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Triple drug combination of telmisartan, amlodipine and hydrochlorothiazide in the treatment of essential hypertension

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Open Journal of Internal Medicine 2012年第2期2卷 67-71页

作者： Manish Maladkar Vijay Kumar Verma Keshav A. Narsikar Rajan D. Walinjkar W. R. patil N. J. S. Saggu Suresh P. Kulkarni 8 Shalom Navi Mumbai India Agarwal Hospital Thane (West) India Clinic 411 Jack Chambers Navi Mumbai India Head-Medical & Regulatory Affairs Aristo Pharmaceuticals Pvt Ltd Mumbai India JN-2/47/P2 Navi Mumbai India Shree Polyclinic 114 Nirman Vyapar Kendra Navi Mumbai India Yash Speciality Clinic Nirman Vyapar Kendra Navi Mumbai India

background: Triple drug therapy comprising angiotensin receptor blocker (ARb), calcium channel blocker (CCb) and hydrochlorothiazide (HCT) effectively controls essential hypertension as evident from the literature. This study was undertaken to assess the efficacy and safety of triple combination compared to the dual drug therapy. Methodologies: A total of 220 male and female patients with essential hypertension were enrolled in the study. The patients were divided into two groups. Group A received a bilayer tablet of FDC of Telmisartan + Amlodipine + HCT and group b received FDC tablet of Telmisartan + HCT. both the treatments were administered once daily for twelve weeks. The patients were asked to follow-up on week 1, 2, 4, 6, 8 and 10 for periodic efficacy and safety evaluations. Effect on systolic blood pressure (SbP), diastolic blood pressure (DbP) and quality of life (QOL) were recorded during the course of the trial. Results: blood pressure reduction (bP) to the desired goals was observed with both the treatments. The SbP and DbP reductions were superior in triple combination therapy than double combination. both treatments improved QOL of patients. Conclusion: Triple drug combination of telmisartan, amlodipine and HCT may serve a potential role in achieving desired bP goals, in patients with essential hypertension, which are otherwise poorly managed by either monotherapy or dual drug therapy.

关键词： Essential Hypertension Telmisartan Amlodipine and HCT

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水分胁迫情况下甘蔗叶片脯氨酸累积和活体内硝酸还原酶活性的遗传

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福建甘蔗 2004年第2期 42-44页

作者： R．M．Naik b．S．Kadam R．A．Pandhare S．M．Pawar R．C．patil P.G．bhoi 陈玉水中央甘蔗研究站，Padegaon 不详

评价了以甘蔗品种Co740和Co671作为父本或母本杂交选育的几个甘蔗品系在水分胁迫下叶片渗透保护剂脯氨酸和叶片体内硝酸还原酶活性的遗传。结果表明，在水分胁迫下，抗旱耐盐甘蔗品种Co740的叶片脯氨酸含量比Co671高，叶片硝酸还原酶活... 详细信息

评价了以甘蔗品种Co740和Co671作为父本或母本杂交选育的几个甘蔗品系在水分胁迫下叶片渗透保护剂脯氨酸和叶片体内硝酸还原酶活性的遗传。结果表明，在水分胁迫下，抗旱耐盐甘蔗品种Co740的叶片脯氨酸含量比Co671高，叶片硝酸还原酶活性比Co671低，而且，以Co740作为母本的甘蔗杂种的叶片脯氨酸含量也比较高，叶片硝酸还原酶活性也比较低。从同样都以Co671作为父本的甘蔗杂种Co86032与Co94014之间抗旱性的不同或许可以认为所用母本的抗旱性具有天然遗传潜力。

关键词：水分胁迫甘蔗叶片脯氨酸硝酸还原酶遗传品系

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高血压急症住院趋势和终末器官损害与住院死亡率的关系

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中华高血压杂志 2018年第4期26卷 398-398页

作者： Shah M patil S Patel b Arora S Patel N Garg L Agrawal S Jacobs L Steigerwalt SP Martinez MW 陈云叶鹏

迄今为止还没有针对高血压急症（hypertensive emergency，HTNE）和并发症管理的全面性指南。尽管在治疗高血压上有所发展，但是HTNE仍有显著的发病率和死亡率。方法：查询2002—2012年全国住院样本数据库以确定HTNE患者。

关键词：住院死亡率高血压急症器官损害住院趋势并发症发病率数据库

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Human ciliary muscle cell responses to kinins:Activation of ERK1/2 and pro-matrix metalloproteinases secretion

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World Journal of Ophthalmology 2016年第3期6卷 20-27页

作者： Najam A Sharif Rajkumar patil Linya Li Shahid Husain Pharmaceutical Research Alcon Research Ltd. (A Novartis Company) Ophthalmology Medical University of South Carolina

AIM To study activation of extracellular signal-regulated kinase-1/2(ERK1/2) and pro-matrix metalloproteinases(pro-MMPs) secretion from isolated primary human ciliary muscle(h-CM) cells in response to bradykinin(bK) and other agonists. METHODS Serum-starved h-CM cells were challenged with vehicle, bK agonists or antagonists. Cell lysates were evaluated for phosphorylated ERK1/2 using homogeneous timeresolved fluorescence technology based on a sandwich immunoassay. Rabbit polyclonal anti-pro-MMP antibodies were used to measure pro-MMPs using immunoblot *** A 10 min incubation time using 5 × 104 h-CM cells/well was optimum condition for studying stimulation of ERK1/2 phosphorylation. bK(100 nmol/L) caused a 1.86 ± 0.26 fold(n = 3) increase in ERK1/2 phosphorylation above baseline. bK analogs, Met-Lys-bK and RMP-7(100 nmol/L), also stimulated ERK1/2 phosphorylation by 1.57 ± 0.04 and 1.55 ± 0.09 fold, respectively. However, DesArg9-bradykinin, a b1 receptor-selective agonist(0.1-1 μmol/L), was essentially inactive. HOE-140 or WIN-64338(b2-antagonists) appreciably blocked phosphorylation of ERK1/2 induced by various bK agonists. Pre-treatmentof cells with a prostaglandin(PG) synthase inhibitor(bromfenac; 1 μmol/L) failed to alter kinin-induced ERK1/2 activation. bK and a non-peptide bK agonist(FR-190997)(10 nmol/L-1 μmol/L) also enhanced pro-MMPs secretion(pro-MMP-1 > pro-MMP-3 > pro-MMP-2; 1.45-1.75-fold over baseline) from h-CM cells. CONCLUSION These collective data suggest that b2 kinin receptors initiate signaling in h-CM cells by a relatively rapid mechanism(within minutes) involving ERK1/2 activation which in turn regulates MMPs production(within hours). The latter process does not involve PGs.

关键词： Extracellular signal-regulated kinase-1/2 bradykinin Ciliary muscle Matrix metalloproteinases b2-receptor

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Microwave assisted convenient synthesis of quino[2,3-b][1,5]benzoxazepines

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Chinese Chemical Letters 2009年第5期20卷 557-561页

作者： Swapnil S.Sonar Sandip A.Sadaphal Shivaji S.Pawar bapurao b.Shingate Murlidhar S.Shingare Department of Chemistry Dr. Babasaheb Ambedkar Marathwada UniversityAurangabad 431004MSIndia Department of Chemistry Vinayakrao Patil Mahavidyalaya VaijapurAurangabad 423701MSIndia National Chemical Laboratory Pune 411008MSIndia

A convenient synthesis of quino[2,3-b] [ 1,5]benzoxazepines from substituted 2-chloroquinoline-3-carbaldehyde and 2-hydroxy- aniline by using stable, non-toxic and inexpensive catalyst 1,8-diazabicyclo-undecan-7-ene （DbU）/silica gel is described. This method affords the quino[2,3-b][1,5]benzoxazepines under the influence of microwave irradiation （360 W） in solvent-free conditions within short reaction times （2-3 min）, giving high yields of products （93-96%）.

关键词： Quino[2,3-b][1.,5]benzoxazepines DbU/silica gel Microwave irradiation Solvent-free

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Zinc:an essential trace element for human health and beyond

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Food and Health 2023年第3期5卷 12-18页

作者： Rohit patil Tejswini Sontakke Ashwini biradar Dinesh Nalage Department of botany Government Institute of ScienceAurangabad 431004India Department of Zoology MGV'sMPH Mahila CollegeMalegaon 423105India Department of Microbiology Dr.B.A.M.UniversitySub Campus OsmanabadOsmanabad 413501India Department of Molecular biology&Microbiology One Step Molecular DiagnosticAurangabad 431003India

Zinc is an essential element that plays a crucial role in the chemistry and biochemistry of living *** serves as a cofactor for numerous enzymes and transcription factors,contributing to DNA synthesis,protein synthesis and cellular ***,zinc acts as a structural component of proteins and participates in cellular signaling *** chemistry of zinc is determined by its electronic configuration,and it readily forms coordination complexes with various *** review explores the diverse functions of zinc in the body,including its involvement in enzyme activity,immunity,neutrophil function,modulation of allergies,its relationship with COVID-19,antioxidant and anti-inflammatory properties,mental health,pregnancy and wound *** has a history of use in traditional medicine systems,and its benefits and applications should be evaluated in the context of current scientific research and medical *** the roles of zinc in these processes highlights its importance as an essential nutrient for overall health and provides insights into potential therapeutic ***,further advancement in understanding the biological function of zinc requires addressing certain *** include overcoming methodological challenges,investigating tissue and cell-type specificity,understanding zinc interactions and redundancy,and employing integrated approaches,advanced imaging techniques,comparative studies,and systems biology approaches to gain a deeper understanding of zinc’s implications in health and disease.

关键词： zinc biochemistry deficiency immune system enzymes

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世界家庭医生组织(WONCA)研究论文摘要汇编——动态电子病历笔记原型:显示更少,查看更多

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中国全科医学 2018年第7期 760-760页

作者： bELDEN J L KOOPMAN R J patil S J 本刊编辑部

背景杂乱无章的文档会增加医生的认知负担,而高价值的信息往往会隐藏在低价值信息之中。本研究旨在探讨在寻找慢性病护理所需信息时,一种新型可折叠的评估、计划、主观、客观(APSO)笔记法是否较传统电子病历(EHR)的主观、客观、评估、计... 详细信息

背景杂乱无章的文档会增加医生的认知负担,而高价值的信息往往会隐藏在低价值信息之中。本研究旨在探讨在寻找慢性病护理所需信息时,一种新型可折叠的评估、计划、主观、客观(APSO)笔记法是否较传统电子病历(EHR)的主观、客观、评估、计划(SOAP)笔记法更快捷、准确、令人满意。方法经过反复试验,开发出强调重要临床信息、弱化非重要临床信息的医生笔记原型。在规定时间内,由16名初级卫生保健医生对4种随机排列的笔记法进行评估,并找出笔记中的关键信息。该4种笔记法分别为A(传统SOAP笔记法)、b(2列APSO笔记法)、C(可折叠APSO笔记法)、D(2列可折叠APSO笔记法),4种笔记法的各部分信息量相同。通过施加时间限制和临床中断典型案例,模拟4种笔记法在临床实践中的效用。记录医生使用各部分时的音频、电脑屏幕活动、眼动追踪,以获得可用性评分(系统可用性量表)和新特性偏好评分,并根据后续分析内容对医生进行半结构化访谈。根据医生的完成任务时间、任务成功度(准确度)、美国国家航空航天局主观任务负荷指数量表(NASA-TLX)中努力负荷得分,比较4种笔记法的可用性。结果 C和D在系统回顾和体格检查任务中所耗时间较A和b短,b和C在查找所需数据任务中效果较好。初级卫生保健医生对新型笔记法中的所有新功能持支持态度,对笔记法中因使用手风琴展示模式而被暂时隐藏部分的担忧有所缓解。A的可用性最差,b、C、D的可用性相对较好。讨论在初级卫生保健中,医生采用APSO笔记法获取慢性病信息的速度、任务成功度(准确度)、可用性优于传统SOAP笔记法。将评估和计划移动到顶部的特性变更具有技巧性。创新EHR数据文档显示模式提高了信息显示的安全性,避免了从访问记录中删除数据。

关键词：电子病历初级卫生保健 WONCA

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织造车间生产效率的提高

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国际纺织导报 2014年第4期42卷 24-26页

作者： V.A.Dorugade T.C.patil D.R.Mali I.T.Mali R.M.Mali 杨婷婷 MNIMS(印度)

对于纺织行业,尤其是织造部门来说,效率损失是一个亟待解决的问题。影响织机性能的因素大致可分为3类,即技术因素,织机的运转状态和配置都对经纬纱断头有一定的影响;人为因素,如操作工人的技能水平、工作方法及工作积极性等;管理因素,... 详细信息

对于纺织行业,尤其是织造部门来说,效率损失是一个亟待解决的问题。影响织机性能的因素大致可分为3类,即技术因素,织机的运转状态和配置都对经纬纱断头有一定的影响;人为因素,如操作工人的技能水平、工作方法及工作积极性等;管理因素,如生产计划的设计和实施等。不合理的机器配置会增加经纱和纬纱的断头次数,尝试通过优化机器配置提高织造车间的生产效率。

关键词：织造效率开口高度引纬组件断头

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Standardization and Quality control parameters of Kayam Churna

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TMR Modern Herbal Medicine 2022年第3期5卷 39-47页

作者： Prajwal Gupta Ashwini Kendle Diksha bhagat Mahera Khan Prabuddha Wakode Shruti Shah Sonali patil Department of bioanalytical Sciences B.K.Birla College(Autonomous)KalyanMaharashtraIndia

Kayam Churna is proprietary ayurvedic formulation which is blend of seven ingredients which are Senna leaves(Cassia angustifolia),black Salt,Mulethi(Glycyrrhiza glabra),Nishoth(Operculina turpethum),Ajwain(Trachyspermum ammi),Haritaki(Terminalia chebula)and Svarjikshara(Sodium bicarbonate)with Senna as a major *** and stability studies play a vital role for each herbal formulation,so the research was carried out to prepare the formulation in the laboratory and to standardize the Churna,by means of its physicochemical properties,phytochemical analysis and microbiology *** organoleptic and powdered characteristics were studied and compared with *** physicochemical analysis was carried out like bulk density,tapped density,percent compressibility,loss on drying,ash value and heavy metal *** analysis was carried out to find the presence of tannins,alkaloids,glycosides,flavonoids and *** analysis was evaluated using the Total Viable Count *** Chromatographic technique was used for *** analysis of Formulation showed the presence of Vessels,Fibre,Calcium oxalate crystals,***,Alkaloids,flavonoids were found to be present in the *** count and all physicochemical parameters were found to be within the limits as per the WHO *** studies can be carried out for finding out its efficacy and potency.

关键词： Herbal formulation Standardization Evaluation Quality control tests Fingerprinting

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急性肺栓塞的早期死亡率:CT肺血管成像中血栓负荷和右心衰竭征象

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国际医学放射学杂志 2012年第6期 594-594页

作者： A.Furlan A.Aghayev C.C.H.Chang A.patil K.N.Jeon b.Park 高晓 Department of Radiology University of Pittsburgh Medical Center200 Lothrop StPittsburghPA 15213

摘要目的依据CT肺血管成像,评价急性肺栓塞病人血栓体积、半定量血栓负荷指标与右心衰竭征象之间的关系,并确定血栓负荷及右心衰竭与早期死亡率是否相关。材料与方法本回顾性研究得到了伦理审查委员会的批准并符合HIPAA规定。

关键词：血管成像右心衰竭急性肺栓塞血栓征象死亡率 CT

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