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Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu yang guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun zhi-Cheng Jin jian-jian Chen Nai-jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-zhi gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao jian-Bing Wu Song Wang Xu Zhu jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing yong fan Hai-Lan Lin zi-Shu zhang guo-Hui Xu Wen-hao Hu qiang Tu Hong-ying Su Chuan-Sheng zheng yong Chen Xu-Ya Zhao Zhu-Ting fang qi Wang Jin-Wei Zhao Ai-Bing Xu jian Xu qing-Hua Wu Huan-zhang Niu jian Wang feng Dai Dui-Ping feng qing-Dong Li Rong-Shu Shi Jia-Rui Li guang yang Hai-Bin Shi jian-Song Ji Yu-E Liu zheng Cai Po yang yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China Department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China Department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China Department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China Department of Interventional Radiology Nantong First People’s HospitalNantong 226001China Department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China Department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China Department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. Department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China Department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China Department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China Department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,228 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,*** results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching

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Data release of the LAMOST pilot survey

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Research in Astronomy and Astrophysics 2012年第9期12卷 1243-1246页

作者： A-Li Luo hao-Tong zhang yong-Heng Zhao Gang Zhao Xiang-Qun Cui guo-Ping Li Yao-Quan Chu jian-Rong Shi Gang Wang jian-Nan zhang Zhong-Rui Bai Xiao-Yan Chen feng-Fei Wang Yan-Xin guo jian-Jun Chen Bing Du Xiao Kong Ya-Juan Lei Yin-Bi Li Yi-Han Song Yue Wu Yan-Xia zhang Xin-Lin Zhou fang Zuo Peng Du Lin He Wen Hou Yi-qiao Dong jian Li guang-Wei Li Shuang Li Jing Song Yuan Tian Meng-Xin Wang yong-Hui Hou zhi-ying Huo Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Lei Jia fang-Hua jiang Xiang jiang zi-Bo jiang Ge Jin Ai-Hua Li qi Li Yin-Dun Mao zheng-Hong Tang qing-Sheng Tao Liang-Ping Tu Da-qing Wang Dan Wang jian-Ping Wang Lei Wang Shou-guan Wang Shu-qing Wang Ya-Nan Wang You Wang Yue-Fei Wang Ming-zhi Wei Xiang-Xiang Xue Xiao-zheng Xing Ling-Zhe Xu Xin-qi Xu Yan Xu De-Hua yang Shi-Hai yang zheng-qiu Yao yong Yu Hui Yuan Chao Zhai En-Peng zhang Jing zhang Li-Ping zhang Weizhang yong zhang zhen-Chao zhang Ming Zhao fang Zhou yong-Tian Zhu Jie Zhu Si-Cheng Zou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China lal @ lamost o rg Nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Technologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

This paper describes the data release of the LAMOST pilot survey, which includes data reduction, calibration, spectral analysis, data products and data access. The accuracy of the released data and the information about the FITS headers of spectra are also introduced. The released data set includes 319 000 spectra and a catalog of these objects.

关键词： techniques: spectroscopic survey — data reduction — data release

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The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-Li Luo yong-Heng Zhao Gang Zhao Li-Cai Deng Xiao-Wei Liu Yi-Peng Jing Gang Wang hao-Tong zhang jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu guo-Ping Li Zhong-Rui Bai Yue Wu Yan Cai Shu-Yun Cao zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen jian-Jun Chen Kun-Xin Chen Li Chen Xue-Lei Chen Xiao-Yan Chen ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-qiao Dong Bing Du Dong-Wei fan Lei feng jian-Ning Fu Peng Gao Xue-Fei Gong Bo-Zhong gu Yan-Xin guo Zhan-Wen Han Bo-Liang He Jin-Liang Hou yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu zhi-ying Huo Lei Jia fang-Hua jiang Xiang jiang zhi-Bo jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-Hua Li Chang-Hua Li guang-Wei Li Hai-Ning Li jian Li qi Li Shuang Li Sha-Sha Li Xin-Nan Li Yan Li Yin-Bi Li Ye-Ping Li Yuan Liang Chien-Cheng Lin Chao Liu Gen-Rong Liu guan-Qun Liu zhi-Gang Liu Wen-zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang qi yong-Jun qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-qiang Su Hong-Jun Su zheng-Hong Tang qing-Sheng Tao Yuan Tian Dan Wang Da-qi Wang feng-Fei Wang guo-Min Wang Hai Wang Hong-Chi Wang jian Wang Jia-Ning Wang jian-Ling Wang jian-Ping Wang Jun-Xian Wang Lei Wang Meng-Xin Wang Shou-guan Wang Shu-qing Wang Xia Wang Ya-Nan Wang You Wang Yue-Fei Wang You-Fen Wang Peng Wei Ming-zhi Wei Hong Wu Ke-Fei Wu Xue-Bing Wu Yu-Zhong Wu Xiao-zheng Xing Ling-Zhe Xu Xin-qi Xu Yan Xu Tai-Sheng Yan De-Hua yang Hai-feng yang Hui-qin yang Ming yang zheng-qiu Yao yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng zhang Hua-Wei zhang jian-Nan zhang Li-Pin zhang Wei zhang yong zhang Yan-Xia zhang zheng-Chao zhang Ming Zhao fang Zhou Xu Zhou Jie Zhu yong-Tian Zhu Si-Cheng Zou fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients

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Chinese Medical Journal 2013年第12期126卷 2276-2280页

作者： zhenG ying CAI guang-yan CHEN Xiang-mei FU Ping CHEN jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU jian-she HE Ya-ni DING guo-hua LI Wen-ge WU guang-li MIAO Li-ning CHEN Nan SU zhen MEI Chang-lin Zhao Jiu-yang gu yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li yang Yi-bin yang Xiao-ping LI ying WAN jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng hao Li XU Yan faNG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong zhang Jing-hong WANG jian-qin LOU Tan-qi Shao feng-min MEI feng LIU zhi-hong YUAN Wei-jie SUN Shi-ren zhang Ling ZHOU Chun-hua CHEN qin-kai JIA Shun-lian GONG zhi-feng guAN guang-ju XIA Tian ZHONG Liang-bao Department of Nephrology State key Laboratory of Kidney Disease Chinese PLA General Hospital Beijing 100853 China Nephrology Institute of the Chinese People's Liberation Army Chinese People's Liberation Army Key Laboratory of Nephrology Beijing 100853 China Department of Nephrology West China Hospital of Sichuan University Chengdu Sichuan 610041 China Department of Nephrology First Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310003 China Department of Nephrology Zhongshan Hospital Fudan University Shanghai 200032 China Department of Nephrology First Affiiated Hospital of Sun Yat-sen University Guangzhou Guangdong 510080 China Department of Nephrology First Affiliated Hospital of Dalian Medical University Dalian Liaoning 116011 China Department of Nephrology First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang 830054 China Department of Nephrology First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Nephrology First Afftiated Hospital of China Medical University Shenyang Liaoning 110001 China Department of Nephrology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200025 China Department of Nephrology Second Xiangya Hospital Central South University Changsha Hunan 410000 China Department of Nephrology First Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an Shaanxi 710061 China Department of Nephrology First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital) Nanjing Jiangsu 210029 China Department of Nephrology Sichuan Provincial People's Hospital Chengdu Sichuan 610072 China Department of Nephrology Guangdong Provincial People's Hospital Guangzhou Guangdong 510030 China Department of Nephrology Affliated Xiehe Hospital Tongji Medical College Huazhong Science and Technology University Wuhan Hubei 430022 China Department of Nephrology Daping Hospital Third Military Medi

Background Data on the epidemiology of hypertension in Chinese non-dialysis chronic kidney disease （CKD） patients are *** aim of the present study was to investigate the prevalence,awareness,treatment,and control of hypertension in the non-dialysis CKD patients through a nationwide,multicenter study in *** The survey was performed in 61 tertiary hospitals in 31 provinces,municipalities,and autonomous regions in China （except Hong Kong,Macao,and Taiwan）.Trained physicians collected demographic and clinical data and measured blood pressure （BP） using a standardized *** was defned as systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg,and/or use of antihypertensive *** 〈140/90 mmHg and 〈130/80 mmHg were used as the 2 thresholds of hypertension *** multivariate logistic regression with adjustment for sex and age,we analyzed the association between CKD stages and uncontrolled hypertension in non-dialysis CKD *** The analysis included 8927 non-dialysis CKD *** prevalence,awareness,and treatment of hypertension in non-dialysis CKD patients were 67.3%,85.8%,and 81.0%,*** hypertensive CKD patients,33.1% and 14.1% had controlled BP to 〈140/90 mmHg and 〈130/80 mmHg,*** successive CKD stages,the prevalence of hypertension in non-dialysis CKD patients increased,but the control of hypertension decreased （P〈0.001）.When the threshold of BP 〈130/80 mmHg was considered,the risk of uncontrolled hypertension in CKD 2,3a,3b,4,and 5 stages increased 1.3,1.4,1.4,2.5,and 4.0 times compared with CKD 1 stage,respectively （P〈0.05）.Using the threshold of 〈140/90 mmHg,the risk of uncontrolled hypertension increased in advanced stages （P〈0.05）.Conclusions The prevalence of hypertension Chinese non-dialysis CKD patients was high,and the hypertension control was *** successive CKD stages,the risk of uncontrolled hypertension increased.

关键词： non-dialysis chronic kidney disease chronic kidney disease stages hypertension epidemiology

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基于单中心的局部巨大乳腺癌手术切除后胸壁重建及巨大创面修复策略

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中国临床医学 2018年第2期25卷 182-187页

作者：朱明马晓飞杨燕文张勇冯自豪亓发芝顾建英复旦大学附属中山医院整形外科上海200032 御颜医疗美容诊所北京100000

目的:基于单中心11年的临床实践探讨局部巨大乳腺癌(locally advanced breast cancer,LABC)手术切除后胸壁重建及巨大创面修复策略。方法:回顾性分析2006年3月至2017年8月收治的252例LABC患者的临床资料,其中197例为原发肿瘤,55例为复... 详细信息

目的:基于单中心11年的临床实践探讨局部巨大乳腺癌(locally advanced breast cancer,LABC)手术切除后胸壁重建及巨大创面修复策略。方法:回顾性分析2006年3月至2017年8月收治的252例LABC患者的临床资料,其中197例为原发肿瘤,55例为复发肿瘤。所有患者术前均接受新辅助化疗。入院后完善相关术前检查后行乳腺肿块切除手术及术后创面修复重建,观察手术相关指标及患者术后远期预后,总结临床诊疗经验。结果:患者均为女性,年龄38~67岁,平均(47.5±9.2)岁,均为单侧,左侧肿物137例(54.4%),右侧肿物115例(45.6%)。所有患者乳腺肿瘤均顺利切除,住院时间9~45d,平均(12.9±3.4)d,术后随访5~72个月,平均(18.7±9.6)个月。平均手术时长(3.8±1.7)h,术中平均出血(348.4±106.6)mL。肿物面积最大为30cm×25cm,最小为5cm×13cm,合并胸骨或肋骨缺损71例(28.2%),其中30例无需钛网修复,41例应用个性化钛网重建胸壁。修复软组织缺损的皮瓣面积为14cm×6cm^29cm×30cm,应用带蒂背阔肌肌皮瓣98例(38.9%),腹直肌肌皮瓣56例(22.2%),侧胸壁皮瓣34例(13.5%),胸大肌肌皮瓣及乳房瓣31例(12.3%),游离腹壁下动脉穿支(DIEP)皮瓣17例(6.7%),局部皮瓣16例(6.3%)。所有病例均恢复良好,皮瓣外形及功能恢复满意,患者生活质量明显改善(P<0.05)。结论:LABC患者的治疗需要多学科的协作,术前新辅助化疗的应用、术中适当扩大肿瘤切除范围、多种途径重建胸壁及修复术后巨大创面可提升患者的生存质量,改善患者预后。

关键词：局部巨大乳腺癌手术治疗胸壁缺损胸壁重建

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中国散裂中子源反角白光中子源束内伽马射线研究

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物理学报 2020年第17期69卷 61-69页

作者：任杰阮锡超陈永浩蒋伟鲍杰栾广源张奇玮黄翰雄王朝辉安琪白怀勇鲍煜曹平陈昊磊陈琪萍陈裕凯陈朕崔增琪樊瑞睿封常青高可庆顾旻皓韩长材韩子杰贺国珠何泳成洪杨黄蔚玲黄锡汝季筱璐吉旭阳江浩雨姜智杰敬罕涛康玲康明涛李波李超李嘉雯李论李强李晓李样刘荣刘树彬刘星言穆奇丽宁常军齐斌斌任智洲宋英鹏宋朝晖孙虹孙康孙晓阳孙志嘉谭志新唐洪庆唐靖宇唐新懿田斌斌王丽娇王鹏程王琦王涛峰文杰温中伟吴青彪吴晓光吴煊解立坤羊奕伟易晗于莉余滔于永积张国辉张林浩张显鹏张玉亮张志永赵豫斌周路平周祖英朱丹阳朱科军朱鹏中国原子能科学研究院核数据重点实验室北京102413 中国科学院高能物理研究所北京100049 散裂中子源科学中心东莞523803 核探测与核电子学国家重点实验室北京100049 中国科学技术大学近代物理系合肥230026 北京大学物理学院核物理与核技术国家重点实验室北京100871 中国工程物理研究院核物理与化学研究所绵阳621900 西北核技术研究所西安710024 中国科学院大学北京100049 中国科学技术大学工程与应用物理系合肥230026 北京航空航天大学物理学院北京100083

在基于白光中子源的中子核反应测量中,伴随中子束的伽马射线是重要的实验本底之一.本文对中国散裂中子源反角白光中子源的束内伽马射线进行了研究.通过蒙特卡罗模拟,得到了伽马射线的能量分布和时间结构.通过直接测量和间接测量两种方... 详细信息

在基于白光中子源的中子核反应测量中,伴随中子束的伽马射线是重要的实验本底之一.本文对中国散裂中子源反角白光中子源的束内伽马射线进行了研究.通过蒙特卡罗模拟,得到了伽马射线的能量分布和时间结构.通过直接测量和间接测量两种方法测得低能中子区的束内伽马射线的时间结构.直接测量实验中,将载6Li的ZnS(Ag)闪烁体探测器置于束流线上,通过飞行时间法直接测量束内的中子和伽马射线的时间结构,并利用波形甄别技术进行粒子鉴别.间接测量法是将铅样品置于束流线上,利用C6D6闪烁体探测器测量样品上的散射伽马射线,从而得到入射伽马射线的时间结构.实验测量结果与模拟结果在12μs—2.0 ms的时间区间内具有较好的一致性.

关键词：反角白光中子源束内伽马射线测量飞行时间法蒙特卡罗模拟

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基于反角白光中子源次级质子的探测器标定

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物理学报 2021年第8期70卷 28-36页

作者：蒋伟江浩雨易晗樊瑞睿崔增琪孙康张国辉唐靖宇孙志嘉宁常军高可庆安琪白怀勇鲍杰鲍煜曹平陈昊磊陈琪萍陈永浩陈裕凯陈朕封常青顾旻皓韩长材韩子杰贺国珠何泳成洪杨黄翰雄黄蔚玲黄锡汝季筱璐吉旭阳姜智杰敬罕涛康玲康明涛李波李超李嘉雯李论李强李晓李样刘荣刘树彬刘星言栾广源穆奇丽齐斌斌任杰任智洲阮锡超宋朝晖宋英鹏孙虹孙晓阳谭志新唐洪庆唐新懿田斌斌王丽娇王鹏程王琦王涛峰王朝辉文杰温中伟吴青彪吴晓光吴煊解立坤羊奕伟于莉余滔于永积张林浩张奇玮张显鹏张玉亮张志永赵豫斌周路平周祖英朱丹阳朱科军朱鹏中国科学院高能物理研究所北京100049 散裂中子源科学中心东莞523803 北京大学物理学院核物理与核技术国家重点实验室北京100871 核探测与核电子学国家重点实验室中国科学院大学北京100049 中国科学技术大学近代物理系合肥230026 中国原子能科学研究院核数据重点实验室北京102413 中国工程物理研究院核物理与化学研究所绵阳621900 西北核技术研究院西安710024 中国科学技术大学工程与应用物理系合肥230026 北京航空航天大学物理学院北京100083

目前国内外的质子标定终端较少,且普遍为单能质子束流.基于中国散裂中子源的反角白光中子源的eV—200 MeV中子能量区间的白光中子束流,以及中子与氢的~1H(n, el)反应,可以获得宽能谱的能量连续次级质子.利用1 GSps采样率、12 bit的波形... 详细信息

目前国内外的质子标定终端较少,且普遍为单能质子束流.基于中国散裂中子源的反角白光中子源的eV—200 MeV中子能量区间的白光中子束流,以及中子与氢的~1H(n, el)反应,可以获得宽能谱的能量连续次级质子.利用1 GSps采样率、12 bit的波形数字化获取系统采集探测器输出波形信号,通过对波形信号的分析,得到中子及反冲质子的飞行时间,进而得到反冲质子的动能.利用该方法得到的质子,为探测器质子标定等研究提供了新的研究平台.在该研究平台已经开展了带电粒子望远镜的标定实验.研究了CsI (Tl)探测器不同的信号读出方式对望远镜的DE-E二维谱、幅度-质子动能二维谱等粒子鉴别方法得到的粒子鉴别的效果,得到了较优的探测器信号读出方案.该研究为带电粒子望远镜的建设提供了实验依据,也说明了基于反角白光中子源的宽能谱质子标定的可行性.

关键词：质子标定探测器 ~1H(n,el)反应反角白光中子源

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Consensus statement on layout and delivery of automatic external defibrillator in China

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Journal of Hainan Medical University 2020年第15期26卷 18-23页

作者： Yu Cao Song Chen Yan-Fen Chai Xiao-Hui Chen Yu-guo Chen Shao-Wen Cheng Wen-Wei Cheng Bang-Han Ding yang Deng Jie Fu Bang-jiang fang Mai-ying fan Li gui Ping Gong Wei guo Shu-Bin guo Liang Huang Ji-Yuan Han Zhong Ji Xian-Fei Ji Xin-Cai Ji Hong-Xu Jin Xin-Jun jiang Wang-Xiang jiang Jia-Liang Liu Xiao-Ran Liu zhi Liu Chuan-Zhu Lv feng Lu Tan-Shi Li Xin Li yong Li Shang-Lun Li Shuang-Ming Li Xiao-Gang Li Bao-Jun Li Pei-Wu Li Chun-Sheng Li zhi-Jun Li Chang-Luo Li Xiang-Min Li Yin-Ping Li Zong-Jun Lu Zu-Xun Lu Zhong-qiu Lu zhi-qian Luo Xiao-Xing Liao jian-Bo Lei Tao Ma Yu Ma Yue-feng Ma qing-Bian Ma Lin-hao Ma Jun-qi Ma Shi-Nan Nie Jie-Miao Ou-yang Peng Peng qiao Pei Shu-Ming Pan guo-Zhong qing Li-Jie qin Wu-ying qiao Fei Shao Wei Song Xing-Yue Song zhen-Ju Song Rong-Ju Sun De-Ya Shang Du-Juan Sha gui-Lan Tao guo-Gang Tian ying-Ping Tian jian-guang Tian Chao-yang Tong zi-Ren Tang Meng-Xiong Tang guo-Ping Wu zhi Wan Tao Wang Xin Wang Peng Wang Zhong Wang Tong Wang Ri-Xing Wang Yi-Xin Wang Xiao-Dan Wang Ling Wu Wei Wei Hua Xiang feng Xu Jun Xu Jie Xu Miao-Rong Xie Shuo-gui Xu Tie Xu feng Yu Wen Yi Li-Shan yang Shi-Jiao Yan Jin-jian Yao Shou-Chun Yan Xue-Zhong Yu Xian-zhi Ye Xian-Liang Yan Fu-Bing Zhou Rong-Bin Zhou Ming Zhou qiang Zhou Jin Zhou Ping Zhou Chang-Ju Zhu Hua-Dong Zhu Ji-Hong Zhu Hong zhang Mao zhang Hua zhang Na zhang guo-qiang zhang guo-Xiu zhang Jin-Song zhang Wen-Wu zhang Wen-Zhong zhang jian-feng zhang Yi-Min Zhu Jun Zeng Yuan zheng zhi-Jie zheng Shen Zhao Yan Zhao Min Zhao Bin Zhao Xiao-Dong Zhao Xiao-Jing Zhao Hong-Ke Zeng Sheng-qiang Zou The Chinese Society of Emergency Medicine Research Unit of Island Emergency Medicine Chinese Academy of Medical SciencesHainan Medical University Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical UniversityHaikouHainanChina Emergency and Trauma College Hainan Medical UniversityHaikouHainanChina Department of Emergency Hainan Clinical Research Center for Acute and Critical DiseasesThe Second Affiliated Hospital of Hainan Medical UniversityHaikouHainanChina Key Laboratory of Hainan Trauma and Disaster Rescue Key Laboratory of Trauma of Hainan Medical University

*** Sudden cardiac death(SCD)refers to sudden death due to a variety of cardiac *** is manifested as a sudden loss of consciousness,cardiac arrest,and respiratory arrest and generally shows early symptoms that are atypical and not easily detected[1].According to a recent study,nearly 544000 patients suffer from SCD every year in China[2].

关键词： cardiac death respiratory

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基于白光中子源的^(197)Au中子辐射俘获截面测量及共振参数分析

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物理学报 2024年第7期73卷 104-113页

作者：罗淏天张奇玮栾广源王晓宇邹翀任杰阮锡超贺国珠鲍杰孙琪黄翰雄王朝辉吴鸿毅顾旻皓余滔解立坤陈永浩安琪白怀勇鲍煜曹平陈昊磊陈琪萍陈裕凯陈朕崔增琪樊瑞睿封常青高可庆韩长材韩子杰何泳成洪杨黄蔚玲黄锡汝季筱璐吉旭阳蒋伟江浩雨姜智杰敬罕涛康玲康明涛李波李超李嘉雯李论李强李晓李样刘荣刘树彬刘星言穆奇丽宁常军齐斌斌任智洲宋英鹏宋朝晖孙虹孙康孙晓阳孙志嘉谭志新唐洪庆唐靖宇唐新懿田斌斌王丽娇王鹏程王琦王涛峰文杰温中伟吴青彪吴晓光吴煊羊奕伟易晗于莉于永积张国辉张林浩张显鹏张玉亮张志永赵豫斌周路平周祖英朱丹阳朱科军朱鹏朱兴华中国原子能科学研究院核数据重点实验室北京102413 中国科学院高能物理研究所北京100049 散裂中子源科学中心东莞523803 核探测与核电子学国家重点实验室北京100049 中国科学技术大学近代物理系核探测与核电子学国家重点实验室合肥230026 北京大学物理学院核物理与核技术国家重点实验室北京100871 中国工程物理研究院核物理与化学研究所绵阳621900 西北核技术研究院西安710024 中国科学院大学北京100049 中国科学技术大学工程与应用物理系合肥230026 北京航空航天大学物理学院北京100083 华能山东石岛湾核电有限公司荣成264312

中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室... 详细信息

中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室建立了伽马全吸收装置(Gamma total absorption facility,GTAF),该装置用28块六棱BaF_(2)晶体和12块五棱BaF_(2)晶体构成了外径25 cm,内径10 cm的球壳,覆盖了95.2%的立体角.利用GTAF在中国散裂中子源Back-n束线上,测量了197Au(n,γ)的反应截面数据.测量数据通过能量筛选、PSD方法、晶体多重性筛选进行了初步本底扣除,随后结合对^(nat)C及空样品的测量数据对本底进行了分析及扣除,获得了197Au俘获反应的产额,利用SAMMY程序拟合得到了^(197)Au在1—100 e V的共振能量、中子共振宽度和伽马共振宽度参数.实验测量结果与ENDF/B-VIII.0数据库符合良好,其共振参数存在一定差异,分析原因可能与GTAF能量分辨率、Back-n的中子能谱测量精度、以及实验本底扣除方法相关,这也是下一步工作的重点.

关键词：中子辐射俘获截面共振参数白光中子源伽马全吸收装置

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基于CSNS反角白光中子源的中子俘获反应截面测量技术研究

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物理学报 2021年第22期70卷 28-39页

作者：张奇玮栾广源任杰阮锡超贺国珠鲍杰孙琪黄翰雄王朝辉顾旻皓余滔解立坤陈永浩安琪白怀勇鲍煜曹平陈昊磊陈琪萍陈裕凯陈朕崔增琪樊瑞睿封常青高可庆韩长材韩子杰何泳成洪杨黄蔚玲黄锡汝季筱璐吉旭阳蒋伟江浩雨姜智杰敬罕涛康玲康明涛李波李超李嘉雯李论李强李晓李样刘荣刘树彬刘星言穆奇丽宁常军齐斌斌任智洲宋英鹏宋朝晖孙虹孙康孙晓阳孙志嘉谭志新唐洪庆唐靖宇唐新懿田斌斌王丽娇王鹏程王琦王涛峰文杰温中伟吴青彪吴晓光吴煊羊奕伟易晗于莉于永积张国辉张林浩张显鹏张玉亮张志永赵豫斌周路平周祖英朱丹阳朱科军朱鹏朱兴华中国原子能科学研究院核数据重点实验室北京102413 中国科学院高能物理研究所北京100049 散裂中子源科学中心东莞523803 核探测与核电子学国家重点实验室北京100049 中国科学技术大学近代物理系合肥230026 北京大学物理学院核物理与核技术国家重点实验室北京100871 中国工程物理研究院核物理与化学研究所绵阳621900 西北核技术研究院西安710024 中国科学院大学北京100049 中国科学技术大学工程与应用物理系合肥230026 北京航空航天大学物理学院北京100083 华能山东石岛湾核电有限公司荣成264312

中子俘获反应截面数据在核天体物理研究、先进核能开发中具有非常重要的应用,由于缺乏合适的白光中子源和探测装置,国内在keV能区(1 eV-100 keV)中子俘获反应截面的实验数据几乎是空白.中国原子能科学研究院核数据重点实验室建造了国内... 详细信息

中子俘获反应截面数据在核天体物理研究、先进核能开发中具有非常重要的应用,由于缺乏合适的白光中子源和探测装置,国内在keV能区(1 eV-100 keV)中子俘获反应截面的实验数据几乎是空白.中国原子能科学研究院核数据重点实验室建造了国内第一台γ全吸收型探测装置,由40块BaF_(2)探测器单元组成厚度为15 cm,内半径为10 cm的BaF_(2)晶体球壳,共覆盖了95.2%的立体角.利用升级后的装置在中国散裂中子源的反角白光中子源上建立了中子俘获反应截面在线测量技术.在不规则的φ30 mm中子束斑的实验条件下,完成首次197Au中子俘获反应截面的在线测量,利用加和能谱和多重数分布扣除本底,反演飞行时间谱得到keV能区197Au中子俘获反应截面的实验数据.通过与ENDF评价数据库相关数据的比较,共振峰位置能够很好地吻合,从而验证了测量装置和测量技术的可靠性,为下一步高精度截面数据的获取奠定基础.

关键词： γ全吸收型探测装置中子俘获反应截面中国散裂中子源白光中子源

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