, P = 0.003, respectively) and mortality(5.8% vs. 1.4%, P = 0.014;12.3% vs. 4.6%, P = 0.002, respectively) in patients with and without emergent CAG/PPCI. Multivariate Cox regression analysis confirmed that AKI was independently associated with long-term mortality rate at 40 months follow-up in patients with and without emergent CAG/PPCI(HR = 1.867, 95% CI:1.086–3.210, P = 0.024;HR = 1.7

关键词： patients coronary infarction

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活性氧在脑缺血-再灌注损伤后动态表达

脑与神经疾病杂志 2016年第12期24卷 731-734页

作者：杨冀萍齐进冲杨北修宝新牛彩虹河北医科大学第二医院医学影像科石家庄050000

目的观察活性氧(ROS)在大鼠脑缺血—再灌注损伤不同时间缺血灶周区皮质的动态表达。方法健康成年SD雄性大鼠(n=55),随机分成假手术组(n=5)和模型组(n=50),模型组按再灌注时间分为10个组,即脑缺血—再灌注1h、3h、6h、12h、1d、3d、5d、7... 详细信息

目的观察活性氧(ROS)在大鼠脑缺血—再灌注损伤不同时间缺血灶周区皮质的动态表达。方法健康成年SD雄性大鼠(n=55),随机分成假手术组(n=5)和模型组(n=50),模型组按再灌注时间分为10个组,即脑缺血—再灌注1h、3h、6h、12h、1d、3d、5d、7d、14d和28d组,每组5只大鼠。通过阻塞大脑中动脉(MCAO)制作大鼠局灶性脑缺血—再灌注损伤模型,采用改良神经功能严重性评分(m NSS)对不同时间点大鼠的神经功能进行评价,采用流式细胞术检测缺血灶周区ROS和血管内皮生长因子(VEGF)动态时空表达。结果假手术组未见神经功能损伤,评分为0。脑缺血—再灌注1h大鼠出现神经损伤,3h^1d时症状加重,3~7d时症状有所改善,14~28d症状明显好转。假手术组有少量ROS和VEGF表达,脑缺血再灌注损伤后1h缺血灶周区ROS急剧上升,3~6h有所下降,但仍远高于假手术组,后逐渐下降,3d时降到最低,与假手术组相仿,随后迅速上升,5d时已超过6h数值,7d时接近1h高度,后ROS表达呈平台期,VEGF表达趋势与其相仿,ROS表达与神经功能评分呈负相关。结论 ROS可能在脑缺血损伤中起双相作用,在超早期参与脑损伤过程,后期可能参与脑修复作用。

关键词：活性氧脑缺血损伤修复血管发生

Tuning Aggregation Behavior of Polymer Donor via Molecular-Weight Control for Achieving 17.1%Efficiency Inverted Polymer Solar Cells

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Chinese Journal of Chemistry 2021年第7期39卷 1941-1947页

作者： qi Liu jin Fang jingnan Wu Lei Zhu Xia Guo Feng Liu Maojie Zhang Laboratory of Advanced Optoelectronic Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhouJiangsu 215123China Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Main observation and conclusion Recently,the polymer solar cells(PSCs)based on the PM6 and small molecular acceptor(SMA)Y6 have attracted considerable attention in this community for their outstanding photovoltaic per... 详细信息

关键词： Organic solar cells Power conversion efficiency Polymers Donor-acceptor systems Molecular weight

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中医面部美容的研究进展

世界最新医学信息文摘 2019年第55期19卷 34-35页

作者：关金琦苟德胜刘超韩东岳王朝辉长春中医药大学

对中医面部美容的研究进展进行综述。采取计算机对近二十年中国期刊全文数据库(CNKI)中关于中医面部美容文献进行检索及整理,对中医面部美容的研究进展进行综述。大量文献及研究证明中医面部美容切实有效。中医面部美容可进行针对性治疗... 详细信息

对中医面部美容的研究进展进行综述。采取计算机对近二十年中国期刊全文数据库(CNKI)中关于中医面部美容文献进行检索及整理,对中医面部美容的研究进展进行综述。大量文献及研究证明中医面部美容切实有效。中医面部美容可进行针对性治疗,并且具有安全、绿色、副作用少、廉价等优点,值得大力推广。

关键词：中医面部美容针灸刮痧推拿中药

气膀胱腹腔镜联合电切镜在膀胱肿瘤剜除术中的应用研究

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河北医科大学学报 2019年第9期40卷 1026-1028,1033页

作者：汪鑫贾江华张明齐进春瞿长宝王东彬河北医科大学第二医院泌尿外科

目的探讨气膀胱腹腔镜联合电切镜技术在膀胱肿瘤剜除术中的应用价值。方法选取膀胱肿瘤患者17例,应用电切镜完整剜除肿瘤,经耻骨上穿刺建立人工气膀胱,在膀胱腔内缝合创面,记录手术时间、手术出血量、是否有尿外渗及直肠损伤、术后疼痛... 详细信息

目的探讨气膀胱腹腔镜联合电切镜技术在膀胱肿瘤剜除术中的应用价值。方法选取膀胱肿瘤患者17例,应用电切镜完整剜除肿瘤,经耻骨上穿刺建立人工气膀胱,在膀胱腔内缝合创面,记录手术时间、手术出血量、是否有尿外渗及直肠损伤、术后疼痛评分、术后住院时间等。结果17例患者全部完成手术,无中转开放,平均手术时间(77.3±13.9)min,平均出血量(6.3±2.9)mL,17例患者均未出现尿外渗,无直肠损伤等严重并发症,术后4h平均疼痛评分(4.2±1.3)分,术后12h平均疼痛评分(1.8±0.7)分,术后平均住院时间(3.7±1.1)d。结论气膀胱腹腔镜联合电切镜技术在膀胱肿瘤剜除术中安全有效,是膀胱肿瘤手术中重要的补充方法。

关键词：膀胱肿瘤腹腔镜检查经尿道膀胱肿瘤剜除术

In Situ Growth of Vanadium Oxide on Reduced Graphene Oxide for the Low-Temperature NO-SCR by NH3

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Journal of Wuhan University of Technology(Materials Science) 2019年第3期34卷 572-578页

作者： LI Meiyan jin Wei State Key Laboratory of Silicate Materials for Architectures School of Materials Science and EngineeringWuhan University of TechnologyWuhan430070China Center for Material Research and Analysis Wuhan University of TechnologyWuhan430070China

The vanadium oxide/reduced graphene oxide（V2 O5/rGO） composite catalyst which determined the selective catalytic reduction activity（SCR） of NO with NH3 was prepared by a simple solvothermal method. The physicochemical properties of the catalysts were characterized by X-ray diffraction（XRD）, scanning electron microscopy（SEM）, Raman, X-ray energy spectrometer（XPS） and N2 sorption isotherm measurement（BET）. Results of NH3-SCR showed that the NO conversion of V2 O5/rGO catalyst could reach 54.3% at 100 ℃. And the removal of NO increased to 74.6% when the temperature was up to 220 ℃. By characterizing the microstructure and morphology of the V2 O5/rGO catalysts prepared by in-situ growth and mechanical mixing methods, it was further shown that V2 O5 nanoparticles were highly dispersed and in situ growth on the rGO surface. Based on X-ray energy spectrometer, V2 O5/r GO catalyst had good low temperature denitrification performance due to the chemical adsorption oxygen and low-valent vanadium oxide contained in V2 O5/rGO catalyst, which was beneficial to the redox reaction between V2 O5 and graphene.

关键词： V2O5/rGO catalyst NH3-SCR graphene in situ growth

A review of the phytochemistry and pharmacological activities of Ephedra herb

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Chinese Journal of Natural Medicines 2020年第5期18卷 321-344页

作者： MIAO Shuang-Man ZHANG qi BI Xiao-Bao CUI jin-Long WANG Meng-Liang Institute of Applied Chemistry Shanxi UniversityTaiyuan 030006China Modern Research Center for Traditional Chinese Medicine Shanxi UniversityTaiyuan 030006China Centre for Biomimetic Sensor Science(CBSS) School of Materials Science&EngineeringNanyang Technological UniversitySingapore 637553Singapore

Ephedra herb is a traditional Chinese medicine with a long history. Conventionally, it was used as a folk phytomedicine in many ancient medical books and traditional prescriptions. Up to date, a variety of specific ingredients have been found in Ephedra herb, mainly including alkaloids, flavonoids, tannins, polysaccharides, organic acids, volatile oils, and many other active compounds. These components from Ephedra herb account for its use as the accurate treatment of cold, cough, cardiovascular and immune system disease, cancer, microbial infection, and other diseases. Moreover, with the fast development of novel chemistry and medicine technology, new chemical constituents and pharmacological effects of Ephedra herb are increasingly identified, demonstrating their great potential for various diseases treatment. Therefore, further detailed understanding and investigation of this ancient herb will offer new opportunities to develop novel therapeutics. This study systematically reviews its progress of phytochemistry, traditional and modern pharmacology based on research data that have been reported, aiming at providing useful insight for commercial exploitation, further study and precision medication of Ephedra herb in future.

关键词： Traditional Chinese medicine Phytochemistry Ethnopharmacology Bioactivity Phytomedicine

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络治法对黄斑区微血管损伤的保护研究

辽宁中医杂志 2023年第12期50卷 160-163页

作者：金琪谢立科孙梅苗梦璐张孟娇郝晓凤中国中医科学院眼科医院北京100091

目的探究络治法(祛积通络方联合络刺)对视网膜分支静脉阻塞(branch retinal vein occlusion,BRVO)继发黄斑水肿(macular edema,ME)微血管的保护作用。方法收集2018年10月—2022年2月BRVO-ME患者147例,随机分为3组,每组49例。中药组口服... 详细信息

目的探究络治法(祛积通络方联合络刺)对视网膜分支静脉阻塞(branch retinal vein occlusion,BRVO)继发黄斑水肿(macular edema,ME)微血管的保护作用。方法收集2018年10月—2022年2月BRVO-ME患者147例,随机分为3组,每组49例。中药组口服祛积通络方;络治组在中药组的基础上穴选太冲、百会,常规消毒后三棱针点刺致少量出血;西药组玻璃体腔注射雷珠单抗眼用注射液,采取“1+PRN(按需治疗)”方案。3组均治疗3个月,随访3个月。观察每组治疗前,治疗后1个月、2个月和3个月的最佳矫正视力(best corrected visual acuity,BCVA)、视网膜浅层毛细血管丛的血流密度(vessel density of retinal superficial capillary plexus,VD-SCP)、视网膜深层毛细血管丛的血流密度(vessel density of retinal deep capillary plexus,VD-DCP)、黄斑中心凹无血管区(foveal avascular zone,FAZ)面积的变化。结果最终有效病例135例,络治组46例,中药组44例,西药组45例。(1)最小分辨角对数(logMAR)的BCVA:治疗后3个月,组内比较,3组较治疗前差异具有统计学意义(P0.05)。(2)VD-SCP:治疗后3个月,组内比较,3组较治疗前差异具有统计学意义(P0.05)。(3)VD-DCP:治疗后3个月,组内比较,3组较治疗前差异具有统计学意义(P0.05)。(4)FAZ面积:治疗后3个月,组内比较,3组较治疗前差异具有统计学意义(P0.05)。(5)安全性:无不良事件发生。结论3组在改善VD-SCP、VD-DCP、FAZ面积上临床疗效相当。3组均可提升BCVA,其中络治组优于中药组和西药组。

关键词：视网膜静脉阻塞黄斑水肿微血管

不同CRISPR-Cas12f系统的编辑效率比较

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作物学报 2024年第10期50卷 2425-2434页

作者：黄灵芝符晓祁显涛刘昌林谢传晓吴鹏昊任姣姣朱金洁新疆农业大学农学院新疆乌鲁木齐830052 中国农业科学院作物科学研究所北京100081

来自Type V-F家族的CRISPR/Cas12f蛋白报道仅为Cas9蛋白分子的1/4到1/3大小,在病毒载体的递送上具有重要优势。然而,CRISPR/Cas12f系统介导植物基因编辑的报道较少,编辑活性相对较低,限制了该系统在植物上的进一步应用。本研究分别在体... 详细信息

来自Type V-F家族的CRISPR/Cas12f蛋白报道仅为Cas9蛋白分子的1/4到1/3大小,在病毒载体的递送上具有重要优势。然而,CRISPR/Cas12f系统介导植物基因编辑的报道较少,编辑活性相对较低,限制了该系统在植物上的进一步应用。本研究分别在体外酶切、酵母以及玉米原生质体瞬时表达3个体系中比较了OsCas12f、SpCas12f及UnCas12f的编辑活性。结果表明,基于Cas12f/sgRNA的体外酶切,OsCas12f与SpCas12f蛋白的编辑活性相当,未检测到UnCas12f对底物酶切活性;在酵母突变eGFP的恢复表达试验中,OsCas12f在2个测试位点对eGFP蛋白的表达恢复效率达到95%以上,效率与Cas12i.3相当;SpCas12f介导的2个位点eGFP蛋白表达恢复效率分别是1.63%与3.20%,效果次之;UnCas12f蛋白几乎无编辑活性;玉米原生质体瞬时表达比较OsCas12f和SpCas12f介导的玉米内源位点的编辑效率,发现OsCas12f对2个位点的编辑效率分别为2.72%和1.97%,而SpCas12f仅能介导其中1个位点的定点编辑,编辑效率为1.09%。Cas12f蛋白在靶位点处引入的突变类型以碱基的缺失为主,缺失碱基长度在-9~-17 bp之间。综上,OsCas12f可以作为植物微型基因编辑器及衍生技术开发的底盘工具酶。

关键词： Cas12f sgRNA/Cas12核糖核蛋白复合体原生质体编辑效率

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