We discovered a high-level amplicon involving the ehrl9ql3.41 microRNA (miRNA) duster (c19Mc) in 11/45 (approximately 25%) primary cNS-PNET, which results in striking overexpression of nfiR-517c and 520g. constitutive...
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We discovered a high-level amplicon involving the ehrl9ql3.41 microRNA (miRNA) duster (c19Mc) in 11/45 (approximately 25%) primary cNS-PNET, which results in striking overexpression of nfiR-517c and 520g. constitutive expression of miR-517c or 520g protnotes in vitro and in vivo oncogenicity, modulates cell survival, and robustly enhances growth of untransformed human neural stem cells (hNScs) in part by upregulating WNT pathway signaling and restricting differentiation of hNScs.
We report the discovery of KMT-2020-BLg-0414 Lb,with a planet-to-host mass ratio q2=0.9-1.2×10-5=3-4 q⊕at 1σ,which is the lowest mass-ratio microlensing planet to *** with two other recent discoveries(4?q/q⊕?6),it...
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We report the discovery of KMT-2020-BLg-0414 Lb,with a planet-to-host mass ratio q2=0.9-1.2×10-5=3-4 q⊕at 1σ,which is the lowest mass-ratio microlensing planet to *** with two other recent discoveries(4?q/q⊕?6),it fills out the previous empty sector at the bottom of the triangular(log s,log q)diagram,where s is the planet-host separation in units of the angular Einstein radiusθ***,these discoveries call into question the existence,or at least the strength,of the break in the mass-ratio function that was previously suggested to account for the paucity of very low-q *** to the extreme magnification of the event,Amax~1450 for the underlying single-lens event,its light curve revealed a second companion with q3~0.05 and|log s3|~1,i.e.,a factor~10 closer to or farther from the host in *** measurements of the microlens parallaxπE and the angular Einstein radiusθE allow estimates of the host,planet and second companion masses,(M1,M2,M3)~(0.3 M⊙,1.0 M⊕,17 MJ),the planet and second companion projected separations,(a⊥,2,a⊥,3)~(1.5,0.15 or 15)au,and system distance DL~1 *** lens could account for most or all of the blended light(I~19.3)and so can be studied immediately with high-resolution photometric and spectroscopic observations that can further clarify the nature of the *** planet was found as part of a new program of high-cadence follow-up observations of high-magnification *** detection of this planet,despite the considerable difficulties imposed by cOVID-19(two KMT sites and OgLE were shut down),illustrates the potential utility of this program.
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