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Evidence for particle acceleration approaching PeV energies in the W51 complex

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Science Bulletin 2024年第18期69卷 2833-2841页

作者： LHAASO Collaboration Zhen Cao F.Aharonian Axikegu y.X.Bai y.W.Bao D.Bastieri X.J.Bi y.J.Bi W.Bian A.V.Bukevich q.Cao W.y.Cao Zhe Cao J.Chang J.F.Chang A.M.Chen E.S.Chen H.X.Chen Liang Chen Lin Chen Long Chen M.J.Chen M.L.Chen q.H.Chen S.Chen S.H.Chen S.Z.Chen T.L.Chen y.Chen N.Cheng y.D.Cheng M.y.Cui S.W.Cui X.H.Cui y.D.Cui B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu X.q.Dong K.K.Duan J.H.Fan y.Z.Fan J.Fang J.H.Fang K.Fang C.F.Feng H.Feng L.Feng S.H.Feng X.T.Feng y.Feng y.L.Feng S.Gabici B.Gao C.D.Gao q.Gao W.Gao W.K.Gao M.M.Ge L.S.Geng G.Giacinti G.H.Gong q.B.Gou M.H.Gu F.L.Guo X.L.Guo y.q.Guo y.y.Guo y.A.Han M.Hasan H.H.He H.N.He J.y.He y.He y.K.Hor B.W.Hou C.Hou X.Hou H.B.Hu q.Hu S.C.Hu D.H.Huang T.q.Huang W.J.Huang X.T.Huang X.y.Huang y.Huang X.L.Ji H.y.Jia K.Jia K.Jiang X.W.Jiang Z.J.Jiang M.Jin M.M.Kang I.Karpikov D.Kuleshov K.Kurinov B.B.Li C.M.Li Cheng Li Cong Li D.Li F.Li H.B.Li H.C.Li Jian Li Jie Li K.Li S.D.Li W.L.Li W.L.Li X.R.Li Xin Li y.Z.Li Zhe Li Zhuo Li E.W.Liang y.F.Liang S.J.Lin B.Liu C.Liu D.Liu D.B.Liu H.Liu H.D.Liu J.Liu J.L.Liu M.y.Liu R.y.Liu S.M.Liu W.Liu y.Liu y.N.Liu q.Luo y.Luo H.K.Lv B.q.Ma L.L.Ma X.H.Ma J.R.Mao Z.Min W.Mitthumsiri H.J.Mu y.C.Nan A.Neronov L.J.Ou P.Pattarakijwanich Z.y.Pei J.C.qi M.y.qi B.q.qiao J.J.qin A.Raza D.Ruffolo A.Sáiz M.Saeed D.Semikoz L.Shao O.Shchegolev X.D.Sheng F.W.Shu H.C.Song yu.V.Stenkin V.Stepanov y.Su D.X.Sun q.N.Sun X.N.Sun Z.B.Sun J.Takata P.H.T.Tam q.W.Tang R.Tang Z.B.Tang W.W.Tian C.Wang C.B.Wang G.W.Wang H.G.Wang H.H.Wang J.C.Wang Kai Wang Kai Wang L.P.Wang L.y.Wang P.H.Wang R.Wang W.Wang X.G.Wang X.y.Wang y.Wang y.D.Wang y.J.Wang Z.H.Wang Z.X.Wang Zhen Wang Zheng Wang D.M.Wei J.J.Wei y.J.Wei T.Wen C.y.Wu H.R.Wu q.W.Wu S.Wu X.F.Wu y.S.Wu S.q.Xi J.Xia G.M.Xiang D.X.Xiao G.Xiao y.L.Xin y.Xing D.R.Xiong Z.Xiong D.L.Xu R.F.Xu R.X.Xu W.L.Xu L.Xue D.H.yan J.Z.yan T.yan C.W.yang C.y.yang F.yang F.F.yang L.L.yang M.J.yang R.Z.yang W.X.yang y.H.yao Z.G.yao L.q.yin N.yin X.H.you Z.y.you y.H.yu q.yuan H.yue H.D.Zeng T.X.Zeng W.Zeng M.Zha B.B.Zhang F.Zhang H.Zhang 不详 Key Laboratory of Particle Astrophysics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduChina Dublin Institute for Advanced Studies 31 Fitzwilliam Place2 DublinIreland Max-Planck-Institut for Nuclear Physics P.O.Box 103980Heidelberg 69029Germany School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Institute for Nuclear Research of Russian Academy of Sciences Moscow 117312Russia Hebei Normal University Shijiazhuang 050024China University of Science and Technology of China Hefei 230026China State Key Laboratory of Particle Detection and Electronics China Key Laboratory of Dark Matter and Space Astronomy&Key Laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Research Center for Astronomical Computing Zhejiang LaboratoryHangzhou 311121China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China School of Physics and Astronomy Yunnan UniversityKunming 650091China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Physics and Astronomy(Zhuhai)&School of Physics(Guangzhou)&Sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275GuangdongChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China APC UniversitéParis Cité

Theγ-ray emission from the W51 complex is widely acknowledged to be attributed to the interaction between the cosmic rays(CRs)accelerated by the shock of supernova remnant(SNR)W51C and the dense molecular clouds in the adjacent star-forming region,***,the maximum acceleration capability of W51C for CRs remains *** on observations conducted with the Large High Altitude Air Shower Observatory(LHAASO),we report a significant detection ofγrays emanating from the W51 complex,with energies from 2 to 200 *** LHAASO measurements,for the first time,extend theγ-ray emission from the W51 complex beyond 100 TeV and reveal a significant spectrum bending at tens of *** combining the"π^(0)-decay bump"featured data from Fermi-LAT,the broadbandγ-ray spectrum of the W51 region can be well-characterized by a simple pp-collision *** observed spectral bending feature suggests an exponential cutoff at~400 TeV or a power-law break at~200 TeV in the CR proton spectrum,most likely providing the first evidence of SNRs serving as CR accelerators approaching the PeV ***,two young star clusters within W51B could also be theoretically viable to produce the most energeticγrays observed by *** findings strongly support the presence of extreme CR accelerators within the W51 complex and provide new insights into the origin of Galactic CRs.

关键词： UHE c-ray Cosmic rays SNR W51C Star clusters

Long-chain acyl-CoA synthetase regulates systemic lipid homeostasis via glycosylation-dependent lipoprotein production

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Life Metabolism 2024年第2期3卷 38-54页

作者： Jie Li yue Dong Tianxing Zhou He Tian Xiahe Huang yong q.Zhang yingchun Wang Sin Man Lam Guanghou Shui State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China Lipidall Technologies Company Limited ChangzhouJiangsu 213000China

Interorgan lipid transport is crucial for organism development and the maintenance of physiological ***,we demonstrate that Drosophila long-chain acyl-CoA synthetase(dAcsl),which catalyzes the conversion of fatty acids into acyl-coenzyme As(acyl-CoAs),plays a critical role in regulating systemic lipid *** deficiency in the fat body led to the ectopic accumulation of neutral lipids in the gut,along with significantly reduced lipoprotein contents in both the fat body and *** aberrant phenotypes were rescued by fat body-specific overexpression of apolipophorin.A multi-omics investigation comprising lipidomics,metabolomics,and proteomics in conjunction with genetic screening revealed that glycosylation processes were suppressed in dAcsl knockdown *** of CG9035,human ortholog of which is implicated in the congenital disorder of glycosylation,ame-liorated gut lipid accumulation in *** lipoprotein glycosylation led to accelerated proteasome-related degradation and induced ER stress in dAcsl knockdown flies,impairing lipoprotein release into the circulation which compromised interorgan lipid transport between the fat body and the *** of ubiquitin-proteasome-dependent degradation alleviated the phenotype of gut ectopic fat accumulation in dAcsl knockdown ***,we verified that ACSL4,the human homolog of dAcsl,also regulated lipoprotein levels in HepG2 cells,indicating that the role of dAcsl in modulating lipoprotein secretion and systemic lipid homeostasis is possibly conserved in humans.

关键词： lipid homeostasis apolipoprotein glycosylation lipidomics metabolomics proteomics

Enhanced angiogenesis in porous poly(ε-caprolactone) scaffolds fortified with methacrylated hyaluronic acid hydrogel after subcutaneous transplantation

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Biomaterials Translational 2024年第1期5卷 59-68页

作者： yang H. Zheng M. Zhang y. Li C. Lai J.H.C. Zhang q. Chan K.W.y. Wang H. Zhao X. yang Z. Xu C. Department of Biomedical Engineering City University of Hong Kong Hong Kong Center for Pluripotent Stem Cell Research and Engineering Research Institute of Tsinghua Guangdong Province Guangzhou China Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Hong Kong

A composite scaffold composed of a porous scaffold and hydrogel filling can facilitate engraftment, survival, and retention in cell transplantation processes. This study presents a composite scaffold made of poly(ε-caprolactone) (PCL) and methacrylated hyaluronic acid (MeHA) hydrogel and describes the corresponding physical properties (surface area, porosity, and mechanical strength) and host response (angiogenesis and fibrosis) after subcutaneous transplantation. Specifically, we synthesise MeHA with different degrees of substitution and fabricate a PCL scaffold with different porosities. Subsequently, we construct a series of PCL/MeHA composite scaffolds by combining these hydrogels and scaffolds. In experiments with mice, the scaffold composed of 3% PCL and 10–100 kDa, degree of substitution 70% MeHA results in the least fibrosis and a higher degree of angiogenesis. This study highlights the potential of PCL/MeHA composite scaffolds for subcutaneous cell transplantation, given their desirable physical properties and host response. © 2024, Chinese Medical Multimedia Press Co Ltd. All rights reserved.

关键词： angiogenesis cell transplantation hyaluronic acid poly(ε-caprolactone) scaffold

基于MRI的自动化多任务深度学习系统评估冈上肌腱损伤

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国际医学放射学杂志 2024年第4期 499-500页

作者： M.Ni y.q.Zhao L.H.Zhang W.Chen q.Z.Wang C.y.Tian 常雪

摘要目的建立一个自动化、多任务、基于MRI的深度学习系统，用于精细评估冈上肌腱（SST）损伤。方法根据关节镜检查结果，将3 087例病人分为SST正常组、退变组和

关键词：

颅脑外伤后夸大视力障碍程度残疾等级评定1例

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法医学杂志 2024年第1期40卷 98-100页

作者：李陨石高炜张艳琴徐强沈晓林南京东南司法鉴定中心江苏南京210000 安徽中衡司法鉴定中心安徽合肥230000

1案例1.1简要案情张某,男,57岁,某年7月2日因交通事故受伤,伤后即感视物不清,并住院治疗。现距离伤后已1年余,张某仍觉视物不清,故诉讼至当地法院,申请对其视觉功能的残疾等级进行评定。1.2病史摘要某年7月2日张某因“外伤后头部疼痛伴... 详细信息

1案例1.1简要案情张某,男,57岁,某年7月2日因交通事故受伤,伤后即感视物不清,并住院治疗。现距离伤后已1年余,张某仍觉视物不清,故诉讼至当地法院,申请对其视觉功能的残疾等级进行评定。1.2病史摘要某年7月2日张某因“外伤后头部疼痛伴视物模糊”入住某市人民医院神经外科。查体:额部右侧约2 cm×2 cm擦伤,红肿、压痛伴血性渗出;双眼第一眼位正,左眼外展不到位,双眼结膜无充血,角膜透明,前房深度正常,双侧瞳孔等大等圆,直径均约3 mm,对光反射灵敏,虹膜纹理清,晶体透明,眼底未见明显异常。

关键词：法医学视力颅脑损伤伪装残疾等级评定

VisqAC: Visual Analytics for Online q&A Communities

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Journal of Beijing Institute of Technology 2019年第2期28卷 305-317页

作者： Jing Liang Ruoyu Jia Min Zhu Henry B L duh School of Computer Science Sichuan UniversityChengdu 610065China Department of Computer Science and Information Technology La Trobe UniversityMelbourne 3086Australia

Online question and answer(q&A)communities,which allow users to exchange knowledge by asking and answering questions,have become increasingly *** a result of user active participation,these communities store overwhelming volumes of ***,existing related methods are unable to meet community operators’needs for analyzing multi-dimensional q&A sequences and understanding user *** this paper,collaborating with domain experts in online community,we present a system,VisqAC,which explores the patterns of q&A sequence and user *** the system,a novel visual design is proposed,which is combined with flexible mapping measures for analyzing critical characteristics of sequence ***,a timeline visualization method is designed to visualize data with categorical attributes and its correlation can be displayed flexibly by choosing time mode and time *** usefulness and effectiveness of the system are demonstrated with several case studies of VisqAC with community operators based on the Zhihu *** evaluation shows that VisqAC is beneficial to the understanding of q&A sequence and associated user behavior.

关键词： online q&A community visual analytics sequence data user behavior

Bilateral Retinal Nerve Fiber Layer Loss and Recovery with Teprotumumab in Thyroid Eye Disease

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Open Journal of Ophthalmology 2024年第3期14卷 196-203页

作者： Christine Wang Abdulaziz Alsumait Nikisha q. Richards Surbhi Bansal Department of Ophthalmology Virginia Commonwealth University School of Medicine Richmond VA USA School of Medicine Virginia Commonwealth University Richmond VA USA

Background: Thyroid Eye Disease (TED) is known to alter tissues of the orbital cavity, including the optic nerve. However, its effect on measured global Retinal Nerve Fiber Layer (gRNFL) is not well elucidated. This case evaluates the effect of teprotumumab on gRNFL in a patient with moderate TED. Observations: A 60-year-old female with controlled ocular hypertension and moderate TED received 8 standard IV teprotumumab infusions. Comprehensive ocular evaluations were performed pre-, during-, and post-treatment. Bilateral gRNFL thickness decreased (10 m OD;12 m OS) at 4 months post-treatment start, persisting at 8 months, but recovered at 20 months. Conclusions and Importance: Teprotumumab treatment in patients with TED led to a transient bilateral decrease in gRNFL thickness, which was restored to baseline levels with no adverse events reported. Monitoring gRNFL changes in teprotumumab-treated patients is crucial as gRNFL thinning indicates retinal ganglion cell damage. Teprotumumabs ability to dampen the IGF-IR inflammatory cascade may have reduced retinal inflammation, leading to recovery.

关键词： Teprotumumab Thyroid Eye Disease RNFL Clinical Activity Score Ocular Hypertension

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青藏高原冰尘微生物对有机质的潜在转化过程

中国科学：地球科学 2024年第6期54卷 2008-2019页

作者：郭泌汐刘勇勤钟旭史权何晨郑强蔡阮鸿青藏高原地球系统与资源环境重点实验室中国科学院青藏高原研究所北京100101 兰州大学泛第三极环境中心兰州730000 Department of Earth Oceanand Atmospheric SciencesUniversity of British ColumbiaVancouverBC V6T 1Z4Canada 中国石油大学重质油国家重点实验室北京102249 厦门大学近海海洋环境科学国家重点实验室厦门361102 厦门大学福建省海洋碳汇重点实验室厦门361005

微生物在冰川碳循环中发挥着重要作用,然而当前缺乏对冰尘微生物参与的溶解性有机质(DOM)转化过程的深入研究.本研究利用了分析化学和微生物生态学的主流手段——超高分辨率的傅里叶变换离子回旋共振质谱(FT-ICR MS)和微生物16S rRNA测... 详细信息

微生物在冰川碳循环中发挥着重要作用,然而当前缺乏对冰尘微生物参与的溶解性有机质(DOM)转化过程的深入研究.本研究利用了分析化学和微生物生态学的主流手段——超高分辨率的傅里叶变换离子回旋共振质谱(FT-ICR MS)和微生物16S rRNA测序技术,分别解析了培养实验中青藏高原龙匣宰陇巴冰川冰尘的DOM分子组成以及微生物群落,并耦联两者构建了复杂微生物参与的冰川DOM转化过程.研究结果表明:在60天的培养实验中,冰尘DOM的生物可利用性随着培养时间的增加而降低,微生物对DOM组分的转化过程可分为三个阶段.在前7天里,微生物选择性降解了具有较高H/Cwa和较低O/Cwa的DOM分子,且群落变化不大;在第15至30天期间,DOM组分保持稳定,但微生物多样性增加;到培养末期, DOM分子在微生物作用下转化为难降解的惰性DOM组分,这些惰性DOM具有更高的芳香指数和O/Cwa、更低的H/Cwa以及含有更多的杂原子.此外,培养实验揭示了冰尘中Cyanobacteria、Bacteroidota、Gammaproteobacteria、Firmicutes和Actinobacteriota等类群协同作用于DOM组分转化,使其变得惰性.本研究揭示了冰尘中微生物转化DOM组分的过程,为理解微生物在冰川有机碳循环中的作用提供了新见解.

关键词：冰尘溶解性有机质微生物降解微生物群落时间变化

青藏高原及邻区岩石圈应力状态特征及其地质意义

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中国科学：地球科学 2024年第6期54卷 1863-1882页

作者：张倩文徐亚褚伟路书鹏中国科学院地质与地球物理研究所中国科学院油气资源研究重点实验室北京100029 中国科学院大学地球与行星科学学院北京100049

青藏高原及邻区现今岩石圈应力状态受到岩石圈本身及下部地幔作用的共同控制,即受岩石圈内部密度分布变化造成重力势能差及地幔对流作用对岩石圈底部拖曳力共同影响.研究岩石圈应力状态对进一步认识青藏高原演化的动力学背景及机制具有... 详细信息

青藏高原及邻区现今岩石圈应力状态受到岩石圈本身及下部地幔作用的共同控制,即受岩石圈内部密度分布变化造成重力势能差及地幔对流作用对岩石圈底部拖曳力共同影响.研究岩石圈应力状态对进一步认识青藏高原演化的动力学背景及机制具有重要作用.本文利用Crust1.0地壳密度模型结合S40RTS地幔横波速度变化模型计算重力势能,利用EGM2008重力场模型计算地幔对流作用在岩石圈底部的拖曳力,通过求解薄板近似下的力平衡方程分别得到这两种力源的岩石圈应力场以及两种力源的联合应力场,综合分析青藏高原地区应力状态特征,并根据重力势能应力场、地幔拖曳力应力场、两种应力场的相对大小,以及两种应力场与地表形变的相关关系特征划分了6个区域.综合分析表明,塔里木盆地等稳定地块区的岩石圈应力场主要受重力势能差控制;印度板块与青藏高原碰撞带岩石圈应力场主要受控于深部地幔拖曳力;青藏高原内部岩石圈应力场受重力势能和地幔拖曳力共同控制.青藏高原东南缘岩石圈应力场与地表形变相关性较差,推测该地区由于存在有效黏度更低的下地壳流使壳幔解耦,地幔拖曳力对浅部地壳影响较弱,导致岩石圈平均应力场与地表形变不一致.

关键词：青藏高原重力势能地幔对流岩石圈偏应力场 GPS应变率场