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Toughening additive manufactured Zr-based bulk metallic glass composites by martensite phase transformation

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Journal of Materials Science & Technology 2024年第3期170卷 95-102页

作者： Pengcheng zhang Cheng zhang Jie Pan Di Ouyang Lin Liu State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

Additive manufacturing technology based on laser powder bed fusion(LPBf)offers a novel approach for fabricating bulk metallic glass(BMG)products without restriction in size and ***,the BMGs prepared by LPBf usually suffered from less plasticity and poorer fracture toughness as compared to their cast counterparts due to partial crystallization in heat-affected zones(HAZs).Since crystallization in HAZs is hard to avoid completely in LPBf BMGs,it is desirable to design a suitable alloy system,in which only ductile crystalline phase,instead of brittle intermetallics,is formed in *** uniq.e structure could effectively increase the toughness/plasticity of the LPBf *** achieve this goal,a q.aternary BMG system with a composition of Zr_(47.5)Cu_(45.5)Al_(5)Co_(2)is adopted and subjected to *** is found that nearly a single phase of B_(2)-ZrCu is precipitated in HAZs,while a fully amorphous phase is formed in molten pools(MPs).This B_(2)phase reinforced BMG composite exhibits excellent mechanical properties with enhanced plasticity and ***,it is easy to modulate the mechanical properties by altering the amount of the B_(2)phase via adjusting the laser energy ***,the best combination of strength,plasticity,and notch toughness is obtained in the BMG composite containing 27.4%B_(2)phase and 72.6%amorphous phase,which exhibits yield strength(σ_(s))of 1423 MPa,plastic strain(ε_(p))of 4.65%,and notch toughness(K_(q.)of 53.9 MPa m 1/***,a notable strain-hardening is also *** improvement of plasticity/toughness and appearance of strain-hardening behavior are mainly due to the martensite phase transformation from the B_(2)phase to the Cm phase during plastic deformation(i.e.,the phase transformation-induced plasticity effect).The current work provides a guide for making advanced BMGs and BMG composites by additive manufacturing.

关键词： Laser powder bed fusion Bulk metallic glass composites Phase transformation-induced plasticity Deformation mechanism

Identification of human microRNA-disease association via low-rank approximation-based link propagation and multiple kernel learning

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frontiers of Computer Science 2024年第2期18卷 217-229页

作者： Yizheng WANG Xin zhang Ying JU q.ng LIU q.an ZOU Yazhou zhang Yijie DING Ying zhang Institute of fundamental and frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Yangtze Delta Region Institute(q.zhou) University of Electronic Science and Technology of ChinaQuzhou 324000China Beidahuang Industry Group General Hospital Harbin 150088China School of Informatics Xiamen UniversityXiamen 361005China Department of Anesthesiology Hospital(T.C.M)Affiliated to Southwest Medical UniversityLuzhou 646000China Software Engineering College Zhengzhou University of Light IndustryZhengzhou 450002China

Numerous studies have demonstrated that human microRNAs(miRNAs)and diseases are associated and studies on the microRNA-disease association(MDA)have been *** developed a model using a low-rank approximation-based link propagation algorithm with Hilbert–Schmidt independence criterion-based multiple kernel learning(HSIC-MKL)to solve the problem of the large time commitment and cost of traditional biological experiments involving miRNAs and diseases,and improve the model *** constructed three kernels in miRNA and disease space and conducted kernel fusion using *** propagation uses matrix factorization and matrix approximation to effectively reduce computation and time *** results of the experiment show that the approach we proposed has a good effect,and,in some respects,exceeds what existing models can do.

关键词： human miRNA-disease association multiple kernel learning link propagation miRNA similarity disease similarity

An intrinsically self-healing and anti-freezing molecular chains induced polyacrylamide-based hydrogel electrolytes for zinc manganese dioxide batteries

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Journal of Energy Chemistry 2024年第2期89卷 565-578,I0013页

作者： Haiyang Liao Wenzhao Zhong Chen Li Jieling Han Xiao Sun Xinhui Xia Ting Li Abolhassan Noori Mir f.Mousavi Xin Liu Yongq. zhang Institute of fundamental and frontier Sciences University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina School of Mechanical Engineering Hunan University of TechnologyZhuzhou 412007HunanChina School of Materials Science and Engineering Zhejiang University of TechnologyHangzhou 310014ZhejiangChina Department of Chemistry Faculty of Basic SciencesTarbiat Modares UniversityTehran 14117-13116Iran State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200HubeiChina

The anti-freezing strategy of hydrogels and their self-healing structure are often contradictory,it is vital to break through the molecular structure to design and construct hydrogels with intrinsic anti-freezing/self-healing for meeting the rapid development of flexible and wearable devices in diverse service ***,we design a new hydrogel electrolyte(Af/SH-Hydrogel)with intrinsic anti-freezing/self-healing capabilities by introducing ethylene glycol molecules,dynamic chemical bonding(disulfide bond),and supramolecular interaction(multi-hydrogen bond)into the polyacrylamide molecular *** to the exceptional freeze resistance(84%capacity retention at-20℃)and intrinsic self-healing capabilities(95%capacity retention after 5 cutting/self-healing cycles),the obtained Af/SH-Hydrogel makes the zinc||manganese dioxide cell an economically feasible battery for the state-of-the-art *** Zn||Af/SH-Hydrogel||MnO_(2)device offers a near-theoretical specific capacity of 285 m A h g^(-1)at 0.1 A g^(-1)(Coulombic efficiency≈100%),as well as good self-healing capability and mechanical flexibility in an ice *** work provides insight that can be utilized to develop multifunctional hydrogel electrolytes for application in next generation of self-healable and freeze-resistance smart aq.eous energy storage devices.

关键词： flexible aq.eous battery Hydrogel electrolyte Anti-freezing Self-healing Dual-dynamic reversible bond

Symmetrically dispersed spectroscopic singlemolecule localization microscopy

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Light(Science & Applications) 2020年第1期9卷 1154-1163页

作者： Ki-Hee Song Yang zhang Benjamin Brenner Cheng Sun Hao f.zhang Department of Biomedical Engineering Northwestern University2145 Sheridan Rd.EvanstonIL 60208USA Department of Mechanical Engineering Northwestern University2145

Spectroscopic single-molecule localization microscopy(sSMLM)was used to achieve simultaneous imaging and spectral analysis of single molecules for the first *** sSMLM fundamentally suffers from a reduced photon budget because the photons from individual stochastic emissions are divided into spatial and spectral ***,both spatial localization and spectral analysis only use a portion of the total photons,leading to reduced precisions in both *** improve the spatial and spectral precisions,we present symmetrically dispersed sSMLM,or SDsSMLM,to fully utilize all photons from individual stochastic emissions in both spatial and spectral *** achieved 10-nm spatial and 0.8-nm spectral precisions at a total photon budget of *** with the existing sSMLM using a 1:3 splitting ratio between spatial and spectral channels,SDsSMLM improved the spatial and spectral precisions by 42% and 10%,respectively,under the same photon *** also demonstrated multicolour imaging of fixed cells and three-dimensional single-particle tracking using *** enables more precise spectroscopic single-molecule analysis in broader cell biology and material science applications.

关键词： dispersed spectroscopic stochastic

Low-permittivity LiLn(PO_(3))_(4)(Ln=La,Sm,Eu)dielectric ceramics for microwave/millimeter-wave communication

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Journal of Advanced Ceramics 2024年第5期13卷 602-620页

作者： Huanrong Tian Xiaohan zhang Zidong zhang Yao Liu Haitao Wu Key Laboratory for Liq.id-Solid Structural Evolution and Processing of Materials(Ministry of Education) Shandong UniversityJinan 250061China School of Materials Science and Engineering Shandong UniversityJinan 250061China School of Environmental and Material Engineering Yantai UniversityYantai 264005China

The development of dielectric materials with low permittivity and low loss is a great challenge in wireless *** this study,LiLn(PO_(3))_(4)(Ln=La,Sm,Eu)ceramic systems were successfully prepared using the traditional solid-state method.X-ray diffraction analysis indicated that the LiLn(PO_(3))_(4)ceramics crystallized in a monoclinic structure when sintered at 850–940℃.The characteristic peak shifted to higher angles with variations in the Ln element,which was ascribed to a reduction in the cell *** analysis by structure refinement revealed that the reduction in the cell volume resulted from the decrease in chemical bond lengths and the compression of[LiO_(4)]and[PO_(4)]***,the LiLn(PO_(3))_(4)ceramic system displayed exceptional performance at low sintering temperatures(910–925℃),including a high q.ality factor(q.f)of 41,607–75,968 GHz,low temperature coefficient of resonant freq.ency(τ_(f))ranging from−19.64 to−47.49 ppm/℃,low permittivity(ε_(r))between 5.04 and 5.26,and low density(3.04–3.26 g/cm^(3)).The application of Phillips–van Vechten–Levine(P–V–L)theory revealed that the increased q.f value of the LiLn(PO_(3))_(4)systems can be attributed to the enhanced packing fraction,bond covalency,and lattice energy,and the stability of τ_(f) was associated with the increase in the bond ***,a prototype microstrip patch antenna using LiEu(PO_(3))_(4) ceramics was *** measurement results demonstrated excellent antenna performance with a bandwidth of 360 MHz and a peak gain of 5.11 dB at a central freq.ency of 5.08 ***,low-εr LiLn(PO_(3))_(4)ceramic systems are promising candidates for microwave/millimeter-wave communication.

关键词： low permittivity LiLn(PO_(3))_(4) microwave dielectric properties Phillips-van Vechten-Levine(P-V-L)theory microstrip patch antenna

Resource Allocation for Cognitive Network Slicing in PD-SCMA System Based on Two-Way Deep Reinforcement Learning

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China Communications 2024年第6期21卷 53-68页

作者： zhang Zhenyu zhang Yong Yuan Siyu Cheng Zhenjie School of Electronic Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China Beijing Key Laboratory of Work Safety Intelligent Monitoring(Beijing University of Posts and Telecommunications) Beijing 100876China

In this paper,we propose the Two-way Deep Reinforcement Learning(DRL)-Based resource allocation algorithm,which solves the problem of resource allocation in the cognitive downlink network based on the underlay *** users(SUs)in the cognitive network are multiplexed by a new Power Domain Sparse Code Multiple Access(PD-SCMA)scheme,and the physical resources of the cognitive base station are virtualized into two types of slices:enhanced mobile broadband(eMBB)slice and ultrareliable low latency communication(URLLC)*** design the Double Deep q.Network(DDq.)network output the optimal codebook assignment scheme and simultaneously use the Deep Deterministic Policy Gradient(DDPG)network output the optimal power allocation *** objective is to jointly optimize the spectral efficiency of the system and the q.ality of Service(q.S)of *** results show that the proposed algorithm outperforms the CNDDq. algorithm and modified JEERA algorithm in terms of spectral efficiency and q.S ***,compared with the Power Domain Non-orthogonal Multiple Access(PD-NOMA)slices and the Sparse Code Multiple Access(SCMA)slices,the PD-SCMA slices can dramatically enhance spectral efficiency and increase the number of accessible users.

关键词： cognitive radio deep reinforcement learning network slicing power-domain non-orthogonal multiple access resource allocation

Nonconserved epitopes dominate reverse preexisting T cell immunity in COVID-19 convalescents

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2984-2998页

作者： Xin Wang Jie zhang Maoshun Liu Yuanyuan Guo Peipei Guo Xiaonan Yang Bingli Shang Min Li Jinmin Tian Ting zhang Xi Wang Ronghua Jin Jikun Zhou George f.Gao Jun Liu Department of Epidemiology School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China NHC Key Laboratory of Biosafety Research Unit of Adaptive Evolution and Control of Emerging VirusesChinese Academy of Medical SciencesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention(China CDC)Beijing 102206China Beijing Key Laboratory of Emerging Infectious Diseases Institute of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing Institute of Infectious Diseases Beijing 100015China National Center for Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015P.R.China School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityWenzhou 325035China School of Ophthalmology&Optometry Wenzhou Medical UniversityWenzhou 325027China Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanningGuangxi 530021China Shijiazhuang fifth Hospital Shijiazhuang 050011China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences(CAS)Beijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100049China

The herd immunity against SARS-CoV-2 is continuously consolidated across the world during the ongoing ***,the potential function of the nonconserved epitopes in the reverse preexisting cross-reactivity induced by SARS-CoV-2 to other human coronaviruses is not well *** our research,we assessed T cell responses to both conserved and nonconserved peptides shared by SARS-CoV-2 and SARS-CoV,identifying cross-reactive CD8^(+)T cell epitopes using enzyme-linked immunospot and intracellular cytokine staining ***,in vitro refolding and circular dichroism were performed to evaluate the thermal stability of the HLA/peptide ***,single-cell T cell receptor reservoir was analyzed based on tetramer ***,we discovered that cross-reactive T cells targeting SARS-CoV were present in individuals who had recovered from COVID-19,and identified SARS-CoV-2 CD8^(+)T cell epitopes spanning the major structural antigens.T cell responses induced by the nonconserved peptides between SARS-CoV-2 and SARS-CoV were higher and played a dominant role in the cross-reactivity in COVID-19 ***-T cell reactivity was also observed within the identified series of CD8^(+)T cell *** representative immunodominant peptide pairs,although the HLA binding capacities for peptides from SARS-CoV-2 and SARS-CoV were similar,the TCR repertoires recognizing these peptides were *** results could provide beneficial information for the development of peptide-based universal vaccines against coronaviruses.

关键词： immunity conserved assessed

Mapping bone marrow niches of disseminated tumor cells

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Science China(Life Sciences) 2017年第10期60卷 1125-1132页

作者： Weijie zhang Hin Ching Lo Xiang H.-f.zhang Lester and Sue Smith Breast Center Baylor College of Medicine Houston TX 77030 USA Dan L. Duncan Cancer Center Baylor College of Medicine Houston TX 77030 USA Department of Molecular and Cellular Biology Baylor College of Medicine Houston TX 77030 USA Graduate Program in Integrative Molecular and Biomedical Sciences Baylor College of Medicine Houston TX 77030 USA McNair Medical Institute Baylor College of Medicine Houston TX 77030 USA

Breast cancer cells may disseminate early, before tumor diagnosis. Disseminated tumor cells, or DTCs, reside in the bone marrow, and may persist for years or even decades. Some of these cells may be re-activated to resume aggressive growth, and eventually become overt bone metastases. Recent studies have begun to shed light on this complicated process and revealed multiple steps and intermediate states of colonizing DTCs. However, how cancer-host interactions evolve during this process needs to be further understood. Most of our current knowledge of the bone microenvironment is obtained through studies looking for the hematopoietic stem cell(HSC) niche. Although this long-standing q.estion has not yet been resolved, our search for the HSC niche has resulted in a detailed map of various cell types in the bone marrow. furthermore, various techniq.es used to find the HSC niche may also be adapted for finding the cancer cell niche. In this article, we will review the recent progress in both the DTC and HSC areas with a focus on their potential microenvironment niches. We will also discuss how to apply what we have learned from HSC studies to map DTCs in the bone context. We hope to stimulate thoughts and ideas to further elucidate the bone colonization process, and develop potential therapeutic interventions.

关键词： disseminated tumor cells bone marrow niches hematopoietic stem cell niches 3D imaging

Microscopic defects formation and dynamic mechanical response analysis of q.45 steel plate subjected to explosive load

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Defence Technology（防务技术） 2024年第2期32卷 430-442页

作者： Zhengq.ng Zhou Zechen Du Yulong zhang Guili Yang Ruixiang Wang Yuzhe Liu Peize zhang Yaxin zhang Xiao Wang Research Institute of Macro-Safety Science University of Science and TechnologyBeijing100083China School of Civil and Resource Engineering University of Science and TechnologyBeijing100083China China North Industry Advanced Technology Generalization Institute Beijing100089China College of field Engineering PLA Army Engineering UniversityNanjing210007China School of Mechanical Engineering Nantong UniversityNantong226019China

As the basic protective element, steel plate had attracted world-wide attention because of freq.ent threats of explosive loads. This paper reports the relationships between microscopic defects of q.45 steel plate under the explosive load and its macroscopic dynamics simulation. firstly, the defect characteristics of the steel plate were investigated by stereoscopic microscope(SM) and scanning electron microscope(SEM). At the macroscopic level, the defect was the formation of cave which was concentrated in the range of 0-3.0 cm from the explosion center, while at the microscopic level, the cavity and void formation were the typical damage characteristics. It also explains that the difference in defect morphology at different positions was the combining results of high temperature and high pressure. Secondly, the variation rules of mechanical properties of steel plate under explosive load were studied. The Arbitrary Lagrange-Euler(ALE) algorithm and multi-material fluid-structure coupling method were used to simulate the explosion process of steel plate. The accuracy of the method was verified by comparing the deformation of the simulation results with the experimental results, the pressure and stress at different positions on the surface of the steel plate were obtained. The simulation results indicated that the critical pressure causing the plate defects may be approximately 2.01 GPa. On this basis, it was found that the variation rules of surface pressure and microscopic defect area of the q.45 steel plate were strikingly similar, and the corresponding mathematical relationship between them was established. Compared with Monomolecular growth fitting models(MGfM) and Logistic fitting models(LfM), the relationship can be better expressed by cubic polynomial fitting model(CPfM). This paper illustrated that the explosive defect characteristics of metal plate at the microscopic level can be explored by analyzing its macroscopic dynamic mechanical response.

关键词： Explosive load q.45 steel Micro defect finite element simulation Dynamic response Data fitting