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Magnitude and direction of temperature variability affect hospitalization for myocardial infarction and stroke:population-based evidence from Guangzhou,China

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Frontiers of Environmental Science & Engineering 2024年第3期18卷 1-11页

作者： Zhou Yang Murui Zheng Ze-Lin Yan Hui Liu Xiangyi Liu Jie-qi jin Jiagang Wu Chun-Quan Ou State Key Laboratory of Organ Failure Research Department of BiostatisticsGuangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public HealthSouthern Medical UniversityGuangzhou 510515China Guangzhou Center for Disease Control and Prevention Guangzhou 510440China

Relationships between nonoptimal temperatures and cardiovascular disease(CVD)mortality have been well ***,evidence of the association between temperature variability(TV)and CVD morbidity is *** study aimed to quantify the risk and burden of CVD-related hospitalization associated with the magnitude and direction of *** on meteorology and population-based hospitalizations for myocardial infarction(MI)and stroke were collected in Guangzhou,China,from 2013 to *** temperature variability(HTV)was measured as the standard deviation of hourly temperature records over specific exposure *** direction(upward or downward)of HTV was defined as the average daily mean temperature change relative to that of the previous day during the exposure ***-Poisson regression was applied to assess the impact of HTV after adjusting for the daily mean temperature,and the hospitalization fractions attributable to HTV were calculated.A 1℃-increase in HTV was significantly associated with a 2.24%and 1.72%increase in hospitalizations for MI and hemorrhagic stroke(HS)at lag 0–1 d,respectively,and a 1.55%increase in hospitalizations for ischemic stroke(IS)at lag 0–3 *** the study period,5.99%,4.64%,and 4.53%of MI,HS,and IS hospitalizations,respectively,were attributable to *** upward TV exerts acute effects on CVD hospital admissions,whereas the impact of downward TV generally *** findings highlight the importance of the magnitude and direction of temperature fluctuations,in addition to the mean level,in assessing the adverse health impacts of temperature variations.

关键词： Hourly temperature variability Cardiovascular Hospitalization Direction China

Hyperlanins A and B, Two Highly Rearranged Meroterpenoids from Hypericum lancasteri

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Chinese Journal of Chemistry 2024年第18期42卷 2180-2186页

作者： jin-qiu You Yun-qi jin Meng-Yu Li Bo-Chao Zhang Xin-Yu Sun Chun-Yong Ding jing-Ya Li Ai-Jun Hou Shanghai Frontiers Science Center of Drug Target Identification and Delivery School of Pharmaceutical SciencesShanghai Jiao Tong UniversityShanghai200240China National Key Laboratory of Innovative Immunotherapy Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Jiao Tong University School of Medicine Shanghai 200025China Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China

Hyperlanins A(1)and B(2),two highly rearranged polycyclic polyprenylated acylphloroglucinol(PPAP)-related meroterpenoids based on different new carbon skeletons,were isolated from Hypericum *** 1 incorporates an unprecedented 5/6/7/5 ring system featuring a 3,13-dioxatetracyclo[9.***.1.12.5.01.8]pentadecane *** 2 possesses a unique compact 6/6/5/6/6/5/6 ring system with a caged tetracyclo[6.***.1.13.8.05,11]dodecane *** structures were established by spectroscopic data,X-ray diffraction,and computational *** compounds showed anti-inflammatory activity in *** 1 and 2 could decrease the lipopolysaccharide(LPS)-/nigericin-induced IL-1βrelease in THP-1 *** compounds also showed inhibition in hypoxia-inducible factor-1α(HIF-1αa)pathway luciferase reporter assay.

关键词： Natural products Hypericum lancasteri Meroterpenoids Structureelucidation Inflammation

VSe_(2)/V_(2)C heterocatalyst with built-in electric field for efficient lithium-sulfur batteries:Remedies polysulfide shuttle and conversion kinetics

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Journal of Energy Chemistry 2024年第2期89卷 397-409,I0010页

作者： Yanwei Lv Lina Bai qi jin Siyu Deng Xinzhi Ma Fengfeng Han Juan Wang Lirong Zhang Lili Wu Xitian Zhang Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of EducationSchool of Physics and Electronic EngineeringHarbin Normal UniversityHarbin 150025HeilongjiangChina

Lithium sulfur(Li-S)battery is a kind of burgeoning energy storage system with high energy ***,the electrolyte-soluble intermediate lithium polysulfides(Li PSs)undergo notorious shuttle effect,which seriously hinders the commercialization of Li-S ***,a unique VSe_(2)/V_(2)C heterostructure with local built-in electric field was rationally engineered from V_(2)C parent via a facile thermal selenization *** exquisitely synergizes the strong affinity of V_(2)C with the effective electrocatalytic activity of VSe_(2).More importantly,the local built-in electric field at the heterointerface can sufficiently promote the electron/ion transport ability and eventually boost the conversion kinetics of sulfur *** Li-S battery equipped with VSe_(2)/V_(2)C-CNTs-PP separator achieved an outstanding initial specific capacity of 1439.1 m A h g^(-1)with a high capacity retention of 73%after 100 cycles at0.1 *** impressively,a wonderful capacity of 571.6 mA h g^(-1)was effectively maintained after 600cycles at 2 C with a capacity decay rate of 0.07%.Even under a sulfur loading of 4.8 mg cm^(-2),areal capacity still can be up to 5.6 m A h cm^(-2).In-situ Raman tests explicitly illustrate the effectiveness of VSe_(2)/V_(2)C-CNTs modifier in restricting Li PSs *** with density functional theory calculations,the underlying mechanism of VSe_(2)/V_(2)C heterostructure for remedying Li PSs shuttling and conversion kinetics was *** strategy of constructing VSe_(2)/V_(2)C heterocatalyst in this work proposes a universal protocol to design metal selenide-based separator modifier for Li-S ***,it opens an efficient avenue for the separator engineering of Li-S batteries.

关键词： Li-S battery Shuttle effect Separator modifier VSe_(2)/V_(2)C heterostructure Built-in electric field

Improved Algorithm for Efficient Extraction of Relaxation Parameter Values from Wideband Permittivity of Baijiu

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Instrumentation 2024年第1期11卷 62-69页

作者： Haoyan Yu qi jin Zhaozong Meng Zhen Li College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China School of Mechanical Engineering Hebei University of TechnologyTianjin 300401China

The complex permittivity of baijiu varies with frequency,and dielectric spectroscopy has been used to evaluate the *** simplify the analysis and reduce the number of the parameters,a dielectric relaxation model is often used to fit the permittivity ***,existing fitting methods such as the least squares and particle swarm optimization methods are often computationally complex and require preset initial ***,a simpler calculation method of the relaxation parameters considering the geometric characteristics of the permittivity spectrum is *** is based on the relationship between the Cole-Cole relaxation parameters and the Cole-Cole diagram,which is fitted by a geometric ***,the concepts of the Cole-Cole parameters and the diagram are introduced,and then the process of obtaining the parameters from the complex permittivity measurement data is *** baijiu with 56%alcohol by volume(ABV)as an example,the fitting is better than the least squares method and similar to the particle swarm *** method is then used for the parameter fitting of baijiu with ABV of 42-52%,and the average error is less than 1%,demonstrating its wider ***,a prediction model is used for baijiu with 53%ABV,and the error is only 1.51%.Hence,the method can be applied to the measurement of ABV of baijiu.

关键词： permittivity cole-cole equation relaxation parameters alcohol by volume baijiu

LA-ICP-MS zircon U-Pb dating of tuffites in the Sachakou Pb-Zn mining area, Karakorum, Xinjiang and its establishment of Early Triassic strata

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China Geology 2024年第1期7卷 150-152页

作者： Xiao-jian Zhao Nuo Li Kai Weng Ming Wang qing-lin Sui Deng-hui Chen Zhou-ping Guo Meng-qi jin Xi’an Center China Geological SurveyMinistry of Natural ResourcesXi’an 710054China Xinjiang Research Center for Mineral Resources Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China College of Geography and Remote Sensing Sciences Xinjiang UniversityUrumqi 830046China University of Chinese Academy of Sciences Beijing 100029China No.8 Geological Party Xinjiang Bureau of Geology and Mineral Exploration and DevelopmentAksu 843000China School of Resource&Environment and Safety Engineering University of South ChinaHengyang 421001China

*** In the past decade,a group of medium to giant lead-zinc deposits,represented by Huoshaoyun,Sachakou,and Yuanbaoling,have been discovered in the Aksai Chin region of Karakoram,*** are all located in the Mesozoic carbonate and clastic rock *** Sachakou leadzinc mining area is adjacent to the northwest of the Huoshaoyun lead-zinc mining area and is in the same stratigraphic layer as *** many scholars have been arguing about the type and age of Huoshaoyun lead-zinc mineralization,few scholars have paid attention to the classification of the ore-bearing strata in the *** stratigraphy of the Lower Permian Shenxianwan Group to the Upper Cretaceous Tielongtan Group is exposed in the Sachakou area of Karakorum,Xinjiang,however,the Late Permian-Early Triassic stratigraphy is missing(Fig.1a).Due to the harsh natural conditions in the area and the low level of work,the stratigraphic delineation is not exhaustive,and the regional lithology is dominated by carbonates and clastic rocks,which makes it difficult to identify the age of the regional lithology and causes problems for the exploration and research of lead-zinc in the area.

关键词： strata Triassic Xinjiang

Vonoprazan-amoxicillin dual therapy for Helicobacter pylori eradication in Chinese population:A prospective,multicenter,randomized,two-stage study

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World Journal of Gastroenterology 2024年第27期30卷 3304-3313页

作者： Xue-Ping Huang Zhi-Hui Lin Yi-Juan Liu Shao-Wei Lin Yan-Feng Shao Feng qiu qing-Wu qiu Zhang-Kun Xu jin-Xian Chen Liang-Huo Chen Zhen-Qun Lin Wen-Hua Dai Ming-qing Zhang qi Jiang Zhong-qin Xiao Xian-Xing Cheng Xiang-Fei Zhang Wen-Bin You Wei Chen Long-qin Li Wei-Xing Lin Yong-Fu Wang Fu-jin Lai Long-Qun Chen Zhong-Hua Huang Wen-qi Zheng jin-qi Wei Department of Gastroenterology Shengli Clinical Medical College of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Fujian Provincial HospitalFuzhou 350001Fujian ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina School of Public Health Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Gastroenterology The Third People’s Hospital of Fujian ProvinceFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Fujian Provincial Hospital North Brance Fujian Provincial Geriatric HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Xiaoao HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology The General Hospital of Fujian Energy GroupFuzhou 350000Fujian ProvinceChina Department of Gastroenterology The Second Hospital of ZhangzhouZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology Anxi Country HospitalQuanzhou 362000Fujian ProvinceChina Department of Gastroenterology Zhangzhou Municipal Hospital of TCMZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology Zhangpu HospitalZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology The Affiliated Dongnan Hospital of Xiamen UniversityZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology First Hospital of Nanping CityNanping 353000Fujian ProvinceChina Department of Gastroenterology Fujian Nanping Second HospitalNanping 353000Fujian ProvinceChina Department of Gastroenterology Wuyishan Municipal HospitalNanping 353000Fujian ProvinceChina Department of Gastroenterology Fuzhou Changle District HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Changle City Second HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Jinjiang Municipal HospitalQuanzhou 362000Fujian ProvinceChina Department of Gastroenterology Fuding Hospital Affiliated to Fuj

BACKGROUND The efficacy of Vonoprazan-amoxicillin dual therapy(VAT)in the treatment of Helicobacter pylori(***)is *** To evaluate the efficacy of VAT in the Chinese *** This prospective,multicenter,randomized,open-label,and two-stage study was conducted at 23 centers in Fujian,China(May 2021-April 2022).***-infected patients were randomized to bismuth quadruple therapy(BQT),BQT-Vonoprazan(BQT-V),seven-day VAT(VAT-7),ten-day VAT(VAT-10),and fourteen-day VAT(VAT-14)*** primary endpoint was the *** eradication *** secondary endpoint was the frequency of adverse *** study was registered with the Chinese Clinical Trial Registry,*** In the first stage,VAT-7 and BQT-V groups were selected for early termination because less than 23 among 28 cases were *** the second stage,the eradication rates for BQT,VAT-10,and VA-14 were 80.2%[95%confidence interval(95%CI):71.4%-86.8%],93.2%(86.6%-96.7%),92.2%(85.3%-96.0%)in the intention-to-treat(ITT)analysis,and 80.9%(95%CI:71.7%-87.5%),94.0%(87.5%-97.2%),and 93.9%(87.4%-97.2%)in the per-protocol *** ITT analysis showed a higher eradication rate in the VAT-10 and VAT-14 groups than in the BQT group(P=0.022 and P=0.046,respectively).The incidence of adverse events in the VAT-10 and VAT-14 groups was lower than in the BQT group(25.27%and 13.73%vs 37.62%,respectively;P<0.001).CONCLUSION VAT with a duration of 10 or 14 days achieves a higher eradication rate than the BQT,with a more tolerable safety profile in ***-infected patients in *** XP et *** for *** eradication.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Bismuth quadruple therapy

Rare earth element-modified MOF materials:synthesis and photocatalytic applications in environmental remediation

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Rare Metals 2024年第4期43卷 1390-1406页

作者： Shu-Kun Le qi-Jie jin Jia-Ao Han Hua-Cong Zhou Quan-Sheng Liu Fu Yang Jie Miao Pei-Pei Liu Cheng-Zhang Zhu Hai-Tao Xu Inner Mongolia Key Laboratory of High-Value Functional Utilization of Low Rank Carbon Resources Chemical Engineering CollegeInner Mongolia University of TechnologyHohhot010050China School of Environmental Science and Engineering Nanjing Tech UniversityNanjing210009China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang212100China Institut National de la Recherche Scientifique-Énergie Matériaux et Télécommunications MontrealQCJ3X 1P7Canada

Metal-organic framework-like materials(MOFs)have been developed in the fields of photocatalysis for their excellent optical properties and physicochemical properties,including environmental remediation,CO_(2)photoreduction,water splitting,and so *** their important roles in various fields,rare earth elements have received growing interests from *** MOFs with rare earth elements for modification allows broadening the absorption spectrum,while the active electrons on their empty 4f orbitals can act as traps to capture photoexcited carriers to inhibit the recombination of electron-hole pairs,thus promoting photocatalytic ***,rare earth elements modified MOFs provide an attractive way to achieve their high value *** this mini-review,the synthesis of rare earth element-modified MOFs photocatalysts and corresponding applications in the removal of antibiotics,CO_(2)reduction,and hydrogen production are constructively summarized and ***,the latest advancements and current difficulties of these materials as well as the application prospects are also provided.

关键词： Rare earth metals MOFs Photocatalytic CO_(2) reduction Environmental remediation Water splitting

FDX1 as a novel biomarker and treatment target for stomach adenocarcinoma

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1803-1824页

作者： Xian-Ze Xie Lei Zuo Wei Huang qiao-Mei Fan Ya-Yun Weng Wen-Dong Yao Jia-Li Jiang Jia-qi jin Department of Pharmacy The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou 310018Zhejiang ProvinceChina Anhui Province Huainan City Shou County Agricultural Machinery Affairs Management Center Huainan 232200Anhui ProvinceChina

BACKGROUND Stomach adenocarcinoma(STAD)is one of the main reasons for cancer-related deaths *** investigation aimed to define the connection between STAD and Cuproptosis-related genes(CRGs).Cuproptosis is a newly identified form of mitochondrial cell death triggered by *** To explore the identification of potential biomarkers for STAD disease based on *** A predictive model using Gene Ontology(GO),Least Absolute Shrinkage and Selection Operator(LASSO),Kyoto Encyclopedia of Genes and Genomes(KEGG),Gene Set Variation Analysis(GSVA),and Gene Set Enrichment Analysis analyzed gene interconnections,focusing on 3 copper-related genes and their expression in The Cancer Genome *** for mRNA-miRNA and mRNA-transcription factor interactions were *** prognostic significance of CRG scores was evaluated using time-receiver operating characteristic,Kaplan-Meier curves,and COX regression *** was conducted with datasets GSE26942,GSE54129,and *** of copper-related differ-entially expressed genes was also analyzed in various human tissues and gastric cancer subpopulations using the human protein *** Three significant genes(FDX1,LIAS,MTF1)were identified and selected via LASSO analysis to predict and classify individuals with STAD into high and low CRG score *** genes were down-regulated in both risk *** and KEGG analyses highlighted their involvement mainly in the electron transport *** validating their differential expression,FDX1 emerged as the most accurate diagnostic marker for gastric ***,the RCircos package localized FDX1 on chromosome *** Our study revealed that FDX1 could be a potential biomarker and treatment target for gastric malignancy,providing new ideas for further scientific research.

关键词： Stomach adenocarcinoma disease Copper death FDX1 prognostic biomarkers Cuproptosis-related genes

基于时空最优低维动力系统的多尺度可压缩湍流数值模拟方法

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应用数学和力学 2024年第3期45卷 318-336页

作者：齐进吴锤结北京应用物理与计算数学研究所北京100088 大连理工大学力学与航空航天学院辽宁大连116024

按照周培源教授关于研究湍流数值模拟建模时必须分析和求解脉动速度场的思想,该研究基于第一性原理,系统地建立了基于时空低维最优动力系统的多尺度可压缩湍流数值模拟方法(LMS方法),并将其应用于多次冲击Richtmyer-Meshkov问题的数值... 详细信息

按照周培源教授关于研究湍流数值模拟建模时必须分析和求解脉动速度场的思想,该研究基于第一性原理,系统地建立了基于时空低维最优动力系统的多尺度可压缩湍流数值模拟方法(LMS方法),并将其应用于多次冲击Richtmyer-Meshkov问题的数值模拟中,首次得到了可压缩湍流的中尺度流场和不同于DNS近似解的湍流近似解.数值结果表明,LMS方法可以用较少的网格获得更精确的湍流近似解.首先解决了研究中遇到的几个问题,为LMS方法的构建铺平了道路.这些问题是:基于湍流的物理特性,提出了湍流大、中、小尺度分解的新概念;找到了box滤波空间相关性的计算方法;指出了湍流建模理论中长期存在的逻辑错误,提出了多尺度湍流模型的概念;讨论了湍流封闭问题的本质和关键,给出了克服湍流封闭问题的数值方法.采用box滤波方法/空间网格平均方法且在大尺度网格的意义下,LMS方法的本质是一种将RANS、LES、DES和DNS等湍流数值模拟方法统一的全新湍流数值模拟方法.需要指出的是,LMS方法也可以作为湍流模型研究的辅助工具,以检验SGS尺度方程/脉动方程中各项所对应的湍流模型是否正确.

关键词：周培源对湍流研究的开拓性贡献时空最优低维动力系统 LMS方法多尺度湍流模型可压缩湍流