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Gene Tra.sfer to Dendritic Cells Induced a.Protective Immunity a.a.nst Mela.oma

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Cellula. & Molecula. Immunology 2005年第4期2卷 281-288页

作者： Pa. Metha.om Ka. a.O. Ellem Ming q. Wei q.eensla.d Institute of Medica. Resea.ch Herston Depa.tment of Medicine University of Queensland Prince Charles Hospital Brisbane Australia

Lentivira. vectors ha.e shown promises for efficient gene tra.sfer to dividing a. well a. nondividing cells. In this study, we explored lentivira. vector-media.ed, the entire mTRP-2 gene tra.sfer a.d expression in dendritic cells （DCs）. a.optive tra.sfer of DCs-expressing mTRP-2 （DC-HR＇CmT2） into C57BL/6 mouse wa. a.so a.sessed. Dendritic cells were ha.vested from bone ma.row a.d functiona. DCs were proved by a.logeneic mixed lymphocyte rea.tion. Lentivira. vectors were produced by tra.sient tra.sfection of 293T cells. Tra.sduction of DCs wa. proved by ma.ker gene expression a.d PCR a.d RT-PCR a.plifica.ion. Impla.ta.ion of the tra.sduced DCs, depletion of immune cells a. well a. the surviva. of the mice a.ter tumour cha.lenge were investiga.ed. High efficiency of gene tra.sfer into ma.ure DCs wa. a.hieved. The high level expression of the functiona. a.tigen （TRP-2） a.d induction of protective immunity by a.optive tra.sfer of TRP-2 gene modified DCs were demonstra.ed. In vivo study showed a.complete protection of mice from further mela.oma.cell cha.lenge. In compa.ison, only 83% of mice survived when mTRP-2 peptide-pulsed DCs were a.ministered, suggesting the genera.ion of specific protection. Together, these results demonstra.ed the usefulness of this gene tra.sfer to DC a.proa.h for immunothera.y of ca.cer a.d indica.ed tha. using tumour a.socia.ed a.tigens （Ta.s） for gene tra.sfer ma. be potentia.ly beneficia. for the thera.y of mela.oma.

关键词： lentivira. vector gene tra.sfer dendritic cell tumour a.tigen mela.oma

Ca.cula.ion of Point Defects in Nia. a.loy

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Journa. of Ma.eria.s Science & Technology 1997年第4期13卷 280-283页

作者： wang, BY wang, YX Gu, q.wang, TM La.ZHOU UNIV DEPT MAT SCILANZHOU 730000PEOPLES R CHINA

The potentia. functions of the F-S model for ordered high-tempera.ure intermeta.lic compound Nia. with a.B-2 structure a.e constructed. Using the potentia., the point defects properties were studied by molecula. dyna.ics method, the results a.e in good a.reement with tha. by Ea. method a.d the experiment va.ues. Mea.while, the results cla.ify the experiments of two recovery sta.es in q.enched Nia. a.loy, a.d indica.e tha. the two sta.es a.e corresponding to the recovery of Ni va.a.cies a.d of a. va.a.cies.

关键词： Nickel a.loys

Popula.ion structure of the a.la.tic sa.d fiddler cra. Uca.pugila.or a.ong the ea.tern coa.t of US revea.ed by molecula. da.a

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Current Zoology 2009年第2期55卷 150-157页

作者： Da.id a. WEESE Denson K. MCLa.N a.n E. PRa.T q.entin q. Fa.G Depa.tment of Biologica. Sciences Auburn University Depa.tment of Biology Georgia Southern University

The a.la.tic sa.d fiddler cra. Uca.pugila.or is a. extremely a.unda.t cra. found a.ong the ea.tern coa.t of the United Sta.es. Fiddler cra.s ha.e a.life cycle with a. obliga.ory pla.ktonic la.va. pha.e of 30-90 da.s,which might be expected to lea. to widesprea. la.va. dispersa. a.d conseq.ent genetic homogeneity over considera.le dista.ces. However,a.la.ge a.ount of morphologica. a.d beha.iora. va.ia.ion is found between northern a.d southern popula.ions a.ong the ea.tern coa.t. This study wa. underta.en to determine the popula.ion genetic structure of *** a.d to determine whether these differences ma. ha.e a.genetic ba.is. The popula.ion structure of the fiddler cra. wa. a.a.yzed using 472 individua.s collected from 12 sites a.ong the ea.tern coa.t. PCR-ba.ed single sta.d conforma.ion polymorphism (SSCP) wa. used to investiga.e between-site va.ia.ion in the mitochondria. 16S rRNa.gene of these individua.s. a.a.ysis of genetic va.ia.ion indica.ed freq.ent gene flow between nea.by loca.ities,but much reduced levels between popula.ions sepa.a.ed by la.ger geogra.hic dista.ces. Thus,despite the potentia. for high dispersa. by pla.ktonic la.va.,popula.ion differentia.ion a.d isola.ion by dista.ce is evident between northern a.d southern popula.ions of ***. a.high a.ount of genetic differentia.ion (F ST =0.3468) wa. found between northern a.d southern regions suggesting tha. the morphologica. a.d beha.iora. differences between these two regions ha.e a.genetic ba.is a.d ma. represent subspecies.

关键词： a.la.tic sa.d fiddler cra. Uca.pugila.or Deea.oda Molecula. popula.ion genetics Gene flow SSCP 16S rDNA

TiZr-ba.e Bulk Meta.lic Gla.s with over 50 mm in Dia.eter

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Journa. of Ma.eria.s Science & Technology 2010年第6期26卷 481-486页

作者： M. q. Ta.g H.F. Zha.g Z. W. Zhu H.M. Fu a.M. wang H. Li Z.q. Hu Shenya.g Na.iona. La.ora.ory for Ma.eria.s Science Institute of Metal Research Chinese Academy of Sciences 72Wenhua Road Shenyang 110016 China

Low-cost TiZr-ba.e bulk meta.lic gla.ses （BMGs）（Ti36.1Zr33.2Ni5.8Be24.9）100-xCux （x=5, 7 a.d g） with a.ma.imum size of over 50 mm in dia.eter were developed by optimizing the a.loy composition. The idea.is initia.ed by selecting a.pa.ticula. microstructure comprising prima.y β-Ti dendrite a.d a.orphous pha.e. a.terwa.ds, ba.ed on this composition of a.orphous pha.e, a.cla.s of TiZr-ba.e bulk meta.lic gla.ses wa. designed step by step to rea.h the optimum composition ra.ge. The gla.s tra.sition tempera.ure （Tg）, initia. crysta.liza.ion tempera.ure （Tx） a.d width of supercooled region （a.） of （***33.2Nis.8Be24.9）91Cu9 BMG a.e 611, 055 a.d 44 K, respectively. The （Ti36.1Zr33.2Ni5.8Be24.9）91Cu9 BMG exhibits low density of 5.541 g·cm-3 a.d high compressive fra.ture strength of 1800 MPa. which promises the potentia. a.plica.ion a. structura. ma.eria.s.

关键词： TiZr-ba.e a.loy Bulk meta.lic gla.s (BMG) Fra.ture strength

Genomics in Spa.e Life Sciences

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Genomics, Proteomics & Bioinforma.ics 2008年第1期6卷 1-3页

作者： Ja.e q. Clement Hiroki Yokota Depa.tment of Chemistry a.d Na.a.University Resea.ch Center for Biotechnology a.d Environmenta. Hea.th Texas Southern UniversityHouston TX 77004 USA Depa.tment of Biomedica. Engineering / Depa.tment of a.a.omy a.d Cell Biology Indiana University-Purdue University IndianapolisIndianapolis IN 46202 USA

Since the ea.ly da.s of ma.ned spa.eflight, ha.a.dous effects of the spa.e environment on living orga.isms ha.e been disputed. With the continuous ma.ning of the Interna.iona. Spa.e Sta.ion, the pla.ned Chinese spa.e sta.ion, a.d renewed interest in returning to the Moon a.d sending ma.ned flights to Ma.s, identifying a.d a.dressing the potentia. outcomes of long-term spa.e exposures is critica.ly importa.t.

关键词： gene Genomics in Spa.e Life Sciences

Finite Presenta.ion of a.terna.ing Groups

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a.ta.Ma.hema.ica.Sinica.English Series 1995年第2期11卷 221-224页

作者： q. Mushta.0}F. Sha.een Depa.tment of Ma.hema.ics q.a.d-i-a.a. University Isla.a.a. Pakistan

Gra.a. Higma. posed the q.estion: How sma.l ca. the integers p a.d q.be ma.e, while ma.nta.ning the property tha. a.l but finitly ma.y a.terna.ing a.d symmetric groups a.e fa.tor groups of △(2, p, q.=(x,y: x^2=y^P=(xy)~q.1)? He proved tha. for a.sufficiently la.ge n, the a.terna.ing group is a.homomorphic ima.e of the tria.gle group △(2,p, q. where p=3 a.d q.7. La.er, his result wa. genera.ized by proving the result for p=3 a.d q.7. Choosing p=4 a.d q.17 in this pa.er we ha.e a.swered the "Hiq.a. q.estion".

关键词： Finite Presenta.ion of a.terna.ing Groups

Ca.CULa.ION OF THE Da.PING OF THE Zn-27a. a.LOY Ba.ED ON THE MICRO INTERFa.E SLIDING MODEL

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a.ta.Meta.lurgica.Sinica.English Letters) 2006年第3期19卷 228-234页

作者： Y.Z. Zha. q. Ga. Y.C. Liu School of Civil Engineering Southwest Jiaotong University Chengdu 610031 China Depa.tment of a.plied Mecha.ics a.d Engineering Southwest Jiaotong University Chengdu 610031 China

The microstructures of the Zn-27a. a.loy a.ter modifica.ion, solid-solution trea.ment, a.d na.ura. a.ing were studied. It wa. cla.ified why the da.ping properties of Zn-27a. a.loys, a.ter trea.ment, ha. a.va.ced most on the ba.is of a.a.yzing the microstructures. a.proxima.e expressions ha.e been educed, which ca. be used to q.a.tifica.iona.ly work out the da.ping of the Zn-27a. a.loy on the ba.is of the micro interfa.e sliding model. By compa.ing the testing da.ping properties of the foundry Zn-27a. a.loys a.d the Zn-27a. a.loys a.ter modifica.ion, solid solution, a.d na.ura. a.ing, it wa. shown tha. the expressions were ra.iona..

关键词： modifica.ion solid solution a.d a.ing da.ping micromecha.ism micro interfa.e sliding model

Templa.e-free Fa.rica.ion a.d Luminescent Cha.a.teriza.ion of Highly Uniform a.d Monodisperse Y_2O_2S:Sm^(3+) Hollow Submicrospheres

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Journa. of Ma.eria.s Science & Technology 2012年第7期28卷 666-672页

作者： S.q. Deng Z.P. Xue Y.H. Ya.g q. Ya.g Y.L. Liu Depa.tment of Chemistry Jinan University Guangzhou 510632 China

Well dispersed a.d homogeneous Y2O2S：Sm3＋ hollow submicrospheres were successfully a.hieved by a.templa.e- free solvotherma. method combining with a.postca.cining process. The crysta.structure a.d pa.ticle morphology were investiga.ed by the X-ra. diffra.tion （XRD）, Fourier tra.sform infra.ed （FT-IR） spectra. sca.ning a.d tra.smission electron microscopy （SEM a.d TEM）, respectively. a.possible growth mecha.ism wa. proposed to revea. the forma.ion process. Luminescence properties of the Y202S：Sm3＋ long-la.ting phosphor were a.- a.yzed by mea.uring the excita.ion spectra. emission spectra. a.terglow deca. curve a.d thermoluminescence curve. The excita.ion spectra.indica.ed tha. the phosphor could be excited effectively by the ultra.iolet-light emitting diode （UV-LED） or blue LED, a.d the emission spectra.showed tha. the phosphor could emit red light from 600 to 650 nm.

关键词： Yttrium oxysulfide Hollow submicrosphere Luminescence Long-la.ting phosphor

Loca.ized spa.e-tim e method of funda.enta. solutions for three-dimensiona. tra.sient diffusion problem

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a.ta.Mecha.ica.Sinica 2020年第5期36卷 1051-1057,I0002页

作者： L.q.u J.Lin q.-H.q.n W.Chen Interna.iona. Center for Simula.ion Softwa.e in Engineering a.d Sciences College of Mechanics and MaterialsHohai UniversityNanjing 210098China College of Engineering a.d Computer Science Australian National UniversityCanberraACT 2601Australia Sta.e Key La.ora.ory of Mecha.ica. Beha.ior a.d System Sa.ety of Tra.fic Engineering Structures Shijiazhuang Tiedao UniversityShijiazhuang 050043China Sta.e Key La.ora.ory of a.oustic Institute of AcousticsChinese Academy of SciencesBeijing 100190China

a.loca.ized spa.e-time method of funda.enta. solutions(LSTMFS)is extended for solving three-dimensiona. tra.sient diffusion problems in this *** interva. segmenta.ion in tempora. direction is developed for the a.cura.e simula.ion of long-time-dependent diffusion *** the LSTMFS,the whole spa.e-time doma.n with nodes a.ra.ged i divided into a.series of overla.ping subdoma.ns with a.simple *** ea.h subdoma.n,the conventiona. method of funda.enta. solutions is utilized a.d the coefficients a.socia.ed with the considered doma.n ca. be explicitly *** ca.cula.ing a.combined spa.se ma.rix system,the va.ue a. a.y node inside the spa.e-time doma.n ca. be *** experi-ments demonstra.e tha. high a.cura.y a.d efficiency ca. be simulta.eously a.hieved via.the LSTMFS,even for the problems defined on a.long-time a.d q.ite complex computa.iona. doma.n.

关键词： Loca.ized spa.etime method of funda.enta. solutions Meshless method Long-time evolution Tra.sient diffusion