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Protective effect of the extract of Yi-qi-Fu-Mai preparation on hypoxia-induced heart injury in mice

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Chinese Journal of Natural Medicines 2016年第6期14卷 401-406页

作者： FENG Ya-qian JU Ai-Chun LIU Chun-Hua WANG Ting YU Bo-Yang qi Jin State Key Laboratory of Natural Medicines China Pharmaceutical University Jiangsu Key Laboratory of TCM Evaluation and Translational Research China Pharmaceutical University Department of Technology Development Tian Jin Tasly Pride Pharmaceutical Co. Ltd.

Yi-qi-Fu-Mai(YQFM) is extensively used clinically to treat cardiovascular diseases in China. To explore the anti-hypoxia effect of the extract of YQFM preparation(EYQFM), the EYQFM(1.4, 2.8, and 5.5 g·kg-1·d-1) was assessed for its heart-protective effect in a chronic intermittent hypoxia(CIH) animal model(oxygen pressure 7%-8%, 20 min per day) for 28 days of treatment. Betaloc(0.151 6 g·kg^(-1)·d^(-1)) was used as a positive control. The histopathological analyses of heart in CIH mice were conducted. Several cardiac state parameters, such as left ventricular ejection fractions(EF), stroke volume(SV), expression of creatine kinase(CK), lactate dehydrogenase(LDH), superoxide dismutase(SOD), and malondialdehyde(MDA) were measured. The results showed that treatment with EYQFM markedly reversed swelling of the endothelial cells and vacuolization in the heart when compared with the model group. Further study demonstrated that EYQFM significantly improved ventricular myocardial contractility by increasing EF and SV. In addition, EYQFM inhibited the activity of CK, LDH, decreased the level of MDA and improved SOD activity. The results demonstrated that EYQFM significantly improved the tolerability of myocardium to hypoxia and ameliorated the cardiac damage in the CIH model.

关键词： Extract of YQFM preparation Chronic intermittent hypoxia Cardiac damage

qi-Tai-Suan, an oleanolic acid derivative, ameliorates ischemic heart failure via suppression of cardiac apoptosis, inflammation and fibrosis

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Chinese Journal of Natural Medicines 2022年第6期20卷 432-442页

作者： qiAN Ming FENG Zhi-qi ZHENG Ru-Nan HU Kai-Wen SUN Jia-Ze SUN Hong-Bin DAI Liang Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease State Key Laboratory of Natural MedicinesChina Pharmaceutical UniversityNanjing 210009China

Although anti-thrombotic therapy has been successful for prevention of deaths from acute myocardial infarction(MI),by far,there are few preventive and therapeutic options for ischemic heart failure(IHF)after ***-Tai-Suan(QTS)is an oleanolic acid(OA)derivative which once underwent a clinical trial for treating *** this study,we investigated the potential cardioprotective effect of QTS on *** mouse model was constructed by coronary artery ligation in male C57BL/6J mice,and the protective effects of QTS on IHF were examined by echocardiography measurement,histological and TUNEL analysis,*** found that QTS exhibited promising cardioprotective effect on *** treatment significantly improved cardiac function of IHF mice and the symptoms of heart ***,QTS had much better oral bioavailability(F=41.91%)in mice than its parent drug OA,and took effects mainly as its original ***,QTS ameliorated ischemic heart failure likely through suppression of cardiac apoptosis,inflammation and *** together,QTS holds great promise as a preventive and therapeutic agent for ischemic heart failure and related diseases.

关键词： Ischemic heart failure qi-Tai-Suan Apoptosis Inflammation Fibrosis

Therapeutic effects of Buzhong Yiqi decoction in patients with spleen and stomach qi deficiency after routine surgery and chemotherapy for colorectal cancer

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2183-2193页

作者： qi Hu Xiao-Pin Chen Zhi-Jun Tang Xue-Yuan Zhu Chun Liu College of Integrated Traditional Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Department of Anorectal Surgery The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Anorectal Surgery The First Traditional Chinese Medicine Hospital of ChangdeChangde 415000Hunan ProvinceChina Intensive Care Unit The First Traditional Chinese Medicine Hospital of ChangdeChangde 415000Hunan ProvinceChina

BACKGROUND According to the theory of traditional Chinese medicine(TCM),the spleen and stomach are the basis of acquired nature and the source of qi and blood *** surgery and chemotherapy,patients with colorectal cancer often develop spleen and stomach qi deficiency syndrome,leading to decreased immune *** Yiqi decoction,a classic TCM prescription,has the effect of tonifying middle-jiao and invigorating qi,boosting Yang,and suppressing immune-related ***,it is widely used in the treatment of spleen and stomach qi deficiency *** To investigate the effect of Buzhong Yiqi decoction on spleen and stomach qi deficiency in patients with colorectal *** One hundred patients with colorectal cancer who underwent preoperative chemotherapy and laparoscopy at The First TCM Hospital of Changde from January 2022 to October 2023 were retrospectively *** patients were divided equally into control and observation *** groups underwent conventional rehabilitation surgery,and the observation group was supplemented with Buzhong Yiqi *** 26.0 was used for statistical ***χ2 test was used for univariate analysis;independent sample t-tests were used in all *** No significant differences were observed preoperatively in the general characteristics of the two *** days post-surgery,the abdominal distension,emaciation,loose stool,loss of appetite,and vomiting scores were significantly lower in the observation group than in the control group(P<0.05).Immune function and interleukin(IL)-10 levels in the observation group were significantly higher than those of the control group,whereas IL-6,tumor necrosis factor-α,and C-reactive protein levels,tumor biological indexes,and adverse reactions in the observation group were significantly lower than those of the control group(P<0.05).One month after surgery,the patients’quality of life in the observation group was significantly high

关键词： Buzhong Yiqi decoction Colorectal cancer Laparoscopic radical surgery Immune function Inflammatory mediators Spleen

ALLOCUTION PRONONCEE A L′OCCASION DE LA COMMEMORATON DU 5e ANNIVERSAIRE DE LA COOPERATION ENTRE L′UNIVERSITE DE WUHAN ET LA FRANCE DANS LE DOMAINE DE L′ENSEIGNEMENT PAR MONSIEUR qi MINGYOU VICE-PRESIDENT DE L′UNIVERSITE

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法国研究 1985年第4期 11-13页

作者： qi Min-you

Votre Excellence Monsieur le Ministre:Monsieur le Conseiller culturel:Monsieur l′Attaché:…Mesdames et Messieurs:Voici arrivéle 5e anniversaire de nos échanges et de notre coo-pération dans le domaine de l′ensei... 详细信息

关键词：移关

Plasma L-ENK, AVP, ANP and serum gastrin in patients with syndrome of Liver-qi-stagnation

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World Journal of Gastroenterology 1999年第1期5卷 66-68页

作者： CHEN Ze qi, CHEN Guo Lin, LI Xue Wen, ZHAO Yu qiu and SHI Lin Jie

AIM To investigate the pathophysiologic basis of syndrome of Liver qi stagnation and parameters for clinical differentiation. METHODS Plasma L ENK, AVP, ANP and serum gastrin were determined by RIA in 84 patients with neurasthenia, mastodynia, chronic gastritis, and chronic cholecystitis presenting the same syndrome of Liver qi stagnation in traditional Chinese medicine (TCM). Healthy subjects served as controls in comparison with patients having the same syndrome but with different diseases. RESULTS Among the patients with Liver qi stagnation, the plasma L ENK, ANP and gastrin levels were 38 83ng/L ± 6 32ng/L , 104 11ng/L ± 29 01ng/L and 32 20ng/L ± 6 68ng/L , being significantly lower than those in the healthy controls ( t =3 34, 6 17, 4 48; P 0 05. CONCLUSION The syndrome of Liver qi stagnation is closely related to the emotional modulatory abnormality of the brain, with decrease of plasma L ENK, ANP and gastrin, and increase of plasma AVP as the important pathophysiologic basis.

关键词： Syndrome of Liver qi stagnation leucine enkephalin/blood arginine vasopressin/blood atrial natural polypeptide/blood gastrin/blood

Clinical Study on Needling Manipulation for Promoting Circulation of Channel qi in Treatment of Acute Ischemic Stroke

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Clinical Study on Needling Manipulation for Promoting Circul...

乌兰齿犀Ulanodon取代蹄齿犀类乌兰兽Ulania qi,1990(奇蹄目,哺乳动物纲)

Academic Conference of the Tenth Anniversary of World Federation of Acupuncture-Moxibustion

作者： Zhong qi Zhang Jin (Affiliated Hospital Liaoning College of TCM Shenyang 110032 )

＜正＞We emphasized that clearing and activating the channels and collaterals method is mainly consist of two methods i.e. green dragon shaking tail needling and white tiger shaking head needling. The key point of the two needling methods is rocking manipulation, rocking and adding force at the same time. The former means shallow insertion of the needle and rocking forcefully, while the latter deep insertion and rocking slightly, accompanied by performing massage along the channel, grasping skin

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古脊椎动物学报（中英文） 2022年第4期60卷 328-329页

作者：白滨齐陶中国科学院古脊椎动物与古人类研究所中国科学院脊椎动物演化与人类起源重点实验室北京100044 中国科学院生物演化与环境卓越创新中心北京100044

齐陶(1990a)命名了采自内蒙古二连盆地额尔登敖包中始新统地层的蹄齿犀新属种--威氏乌兰兽Ulania wilsoni,但该属名已经被一种寒武纪的三叶虫Ulania Lin&Zhang,1979所占用;因此我们提出以乌兰齿犀Ulanodon ***.取代Ulania qi,1990。“U... 详细信息

齐陶(1990a)命名了采自内蒙古二连盆地额尔登敖包中始新统地层的蹄齿犀新属种--威氏乌兰兽Ulania wilsoni,但该属名已经被一种寒武纪的三叶虫Ulania Lin&Zhang,1979所占用;因此我们提出以乌兰齿犀Ulanodon ***.取代Ulania qi,1990。“Ulan”(乌兰)在蒙古语中意为“红色”,同时也意指标本当时被认为的产出层位“乌兰戈楚组”;希腊语“-odon”是蹄齿犀科中常用的词根,意为“牙齿”。感谢John Ponting先生对Ulania异物同名的告知,和王元青研究员对Ulanodon新属名称和文章内容的建议。

关键词：始新统异物同名哺乳动物纲蒙古语乌兰奇蹄目产出层位

THE INVESTIGATION OF ANALGESIC RESULT OF THE THERPEAUTIC INSTRUMENT TO INDUCE qi-CIRCULATION ALONG CHANNELS AND COLLATERALS

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针刺研究 1989年第Z1期 279-280页

作者： Wang Dan Sen He Cheng qi Insrtuctor: Li Bonin The Research Institute of Acupuncture and Meridian of Sichuan Research Academy of TCM The San Tai County Hospital of TCM

114 cases of pain syndrome including lumbago, belly pain, headache, chest＆ hypochondric pain, and arm Shoulder pain were treated by San Tai Hospitalof TCM and our institute. In the light of the diagnosis of TCM, the involvedchannels are determined and the distant (5 Shu points) and local acupoints are used. The electric stimulation will last for 20 minutes, once a day, 3 timesmake a course. In chronic and serious cases, twice a day, 10-15 times make acourse.

关键词： TCM

Network pharmacology-based exploration of molecular mechanisms underlying therapeutic effects of Jianpi Huatan Quyu recipe on chronic heart failure with spleen qi deficiency syndrome

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World Journal of Cardiology 2024年第7期16卷 422-435页

作者： Si-qi Li Dong-Yu Min Jun-Wen Jiang Xiao-Ying Li Xu-Na Yang Wen-Bo Gu Jia-Hui Jiang Li-Hao Chen Han Nan Ze-Yu Chen Second Department of Cardiology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110000Liaoning ProvinceChina

BACKGROUND Chronic heart failure is a complex clinical *** Chinese herbal compound preparation Jianpi Huatan Quyu recipe has been used to treat chronic heart failure;however,the underlying molecular mechanism is still not *** To identify the effective active ingredients of Jianpi Huatan Quyu recipe and explore its molecular mechanism in the treatment of chronic heart *** The effective active ingredients of eight herbs composing Jianpi Huatan Quyu recipe were identified using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis *** target genes of chronic heart failure were searched in the Genecards *** target proteins of active ingredients were mapped to chronic heart failure target genes to obtain the common drugdisease targets,which were then used to construct a key chemical componenttarget network using Cytoscape 3.7.2 *** protein-protein interaction network was constructed using the String *** Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed through the Metascape ***,our previously published relevant articles were searched to verify the results obtained via network *** A total of 227 effective active ingredients for Jianpi Huatan Quyu recipe were identified,of which quercetin,kaempferol,7-methoxy-2-methyl isoflavone,formononetin,and isorhamnetin may be key active ingredients and involved in the therapeutic effects of TCM by acting on STAT3,MAPK3,AKT1,JUN,MAPK1,TP53,TNF,HSP90AA1,p65,MAPK8,MAPK14,IL6,EGFR,EDN1,FOS,and other *** pathways identified by KEGG enrichment analysis include pathways in cancer,IL-17 signaling pathway,PI3K-Akt signaling pathway,HIF-1 signaling pathway,calcium signaling pathway,cAMP signaling pathway,NF-kappaB signaling pathway,AMPK signaling pathway,*** studies on Jianpi Huatan Quyu recipe suggested that this Chinese compound preparation can regulate the TNF-α,IL-6,MAPK

关键词： Jianpi Huatan Quyu recipe Traditional Chinese medicine Chronic heart failure Data mining Network pharmacology Bioinformatics Spleen qi deficiency syndrome