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Mpox(formerly monkeypox):pathogenesis,prevention,and treatment

Signal Transduction and Targeted Therapy 2024年第1期9卷 234-248页

作者： Junjie Lu Hui xing Chunhua Wang Mengjun Tang Changcheng Wu Fan Ye Lijuan Yin Yang Yang Wenjie Tan Liang Shen Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and ScienceHubei ProvinceXiangyang 441021China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China College of Biotechnology Tianjin University of Science&TechnologyTianjin 300457China Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for infectious diseaseState Key Discipline of Infectious DiseaseShenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China

In 2022,a global outbreak of Mpox(formerly monkeypox)occurred in various countries across Europe and America and rapidly spread to more than 100 countries and *** World Health Organization declared the outbreak to be a public health emergency of international concern due to the rapid spread of the Mpox ***,nations intensified their efforts to explore treatment strategies aimed at combating the infection and its ***,the available therapeutic options for Mpox virus infection remain *** far,only a few numbers of antiviral compounds have been approved by regulatory *** the high mutability of the Mpox virus,certain mutant strains have shown resistance to existing pharmaceutical *** highlights the urgent need to develop novel antiviral drugs that can combat both drug resistance and the potential threat of ***,there is a lack of comprehensive literature on the pathophysiology and treatment of *** address this issue,we conducted a review covering the physiological and pathological processes of Mpox infection,summarizing the latest progress of anti-Mpox *** analysis encompasses approved drugs currently employed in clinical settings,as well as newly identified small-molecule compounds and antibody drugs displaying potential antiviral efficacy against ***,we have gained valuable insights from the process of Mpox drug development,including strategies for repurposing drugs,the discovery of drug targets driven by artificial intelligence,and preclinical drug *** purpose of this review is to provide readers with a comprehensive overview of the current knowledge on Mpox.

关键词： prevention treatment intensified

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Top-quark rare decays with flavor violation

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Chinese Physics C 2024年第9期48卷 68-81页

作者： Ming-Yue Liu Shu-Min Zhao Song gao xing-Yu Han Tai-Fu Feng Department of Physics Hebei UniversityBaoding 071002China Hebei Key Laboratory of High-precision Computation and Application of quantum Field Theory Baoding 071002China Hebei Research Center of the Basic Discipline for Computational Physics Baoding 071002China Department of Physics Chongqing UniversityChongqing 401331China

In the present study,we investigated the decays of the top quark:t→cy,t→cg,t→cZ,and t→*** are extremely rare processes in the standard model(SM).As the U(1)extension of the minimal supersymmetric standard model(MSSM),the U(1)_X SSM features new superfields such as the right-handed neutrinos and three Higgs *** analyzed the effects of different sensitive parameters on the results and made reasonable theoretical predictions,thereby providing a useful reference for future experimental *** the constraint set by the updated experimental data,the numerical results show that the branching ratios of the four proccsscs,i.e.,t→cγ,cg,cZ,ch,can reach the same order of magnitude as their experimental upper *** them,tanβhas the most evident effect on these processes and is the main parameter;g_(X),g_(YX),μ,M_(2),λ_(H),M_(U23)^(2),and M_(q23)^(2) are also important parameters for the processes,and have effects on the numerical results.

关键词： Top quark flavor violation U(1)_(X)SSM new physics

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Using Copula functions to predict climatic change impacts on floods in river source regions

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Advances in Climate Change Research 2024年第3期15卷 406-418页

作者： Ting-xing CHEN Hai-Shen LYU Robert HORTON Yong-Hua ZHU Ren-Sheng CHEN Ming-Yue SUN Ming-Wen LIU Yu LIN The National Key Laboratory of Water Disaster Prevention College of Hydrology and Water ResourcesHohai UniversityNanjing 2098China College of Hydrology and Water Resources Hohai UniversityNanjing 210098China Departmentof Agronomy lowa State UniversityAmes IA5oollUSA qilian Alpine Eology and Hydrology Research Station Northwest Instiuteof Eco-Environmentand ReourcesChinese Academy of SciencesLanzhou0000 China

Flood frequency in river source regions is significantly affected by rainfall and snowmelt as part of climatic changes.A traditional univariate flood frequency analysis cannot reflect the complexity of floods,and when used in isolation,it can only underestimate flood *** effective flood prevention and mitigation,it is essential to consider the combined effects of precipitation and *** functions can effectively quantify the joint distribution relationship between floods and their associated variables without restrictions on their distribution *** study uses copula functions to consider a multivariate probability distribution model of flood peak flow(q)with cumulative snowmelt(CSm)and cumulative precipitation(CPr)for the Hutubi River basin located in northern Xinjiang,*** joint frequencies of rainfall and snowmelt floods are predicted using copula models based on the Coupled Model Intercomparison Project Phase 6 *** results show that q has a significant positive correlation with 24-d CSm(r=0.559,p=0.002)and 23-d CPr(r=0.965,pquency will increase in the future,and mid-(2050e2074)and long-term(2075e2099)floods will be more severe than those in the near-term(2025e2049).The probability of flood occurrence is higher under the SSP2-4.5 and SSP1-2.6 scenarios than under *** during the historical period(1990e2014)led to extreme floods,and increasing future precipitation trends are found to be *** increases with rising temperatures and occurs earlier than estimated,leading to an earlier flood period in the basin and more frequent snowmelt *** q under the joint return period is larger than that during the same univariate return *** difference indicates that neglecting the interaction between precipitation and snowmelt for floods leads to an underestimation of the flood risk(with underestimations ranging from 0.3%to 22%).The underestimations decrease with an increase

关键词： Climate change Flood frequency Copula CMIP6 River source regions

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Versatile photonic molecule switch in multimode microresonators

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Light(Science & Applications) 2024年第3期13卷 498-509页

作者： Zihan Tao Bitao Shen Wencan Li Luwen xing Haoyu Wang Yichen Wu Yuansheng Tao Yan Zhou Yandong He Chao Peng Haowen Shu xingjun Wang State Key Laboratory of Advanced Optical Communications System and Networks School of ElectronicsPeking UniversityBeijing 100871China College of Engineering Peking UniversityBeijing 100871China School of Integrated Circuits Peking University100871 BejingChina Peking University Yangtze Delta Institute of Optoelectronics Nantong 226010China Frontiers Science Center for Nano-optoelectronics Peking UniversityBeijing 100871China Peng Cheng Laboratory Shenzhen 518055China

Harnessing optical supermode interaction to construct artificial photonic molecules has uncovered a series of fundamental optical phenomena analogous to atomic ***,the distinct energy levels and interactions in such two-level systems were provided by coupled *** reconfigurability is limited,as they often require delicate external field stimuli or mechanically altering the geometric *** highly specific approaches also limit potential ***,we propose a versatile on-chip photonic molecule in a multimode microring,utilizing a flexible regulation methodology to dynamically control the existence and interaction strength of spatial *** transition between single/multi-mode states enables the“switched-off/on”functionality of the photonic molecule,supporting wider generalized applications *** particular,“switched-on”state shows flexible and multidimensional mode splitting control in aspects of both coupling strength and phase difference,equivalent to the *** *** effect.“Switched-off”state allows for perfect low-loss single-mode transition(qi~10 million)under an ultra-compact bend size(FSR~115 gHz)in a foundry-based silicon *** breaks the stereotyped image of the FSR-q factor trade-off,enabling ultra-wideband and high-resolution millimeter-wave photonic *** demonstration provides a flexible and portable solution for the integrated photonic molecule system,extending its research scope from fundamental physics to real-world applications such as nonlinear optical signal processing and sixth-generation wireless communication.

关键词： switched multimode millimeter

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Cambricon-qR:a sparse and bitwise reproducible quantized training accelerator

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High Technology Letters 2024年第1期30卷 52-60页

作者：李楠 ZHAO Yongwei ZHI Tian LIU Chang DU Zidong HU xing LI Wei ZHANg Xishan LI Ling SUN guangzhong School of Computer Science and Technology University of Science and Technology of ChinaHefei 230026P.R.China State Key Laboratory of Processors Institute of Computing TechnologyChinese Academy of SciencesBeijing 100086P.R.China Cambricon Tech.Ltd Beijing 100191P.R.China Institute of Software Chinese Academy of SciencesBeijing 100086P.R.China

quantized training has been proven to be a prominent method to achieve deep neural network training under limited computational *** uses low bit-width arithmetics with a proper scaling factor to achieve negligible accuracy ***-q is the ASIC design proposed to efficiently support quantized training,and achieves significant performance ***,there are still two caveats in the ***,Cambricon-q with different hardware specifications may lead to different numerical errors,resulting in non-reproducible behaviors which may become a major concern in critical ***,Cambricon-q cannot leverage data sparsity,where considerable cycles could still be squeezed *** address the caveats,the acceleration core of Cambricon-q is redesigned to support fine-grained irregular data *** new design not only enables acceleration on sparse data,but also enables performing local dynamic quantization by contiguous value ranges(which is hardware independent),instead of contiguous addresses(which is dependent on hardware factors).Experimental results show that the accuracy loss of the method still keeps negligible,and the accelerator achieves 1.61×performance improvement over Cambricon-q,with about 10%energy increase.

关键词： quantized training sparse accelerator Cambricon-qR

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Influence of organic matter input and temperature change on soil aggregate-associated respiration and microbial carbon use efficiency in alpine agricultural soils

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Soil Ecology Letters 2024年第3期6卷 177-188页

作者： Shuaiwen Zhang Wei gong Xin Wan Junya Li Zhiguo Li Peng Chen Shunlin xing Ziyan Li Yi Liu School of Ecology and Environment Tibet UniversityLhasa 850000China Key Laboratory of Aquatic Botany and Watershed Ecology Wuhan Botanical GardenChinese Academy of SciencesWuhan 430074China College of Resources and Environment Northwest A&F UniversityYangling 712100China

Understanding the dynamics of soil respiration,microbial carbon use efficiency(CUE),and temperature sensitivity(q_(10))in response to exogenous organic matter(EOM)input,soil aggregate size,and incubation temperature is crucial for predicting soil carbon cycling responses to environmental *** this study,these interactions were investigated by 180-day incubation of soil aggregates supplemented with EOM at various temperatures(5°C,15°C and 25°C).The results reveal an‘L-shaped’trend in soil respiration on the time scale across all treatments,characterized by initial rapid declines followed by *** input and higher temperatures significantly enhance respiration ***,the respiratory rates of soil aggregates of different sizes exhibit distinct patterns based on the presence or absence of *** conditions without the addition of EOM,larger aggregates show relatively lower respiration ***,in the presence of EOM,larger aggregates exhibit higher respiratory ***,q_(10)decreases with increasing aggregate *** relationship between q_(10)and the substrate quality index(SqI)supports the carbon quality temperature(CqT)hypothesis,highlighting SqI’s influence on q_(10)values,particularly during later incubation *** CUE decreases with EOM input and rising ***,aggregate size plays a role in microbial CUE,with smaller aggregates exhibiting higher CUE due to enhanced nutrient *** conclusion,the intricate interplay of EOM input,aggregate size,and temperature significantly shapes soil respiration,microbial CUE,and q_(10).These findings underscore the complexity of these interactions and their importance in modeling soil carbon dynamics under changing environmental conditions.

关键词： soil aggregates soil respiration temperature sensitivity Tibetan Plateau

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论公共卫生治理的政府责任

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求是学刊 2024年第2期51卷 113-123页

作者：邢昕郑州大学法学院郑州450001

多元共治时代,公共卫生治理中政府责任要打破基于行政任务进行责任配置的传统逻辑,将政府责任的厘定置于“公共任务公私合作”和“行政任务公私合作”的双重视域。公共卫生治理中行政机关作为公共任务公私合作的主导者和行政任务公私合... 详细信息

多元共治时代,公共卫生治理中政府责任要打破基于行政任务进行责任配置的传统逻辑,将政府责任的厘定置于“公共任务公私合作”和“行政任务公私合作”的双重视域。公共卫生治理中行政机关作为公共任务公私合作的主导者和行政任务公私合作的责任方,在承担领导与促进责任、组织与动员责任、履行或担保责任、监督与救济责任之时,其内部构造差异明显。新时代公共卫生治理体系建构必须着眼于中国式社会治理共同体这一整体性视角,科学厘定公共卫生治理中政府责任的内部法律构造,统筹推动公共卫生治理法治化进程。

关键词：公共卫生治理政府责任公私合作行政组织法

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STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao q.H.Cao X.Cao Z.Cao q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.q.Chen H.Y.Cheng J.Cheng S.Cheng T.g.Cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.g.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang g.Fedotovich C.q.Feng X.Feng Y.T.Feng J.L.Fu J.gao Y.N.gao P.S.ge C.q.geng L.S.geng A.gilman L.gong T.gong B.gou W.gradl J.L.gu A.guevara L.C.gui A.q.guo F.K.guo J.C.guo J.guo Y.P.guo Z.H.guo A.guskov K.L.Han L.Han M.Han X.q.Hao J.B.He S.q.He X.g.He Y.L.He Z.B.He Z.X.Heng B.L.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua g.S.Huang J.S.Huang M.Huang q.Y.Huang W.q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.Li C.Li D.Y.Li F.Li g.Li g.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.q.Li X.H.Li Y.Li Y.Y.Li Z.J.Li H.Liang J.H.Liang Y.T.Liang g.R.Liao L.Z.Liao Y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu g.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu q.Liu S.B.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long C.g.Lu J.X.Lu N.Lu q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen q.Ouyang P.Pakhlov g.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.qi Y.q.qi W.B.qian Y.qian C.F.qiao J.J.qin J.J.qin L.q.qin X.S.qin T.L.qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China goethe University Frankfurt D-60325 Frankfurt am MainGermany guangxi Normal University Guilin 541004China guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 geV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

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Lycorine derivative effectively inhibits the replication of coronaviruses both in vitro and in vivo

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hLife 2024年第2期2卷 75-87页

作者： Liang Shen Jianzhong Zhao Ying Xia Junjie Lu Jiali Sun Jian Tang Hui xing Lijuan Yin Yang Yang Chunhua Wang Department of Clinical Laboratory Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceHubeiChina Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for Infectious DiseaseState Key Discipline of Infectious DiseaseShenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyGuangdongChina Department of Clinical Laboratory Xiangyang No.1 People’s HospitalHubei University of MedicineHubeiChina State Key Laboratory of Food Nutrition and Safety Key Laboratory of Industrial MicrobiologyMinistry of EducationTianjin Key Laboratory of Industry MicrobiologyNational and Local United Engineering Lab of Metabolic Control Fermentation TechnologyChina International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal ChemistryCollege of BiotechnologyTianjin University of Science&TechnologyTianjinChina

The established and ongoing prevalence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and seasonal human coronaviruses(HCoV)like HCoV-OC43,HCoV-NL63,and HCoV-229E,pose a continuous threat to public ***,it is urgently needed to explore antiviral drugs with broad-spectrum anti-coronavirus *** previous studies have revealed that lycorine is a potent broad-spectrum anti-coronavirus drug,a natural alkaloid extracted from Amaryllidaceae with various pharmacological and microbiological ***,it is unsafe to directly use lycorine as a clinical antiviral drug due to the cytotoxicity and induction of cell *** this study,a series of lycorine derivatives were designed and *** of them,named Ly-8,was found to effectively inhibit the replication of different coronavirus strains in vitro,including ***,Ly-8 was also shown to effectively inhibit HCoVOC43 replication in the central nervous system,and provide effective protection against HCoV-OC43 infection in mice with low drug ***,Ly-8-resistant mutants were not observed during the 30 times sequential passages in cell ***,these findings suggest that Ly-8 may be a potential candidate drug for the future development of broad-spectrum anti-coronavirus drugs.

关键词： broad-spectrum antiviral drug lycorine derivative Ly-8

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高温作用后新型高强qN1803不锈钢轴压构件局部稳定性能研究

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湖南大学学报（自然科学版） 2024年第7期51卷 192-205页

作者：伞冰冰雷婧邢哲河海大学土木与交通学院江苏南京210098

通过建立新型高强度qN1803不锈钢工字形和方矩形截面短柱的有限元模型对其高温作用后的局部稳定性能进行了数值模拟分析.通过参数分析探究了残余应力、局部初始几何缺陷及温度工况对构件局部稳定性能及极限承载力的影响.研究结果表明:... 详细信息

通过建立新型高强度qN1803不锈钢工字形和方矩形截面短柱的有限元模型对其高温作用后的局部稳定性能进行了数值模拟分析.通过参数分析探究了残余应力、局部初始几何缺陷及温度工况对构件局部稳定性能及极限承载力的影响.研究结果表明:对于方矩形构件及截面正则化长细比小于1.0的厚实工字形构件,残余应力对承载力的影响较小;对于薄柔工字形构件,残余应力会降低其截面承载力,且降低幅度随着温度的升高而下降.此外,随着温度升高,初始几何缺陷对不锈钢工字形构件承载力产生显著影响且正则化宽厚比的影响限值变大,对不锈钢方矩形构件承载力的影响则相反.最后,本文基于参数分析结果,评估了现行欧洲规范EN 1993-1-4、美国规范ASCE/SEI-8-02以及中国《不锈钢结构技术规程》(CECS 410:2015)中不锈钢构件局部稳定性能常温设计方法的适用性,发现了现有设计方法中对高强不锈钢轴心受压构件的高温作用后设计指导尚存在不合理之处并提出了优化建议.

关键词：不锈钢稳定高温受压构件有限元模拟设计方法

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