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PROCOAGULANT EFFECTS OF THROMBOLYTICTHERAPY IN ACUTE MYOCARDIAL INFARCTION

Chinese Medical Sciences Journal 2002年第1期17卷 36-39页

作者： Wang Y liu q Zhu J Yuan Z Ma x Department of Cardiology First Hospital Xi'an Jiaotong University Xi'an 710061 China

To examine the procoagulant effects of thrombolytic agent on h emostasis and study the role of hemostatic markers as predictors of clinical outcomes. Methods. In the present study, eighteen patients with acute myocardial in farction(AMI) received 1.5 or 2.0 million U nonspecific urokinase(UK), or 70～80 mg fibrin specific recombinant tissue plasminogen activator(rt PA)and did not use heparin until 8 hours after intravenous injection of the above agents. Eig ht patients with AMI and without thrombolytic therapy were enrolled as controls. Coagulant and thrombolytic activity markers included thrombin antithrombin Ⅲ complex (TAT), D dimer, fibrinogen (Fg), FMPV/Amax. All markers were determined before,immediately,1,2,4 and 8 hours after the administration of thrombolytic a gents respectively. Results. Molecular marker of thrombin generation——TAT showed an activated coa gulant state immediately after thrombolytic therapy. Level of TAT showed no sign ificant changes between every two observed phases in controls. However, level of TAT increased significantly from 4.95±1.75μg/L ( 4.63±1.37μg/L) to 14.71±3 .31μg/L ( 14.25±2.53μg/L) before and immediately after administration of thro mbolytic agents UK(or rt PA). There was significant difference between level of serum TAT of patients with and without thrombolytic therapy (Px level than controls. D dimer, a surrogate of thrombolytic activity increased markedly and Fg significantly declined afte r thrombolytic therapy(Pxcess fibri nolysis induced by thrombolytic therapy. Both urokinase and rt PA had procoagul ant action. This transient activation of the coagulant system might contribute t o early reocclusion. These data provided the theoretical support for simultaneou s administration of antico

关键词： acute myocardial infarction thrombolysis urokinase rt PA

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Micro-sized and Nano-sized Fe_3O_4 Particles as Anode Materials for Lithium-ion Batteries

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Journal of Materials Science & Technology 2011年第1期27卷 41-45页

作者： Y.x.Chen L.H.He P.J.Shang q.L.Tang Z.q.liu H.B.liu L.P.Zhou College of Materials Science and Engineering Hunan UniversityChangsha 410082China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

Micro-sized（1030.3±178.4 nm） and nano-sized（50.4±8.0 nm） Fe3O4 particles have been fabricated through hydrogen thermal reduction of α-Fe2O3 particles synthesized by means of a hydrothermal *** morphology and microstructure of the micro-sized and the nano-sized Fe3O4 particles were characterized by x-ray diffraction,field-emission gun scanning electron microscopy,transmission electron microscopy and highresolution electron *** micro-sized Fe3O4 particles exhibit porous structure,while the nano-sized Fe3O4 particles are solid *** electrochemical performance was also *** nano-sized solid Fe3O4 particles exhibit gradual capacity fading with initial discharge capacity of 1083.1 mAhg-1 and reversible capacity retention of 32.6% over 50 ***,the micro-sized porous Fe3O4 particles display very stable capacity-cycling behavior,with initial discharge capacity of 887.5 mAhg-1 and charge capacity of 684.4 mAhg-1 at the 50th ***,77.1% of the reversible capacity can be maintained over 50 *** micro-sized porous Fe3O4 particles with facile synthesis,good cycling performance and high capacity retention are promising candidate as anode materials for high energy-density lithium-ion batteries.

关键词： Lithium-ion battery Fe3O4 Porous structure Anode materials

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First-Principles Study of the Influence of Lattice Misfit on the Behavior and the Ductility Effect of Hafnium in Ni-Ni3AI System

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Acta Metallurgica Sinica(English Letters) 2014年第1期27卷 87-94页

作者： Y. Wu J. Guo W. Zhang x. Ma q. Zhang J. Hou R. Huang x. liu Institute of Molecular Engineering and Applied Chemistry Anhui University of Technology Ma'anshan 243002 China Shenyang National Laboratory for Materials Science Instituteof Metal Research Chinese Academy of SciencesShenyang 110016 China College of Physics Science and Technology Shenyang NormalUniversity Huanghe Street 253 Shengyang 110034 China School of Materials Science and Engineering Anhui Universityof Technology Ma'anshan 243002 China

Two Ni/Ni3Al-interface-contained cluster models with/without lattice misfit are studied by first-principles method to clarify the debates about the segregation behaviors of Hafnium （Hf） and explore the influence of lattice misfit on the ductility effect of Hr. It is found that though Hf prefers to substitute A1 rather than Ni in Ni3A1 phase within most of the investigated misfit range, its stronger preferring to Ni phase than NiaA1 phase makes it impossible to go into Ni3A1 phase to occupy A1 site in Ni-Ni3A1 alloys. Bond order analysis in Hf-free case shows that lattice misfit has different effects on the Griffith work of interfacial cleavage 27int/E and the maximum theoretical shear stress Zmax of Ni and Ni3A1, contributing to the existence of anomalous strength-temperature phenomena in NiaA1 alloys. However, the addition of Hf will make the 27int/E （or Zmax） of both Ni3A1 and Ni decrease （or increase） with lattice misfit, indicating that the addition of Hf may make the anomalous strength-temperature relationship in Ni3A1 region disappear locally.

关键词： Hafnium Lattice misfit Segregation Ductility

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FREEZE PROFILE AND HEAT BALANCE CALCULATION OF THE 160kA DRAINED CELL

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Acta Metallurgica Sinica(English Letters) 2004年第2期17卷 215-220页

作者： x.P. Li J. Li Y.q. Lai H.q.Zhao Y.x.liu School of Metallurgical Science and Engineering, Central South University, Changsha 410083, China Sch. of Metall. Sci. and Eng. Central South Univ. Changsha 410083 China

A 2D full cell thermo-electric model of 160kA drained cell was set up using finiteelement code to calculate its freeze profile, then the drained cell model was modifiedaccording to the freeze profile computed and its heat balance was calculated. Comparedwith that of a 160kA conventional Hall-Heroult cell (H-H cell), though the melts vol-ume of the drained cell reduced greatly, the whole heat loss from it didn't drop downapparently, and an analysis was presented in the paper. On the other hand, the anode-cathode distance (ACD) of a drained cell was much less than that of a H-H cell, sothe voltage drop on it and heat produced decreased too, steps should be taken to keepa workable heat balance on a drained cell.

关键词： drained cell freeze profile heat balance finite element code

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LITHIUM ORDERING IN CHEMICALLY DELITHIATED Li_xCoO_2

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Acta Metallurgica Sinica(English Letters) 2006年第3期19卷 197-202页

作者： x. liu W.H. Tian H.x. Yang Y. G. Shi J. q. Li Department of Materials Physics and Chemistry University of Science and Technology Beijing Beijing 100083 China Beijing National Laboratory for Gondensed Matter Physics Institute of Physics The Chinese Academy of Sciences Beijing 100080 Ghina

Chemical delithiated LixCoO2 （x=1, 0.7, 0.66 and 0.57） has been synthesized by using a strong oxidant, NaS2O8 .The structure investigations indicate that all the samples remain with hexagonal cells, which have expansion of c axis during Li extraction. Transmission electron microscopy （TEM） observations revealed the presence of superstructures arising from intercalated U-ordering corresponding to first-principle calculations. The measurements of the physical properties are also influenced by Li concentration.

关键词： LixCoO2 delithiated Li-ordering

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Effects of electron heating and surface rippling on Rayleigh–Taylor instability in radiation pressure acceleration

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Matter and Radiation at Extremes 2023年第3期8卷 47-54页

作者： x.Z.Wu Y.R.Shou Z.B.Guo H.G.Lu J.x.liu D.Wu Z.Gong x.q.Yan State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Center for Relativistic Laser Science Institute for Basic ScienceGwangju 61005Republic of Korea Max-Planck-Institut für Kernphysik Saupfercheckweg 1Heidelberg 69117Germany Collaborative Innovation Center of Extreme Optics Shanxi UniversityShanxi 030006China

The acceleration of ultrathin targets driven by intense laser pulses induces Rayleigh–Taylor-like *** from laser and target con-figurations,we find that electron heating and surface rippling,effects inherent to the interaction process,have an important role in instability evolution and *** employing a simple analytical model and two-dimensional particle-in-cell simulations,we show that the onset of electron heating in the early stage of the acceleration suppresses the growth of small-scale modes,but it has little influence on the growth of large-scale modes,which thus become *** the growth of surface ripples,a mechanism that can significantly influence the growth of these large-scale modes is *** laser field modulation caused by surface rippling generates an oscillatory ponderomotive force,directly modulating transverse electron density at a faster growth rate than that of ions and eventually enhancing instability *** results show that when surface deformation becomes obvious,electron surface oscillation at 2ω0(whereω0 is the laser frequency)is excited simultaneously,which can be seen as a signature of this mechanism.

关键词： acceleration surface eventually

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Macroscopic and microscopic mechanical behaviors of climbing tendrils

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Acta Mechanica Sinica 2019年第3期35卷 702-710页

作者： q.Guo J.J.Dong Y.liu x.H.xu q.H.qin J.S.Wang Tianjin Key Laboratory of Modern Engineering Mechanics Department of MechanicsTianjin UniversityTianjin 300054China State Key Laboratory of Nonlinear Mechanics (LNM) Institute of MechanicsChinese Academy of ScienceBeijing 100080China Research School of Engineering Australian National UniversityCanberraACT 2601Australia

Tendril-bearing climbing plants must recur to the tendril helices with chiral perversion or dual chirality for climbing and to obtain sun exposure. Despite researchers' prolonged fascination with climbing tendrils since Darwin's time and even earlier, why the soft and slender tendrils can bear heavy loads such as the self-weight of a plant or additional load caused by rain remains elusive. In this paper, we take towel gourd tendrils as an example and investigate the macroscopic and microscopic mechanical behaviors of tendrils through experiments and simulations. Our study indicates that the tendril filament exhibits rubber-like hyperelastic behaviors and can particularly endure large elongation, which is mainly attributed to the superelasticity of the cellulose fibril helix contained in the cell wall. Combination of the tendril helical structure with dual chirality or chiral perversion at a macroscale and a cellulose filament helix at a subcellular level creates superior elasticity for biological species relying on support and climbing. This study provides deep insight into the structure-property relationship of climbing tendrils, and the relationship is useful for the bioinspired design of composite systems with superior elasticity.

关键词： Climbing tendril Mechanical behaviors Structure-property relationship Large elongation

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Identification of cell surface markers for acute myeloid leukemia prognosis based on multi-model analysis

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Journal of Biomedical Research 2024年第4期38卷 397-412页

作者： Jiaqi Tang Lin Luo Bakwatanisa Bosco Ning Li Bin Huang Rongrong Wu Zihan Lin Ming Hong Wenjie liu Lingxiang Wu Wei Wu Mengyan Zhu quanzhong liu Peng xia Miao Yu Diru Yao Sali Lv Ruohan Zhang Wentao liu qianghu Wang Kening Li Department of Bioinformatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjingJiangsu 211166China Department of Hematology of the Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University Northern Jiangsu Institute of Clinical MedicineHuai'anJiangsu 223300China Collaborative Innovation Center for Personalized Cancer Medicine Jiangsu Key Lab of Cancer BiomarkersPrevention and TreatmentNanjing Medical UniversityNanjingJiangsu 211166China Department of Hematology the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Key Laboratory of Hematology of Nanjing Medical University NanjingJiangsu 210029China Department of Pharmacology School of Basic Medical SciencesNanjing Medical UniversityNanjingJiangsu 211166China The Affiliated Cancer Hospital of Nanjing Medical University Jiangsu Cancer HospitalJiangsu Institute of Cancer ResearchNanjingJiangsu 210002China

Given the extremely high inter-patient heterogeneity of acute myeloid leukemia(AML),the identification of biomarkers for prognostic assessment and therapeutic guidance is *** surface markers(CSMs)have been shown to play an important role in AML leukemogenesis and *** the current study,we evaluated the prognostic potential of all human CSMs in 130 AML patients from The Cancer Genome Atlas(TCGA)based on differential gene expression analysis and univariable Cox proportional hazards regression *** using multi-model analysis,including Adaptive LASSO regression,LASSO regression,and Elastic Net,we constructed a 9-CSMs prognostic model for risk stratification of the AML *** predictive value of the 9-CSMs risk score was further validated at the transcriptome and proteome *** Cox regression analysis showed that the risk score was an independent prognostic factor for the AML *** AML patients with high 9-CSMs risk scores had a shorter overall and event-free survival time than those with low ***,single-cell RNA-sequencing analysis indicated that patients with high 9-CSMs risk scores exhibited chemotherapy ***,PI3K inhibitors were identified as potential treatments for these high-risk *** conclusion,we constructed a 9-CSMs prognostic model that served as an independent prognostic factor for the survival of AML patients and held the potential for guiding drug therapy.

关键词： acute myeloid leukemia cell surface markers prognosis drug sensitivity multi-model analysis

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The pathogenic mechanism of syndactyly type V identified in aHoxd13q50R knock-in mice

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Bone Research 2024年第2期12卷 349-360页

作者： Han Wang xiumin Chen xiaolu Meng Yixuan Cao Shirui Han Keqiang liu ximeng Zhao xiuli Zhao xue Zhang McKusick-Zhang Center for Genetic Medicine State Key Laboratory of Complex Severe and Rare DiseasesDepartment of Medical GeneticsInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Department of Orthopedics State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Syndactyly type V (SDTY5) is an autosomal dominant extremity malformation characterized by fusion of the fourth and fifthmetacarpals. In the previous publication, we first identified a heterozygous missense mutation q50R in homeobox domain (HD) ofHOxD13 in a large Chinese family with SDTY5. In order to substantiate the pathogenicity of the variant and elucidate the underlyingpathogenic mechanism causing limb malformation, transcription-activator-like effector nucleases (TALEN) was employed togenerate a Hoxd13q50R mutant mouse. The mutant mice exhibited obvious limb malformations including slight brachydactyly andpartial syndactyly between digits 2-4 in the heterozygotes, and severe syndactyly, brachydactyly and polydactyly in *** on BMP2 and SHH/GREM1/AER-FGF epithelial mesenchymal (e-m) feedback, a crucial signal pathway for limbdevelopment, we found the ectopically expressed Shh, Grem1 and Fgf8 and down-regulated Bmp2 in the embryonic limb bud atE10.5 to E12.5. A transcriptome sequencing analysis was conducted on limb buds (LBs) at E11.5, revealing 31 genes that exhibitednotable disparities in mRNA level between the Hoxd13q50R homozygotes and the wild-type. These genes are known to be involvedin various processes such as limb development, cell proliferation, migration, and apoptosis. Our findings indicate that the ectopicexpression of Shh and Fgf8, in conjunction with the down-regulation of Bmp2, results in a failure of patterning along both theanterior-posterior and proximal-distal axes, as well as a decrease in interdigital programmed cell death (PCD). This cascadeultimately leads to the development of syndactyly and brachydactyly in heterozygous mice, and severe limb malformations inhomozygous mice. These findings suggest that abnormal expression of SHH, FGF8, and BMP2 induced by HOxD13q50R may beresponsible for the manifestation of human SDTY5.

关键词： BMP2 mechanism finding

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INVESTIGATION OF WO3-DOPED TiO2 FILM COMPOSITE PHOTOCATALYST

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Acta Metallurgica Sinica(English Letters) 2004年第3期17卷 263-268页

作者： q.F. Meng K.R. liu L. Jiang q. Han J.S. Chen x.J. Wei School of Materials & Metallurgy Northeastern University Shenyang 110004 ChinaSchool of Materials & MetallurgyNortheastern University Shenyang 110004 ChinaSchool of Materials & MetallurgyNortheastern University Shenyang 110004 ChinaSchool of Materials & MetallurgyNortheastern University Shenyang 110004 ChinaSchool of Materials & MetallurgyNortheastern University Shenyang 110004 ChinaSchool of Materials & MetallurgyNortheastern University Shenyang 110004 China

The nano--crystal composite WO_3-TiO_2 photocatalyst was prepared by ultrasonic as-sisted sol--gel process. The effects of various factors, such as the crystal form, thesubstrates, the pH, the dissolved oxygen and the ultrasonic on the photocatalytic ac-tivity were investigated in view of the photodegradation of Rhodamine B. The resultsshow that the crystal form of WO_3-TiO_2 film with highest photocatalytic activity isrutile. The introduction of ultrasonic to the course of preparation can accelerate thedeposit time of the sol and increase the photocatalytic activity significantly in view ofthe highest photodegradation of Rhodamine B being 72.7% in 5 hours. The poroustitanium plate is the most suitable substrate in four kinds of investigated materials.Meanwhile the smaller the pH and the higher the concentration of the dissolved oxygenin the solution is, the higher the photodegradation is.

关键词： ultrasonic sol-gel process photocatalytic photodegradation

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