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Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang yong-hao Chen Jing-Yu Tang Rui-Rui fan qiang Li Gong Li Dong Liu zheng-Yao Jin Xing-Zhu Cui Tian-Xiang Chen Yi-Wei yang Rong Liu Han Yi yang Li zhen yang qi An hao-fan Bai jiang-Bo Bai Jie Bao Ping Cao qi-Ping Chen zhen Chen Zeng-qi Cui An-Chuan fan Chang-qing feng fan-zhen feng Ke-qing Gao Min-hao gu Chang-Cai Han zi-Jie Han guo-Zhu He yong-Cheng He yang Hong Yi-Wei Hu Han-Xiong Huang Wei-Hua Jia hao-yu jiang Wei jiang zhi-jie jiang Ling Kang Bo Li Chao Li Jia-Wen Li Xiao Li Jie Liu Shu-Bin Liu guang-Yuan Luan Chang-Jun Ning Bin-Bin qi Jie Ren zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun zhi-Xin Tan Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-guang Wu Xuan Wu Li-Kun Xie yong-Ji Yu guo-Hui zhang Lin-hao zhang Mo-Han zhang qi-Wei zhang Xian-Peng zhang Yu-Liang zhang Yue zhang zhi-yong zhang Mao-Yuan Zhao Lu-Ping Zhou zhi-hao Zhou Ke-Jun Zhu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the China Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： qiang Li Li‑Jiao Wang Jing‑Yu Tang Xiang‑Biao qiu zhen Chen Mao‑Yuan Zhao Chang‑Jun Ning Kai Pan Wei Xu Tao Li Su‑Peng Lu Han Yi Rui‑Rui fan Chang‑qing feng Rong zhang Xiao‑yang Sun qi An hao‑fan Bai jiang‑Bo Bai Jie Bao Ping Cao qi‑Ping Chen yong‑hao Chen Zeng‑qi Cui An‑Chuan fan fan‑zhen feng Min‑hao gu Chang‑Cai Han zi‑Jie Han guo‑Zhu He yong‑Cheng He yang Hong Yi‑Wei Hu Han‑Xiong Huang Wei jiang zhi‑Jie jiang zheng‑Yao Jin Ling Kang Bo Li Gong Li Xiao Li yang Li Jie Liu Rong Liu Shu‑Bin Liu Yi‑Na Liu guang‑Yuan Luan Jie Ren zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Kang Sun zhi‑Xin Tan Sheng‑Da Tang Jin‑Cheng Wang Peng‑Cheng Wang Zhao‑Hui Wang Zhong‑Wei Wen Xiao‑guang Wu Xuan Wu Cong Xia yong‑Ji Yu guo‑Hui zhang Hang‑Chang zhang Lin‑hao zhang qi‑Wei zhang Xian‑Peng zhang Yu‑Liang zhang Yue zhang zhi‑yong zhang zhi‑hao Zhou Ke‑Jun Zhu Chong Zou Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and Technology(Nanjing)Research Institute Co.Ltd Nanjing 211106China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China China Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China China Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the China Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification

Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： qiang Li Li‑Jiao Wang Xiang‑Biao qiu Jing‑Wen Li Wei Xu Tao Li Ze‑Bin Lin Chang‑Jun Ning yong‑hao Chen Rui‑Rui fan Kang Sun Jing‑Yu Tang Rong zhang Han‑Tao Jing Bo Mei qi An hao‑fan Bai jiang‑Bo Bai Jie Bao Ping Cao qi‑Ping Chen zhen Chen Zeng‑qi Cui An‑Chuan fan Chang‑qing feng fan‑zhen feng Ke‑qing Gao Min‑hao gu Chang‑Cai Han zi‑Jie Han guo‑Zhu He yong‑Cheng He yang Hong Yi‑Wei Hu Han‑Xiong Huang Wei‑Hua Jia hao‑Yu jiang Wei jiang zhi‑Jie jiang zheng‑Yao Jin Ling Kang Bo Li Chao Li Gong Li Jia‑Wen Li Xiao Li yang Li Jie Liu Rong Liu Shu‑Bin Liu guang‑Yuan Luan Bin‑Bin qi Jie Ren zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song zhi‑Xin Tan Sheng‑Da Tang Peng‑Cheng Wang Zhao‑Hui Wang Zhong‑Wei Wen Xiao‑guang Wu Xuan Wu Li‑Kun Xie Yi‑Wei yang Han Yi yong‑Ji Yu guo‑Hui zhang Lin‑hao zhang Mo‑Han zhang qi‑Wei zhang Xian‑Peng zhang Yu‑Liang zhang Yue zhang zhi‑yong zhang Mao‑Yuan Zhao Lu‑Ping Zhou zhi‑hao Zhou Ke‑Jun Zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the China Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons

基于白光中子源的^(197)Au中子辐射俘获截面测量及共振参数分析

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物理学报 2024年第7期73卷 104-113页

作者：罗淏天张奇玮栾广源王晓宇邹翀任杰阮锡超贺国珠鲍杰孙琪黄翰雄王朝辉吴鸿毅顾旻皓余滔解立坤陈永浩安琪白怀勇鲍煜曹平陈昊磊陈琪萍陈裕凯陈朕崔增琪樊瑞睿封常青高可庆韩长材韩子杰何泳成洪杨黄蔚玲黄锡汝季筱璐吉旭阳蒋伟江浩雨姜智杰敬罕涛康玲康明涛李波李超李嘉雯李论李强李晓李样刘荣刘树彬刘星言穆奇丽宁常军齐斌斌任智洲宋英鹏宋朝晖孙虹孙康孙晓阳孙志嘉谭志新唐洪庆唐靖宇唐新懿田斌斌王丽娇王鹏程王琦王涛峰文杰温中伟吴青彪吴晓光吴煊羊奕伟易晗于莉于永积张国辉张林浩张显鹏张玉亮张志永赵豫斌周路平周祖英朱丹阳朱科军朱鹏朱兴华中国原子能科学研究院核数据重点实验室北京102413 中国科学院高能物理研究所北京100049 散裂中子源科学中心东莞523803 核探测与核电子学国家重点实验室北京100049 中国科学技术大学近代物理系核探测与核电子学国家重点实验室合肥230026 北京大学物理学院核物理与核技术国家重点实验室北京100871 中国工程物理研究院核物理与化学研究所绵阳621900 西北核技术研究院西安710024 中国科学院大学北京100049 中国科学技术大学工程与应用物理系合肥230026 北京航空航天大学物理学院北京100083 华能山东石岛湾核电有限公司荣成264312

中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室... 详细信息

中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室建立了伽马全吸收装置(Gamma total absorption facility,GTAF),该装置用28块六棱BaF_(2)晶体和12块五棱BaF_(2)晶体构成了外径25 cm,内径10 cm的球壳,覆盖了95.2%的立体角.利用GTAF在中国散裂中子源Back-n束线上,测量了197Au(n,γ)的反应截面数据.测量数据通过能量筛选、PSD方法、晶体多重性筛选进行了初步本底扣除,随后结合对^(nat)C及空样品的测量数据对本底进行了分析及扣除,获得了197Au俘获反应的产额,利用SAMMY程序拟合得到了^(197)Au在1—100 e V的共振能量、中子共振宽度和伽马共振宽度参数.实验测量结果与ENDF/B-VIII.0数据库符合良好,其共振参数存在一定差异,分析原因可能与GTAF能量分辨率、Back-n的中子能谱测量精度、以及实验本底扣除方法相关,这也是下一步工作的重点.

关键词：中子辐射俘获截面共振参数白光中子源伽马全吸收装置

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SAPT:a synchrotron-based proton therapy facility in Shanghai

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Nuclear Science and Techniques 2023年第10期34卷 36-46页

作者： Man-Zhou zhang De-Ming Li Li-Ren Shen Hai-Rong zhang zhi-Ling Chen Han-Wen Du Ming gu Rui Li De-Kang Liu Yue-Hu Pu Jun-feng Yu jian-feng Chen Chu Chen Chun-Long guo hao guo Ge-yang jiang zhi-qiang jiang Lin Jin Wen-Jing Li Xiu-fang Li Ye Lin Ming Liu yong-hao Liu Ya-Juan Liu Ming Lv qing-Ru Mi Lian-Hua Ouyang Wei-guo Shi Hang Shu qi-Sheng Tang Kun Wang zhi-Shan Wang Jun Wu Xiao-Bing Wu Jia-qiang Xu Wen-zhen Xu Chong-Xian Yin Cheng Yu Ren-Xian Yuan qi-Bing Yuan Hai-Qun zhang Miao zhang Wen-zhi zhang Li-ying Zhao Wei-Min Zhou Shou-Xian fang Xi-Dong Sun zhen-Tang Zhao Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China APACTRON Particle Equipment Co. Ltd.Shanghai 201815China The Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Because of its excellent dose distribution,proton therapy is becoming increasingly popular in the medical application of cancer treatment.A synchrotron-based proton therapy facility was designed and constructed in *** synchrotron,beam delivery system,and other technical systems were commissioned and reached their expected *** a clinical trial of 47 patients was finished,the proton therapy facility obtained a registration certificate from the National Medical Products *** characteristics of the accelerator and treatment systems are described in this article.

关键词： Proton therapy Synchrotron Slow extraction Gantry Beam delivery system

Measurement of the ^(232)Th(n,f)cross section in the 1-200 MeV range at the CSNS Back-n

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Nuclear Science and Techniques 2023年第8期34卷 142-153页

作者： zhi-Zhou Ren Yi-Wei yang yong-hao Chen Rong Liu Bang-Jiao Ye Jie Wen Hai-Rui guo zi-Jie Han qi-Ping Chen Zhong-Wei Wen Wei-Li Sun Han Yi Xing-Yan Liu Tao Ye jiang-Bo Bai qi An Jie Bao Yu Bao Ping Cao hao-Lei Chen zhen Chen Zeng-qi Cui Rui-Rui fan Chang-qing feng Ke-qing Gao Xiao-Long Gao Min-hao gu Chang-Cai Han guo-Zhu He yong-Cheng He yang Hong Yi-Wei Hu Han-Xiong Huang Xi-Ru Huang hao-Yu jiang Wei jiang zhi-Jie jiang Han-Tao Jing Ling Kang Bo Li Chao Li Jia-Wen Li qiang Li Xiao Li yang Li Jie Liu Shu-Bin Liu Ze Long guang-Yuan Luan Chang-Jun Ning Meng-Chen Niu Bin-Bin qi Jie Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun zhi-Jia Sun zhi-Xin Tan Jing-Yu Tang Xin-Yi Tang Bin-Bin Tian Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Xiao-guang Wu Xuan Wu Li-Kun Xie Xiao-Yun yang Li Yu Tao Yu yong-Ji Yu guo-Hui zhang Lin-hao zhang qi-Wei zhang Xian-Peng zhang Yu-Liang zhang zhi-yong zhang Lu-Ping Zhou zhi-hao Zhou Ke-Jun Zhu Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Institute of Applied Physics and Computational Mathematics Beijing 100088China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230027China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China Department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China

The ^(232)Th(n,f)cross section is very important in basic nuclear physics and applications based on the Th/U fuel *** the time-of-flight method and a multi-cell fast-fission ionization chamber,a novel measurement of the^(232)Th(n,f)cross sec-tion relative to^(235)U in the 1–200 MeV range was performed at the China Spallation Neutron Source Back-n white neutron source(Back-n).The fission event-neutron energy spectra of^(232)Th and^(235)U fission cells were measured in the single-bunch *** 232Th/235U fission cross-sectional ratios were obtained,and the measurement uncertainties were 2.5–3.7%for energies in the 2–20 MeV range and 3.6–6.2%for energies in the 20–200 MeV ***^(232)Th(n,f)cross section was obtained by introducing the standard cross section of^(235)U(n,f).The results were compared with those of previous theoreti-cal calculations,measurements,and *** measured 232Th fission cross section agreed with the main evaluation results in terms of the experimental uncertainty,and 232Th fission resonances were observed in the 1–3 MeV *** present results provide^(232)Th(n,f)cross-sectional data for the evaluation and design of Th/U cycle nuclear systems.

关键词： 232Th(n f)cross section fast-fission ionization chamber Back-n white neutron source

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu yang guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun zhi-Cheng Jin jian-jian Chen Nai-jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-zhi gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao jian-Bing Wu Song Wang Xu Zhu jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing yong fan Hai-Lan Lin zi-Shu zhang guo-Hui Xu Wen-hao Hu qiang Tu Hong-ying Su Chuan-Sheng zheng yong Chen Xu-Ya Zhao Zhu-Ting fang qi Wang Jin-Wei Zhao Ai-Bing Xu jian Xu qing-Hua Wu Huan-zhang Niu jian Wang feng Dai Dui-Ping feng qing-Dong Li Rong-Shu Shi Jia-Rui Li guang yang Hai-Bin Shi jian-Song Ji Yu-E Liu zheng Cai Po yang yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China Department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China Department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China Department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China Department of Interventional Radiology Nantong First People’s HospitalNantong 226001China Department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China Department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China Department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. Department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China Department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China Department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China Department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,228 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,*** results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching

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上方宽蒂垂直切口乳房缩小成形术

中华整形外科杂志 2009年第6期25卷 416-419页

作者：亓发芝张勇顾建英冯自豪杨震施越东复旦大学附属中山医院整形外科上海200032

目的探讨一种减少患者乳头乳晕坏死的上方宽蒂垂直切口乳房缩小成形术。方法采用kiour穹窿顶式手术设计，切除乳房下方的皮肤、腺体，乳头乳晕以上方真皮腺体组织宽蒂抬高到正常位置，进行乳房塑形，术后仅留有垂直瘢痕。结果采用上方... 详细信息

目的探讨一种减少患者乳头乳晕坏死的上方宽蒂垂直切口乳房缩小成形术。方法采用kiour穹窿顶式手术设计，切除乳房下方的皮肤、腺体，乳头乳晕以上方真皮腺体组织宽蒂抬高到正常位置，进行乳房塑形，术后仅留有垂直瘢痕。结果采用上方宽蒂垂直切口方法行乳房缩小成形术46例，其中4例为单侧乳房缩小，手术效果满意，乳房形态良好。14侧乳房切口部分裂开，其中3侧经清创缝合愈合，其余经换药后愈合，无乳头乳晕坏死发生。结论上方宽蒂垂直切口乳房缩小成形术效果良好，减少了乳头乳晕坏死的危险，值得推广应用。

关键词：乳房缩小成形术乳房过大

Back-n white neutron source at CSNS and its applications

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Nuclear Science and Techniques 2021年第1期32卷 95-104页

作者： Jing-Yu Tang qi An jiang-Bo Bai Jie Bao Yu Bao Ping Cao hao-Lei Chen qi-Ping Chen yong-hao Chen zhen Chen Zeng-qi Cui Rui-Rui fan Chang-qing feng Ke-qing Gao Xiao-Long Gao Min-hao gu Chang-Cai Han zi-Jie Han guo-Zhu He yong-Cheng He yang Hong Yi-Wei Hu Han-Xiong Huang Xi-Ru Huang hao-Yu jiang Wei jiang zhi-Jie jiang Han-Tao Jing Ling Kang Bo Li Chao Li Jia-Wen Li qiang Li Xiao Li yang Li Jie Liu Rong Liu Shu-Bin Liu Xing-Yan Liu Ze Long guang-Yuan Luan Chang-Jun Ning Meng-Chen Niu Bin-Bin qi Jie Ren zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun zhi-Jia Sun zhi-Xin Tan Xin-Yi Tang Bin-Bin Tian Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-guang Wu Xuan Wu Li-Kun Xie Xiao-Yun yang Yi-Wei yang Han Yi Li Yu Tao Yu yong-Ji Yu guo-Hui zhang Lin-hao zhang qi-Wei zhang Xian-Peng zhang Yu-Liang zhang zhi-yong zhang Lu-Ping Zhou zhi-hao Zhou Ke-Jun Zhu 无 State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China Department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China The CSNS Back-n Collaboration

Back-streaming neutrons from the spallation target of the China Spallation Neutron Source(CSNS)that emit through the incoming proton channel were exploited to build a white neutron beam facility(the so-called Back-n white neutron source),which was completed in March *** Back-n neutron beam is very intense,at approximately 29107 n/cm2/s at 55 m from the target,and has a nominal proton beam with a power of 100 kW in the CSNS-I phase and a kinetic energy of 1.6 GeV and a thick tungsten target in multiple slices with modest moderation from the cooling water through the *** addition,the excellent energy spectrum spanning from 0.5 eV to 200 MeV,and a good time resolution related tothe time-of-flight measurements make it a typical white neutron source for nuclear data measurements;its overall performance is among that of the best white neutron sources in the *** with advanced spectrometers,detectors,and application utilities,the Back-n facility can serve wide applications,with a focus on neutron-induced cross-sectional *** article presents an overview of the neutron beam characteristics,the experimental setups,and the ongoing applications at Backn.

关键词： White neutron source Nuclear data measurements Experimental setups Neutron applications