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Adsorption of Formin Acid Modified Clinoptilolite on *** O55

中国畜牧兽医学会动物营养学分会第十一次全国动物营养学术研讨会

作者： q.wu y.zhou y.wu l.zhang t.wang~* (College of Animal Science and technology,Nanjing Agricultural University,Nanjing 210095,China)

Natural clinoptilolite is a natural,the shelf containing aluminum silicate non-metallic minerals that has monoclinic crystal structure symmetry,strong adsorptive,high ion exchange capacity and high speci ? c surface area,have been widely used as a ***,the hydrophilic surfaces of parent clinoptilolites are less effective in adsorbing bacteria and *** modification of clinoptilolites with organic cations,results in an increased hydrophobicity of the mineral surface providing a high affinity for bacteria *** acid,an organic acidifier,has a dicky causticity and the antibacterial mechanism,which has been overused as a feed additive(acidifer) in the farming *** purpose of this study is to prepare formic acid-modified clinoptilolite by cation exchange and to evaluate its absorption properties on Escherichia coli O under ambient conditions,in *** of clay concentration,ionic concentration,lysine concentration,and time as well as bacterial suspensions concentration on *** O adsorption was also *** results show that(1) the amount of adsorption of *** O from solution to clay minerals were significantly increased with parent clinoptilolite and acid-modified clinoptilolite content increasing.(2) the adsorption processes occurring on each of the tested adsorbents reached equilibrium at 25 mg/ml clay *** discrepancy may result from the different amounts of parent clinoptilolite and acid-modified clinoptilolite added,which were between 30 to 50 mg/ml clay mineral in this study.(3 ) Ionic strength has an importmant influence on bacteria-clay mineral interaction. the amounts of *** O adsorbed on the tested adsorbents were increased with increased concentration of NaCl and CaCl in *** data determined from the adsorption ratio showed that Ca has higher influence than that Na.(4) the adsorption processes of *** O occurring on each of the tested adsorbents reached equilibrium after 2 *** the

关键词： E.coli O55 Clinoptilolite modified Formic acid adsorption

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In situ tEM investigation of electron irradiation and aging-induced high-density nanoprecipitates in an Mg-10Gd-3y-1Zn-0.5Zr alloy

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Journal of Magnesium and Alloys 2024年第5期12卷 1841-1853页

作者： M.lv H.l.Ge q.q.Jin X.H.Shao y.t.zhou B.zhang X.l.Ma Shenyang National laboratory for Materials Science Institute of Metal ResearchChinese Academy of Sciences72 Wenhua RoadShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Materials Science and Engineering Research Center Guangxi University of Science and TechnologyLiuzhou 545006China

In-situ electron irradiation and aging are applied to introduce high-density precipitates in an Mg-10Gd-3y-1Zn-0.5Zr(GWZ1031K,wt.%)alloy to improve the *** results show that the hardness of the Mg alloy after irradiation for 10 h and aging for 9 h at 250℃ is 1.64 GPa,which is approximately 64% higher than that of the samples before being *** is mainly attributed to γ'precipitates on the basal plane after irradiation and the high-density nanoscale β'precipitates on the prismatic plane after aging,which should be closely related to the irradiation-induced homogenous *** latter plays a key role in precipitation *** result paves a way to improve the mechanical properties of metallic materials by tailoring the precipitation through irradiation and aging.

关键词： Mg alloy Electron beam irradiation Hardening Precipitates In-situ tEM

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StCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai l.P.An R.Aliberti q.An X.Z.Bai y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao q.H.Cao X.Cao Z.Cao q.Chang K.t.Chao D.y.Chen H.Chen H.X.Chen J.F.Chen K.Chen l.l.Chen P.Chen S.l.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen y.Chen y.q.Chen H.y.Cheng J.Cheng S.Cheng t.G.Cheng J.P.Dai l.y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding l.y.Dong W.H.Dong V.Druzhinin D.S.Du y.J.Du Z.G.Du l.M.Duan D.Epifanov y.l.Fan S.S.Fang Z.J.Fang G.Fedotovich C.q.Feng X.Feng y.t.Feng J.l.Fu J.Gao y.N.Gao P.S.Ge C.q.Geng l.S.Geng A.Gilman l.Gong t.Gong B.Gou W.Gradl J.l.Gu A.Guevara l.C.Gui A.q.Guo F.K.Guo J.C.Guo J.Guo y.P.Guo Z.H.Guo A.Guskov K.l.Han l.Han M.Han X.q.Hao J.B.He S.q.He X.G.He y.l.He Z.B.He Z.X.Heng B.l.Hou t.J.Hou y.R.Hou C.y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang q.y.Huang W.q.Huang X.t.Huang X.J.Huang y.B.Huang y.S.Huang N.Hüsken V.Ivanov q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.l.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin y.lei E.levichev C.H.li C.li D.y.li F.li G.li G.li H.B.li H.li H.N.li H.J.li H.l.li J.M.li J.li l.li l.li l.y.li N.li P.R.li R.H.li S.li t.li W.J.li X.li X.H.li X.q.li X.H.li y.li y.y.li Z.J.li H.liang J.H.liang y.t.liang G.R.liao l.Z.liao y.liao C.X.lin D.X.lin X.S.lin B.J.liu C.W.liu D.liu F.liu G.M.liu H.B.liu J.liu J.J.liu J.B.liu K.liu K.y.liu K.liu l.liu q.liu S.B.liu t.liu X.liu y.W.liu y.liu y.l.liu Z.q.liu Z.y.liu Z.W.liu I.logashenko y.long C.G.lu J.X.lu N.lu q.F.lü y.lu y.lu Z.lu P.lukin F.J.luo t.luo X.F.luo y.H.luo H.J.lyu X.R.lyu J.P.Ma P.Ma y.Ma y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev y.Nefedov S.l.Olsen q.Ouyang P.Pakhlov G.Pakhlova X.Pan y.Pan E.Passemar y.P.Pei H.P.Peng l.Peng X.y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.qi y.q.qi W.B.qian y.qian C.F.qiao J.J.qin J.J.qin l.q.qin X.S.qin t.l.qiu J.Rademacker C.F.Redmer H.y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key laboratory of theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and technology Xuzhou 221116China École Polytechnique Fédérale de lausanne(EPFl) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

the superτ-charm facility(StCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** StCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** StCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the StCF,describes conceptual designs of the StCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity StCF detector conceptual design

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Hemin blocks tIGIt/PVR interaction and induces ferroptosis to elicit synergistic effects of cancer immunotherapy

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Science China(life Sciences) 2024年第5期67卷 996-1009页

作者： Xiaowen zhou yang li Xiangrui zhang Beibei li Shengzhe Jin Menghan wu Xiuman zhou qingyu Dong Jiangfeng Du Wenjie Zhai yahong wu lu qiu Guodong li yuanming qi Wenshan Zhao yanfeng Gao School of life Sciences Zhengzhou UniversityZhengzhou 450001China School of Pharmaceutical Sciences(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China

the immune checkpoint tIGIt/PVR blockade exhibits significant antitumor effects through activation of NK and CD8^(+)t cell-mediated *** checkpoint blockade(ICB)could induce tumor ferroptosis through IFN-γreleased by immune cells,indicating the synergetic effects of ICB with ferroptosis in inhibiting tumor ***,the development of tIGIt/PVR inhibitors with ferroptosis-inducing effects has not been explored *** this study,the small molecule Hemin that could bind withtIGIt to block tIGIt/PVR interaction was screened by virtual molecular docking and cell-based blocking *** could effectively restore the Il-2 secretion from Jurkat-htIGIt *** reinvigorated the function of CD8^(+)t cells to secrete IFN-γand the elevated IFN-γcould synergize with Hemin to induce ferroptosis in tumor *** inhibited tumor growth by boosting CD8^(+)t cell immune response and inducing ferroptosis in Ct26 tumor *** importantly,Hemin in combination with PD-1/PD-l1 blockade exhibited more effective antitumor efficacy in anti-PD-1 resistant B16 tumor *** summary,our finding indicated that Hemin blocked tIGIt/PVR interaction and induced tumor cell ferroptosis,which provided a new therapeutic strategy to combine immunotherapy and ferroptosis for cancer treatment.

关键词： cancer immunotherapy tIGIt/PVR small molecule Hemin ferroptosis

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Development of lAG-3/FGl1 blocking peptide and combination with radiotherapy for cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1150-1165页

作者： yuzhen qian yixuan Sun Peishang Shi Xiuman zhou qiongqiong zhang qingyu Dong Shengzhe Jin lu qiu Xiaoshuang Niu Xiaowen zhou Wenshan Zhao yahong wu Wenjie Zhai yanfeng Gao School of life Sciences Zhengzhou UniversityZhengzhou 450001China School of Pharmaceutical Sciences(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China International Joint laboratory for Protein and Peptide Drugs of Henan Province Zhengzhou UniversityZhengzhou 450001China

Aside from antibodies,peptides show great potential as immune checkpoint inhibitors(ICIs)due to several advantages,such as better tumor penetration and lower ***-activation gene 3(lAG-3)is an immune checkpoint which can induce t cell dysfunction through interaction with its soluble ligand fibrinogen like protein-1(FGl1).Here,we found that lAG-3 expression was higher than programmed cell death protein 1(PD-1)in multiple human cancers by tCGA databases,and successfully identified a lAG-3 binding peptide lFP-6 by phage display bio-panning,which specifically blocks the interaction of lAG-3/FGl1 but not lAG-3/***,D-amino acids were introduced to substitute the N-and C-terminus of lFP-6 to obtain the proteolysis-resistant peptide lFP-D1,which restores t cell function in vitro and inhibits tumor growth in ***,a bispecific peptide lFOP targeting both PD-1/PD-l1 and lAG-3/FGl1 was designed by conjugating lFP-D1 with PD-1/PD-l1blocking peptide OPBP-1(8-12),which activates t cell with enhanced proliferation and IFN-γ *** importantly,lFOP combined with radiotherapy significantly improve the t cell infiltration in tumor and elevate systemic antitumor immune *** conclusion,we developed a novel peptide blocking lAG-3/FGl1 which can restore t cell function,and the bispecific peptide synergizes with radiotherapy to further enhance the antitumor immune response.

关键词： lAG-3 FGl1 PD-1 PD-l1 Peptide Immune checkpoint Radiotherapy Cancer immunotherapy

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Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso q.An y.Bai O.Bakina I.Balossino y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.l.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen M.l.Chen S.J.Chen S.l.Chen S.M.Chen t.Chen X.R.Chen X.t.Chen y.B.Chen y.q.Chen Z.J.Chen Z.y.Chen S.K.Choi X.Chu G.Cibinetto F.Cossio J.J.Cui H.l.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.q.Deng Z.y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Fang S.S.Fang W.X.Fang y.Fang y.q.Fang R.Farinelli l.Fava F.Feldbauer G.Felici C.q.Feng J.H.Feng y.t.Feng K.Fischer M.Fritsch C.D.Fu J.l.Fu y.W.Fu H.Gao y.N.Gao yang Gao S.Garbolino I.Garzia P.t.Ge Z.W.Ge C.Geng E.M.Gersabeck B.Ding X.X.Ding y.Ding y.Ding J.Dong l.y.Dong M.y.Dong X.Dong M.C.Du S.X.Du Z.H.Duan P.Egorov y.H.Fan J.Fang JA.Gilman K.Goetzen l.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu y.t.Gu C.y.Guan Z.l.Guan A.q.Guo l.B.Guo M.J.Guo R.P.Guo y.P.Guo A.Guskov J.Gutierrez K.l.Han t.t.Han X.q.Hao F.A.Harris K.K.He K.l.He F.H.Heinsius C.H.Heinz y.K.Heng C.Herold t.Holtmann P.C.Hong G.y.Hou X.t.Hou y.R.Hou Z.l.Hou B.y.Hu H.M.Hu J.F.Hu t.Hu y.Hu G.S.Huang K.X.Huang l.q.Huang X.t.Huang y.P.Huang t.Hussain F.H\"olzken N.H\"usken N.in der Wiesche M.Irshad J.Jackson S.Janchiv J.H.Jeong q.Ji q.P.Ji W.Ji X.B.Ji X.l.Ji y.y.Ji X.q.Jia Z.K.Jia D.Jiang H.B.Jiang P.C.Jiang S.S.Jiang t.J.Jiang X.S.Jiang y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin y.Jin M.q.Jing X.M.Jing t.Johansson S.Kabana N.Kalantar-Nayestanaki X.l.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.lane P.larin l.lavezzi t.t.lei Z.H.lei H.leithoff M.lellmann t.lenz C.li C.li C.H.li Cheng li D.M.li F.li G.li H.li H.B.li H.J.li H.N.li Hui li J.R.li J.S.li K.li l.J.li l.K.li lei li M.H.li P.R.li q.M.li q.X.li R.li S.X.li t.li W.D.li W.G.li X.li X.H.li X.l.li X.y.li y Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSAtS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and technology Luoyang 471003China Henan University of technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).the fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis CP-even fraction

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Somatic GNA11/GNAq variants in a cohort of Chinese children with phakomatosis pigmentovascularis

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Pediatric Investigation 2024年第2期8卷 117-125页

作者： Bin zhang Rui He Riga wu zhou yang Man Hu Nan zhang wu Guo Zigang Xu lin Ma Department of Dermatology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Department of Dermatology Zhengzhou UniversityAffiliated Children’s HospitalHenan Children’s HospitalZhengzhou Children’s HospitalZhengzhouChina Department of Dermatology Affiliated Hospital of Inner Mongolia Medical UniversityHohhotChina Department of Ophthalmology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Department of Pathology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina

Importance:Postzygotic mutations in the GNAq/GNA11 genes,which encode the G-protein nucleotide binding protein alpha subunits,have been identified in patients with phakomatosis pigmentovascularis(PPV).However,little is known about the Chinese ***:to identify pathogenic mutations in pediatric patients with PPV within the Chinese ***:We performed whole-exome sequencing(WES)using skin lesion tissues from pediatric patients diagnosed with ***,ultradeep-targeted sequencing was conducted to validate the somatic mutations.A genotype-phenotype correlation was analyzed by integrating data from previous reports with the findings of the present ***:thirteen patients were enrolled,all diagnosed with the cesioflammea type of PPV,except for one patient with an unclassifiable *** identified somatic GNA11 c.547C>t(p.R183C)variant in seven patients and GNAq c.548G>A(p.R183q)in four patients,with low allelic fractions ranging from 2.1%to 8.6%through ultradeep ***,a GNAq c.548G>A(p.R183q)variant was detected through targeted sequencing in one of two patients who did not exhibit detectable variants via *** genotype-phenotype correlation analysis,involving 15 patients with a GNA11 variant and 10 with a GNAq variant,revealed that facial capillary malformation(87%vs.50%,P=0.075)and ocular melanocytosis(80%vs.40%,P=0.087)appeared to be more frequent in patients with GNA11 mutation compared to those with GNAq *** four patients diagnosed with cesiomarmorata type or overlapping cesioflammea and cesiomarmorata type PPV carried the GNA11 ***:Our study demonstrated that the majority of PPV patients in the Chinese population carried a postzygotic variant of GNAq/GNA11,thus further confirming the pathogenic role of GNAq/GNA11 mosaicism in the development of PPV cesioflammea type.

关键词： Phakomatosis pigmentovascularis GNA11 GNAq Somatic variant

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CHCHD2 thr61Ile mutation impairs F1F0-AtPase assembly in in vitro and in vivo models of Parkinson's disease

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Neural Regeneration Research 2024年第1期19卷 196-204页

作者： Xiang Chen yuwan lin Zhiling zhang yuting tang Panghai ye Wei Dai Wenlong zhang Hanqun liu Guoyou Peng Shuxuan Huang Jiewen qiu Wenyuan Guo Xiaoqin Zhu Zhuohua wu yaoyun Kuang Pingyi Xu Miaomiao zhou Department of Neurology The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Neurology The People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina School of Basic Medical Sciences Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Mitochondrial dysfunction is a significant pathological alte ration that occurs in Parkinson's disease(PD),and the thr61lle(t61I)mutation in coiled-coil helix coiled-coil helix domain containing 2(CHCHD2),a crucial mitochondrial protein,has been reported to cause Parkinson's ***-AtPase participates in the synthesis of cellular adenosine triphosphate(AtP)and plays a central role in mitochondrial energy ***,the specific roles of wild-type(Wt)CHCHD2 and t611-mutant CHCHD2 in regulating F1FO-AtPase activity in Parkinson's disease,as well as whether CHCHD2 or CHCHD2 t61I affects mitochondrial function through regulating F1FO-AtPase activity,remain unclea ***,in this study,we expressed Wt CHCHD2 and t61l-mutant CHCHD2 in an MPP^(+)-induced SH-Sy5y cell model of *** found that CHCHD2 protected mitochondria from developing MPP^(+)-induced *** normal conditions,ove rexpression of Wt CHCHD2 promoted F1FO-AtPase assembly,while t61I-mutant CHCHD2 appeared to have lost the ability to regulate F1FO-AtPase *** addition,mass spectrometry and immunoprecipitation showed that there was an interaction between CHCHD2 and *** weeks after transfection with AAV-CHCHD2 t61I,we intraperitoneally injected 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into mice to establish an animal model of chronic Parkinson's disease and found that exogenous expression of the mutant protein worsened the behavioral deficits and dopaminergic neurodegeneration seen in this *** findings suggest that Wt CHCHD2 can alleviate mitochondrial dysfunction in PD by maintaining F1F0-AtPase structure and function.

关键词： AtP synthase(F1F0-AtPase) coiled-coil helix coiled-coil helix domain containing 2 dopaminergic neuron mitochondrial dysfunction neurodegeneration oligomycin sensitivity-conferring protein Parkinson's disease t61I mutation tyrosine hydroxylase

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Determination of the number ofψ(3686)events taken at BESⅢ

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Chinese Physics C 2024年第9期48卷 8-20页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso q.An y.Bai O.Bakina I.Balossino y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen H.y.Chen M.l.Chen S.J.Chen S.l.Chen S.M.Chen t.Chen X.R.Chen X.t.Chen y.B.Chen y.q.Chen Z.J.Chen Z.y.Chen S.K.Choi G.Cibinetto F.Cossio J.J.Cui H.l.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.q.Deng Z.y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Ding X.X.Ding y.Ding y.Ding J.Dong l.y.Dong M.y.Dong X.Dong M.C.Du S.X.Du y.y.Duan Z.H.Duan P.Egorov y.H.Fan J.Fang J.Fang S.S.Fang W.X.Fang y.Fang y.q.Fang R.Farinelli l.Fava F.Feldbauer G.Felici C.q.Feng J.H.Feng y.t.Feng M.Fritsch C.D.Fu J.l.Fu y.W.Fu H.Gao X.B.Gao y.N.Gao yang Gao S.Garbolino I.Garzia l.Ge P.t.Ge Z.W.Ge C.Geng E.M.Gersabeck A.Gilman K.Goetzen l.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu y.t.Gu C.y.Guan Z.l.Guan A.q.Guo l.B.Guo M.J.Guo R.P.Guo y.P.Guo A.Guskov J.Gutierrez K.l.Han t.t.Han F.Hanisch X.q.Hao F.A.Harris K.K.He K.l.He F.H.Heinsius C.H.Heinz y.K.Heng C.Herold t.Holtmann P.C.Hong G.y.Hou X.t.Hou y.R.Hou Z.l.Hou B.y.Hu H.M.Hu J.F.Hu S.l.Hu t.Hu y.Hu G.S.Huang K.X.Huang l.q.Huang X.t.Huang y.P.Huang t.Hussain F.Hölzken N.Hüsken N.in der Wiesche J.Jackson S.Janchiv J.H.Jeong q.Ji q.P.Ji W.Ji X.B.Ji X.l.Ji y.y.Ji X.q.Jia Z.K.Jia D.Jiang H.B.Jiang P.C.Jiang S.S.Jiang t.J.Jiang X.S.Jiang y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin y.Jin M.q.Jing X.M.Jing t.Johansson S.Kabana N.Kalantar-Nayestanaki X.l.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui N.Kumar A.Kupsc W.Kühn J.J.lane P.larin l.lavezzi t.t.lei Z.H.lei M.lellmann t.lenz C.li C.li C.H.li Cheng li D.M.li F.li G.li H.B.li H.J.li H.N.li Hui li J.R.li J.S.li Ke li l.J.li l.K.li lei li M.H.li P.R.li q.M.li q.X.li R.li S.X.li t.li W.D.li W.G.li X.li X.H.li X.l.li X.Z.li Xi Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSAtS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and technology Luoyang 471003China Henan University of technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN laboratori Nazionali di Frascati (A)INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly(B)INFN Sezione di PerugiaI-06100PerugiaItaly(C)University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara (A)INFN Sezione di FerraraI-44122FerraraItaly(B)University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de Alta Investigación Universidad de TarapacáCasilla 7DArica 1000000Chile Jilin University Changchun 130012China Joha

the number ofψ(3686)events collected by the BESⅢdetector during the 2021 run period is determined to be(2259.3±11.1)×10~6 by counting inclusiveψ(3686)hadronic *** uncertainty is systematic and the statistical uncertainty is ***,the numbers ofψ(3686)events collected during the 2009 and 2012run periods are updated to be(107.7±0.6)×10~6 and(345.4±2.6)×10~6,*** numbers are consistent with the previous measurements within one standard *** total number ofψ(3686)events in the three data samples is(2712.4±14.3)×10~6.

关键词： ψ(3686) inclusive process Hadronic events BESⅢdetector

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terpyridine-based metallo-cuboctahedron nanomaterials for efficient photocatalytic degradation of persistent organic pollutants

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Nano Research 2024年第8期17卷 6833-6840页

作者： qixia Bai yan Huang Zhihong Chen yilin Pan Xiaohan zhang qingwu long qiaoan yang tun wu ting-Zheng Xie Mingjian wang Hongguang luo Chun Hu Pingshan wang Zhe zhang Key laboratory for Water quality and Conservation of the Pearl River Delta(Ministry of Education) Institute of Environmental Research at Greater Bay AreaGuangzhou UniversityGuangzhou 510006China College of light Chemical Industry and Materials Engineering Shunde PolytechnicFoshan 528333China Guangdong Guangye Inspection&testing Group Co. Ltd.Guangzhou 510006China

Metal–organic cage photocatalysts with nanoscale dimensions have received wide attention in the field of photocatalytic environmental pollutant treatment due to their large cavities,easy modification,high tunability,and enriched active ***,we prepared a series of dihydroanthracene-cored terpyridine-based metallo-cuboctahedron nanomaterials through a selfassembly method,which exhibited satisfactory degradation performance for persistent organic pollutants under visible light *** particular,under light conditions,S1-Zn,one of the prepared nanomaterials,produced photogenerated holes oxidizing water molecules to∙OH,which attacked ibuprofen(IBU)for up to 95% ***,the corresponding photogenerated electrons reduced the dissolved oxygen in water,producing 66.2μmol/l hydrogen *** obtained supramolecular photocatalytic materials have a stable structure with non-precious metals and do not require a sacrificial *** metal sites of metallo-cuboctahedrons adsorb pollutants and transfer captured holes to them,accelerating degradation and promoting simultaneous H_(2)O_(2) *** work not only proposes a simple and efficient synthesis method for supramolecular photocatalysts but also opens up opportunities for efficient,low-cost,and multifunctional materials for environmental persistent organic pollutants treatment.

关键词： supramolecular cages self-assembly photocatalytic pollutant degradation H2O2 production

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