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Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan ping Yu Emily Choi Michael qjiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

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HIGH ACCURACY ANALYSIS OF THE WILSON ELEMENT

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journal of Computational Mathematics 1999年第2期17卷 113-124页

作者： Luo, p Lin, q Chinese Acad Sci Inst Math Beijing 100080 Peoples R China Chinese Acad Sci Inst Syst Sci Beijing 100080 Peoples R China

In this paper, the Wilson nonconforming finite element is considered for solving a class of second-order elliptic boundary value problems. Based on an asymptotic error expansion for the Wilson finite element, the glob... 详细信息

关键词： finite elements defect correction global superconvergence Wilson element

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Reducing the anisotropy of a Brazilian disc generated in a bonded-particle model

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Acta Mechanica Sinica 2018年第4期34卷 716-727页

作者： q.Zhang X.p.Zhang p.q.ji The Key Laboratory of Safety for Geotechnical and Structural Engineering of Hubei province School of Civil EngineeringWuhan University

The Brazilian test is a widely used method for determining the tensile strength of rocks and for calibrating parameters in bondedparticle models（BpMs）. In previous studies, the Brazilian disc has typically been trimmed from a compacted rectangular specimen. The present study shows that different tensile strength values are obtained depending on the compressive loading direction. Several measures are proposed to reduce the anisotropy of the disc. The results reveal that the anisotropy of the disc is significantly influenced by the compactibility of the specimen from which it is trimmed. A new method is proposed in which the Brazilian disc is directly generated with a particle boundary, effectively reducing the anisotropy. The stiffness（particle and bond） and strength（bond） of the boundary are set at less than and greater than those of the disc assembly, respectively,which significantly decreases the stress concentration at the boundary contacts and prevents breakage of the boundary particle bonds. This leads to a significant reduction in the anisotropy of the disc and the discreteness of the tensile strength. This method is more suitable for carrying out a realistic Brazilian test for homogeneous rock-like material in the BpM.

关键词： Bonded-particle model Brazilian disc Anisotropy Compactibility particle boundary

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An efficient SpH methodology for modelling mechanical characteristics of particulate composites

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Defence Technology（防务技术） 2021年第1期17卷 135-146页

作者： Z.j.Zheng S.Kulasegaram p.Chen Y.q.Chen Department of Mechanics College of Mechanical EngineeringChongqing University of TechnologyChongqing400054China Institute of Applied and Computational Mechanics Cardiff School of EngineeringCardiff UniversityQueen’s BuildingsThe ParadeCardiffCF243AAWalesUK Department of Mechanics and Engineering Science College of EngineeringPeking UniversityBeijing100871China

particulate composites are one of the widely used materials in producing numerous state-of-the-art components in biomedical,automobile,aerospace including defence *** of modelling techniques have been adopted in the past to model mechanical behaviour of particulate *** to their favourable properties,particle-based methods provide a convenient platform to model failure or fracture of these *** particle hydrodynamics(SpH)is one of such methods which demonstrate excellent potential for modelling failure or fracture of particulate composites in a Lagrangian *** of the major challenges in using SpH method for modelling composite materials depends on accurate and efficient way to treat interface and boundary *** this paper,a masterslave method based multi-freedom constraints is proposed to impose essential boundary conditions and interfacial displacement constraints in modelling mechanical behaviour of composite materials using SpH *** proposed methodology enforces the above constraints more accurately and requires only smaller condition number for system stiffness matrix than the procedures based on typical penalty function approach.A minimum cut-off value-based error criteria is employed to improve the computational efficiency of the proposed *** addition,the proposed method is further enhanced by adopting a modified numerical interpolation scheme along the boundary to increase the accuracy and computational *** numerical examples demonstrate that the proposed master-slave approach yields better accuracy in enforcing displacement constraints and requires approximately the same computational time as that of penalty method.

关键词： particulate composites SpH Essential boundary condition Multi-point constraints Master-slave method

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Synthesis of Single-Crystal TiO_2 Nanowire Using Titanium Monoxide powder by Thermal Evaporation

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journal of Materials Science & Technology 2012年第5期28卷 385-390页

作者： Z.G.Shang Z.q.Liu p.j.Shang j.K.Shang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

TiO 2 nanowires were synthesized successfully in a large quantity by thermal evaporation using titanium monoxide powder as precursor. X-ray diffraction results showed that all the products were pure rutile phase of TiO 2 . According to microstructural observations, the nanowires have two typical morphologies, a long straight type and a short tortuous type. The straight nanowires were obtained at a wide temperature range of 900–1050 ℃, while the tortuous ones were formed below 900 ℃. Transmission electron microscopy characterization revealed that both the straight and the tortuous nanowires are single-crystal rutile TiO 2 . The preferential growth direction of the nanowires was determined as [110] orientation according to electron diffraction and high-resolution image analyses. The morphological change of TiO 2 nanowires was discussed by considering the different atomic diffusion rates of Ti atoms caused by the phase transformation in Ti substrate at around 900 ℃.

关键词： Rutile-TiO 2 Alloy nanowires Transmission electron microscopy (TEM) characterization Crystal structure identification Growth mechanism Thermal evaporation

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Long-term corrosion evolution associated with the structural heterogeneities of an Fe-based amorphous coating in H_(3)BO_(3)solution at various temperatures

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journal of Materials Science & Technology 2023年第9期140卷 233-248页

作者： D.B.Wang j.Wu j.p.Cui q.Wang T.R.Li W.Emori S.D.Zhang j.q.Wang Shenyang National Laboratory for Materials Science Institute of Metal ResearchCASShenyang110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing400044China School of Materials Science and Engineering Sichuan University of Science and EngineeringZigong 643000SichuanChina

Understanding the long-term corrosion behavior of neutron absorber materials in H_(3)BO_(3)solution is crucial for the materials applications in spent fuel *** this paper,long-term corrosion evolution for 180 d in relation to the structural heterogeneities of an Fe-based amorphous coating(AMC)in H_(3)BO_(3)solution at various temperatures was systematically *** indicate that the coating corrosion could be divided into three distinct ***,the corrosion resistance increased owing to the thickening and composition evolution of the passive ***,the corrosion rate was kept almost constant in the second stage,which connected with the steady state of the passive ***,the corrosion resistance of coating reduced gradually owing to the initiation and penetration of local-ized ***,it was revealed that the localized corrosion was initiated at the relatively Cr-depleted amorphous matrix in the deep pores of the *** could be attributed to the synergy of Cr-depletion and occlusive effect in the deep pores during long-term *** the elevation of temperature,the localized corrosion was enhanced due to the accumulation of the H+in the pores to swiftly reach the critical conditions for passive film *** work provides insights into the long-term corrosion mechanism of Fe-based AMCs in H_(3)BO_(3)solution and offers meaningful contributions to the design of new corrosion resistant neutron absorbing coatings for spent fuel storage applications.

关键词： AMC Boric acid EIS Long-term corrosion Temperature

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Stability and optoelectronic property of low-dimensional organic tin bromide perovskites

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Chinese physics B 2021年第3期30卷 483-487页

作者： j H Lei q Tang j He M q Cai School of Science Hunan University of TechnologyZhuzhou 412007China School of physics and Electronics Science Hunan UniversityChangsha 410082China

The toxicity and degradation of hybrid lead-halide perovskites hinder their extensive *** is thus of great importance to explore non-toxic alternative materials with excellent stability and optoelectronic *** investigate the atomic structures and optoelectronic properties of non-toxic organic tin bromide perovskites(OTBp)with one/zerodimensional(1D/0D)structures by first-principles *** calculated atomic structures show that the 1D/0D OTBps are stable and the structure of inorganic octahedra in 0D is higher order than that in ***,the origination of exceptional purity emitting light in experiments is explained based on the calculated electronic structure.

关键词： one/zero dimensional non-toxic organic tin bromide perovskites first principle calculation stability Optoelectronic property

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Effects of the Reversely Rotating Assisted Shoulder on Microstructures During the Reverse Dual-rotation Friction Stir Welding

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journal of Materials Science & Technology 2015年第4期31卷 375-383页

作者： j.q.Li H.j.Liu State Key Laboratory of Advanced Welding and joining Harbin Institute of Technology Capital Aerospace Machinery Company

The reverse dual-rotation friction stir welding(RDR-FSW) has the capability to adjust the heat generation because of the separately designed tool shoulder and tool *** welding torque exerted on the workpiece by the reversely rotating shoulder is opposite to that exerted by the rotating tool pin,so the total welding torque is reduced,which is beneficial to reducing the clamping requirement of *** the present paper,a RDR-FSW joint was welded in a condition similar to the optimal welding condition of conventional FSW,and microstructures in various zones were investigated by comparison,aiming to highlight effects of the reversely rotating assisted *** to the heat conduction of the middle cylinder and the bottom end cover on which the assisted shoulder was machined,the thermal effect of RDR-FSW was smaller than that of the conventional ***,the effect of assisted shoulder on the plastic flow or deformation of material or was constrained in a thin layer near the weld top surface,and thus the flow of material especially along the thickness direction was clearly decreased in the *** the heat-affected zone(HAZ),the precipitate coarsening was the main evolution and was completed through the dissolution of small precipitates and the continuous growth of large *** contrast,the dissolution degree of precipitates increased significantly in the thermomechanically affected zone(TMAZ),and a small amount of original meta-stable precipitates transformed to block-shaped stable *** evolutions in the shoulder affected zone(SAZ)and the weld nugget zone were similar,*** majority of original meta-stable precipitates dissolved into the matrix and the remainder transformed to stable precipitates,though the dissolution degree was greater in the *** with the conventional FSW joint,the coarsening degrees of precipitates in the HAZ and TMAZ of RDR-FSW joint were much smaller,as well as the dissolution degrees of p

关键词： Friction stir welding Reverse dual-rotation fricti

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Bayesian Deep Learning for Dynamic power System State prediction Considering Renewable Energy Uncertainty

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journal of Modern power Systems and Clean Energy 2022年第4期10卷 913-922页

作者： Shiyao Zhang james j.q.Yu Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen 518055China Department of Computer Science and Engineering Southern University of Science and TechnologyShenzhen 518055China

Modern power systems are incorporated with distributed energy sources to be environmental-friendly and ***,due to the uncertainties of the system integrated with renewable energy sources,effective strategies need to be adopted to stabilize the entire power ***,the system operators need accurate prediction tools to forecast the dynamic system states *** this paper,we propose a Bayesian deep learning approach to predict the dynamic system state in a general power ***,the input system dataset with multiple system features requires the data pre-processing ***,we obtain the dynamic state matrix of a general power system through the Newton-Raphson power flow ***,by incorporating the state matrix with the system features,we propose a Bayesian long short-term memory(BLSTM)network to predict the dynamic system state variables *** results show that the accurate prediction can be achieved at different scales of power systems through the proposed Bayesian deep learning approach.

关键词： Bayesian deep learning data analytics NewtonRaphson power flow renewable energy source system state

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pARTICLE SIZE AND MICROSTRUCTURE OF Ni NANOpOWDERS pREpARED BY ANODIC ARC pLASMA

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Acta Metallurgica Sinica(English Letters) 2005年第3期18卷 209-216页

作者： Z.q.Wei H.X.qiao j.F.Dai W.j.Feng q.Wang p.X.Yan SchoolofSciences LanzhouUniversityofTechnologyLanzhou730050China CollegeofCivilEngineering LanzhouUniversityofTechnologyLanzhou730050China SchoolofphysicalScienceandTechnology LanzhouUniversityLanzhou730000China

pure Ni nanopowders were successfully prepared by the method of anodic arc disch arged plasma with homemade experimental apparatus. The particle size, mircostruc ture and morphology of the particles by this process were characterized via X-ra y powder diffraction (XRD), transmission electron microscopy (TEM) and the corre sponding selected area electron diffraction (SAED); The specific surface area an d pore parameters were investigated by multi-point full analysis of nitrogen ads orption-desorption isotherms at 77K by Brunauer- Emmett-Teller (BET) surface are a analyzer; The chemical composition were determined by X-ray energy dispersive spectrometry (XEDS) equipped in SEM and element analyze instrument. The experime nt results indicate that the samples by this method with high purity,the crystal structure of the particles is as same as the bulk material, is fcc structure, w ith average particle sizes about 47nm, ranging from 20 to 70nm, and distributed uniformly in spherical chain shapes, the specific surface areavis 14.23m2/g, po re volume of pore is 0.09cm3/g and average pore diameter is 23nm.

关键词： anodic arc plasma Ni nanopowder particle size structure composition.

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