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国际医学放射学杂志 2023年第6期 746-746页

作者： q.Yu Y.q.Ning A.Wang S.li j.M.Gu q.j.li 罗宇婷

摘要目的开发基于CT影像的深度学习辅助诊断模型，以帮助放射科医生鉴别良性和恶性腮腺肿瘤。方法回顾性收集573例经组织病理证实的腮腺肿瘤病人，包括来自中

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Search for electron-antineutrinos associated with gravitational-wave events GW150914,GW151012,GW151226,GW170104,GW170608,GW170814,and GW170817 at Daya Bay

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Chinese Physics C 2021年第5期45卷 190-201页

作者： F.P.An A.B.Balantekin H.R.Band M.Bishai S.Blyth G.F.Cao j.Cao j.F.Chang Y.Chang H.S.Chen S.M.Chen Y.Chen Y.X.Chen j.Cheng Z.K.Cheng j.j.Cherwinka M.C.Chu j.P.Cummings O.Dalager F.S.Deng Y.Y.Ding M.V.Diwan T.Dohnal j.Dove M.Dvorak D.A.Dwyer j.P.Gallo M.Gonchar G.H.Gong H.Gong W.q.Gu j.Y.Guo L.Guo X.H.Guo Y.H.Guo Z.Guo R.W.Hackenburg S.Hans M.He K.M.Heeger Y.K.Heng A.Higuera Y.K.Hor Y.B.Hsiung B.Z.Hu j.R.Hu T.Hu Z.j.Hu H.X.Huang X.T.Huang Y.B.Huang P.Huber D.E.jaffe K.L.jen X.L.ji X.P.ji R.A.johnson D.jones L.Kang S.H.Kettell S.Kohn M.Kramer T.j.Langford j.Lee j.H.C.Lee R.T.Lei R.Leitner j.K.C.Leung F.li j.j.li q.j.li S.li S.C.li W.D.li X.N.li X.q.li Y.F.li Z.B.li H.liang C.j.lin G.L.lin S.lin j.j.ling j.M.link L.littenberg B.R.littlejohn j.C.liu j.L.liu C.Lu H.q.Lu j.S.Lu K.B.Luk X.B.Ma X.Y.Ma Y.q.Ma C.Marshall D.A.Martinez Caicedo K.T.MeDonald R.D.McKeown Y.Meng j.Napolitano D.Naumov E.Naumova j.P.Ochoa-Ricoux A.OIshevskiy H.-R.Pan j.Park S.Patton j.C.Peng C.S.j.Pun F.Z.qi M.qi X.qian N.Raper j.Ren C.Morales Reveco R.Rosero B.Roskovec X.C.Ruan H.Steiner j.L.Sun T.Tmej K.Treskov W.-H.Tse C.E.Tull B.Viren V.Vorobel C.H.Wang j.Wang M.Wang N.Y.Wang R.G.Wang W.Wang W.Wang X.Wang Y.Wang Y.F.Wang Z.Wang Z.Wang Z.M.Wang H.Y.Wei L.H.Wei L.j.Wen K.Whisnant C.G.White H.L.H.Wong E.Worcester D.R.Wu F.L.Wu q.Wu W.j.Wu D.M.Xia Z.q.Xie Z.Z.Xing j.L.Xu T.Xu T.Xue C.G.Yang L.Yang Y.Z.Yang H.F.Yao M.Ye M.Yeh B.L.Young H.Z.Yu Z.Y.Yu B.B.Yue S.Zeng Y.Zeng L.Zhan C.Zhang F.Y.Zhang H.H.Zhang j.W.Zhang q.M.Zhang X.T.Zhang Y.M.Zhang Y.X.Zhang Y.Y.Zhang Z.j.Zhang Z.P.Zhang Z.Y.Zhang j.Zhao L.Zhou H.L.Zhuang j.H.Zou Instiute of Modern Physics East China University of Science and TechnologyShanghai 200237 University of Wisconsin MadisonWisconsin 53706 Wright Laboratory and Department of Physics Yale UniversityNew HavenConnecticut 06520 Brookhaven National Laboratory UptonNew York 11973 Department of Physics National Taiwan UniversityTaipei Institute of High Energy Physics Beijing 100049 National United University Miao-Li Department of Engineering Physics Tsinghua UniversityBejing 100084 Shenzhen University Shenzhen 518060 Sun Yat-Sen(Zhongshan)University Guangzhou North China Electric Power University Bejjing 102206 Chinese University of Hong Kong Hong Kong 999077 Siena College LoudonvilleNew York 12211 Department of Physics and Astronomy University of CaliforniaIrvineCaliformia 92697 University of Science and Technology of China Hefei 230026 Charles University Faculty of Mathematics and PhysicsPrague Department of Physics University of llinois at Urbana-ChampaignUrbanaIlinois 61801 Lawrence Berkeley National Laboratory BerkeleyCalifornia 94720 Department of Physics Illinois Institute of TechnologyChicagoIllinois 60616 joint Institute for Nuclear Research DubnaMoscow Region Beijing Normal University Beijing 100875 Department of Nuclear Science and Technology School of Energy and Power EngineeringXi'an Jiaotong UniversityXi'an 710049 Department of Physics University of HoustonHoustonTexas 77204 China Institute of Atomic Energy Beijing 102413 Shandong University Jinan 250100 Guangxi University Nanning 530004 Center for Neutrino Physics Virginia TechBlacksburgVirginia 24061 Institute of Physics National Chiao-Tung UniversityHsinchu Department of Physics University of CincinnatiCincinnatiOhio 45221 Department of Physies Collge of Science and TechnologyTemple UniversityPhiladelphiaPennsylvania 19122 Dongguan University of Technology Dongguan 523808 Department of Physics University of CaliforniaBerkeleyCalifornia 94720 Department of Physics The University of Hong KongPokfulamHong Kong 999077 School

The establishment of a possible connection between neutrino emission and gravitational-wave(GW)bursts is important to our understanding of the physical processes that occur when black holes or neutron stars *** the Daya Bay experiment,using the data collected from December 2011 to August 2017,a search was per-formed for electron-antineutrino signals that coincided with detected GW events,including GW150914,GW151012,GW151226,GW170104,GW170608,GW 170814,and GW *** used three time windows of±10,±500,and±1000 s relative to the occurrence of the GW events and a neutrino energy range of 1.8 to 100 MeV to search for correlated neutrino *** detected electron-antineutrino candidates were consistent with the expected background rates for all the three time *** monochromatic spectra,we found upper limits(90%confidence level)of the electron-antineutrino fluence of(1.13-2.44)×10^(11)cm^(-2)at 5 MeV to 8.0×10^(7)cm^(-2)at 100 MeV for the three time w *** the assumption of a Fermi-Dirac spectrum,the upper limits were found to be(5.4-7.0)×10^(9)cm^(2)for the three time windows.

关键词： grav itational waves electron-antineutrinos fluence upper limit

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Antineutrino energy spectrum unfolding based on the Daya Bay measurement and its applications

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Chinese Physics C 2021年第7期45卷 1-19页

作者： F.P.An A.B.Balantekin M.Bishai S.Blyth G.F.Cao j.Cao j.F.Chang Y.Chang H.S.Chen S.M.Chen Y.Chen Y.X.Chen j.Cheng Z.K.Cheng j.j.Cherwinka M.C.Chu j.P.Cummings O.Dalager F.S.Deng Y.Y.Ding M.V.Diwan T.Dohnal D.Dolzhikov j.Dove M.Dvorak D.A.Dwyer j.P.Gallo M.Gonchar G.H.Gong H.Gong M.Grassi W.q.Gu j.Y.Guo L.Guo X.H.Guo Y.H.Guo Z.Guo R.W.Hackenburg S.Hans a M.He K.M.Heeger Y.K.Heng Y.K.Hor Y.B.Hsiung B.Z.Hu j.R.Hu T.Hu Z.j.Hu H.X.Huang j.H.Huang X.T.Huang Y.B.Huang P.Huber D.E.jaffe K.L.jen X.L.ji X.P.ji R.A.johnson D.jones L.Kang S.H.Kettel S.Kohn M.Kramer T.j.Langford j.Lee j.H.C.Lee R.T.Lei R.Leitner j.K.C.Leung F.li H.L.li j.j.li q.j.li R.H.li S.li S.C.li W.D.li X.N.li X.q.li Y.F.li Z.B.li H.liang C.j.lin G.L.lin S.lin j.j.ling j.M.link26 L.littenberg B.R.littlejohn j.C.liu j.L.liu j.X.liu C.Lu H.q.Lu K.B.Luk B.Z.Ma X.B.Ma X.Y.Ma Y.q.Ma R.C.Mandujano C.Marshall K.T.McDonald R.D.McKeown Y.Meng j.Napolitano D.Naumov E.Naumova T.M.T.Nguyen j.P.Ochoa-Ricoux A.Olshevskiy H.-R.Pan j.Park S.Patton j.C.Peng C.S.j.Pun F.Z.qi M.qi X.qian N.Raper j.Ren C.Morales Reveco R.Rosero B.Roskovec X.C.Ruan H.Steiner j.L.Sun T.Tmej1 K.Treskov W.-H.Tse C.E.Tull B.Viren V.Vorobel C.H.Wang j.Wang M.Wang N.Y.Wang R.G.Wang W.Wang W.Wang X.Wang Y.Wang Y.F.Wang Z.Wang Z.Wang Z.M.Wang H.Y.Wei L.H.Wei L.j.Wen K.Whisnant C.G.White H.L.H.Wong E.Worcester D.R.Wu F.L.Wu q.Wu W.j.Wu D.M.Xia Z.q.Xie Z.Z.Xing H.K.Xu j.L.Xu T.Xu T.Xue C.G.Yang L.Yang Y.Z.Yang H.F.Yao M.Ye M.Yeh B.L.Young H.Z.Yu Z.Y.Yu B.B.Yue V.Zavadskyi S.Zeng Y.Zeng L.Zhan C.Zhang F.Y.Zhang H.H.Zhang j.W.Zhang q.M.Zhang S.q.Zhang X.T.Zhang Y.M.Zhang Y.X.Zhang Y.Y.Zhang Z.j.Zhang Z.P.Zhang Z.Y.Zhang j.Zhao R.Z.Zhao L.Zhou H.L.Zhuang j.H.Zou Institute of Modern Physics East China University of Science and TechnologyShanghai 200337 University of Wisconsin MadisonWisconsin 53706 Brookhaven National Laboratory UptonNew York 11973 Department of Physics Nnational Taiwan UniversityTaipei Institute of High Energy Physics Beijing 100049 National United University Miao-Li Department of Engineering Physics Tsinghua UniversityBeijing 100048 Shenzhen University Shenzhen 518061 Sun Yat-Sen(Zhongshan)University Guangzhou 510275 North China Electric Power University Beijing 102206 Chinese University of Hong Kong Hongkong 999077 Siena College LoudonvilleNew York 12211 Department of Physics and Astronomy University of CaliforniaIrvineCalifornia 92697 University of Science and Technology of China Hefei 230022 Charles University Faculty of Mathematics and PhysicsPrague joint Institute for Nuclear Research DubnaMoscow Region Department of Physics University of Illinois at Urbana-ChampaignUrbanaIllinois 61801 Lawrence Berkeley National Laboratory BerkeleyCalifornia 94720 Department of Physics Illinois Institute of TechnologyChicagoIllinois 60616 Beijing Normal University Beijing 100875 Department of Nuclear Science and Technology School of Energy and Power EngineeringXi'an Jiaotong UniversityXi'an 710049 Wright Laboratory and Department of Physics Yale UniversityNew HavenConnecticut 06520 China Institute of Atomic Energy Beijing 102413 Shandong University Jinan 250002 Guangxi University No.100 Daxue East RoadNanning 530004 Center for Neutrino Physics Virginia TechBlacksburgVirginia 24061 Institute of Physics NCTUHsinchu Department of Physics University of CincinnatiCincinnatiOhio 45221 Department of Physics College of Science and TechnologyTemple UniversityPhiladelphiaPennsylvania 19122 Dongguan University of Technology Dongguan 523808 Department of Physics University of CaliforniaBerkeleyCalifornia 94720 Department of Physics The University of Hong KongPokfulamHongkong 999077 School of Physics Nankai UniversityTianjin 300071 Department o

The prediction of reactor antineutrino spectra will play a crucial role as reactor experiments enter the precision *** positron energy spectrum of 3.5 million antineutrino inverse beta decay reactions observed by the Daya Bay experiment,in combination with the fission rates of fissile isotopes in the reactor,is used to extract the positron energy spectra resulting from the fission of specific *** information can be used to produce a precise,data-based prediction of the antineutrino energy spectrum in other reactor antineutrino experiments with different fission fractions than Daya *** positron energy spectra are unfolded to obtain the antineutrino energy spectra by removing the contribution from detector response with the Wiener-SVD unfolding *** results are obtained with other unfolding methods.A technique to construct a data-based prediction of the reactor antineutrino energy spectrum is proposed and *** the reactor fission fractions,the technique can predict the energy spectrum to a 2%*** addition,we illustrate how to perform a rigorous comparison between the unfolded antineutrino spectrum and a theoretical model prediction that avoids the input model bias of the unfolding method.

关键词： reactor antineutrino energy spectrum Daya Bay application

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Design of a cationic accelerator enabling ultrafast ion diffusion kinetics in aqueous zinc-ion batteries

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journal of Energy Chemistry 2025年第1期100卷 377-384页

作者： Yawei Xiao qianqian Gu Haoyu li Mengyao li Yude Wang National Center for International Research on Photoelectric and Energy Materials School of Materials and Energy Yunnan University Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources School of Chemistry and Chemical Engineering Hainan University College of Chemical Engineering Fuzhou University Yunnan Key Laboratory of Carbon Neutrality and Green Low-carbon Technologies Yunnan University

Aqueous zinc-ion batteries are highly favored for grid-level energy storage owing to their low cost and high safety,but their practical application is limited by slow ion *** address this,a strategy has been developed to create a cation-accelerating electric field on the surface of the cathode to achieve ultrafast Zn2+diffusion *** employing electrodeposition to coat MoS2on the surface of BaV6O16·3H2O nanowires,the directional built-in electric field generated at the heterointerface acts as a cation accelerator,continuously accelerating Zn2+diffusion into the active *** optimized Zn2+diffusion coefficient in CC@BaV-6O16·3H2O@MoS2(7.5×10～8cm2s-1) surpasses that of most reported V-based ***,MoS2serving as a cathodic armor extends the cycling life of the Zn-CC@BaV6O16·3H2O@MoS2full batteries to over 10000 *** work provides valuable insights into optimizing ion diffusion kinetics for high-performance energy storage devices.

关键词： Zinc alloys

Late Paleozoic–Early Mesozoic tectonic evolution of the Zongwulong Shan-qinghai Nanshan tectonic belt in the northern qaidam continent， northern Tibet

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journal of Earth Science 2025年

作者： Yonghui Zhao Chen Wu jie li Peter j.Haproff lin Ding State Key Laboratory of Tibetan Plateau Earth System and Resources Environment (TPESRE)， Institute of Tibetan Plateau Research， Chinese Academy of Sciences University of Chinese Academy of Sciences Chongqing Key Laboratory of Complex Oil and Gas Field Exploration and Development， Chongqing University of Science and Technology Department of Earth and Ocean Sciences， University of North Carolina Wilmington

The Zongwulong Shan-qinghai Nanshan tectonic belt of the northern Tibet Plateau experienced a protracted tectonic history， including the openings and closures of the Proto- and Paleo-Tethyan Oceans. Although the tectonic belt has been extensively studied， details regarding the tectonic processes involved in its development remain controversial. To better constrain the tectonic processes of this tectonic belt， we conducted detailed field geological mapping， zircon U-Pb geochronology， and whole-rock geochemical and Sr-Nd isotopic analyses. Our results show that intrusive rocks in the tectonic belt crystallized in ca. 292–233 Ma， perhaps in an arc/subduction setting. Geochemical and Sr-Nd isotopic data suggest that early Permian–late Triassic ultramafic-intermediate intrusions were sourced from the enriched mantle， whereas intermediate-acidic rocks were sourced from mixed crust-mantle. We present the tectonic model that involves: (1) Early Devonian–early Permian intracontinental extension occurred in the northern margin of the qaidam continent (ca. 416 Ma–292 Ma); (2) Early Permian–late Triassic northward subduction of the Paleo-Tethyan Ocean resulted in arc magmatism (ca. 292 Ma–233 Ma); and (3) subsequent late Triassic intracontinental extension (ca. 233 Ma–215 Ma). Our results suggest that the late Paleozoic–early Mesozoic development of the Zongwulong Shan-qinghai Nanshan was related to the opening， subduction， and slab retreat of the Paleo-Tethyan Ocean， which has key implications for the tectonic evolution of the northern Tibetan Plateau.

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High-throughput screening of CO_(2) cycloaddition MOF catalyst with an explainable machine learning model

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Green Energy & Environment 2025年第1期10卷 132-138页

作者： Xuefeng Bai Yi li Yabo Xie qiancheng Chen Xin Zhang jian-Rong li Beijing Key Laboratory for Green Catalysis and Separation and Department of Chemical Engineering College of Materials Science&EngineeringBeijing University of TechnologyBeijing100124China

The high porosity and tunable chemical functionality of metal-organic frameworks(MOFs)make it a promising catalyst design ***-throughput screening of catalytic performance is feasible since the large MOF structure database is *** this study,we report a machine learning model for high-throughput screening of MOF catalysts for the CO_(2) cycloaddition *** descriptors for model training were judiciously chosen according to the reaction mechanism,which leads to high accuracy up to 97%for the 75%quantile of the training set as the classification *** feature contribution was further evaluated with SHAP and PDP analysis to provide a certain physical understanding.12,415 hypothetical MOF structures and 100 reported MOFs were evaluated under 100℃ and 1 bar within one day using the model,and 239 potentially efficient catalysts were *** them,MOF-76(Y)achieved the top performance experimentally among reported MOFs,in good agreement with the prediction.

关键词： Metal-organic frameworks High-throughput screening Machine learning Explainable model CO_(2)cycloaddition

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： jia Fang Zhuangzhuang li Pengjun Wang Xiaoxu Zhang Song Mao Yini li Dongzhen Yu Xiaoyan li Yazhi Xing Haibo Shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6j mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

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Sequence-activated chemiluminescence probes: programmable illumination for high-contrast in vivo sensing and imaging

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Science China Chemistry 2025年第1期68卷 26-34页

作者： Yutao Zhang juan li Wei-Hong Zhu Zhiqian Guo Shanghai Key Laboratory of Functional Materials Chemistry Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology State Key Laboratory of Bioreactor Engineering Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell MetabolismEast China University of Science & Technology

Sequence-activated chemiluminescence(CL) technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial resolution. The fundamental principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest, thus enabling high-contrast signals under complex physiological conditions. This sequential activation could be triggered by enzymes, reactive oxygen species(ROS), biothiols or changes in the microenvironment. These unique sequence-activated CL probes bestow several advantages, including minimal background, deep-tissue penetration, and the ability of non-invasive or minimally invasive detection. The sequence-activated CL techniques represent a significant advancement in molecular imaging and diagnostics. In this mini-review, we focus on the latest developments in sequential CL probes, addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and molecular recognition.

关键词： chemiluminescnece sequence-activation in-vivo bioimaging cyclic peroxide

Single-cell omics: experimental workflow, data analyses and applications

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Science China life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan li Dongqing Sun Shaliu Fu Lei Gu Xin Shao qinqin Wang Xin Dong Bin Duan Feiyang Xing jun Wu Minmin Xiao Fangqing Zhao jing-Dong j.Han qi liu Xiaohui Fan Chen li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of life Science Chinese Academy of Sciences Peking-Tsinghua Center for life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

Double [5]carbohelicene: facile synthesis, chiroptical properties,isomerization study, and lasing application

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Science China Chemistry 2025年第1期68卷 233-240页

作者： Peipei liu Yantong li Meng-Xiang Wu Hao Kang Xiao-li Zhao lin Xu linlin liu Xiaodong li junfeng Fang Zhiwei Fang Ya Cheng Hai-Bo Yang Huakang Yu Xueliang Shi State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University School of Physics and Optoelectronics South China University of Technology Institute of Polymer Optoelectronic Materials & Devices State Key Laboratory of Luminescent Materials & Devices South China University of Technology School of Physics and Electronic Science Engineering Research Center of Nanophotonics & Advanced Instrument Ministry of EducationEast China Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University

Double carbohelicenes have attracted considerable attention due to their aesthetic structures, distinct π-conjugation extension, inherent chirality, and intriguing optical and electronic properties. Herein, the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties, isomerization process and lasing application is presented. 1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key intermediate. It is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM, which were successfully isolated and unambiguously confirmed by Xray crystallography. The optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography（HPLC）, and 1-PP and 1-MM were characterized by circular dichroism. Interestingly, it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating, and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated. 1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%. Consequently, we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously, which the lasing wavelength is 796.6 nm at a threshold of 0.8 m j cm-2. We believe that our studies, including the facile synthesis methodology, detailed isomerization studies, and lasing application, will shed some light on the design and synthesis of novel carbohelical systems with more functions.

关键词： double carbohelicene optical resolution organic laser isomerization X-ray diffraction