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Hexafluoropropylene oxide trimer acid,a perfluorooctanoic acid alternative,induces cardiovascular toxicity in zebrafish embryos

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Journal of Environmental Sciences 2024年第5期139卷 460-472页

作者： Sujie Sun li Zhang Xue li lu Zang ling Huang Junquan zeng Zigang Cao Xinjun liao Zilin Zhong Huiqiang lu Jianjun Chen Jiangxi Engineering laboratory of Zebrafish Modeling and Drug Screening for Human Diseases Jiangxi Key Laboratory of Developmental Biology of OrgansCenter for Clinical Research Center of the Affiliated Hospital of Jinggangshan UniversityJi’an 343009China Translational Research Institute of Brain and Brain-like Intelligence Shanghai Key Laboratory of Anesthesiology and Brain Functional ModulationDepartment of PediatricsShanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China State Environmental Protection Key laboratory of Environmental Health Impact Assessment of Emerging Contaminants School of Environmental Sciences and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Interventional and Vascular Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343009China Department of Internal Medicine and Hematology Affiliated Hospital of Jinggangshan UniversityJi’an 343009China

As an increasingly used alternative to perfluorooctanoic acid(PFOA),hexafluoropropylene oxide trimer acid(HFPO-TA)has been widely detected in global water ***,little is known regarding its toxic effects on cardiovascular ***,zebrafish embryos were treated with egg water containing 0,60,120,or 240 mg/l *** showed that HFPO-TA treatment led to a significant reduction in both larval survival percentage and heart ***,HFPO-TA exposure caused severe pericardial edema and elongation of the sinus venous to bulbus arteriosus distance(SV-BA)in Tg(myl7:GFP)transgenic larvae,disrupting the expression of genes involved in heart development and thus causing abnormal heart *** sprouting angiogenesis was observed in the 120 and 240 mg/l exposed Tg(fli:GFP)transgenic ***-TA treatment also impacted the mRNA levels of genes involved in the vascular endothelial growth factor(VEGF)pathway and embryonic vascular ***-TA exposure significantly decreased erythrocyte number in Tg(gata1:DsRed)transgenic embryos and influenced gene expression associated with the heme metabolism ***-TA also induced oxidative stress and altered the transcriptional levels of genes related to cell cycle and apoptosis,inhibiting cell proliferation while promoting ***,HFPO-TA exposure may induce abnormal development of the cardiovascular and hematopoietic systems in zebrafish embryos,suggesting it may not be a suitable or safe alternative for PFOA.

关键词： Hexafluoropropylene oxide trimer acid Heart development Vascular development Hemopoiesis Zebrafish embryos

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STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai l.P.An R.Aliberti q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao q.H.Cao X.Cao Z.Cao q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen l.l.Chen P.Chen S.l.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.q.Chen H.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai l.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding l.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du l.M.Duan D.Epifanov Y.l.Fan S.S.Fang Z.J.Fang G.Fedotovich C.q.Feng X.Feng Y.T.Feng J.l.Fu J.Gao Y.N.Gao P.S.Ge C.q.Geng l.S.Geng A.Gilman l.Gong T.Gong B.Gou W.Gradl J.l.Gu A.Guevara l.C.Gui A.q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.l.Han l.Han M.Han X.q.Hao J.B.He S.q.He X.G.He Y.l.He Z.B.He Z.X.Heng B.l.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang q.Y.Huang W.q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.l.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.lei E.levichev C.H.li C.li D.Y.li F.li G.li G.li H.B.li H.li H.N.li H.J.li H.l.li J.M.li J.li l.li l.li l.Y.li N.li P.R.li R.H.li S.li T.li W.J.li X.li X.H.li X.q.l. X.H.li Y.li Y.Y.li Z.J.li H.liang J.H.liang Y.T.liang G.R.liao l.Z.liao Y.liao C.X.lin D.X.lin X.S.lin B.J.liu C.W.liu D.liu F.liu G.M.liu H.B.liu J.liu J.J.liu J.B.liu K.liu K.Y.liu K.liu l.liu q.l.u S.B.liu T.liu X.liu Y.W.liu Y.liu Y.l.liu Z.q.l.u Z.Y.liu Z.W.liu I.logashenko Y.long C.G.lu J.X.lu N.lu q.F.lü Y.lu Y.lu Z.lu P.lukin F.J.luo T.luo X.F.luo Y.H.luo H.J.lyu X.R.lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.l.Olsen q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng l.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.qi Y.q.qi W.B.qian Y.qian C.F.qiao J.J.qin J.J.qin l.q.qin X.S.qin T.l.qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de lausanne(EPFl) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

Multi-focus non-periodic scanning method for femtosecond lasers based on DMD and galvanometer scanners[Invited]

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Chinese Optics letters 2024年第5期22卷 89-94页

作者：李华明王雨胡庆磊张卓宇吕晓华曾绍群 Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074China MOE Key laboratory for Biomedical Photonics Collaborative Innovation Center for Biomedical EngineeringSchool of Engineering SciencesHuazhong University of Science and TechnologyWuhan 430074China

Multi-focus parallel scanning can effectively increase laser fabrication ***,the conventional approach of using a spatial light modulator(SlM)to generate multi-foci and scan this fixed number of foci with galvanometer scanners can only achieve a periodic scanning trajectory due to the low switching speed of the *** we demonstrate a multifocus non-periodic scanning method for femtosecond lasers by using,instead,a fast-switching digital micromirror device(DMD)to generate a dynamic number of *** number of effective foci is quickly switched by introducing aberration to the undesired *** this way,the intensity allocated to each focus will not be affected by the number of foci,and a uniformity of 98%with different numbers of foci is achieved without adjusting the total laser ***,we validate the effectiveness of this scanning method by demonstrating corneal flap fabrication of porcine cornea in vitro.

关键词： multi-focus non-periodic trajectory digital micromirror device aberration control corneal cutting

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Compound heterozygous mutation of AFG3l2 causes autosomal recessive spinocerebellar ataxia through mitochondrial impairment and MICU1 mediated Caoverload

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Science China life Sciences 2024年

作者： Hongyu li qingwen Ma Yan Xue linlin Cai liwen Bao lei Hong Yitao zeng Shuzhen Huang Richard H.Finnell Fanyi zeng Shanghai Institute of Medical Genetics Shanghai Children's Hospital Shanghai Jiao Tong University School of Medicine Department of Histo-Embryology Genetics and Developmental Biology Shanghai Jiao Tong University School of Medicine NHC Key laboratory of Medical Embryogenesis and Developmental Molecular Biology Shanghai Key Laboratory of Embryo and Reproduction Engineering Center for Precision Environmental Health Baylor College of Medicine School of Pharmacy Macau University of Science and Technology

Autosomal recessive spinocerebellar ataxias（SCARs） are one of the most common neurodegenerative diseases characterized by progressive ataxia. Although SCARs are known to be caused by mutations in multiple genes, there are still many cases that go undiagnosed or are misdiagnosed. In this study, we presented a SCAR patient, and identified a probable novel pathogenic mutation（c.1A>G, p.M1V） in the AFG3l2 start codon. The proband's genotype included heterozygous mutations of the compound AFG3l2(p.[M1V]; [R632X]（c.[1A>G];[1894.C>T]）), which were inherited from the father（c.1A>G, p.M1V） and mother（c.1894C>T, p.R632X）. Functional studies performed on hiPSCs（human induced pluripotent stem cells） generated from the patients and HEK293T cells showed that the mutations impair mitochondrial function and the unbalanced expression of AFG3l2 mRNA and protein levels. Furthermore, this novel mutation resulted in the degradation of the protein and the reduction of the stability of the AFG3l2 protein, and MCU（mitochondrial calcium uniporter） complex mediated Ca2+overload.

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Enhanced SERS aptasensor for sensitive detection of saxitoxin based on HAuCl/HOreaction system and Pt/Au nanozyme

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Food Science and Human Wellness 2024年

作者： Yueqing li Xuemei Tang Wei zeng Ting Wu long Wu School of Food Science and Engineering， Key laboratory of Tropical Fruits and Vegetables quality and Safety for State Market Regulation， Hainan University

Saxitoxin （STX） is a marine biotoxin produced by cyanobacteria and methanobacteria， which is harmful to humans and aquatic organisms. Therefore， it is urgent to establish an efficient， sensitive and selective method for the screening of STX. In this paper， based on the HAuCl4/H2O2reaction system， gold nanoparticles （Au NPs） decorated Fe3O4magnetic beads (Fe3O4@Au NPs) and Pt/Au nanozymes （Pt/Au NZs）， an enhanced SERS aptasensor was proposed for sensitive and selective detection of STX. Firstly， SERS tag （4-MBA） and aptamer modified Fe3O4@Au NPs were hybridized with complementary DNA modified Pt/Au NZs （Pt/Au-cDNA） to form the specific complexes. Wherein， aptamer acted as capture agent to specifically recognize STX， Pt/Au NZs catalyzed HAuCl4/H2O2reaction to enhance SERS signal， and Fe3O4facilitated the magnetic separation and simple detection operations. The SERS aptasensor achieved sensitive detection of STX with a wide linear range from 0.02 μmol/l to 0.8 μmol/l and a low detection limit of 13 nmol/l （lOD， S/N=3）. To evaluate the performance of this method， STX were detected in the spiked seafood samples with recoveries from 78.75% to 150% with relative errors below 6.52%. Besides， the SERS aptasensor behaved good stability and repeatability， revealing its promising potential in STX detection and food safety detection.

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Opening the“Black Box”:How Out-of-Class Use of Duolingo Impacts Chinese Junior High School Students'Intrinsic Motivation for English

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ECNU Review of Education 2024年第2期7卷 283-307页

作者：曾成 linda Fisher 184 Hills Road Cambridge CB28PQUK

Purpose:Mobile-assisted language learning(MAll)apps such as Duolingo have great potential for promoting learners'motivation to learn a second language(l2).However,little research has investigated how this motivational impact takes ***,despite the flexibility of mobile learning,most existing studies are conducted in classroom settings,with less attention paid to out-of-school technology ***/Approach/Methods:To address these gaps,we present a model based on self-determination theory and propose the idea of“motivational transfer”to explain the psychological mechanism underpinning the impact of *** examine the model,we conducted a case study with 20 Year 8 Chinese junior school students who used Duolingo to learn English as a foreign language(EFl)after school for 6 ***:questionnaire and group interview data support our hypothesized mechanism:learners'activity-specific intrinsic motivation(IM)for using Duolingo and their underlying psychological need for autonomy and competence can be transferred to a more general level,thereby enhancing learners'global ***:The proposed theoretical model expands our understanding of how digital technology stimulates learners'l2 motivation;it can help l2 educators design better technological affordances to promote learners'motivation both in and outside the classroom.

关键词： Digital game-based learning l2 motivation MAll self-determination theory

Synthesis and Room Temperature Ferromagnetism of Flower-shaped Mn Doped ZnO Nanostructures

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Journal of Materials Science & Technology 2011年第6期27卷 513-517页

作者： Y.q. Chang P.W. Wang R.H. Tang q.l. Sun Y. long School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China Department of Physics National Key Laboratory of Mesoscopic Physics Peking University Beijing 100871 China

large-scale flower-shaped Mn doped ZnO nanostructures have been grown on silicon substrates by simple thermal evaporation at atmospheric *** flower-shaped nanostructure makes up of many nanorods,which are rooted in one *** of X-ray diffraction,high-resolution transmission electron microscopy and Raman spectra results reveal that the products are of single phase with wurtzite *** mapping results show that no impurity clusters exist in the doped *** photoluminescence spectra demonstrate that many oxygen vacancies exist in the doped materials,and the crystal quality is improved and the content of oxygen vacancies is decreased by annealing *** flower-shaped Mn doped ZnO nanostructures exhibit ferromagnetic ordering above room temperature,and its magnetization is decreased by the annealing treatment,which indicates that the magnetic behavior of the doped materials may be related to the interaction between Mn doping and the oxygen vacancies.

关键词： Mn doped ZnO nanomaterials Ferromagnetism Annealing treatment Chemical vapor deposition

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Genetic and lipidomic analyses reveal the key role of lipid metabolism for cold tolerance in maize

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Journal of Genetics and Genomics 2024年第3期51卷 326-337页

作者： lei Gao Haifang Jiang Minze li Danfeng Wang Hongtao Xiang Rong zeng limei Chen Xiaoyan Zhang Jianru Zuo Shuhua Yang Yiting Shi State Key laboratory of Plant Environmental Resilience College of Biological SciencesFrontiers Science Center for Molecular Design BreedingCenter for Crop Functional Genomics and Molecular BreedingChina Agricultural UniversityBeijing 100193China State Key laboratory of Wheat&Maize Crop Science College of Life SciencesHenan Agricultural UniversityZhengzhouHenan 450002China State Key laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Suihua Branch of Heilongjiang Academy of Agricultural Machinery Sciences SuihuaHeilongjiang 152052China

lipid remodeling is crucial for cold tolerance in ***,the precise alternations of lipidomics during cold responses remain elusive,especially in maize(Zea mays l.).In addition,the key genes responsible for cold tolerance in maize lipid metabolism have not been ***,we integrate lipidomic,transcriptomic,and genetic analysis to determine the profile of lipid remodeling caused by cold *** find that the homeostasis of cellular lipid metabolism is essential for maintaining cold tolerance of ***,we detect 210 lipid species belonging to 13 major classes,covering phospholipids,glycerides,glycolipids,and free fatty *** lipid metabolites undergo specific and selective alterations in response to cold stress,especially mono-/di-unsaturated lysophosphatidic acid,lysophosphatidylcholine,phosphatidylcholine,and phosphatidylinositol,as well as polyunsaturated phosphatidic acid,monogalactosyldiacylglycerol,diacylglycerol,and *** addition,we identify a subset of key enzymes,including ketoacyl-acyl-carrier protein synthase II(KAS II),acyl-carrier protein 2(ACP2),male sterility33(Ms33),and stearoyl-acyl-carrier protein desaturase 2(SAD2)involved in glycerolipid biosynthetic pathways are positive regulators of maize cold *** results reveal a comprehensive lipidomic profile during the cold response of maize and provide genetic resources for enhancing cold tolerance in crops.

关键词： Maize Cold stress lipid metabolism Transcriptome lipidomic

A social computing method for energy safety

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Journal of Safety Science and Resilience 2024年第1期5卷 64-82页

作者： Pengfei Zhao Shuangqi li Zhidong Cao Paul Jen-Hwa Hu Daniel Dajun zeng Da Xie Yichen Shen Jiangfeng li Tianyi luo Institute of Automation Chinese Academy of SciencesUniversity of Chinese Academy of SciencesBeijing 100090China Systems Engineering Cornell UniversityIthacaNY 14853USA David Eccles School of Business the University of UtahUtahUSA Department of Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China China University of Mining and Technology China

Information and communication technologies enable the transformation of traditional energy systems into cyber-physical energy systems(CPESs),but such systems have also become popular targets of ***,available methods for evaluating the impacts of cyberattacks suffer from limited resilience,efficacy,and practical *** mitigate their potentially disastrous consequences,this study suggests a two-stage,discrepancy-based optimization approach that considers both preparatory actions and response measures,integrating concepts from social *** proposed Kullback-leibler divergence-based,distributionally robust optimization(KDR)method has a hierarchical,two-stage objective function that incorporates the operating costs of both system infrastructures(e.g.,energy resources,reserve capacity)and real-time response measures(e.g.,load shedding,demand-side management,electric vehicle charging station management).By incorporating social computing principles,the optimization framework can also capture the social behavior and interactions of energy consumers in response to *** preparatory stage entails day-ahead operational decisions,leveraging insights from social computing to model and predict the behaviors of individuals and communities affected by potential *** mitigation stage generates responses designed to contain the consequences of the attack by directing and optimizing energy use from the demand side,taking into account the social context and preferences of energy consumers,to ensure resilient,economically efficient CPES *** method can determine optimal schemes in both stages,accounting for the social dimensions of the *** original disaster mitigation model uses an abstract formulation to develop a risk-neutral model that characterizes cyberattacks through KDR,incorporating social computing techniques to enhance the understanding and response to cyber *** approach can mitigate the impacts more

关键词： Cyberattacks Cyber-physical energy systems Distributionally robust optimization False data injections Two-stage modeling Social computing