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Liver transplant in primary sclerosing cholangitis:Current trends and future directions

世界肝病学杂志:英文版(电子版) 2023年第8期15卷 939-953页

作者： Yash R shah Natalia Nombera-Aznaran David Guevara-Lazo Ernesto Calderon-Martinez Angad Tiwari SriLakshmiDevi Kanumilli purva shah Bhanu Siva Mohan Pinnam Hassam Ali Dushyant Singh Dahiya Department of Internal Medicine Trinity Health OaklandPontiacMI 48341United States Faculty of Medicine Universidad Peruana Cayetano HerediaLima 15102Peru Department of Internal Medicine Universidad Nacional Autonoma de MexicoCiudad De Mexico 04510Mexico Department of Internal Medicine Maharani Laxmi Bai Medical CollegeJhansi 284001India Department of Internal Medicine GSL Medical CollegeRajamahendravaram 533296India Department of Postgraduate Education Harvard Medical SchoolBostonMA 02115United States Department of Internal Medicine John H.Stroger Hospital of Cook CountyChicagoIL 60612United States Department of Internal Medicine East Carolina University/Brody School of MedicineGreenvilleNC 27858United States Division of Gastroenterology Hepatology and MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States

Primary sclerosing cholangitis(PSC)is a chronic and progressive immunemediated cholangiopathy causing biliary tree inflammation and scarring,leading to liver cirrhosis and end-stage liver *** of PSC is challenging due to its nonspecific symptoms and overlap with other liver *** the rising incidence of PSC,there is no proven medical therapy that can alter the natural history of the *** liver transplantation(LT)is the most effective approach for managing advanced liver disease caused by PSC,post-transplantation recurrence of PSC remains a ***,ongoing research aims to develop better therapies for PSC,and continued efforts are necessary to improve outcomes for patients with *** article provides an overview of PSC’s pathogenesis,clinical presentation,and management options,including LT trends and future *** also highlights the need for improved therapeutic options and ethical considerations in providing equitable access to LT for patients with ***,the impact of liver transplant on the quality of life and psychological outcomes of patients with PSC is *** research into PSC’s pathogenesis and post-transplant recurrence is crucial for improved understanding of the disease and more effective treatment options.

关键词： Primary sclerosing cholangitis Liver transplantation Management Psychosocial outcomes Pathogenesis

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Surging footprints of mathematical modeling for prediction of transdermal permeability

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Asian Journal of Pharmaceutical Sciences 2017年第4期12卷 299-325页

作者： Neha Goyal purva Thatai Bharti Sapra Pharmaceutics Division Department of Pharmaceutical Sciences Punjabi University

In vivo skin permeation studies are considered gold standard but are difficult to perform and evaluate due to ethical issues and complexity of process involved. In recent past, a useful tool has been developed by combining the computational modeling and experimental data for expounding biological complexity. Modeling of percutaneous permeation studies provides an ethical and viable alternative to laboratory experimentation. Scientists are exploring complex models in magnificent details with advancement in computational power and technology. Mathematical models of skin permeability are highly relevant with respect to transdermal drug delivery, assessment of dermal exposure to industrial and environmental hazards as well as in developing fundamental understanding of biotransport *** review focuses on various mathematical models developed till now for the transdermal drug delivery along with their applications.

关键词： Mathematical models Multiple linear regression Artificial neural network Iontophoresis based models Compartmental modeling Porous pathway models

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Profiles of HIV-infected anti-retroviral therapy naïve children from Mumbai,India

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世界儿科杂志:英文版 2016年第4期12卷 430-435页

作者： Supriya Mayur Paranjpe purva Pankaj Sarkate Nayana Avinash Ingole Shweta Sadanand Raut Preeti Rajeev Mehta Department of Microbiology 5th floorMulti-Storey BuildingSeth G.S.Medical College and K.E.M.HospitalParelMumbaiIndia

Background:This study aimed to investigate the demographic profiles of human immunodifficiency virus(HIV)infected anti-retroviral therapy(ART)naïve children in our hospital and their relations to the clinical,immunological and nutritional ***:A cross-sectional study was conducted in an Integrated Counselling and Testing Center(ICTC)at a tertiary care hospital in *** naïve HIV positive children were enrolled in the *** demographic profiles,clinical features,immunological(CD4%/CD4 count)and nutritional status of these children were *** agreement between clinical,immunological and nutritional staging was determined using Cohen’s kappa ***:In 192 HIV-infected ART naive children enrolled with a median age of 9 years(range 3 months-14 years),97.4%acquired infection through vertical *** most common clinical presentation was fever(39.6%),followed by generalized lymphadenopathy(32.3%),cough(22.4%)and diarrhoea(9.9%).Tuberculosis was seen in 22.9%of the *** agreement was fair between clinical and immunological staging,and slight between nutritional,immunological and clinical ***:Perinatal transmission is the most common mode of acquiring HIV infection in *** Prevention of Parent to Child Transmission(PPTCT)program should be strengthened for lowering the transmission rate by providing extended ART to mothers during pregnancy and *** remains a major concern in HIV-infected *** poor correlation between WHO clinical and immunological staging emphasizes the importance of making CD4 facilities available in HIV prevalent *** cannot be used as a surrogate marker for predicting stage or severity as it is common at all stages of HIV disease.

关键词： anti-retroviral therapy CD4 count clinical stage HIV nutritional status

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AACA Element Negatively Regulates Expression of Protein Phosphatase 2C (PP2C) like Promoter in Arabidopsis thaliana

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American Journal of Plant Sciences 2013年第3期4卷 549-554页

作者： purva Bhalothia Anshu Alok Sandhya Mehrotra Rajesh Mehrotra Department of Biological Sciences Birla Institute of Technology & Sciences (BITS) Pilani India Department of Biological Sciences Birla Institute of Technology & Sciences (BITS) Pilani India. National Agri-Food Biotechnology Institute (NABI) Department of Biotechnology Government of India Mohali India

Genome wide analysis of Arabidopsis thaliana reveals a unique genetic arrangement of ACGT motif in the protein phosphatase 2C (PP2C) like promoter (accession number AT5G59220). In the present study, full length, 900 base pair, 500 base pair, 400 base pair and NRM deletion variants of PP2C like promoter were constructed to investigate the activity of PP2C like promoter in the presence of inducers like abscisic acid, jasmonic acid and salicylic acid. The PP2C promoter has three ACGT elements in close vicinity. They are so positioned that they are separated by a spacer of 30 base pair and 5 base pair respectively from each other. The study has shown that ACGTN30ACGT genetic architecture is essential for the promoter to be induced in response to abscisic acid. The synergistic and antagonistic effects of cis elements were observed. AACA is a positive regulatory element in endosperm and is known to act as negative regulatory element in other tissues. In this study AACA, have been found to negatively regulate the expression of reporter gene EGFP in both induced and under uninduced conditions.

关键词： Abscisic Acid ACGT AACA Abiotic Stress

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Chemical Compositions of the Leaf Essential Oils of Aralia spinosafrom Three Habitats in Northern Alabama

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American Journal of Plant Sciences 2011年第3期2卷 507-510页

作者： purva C. Davé Bernhard Vogler William N. Setzer 不详

Aralia spinosa leaves were collected from three different habitats in north Alabama. The leaf essential oils were collected by hydrodistillation and analyzed by gas chromatography / mass spectrometry (GC-MS). The most abundant components of A. spinosa essential oils were the sesquiterpenes germacrene D (28.0% - 37.3%), (E)-caryophyllene (8.2% - 15.7%), and α-humulene (1.9% - 4.9%);the monoterpene myrcene (up to 15.1%), and the fatty-acid-derivative (2E)-hexenal (trace to 28.9%). Fatty-acid derivatives and monoterpene hydrocarbons were more abundant in samples from suburban Huntsville than those from “natural” habitats (Monte Sano Mountain, Wheeler National Wildlife Refuge), while sesquiterpene hydrocarbons were more abundant in the natural/wild samples.

关键词： Aralia spinosa Araliaceae Leaf Essential Oil Chemical Composition Germacrene D Myrcene (E)-Caryophyllene (2E)-Hexenal

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HIV Diagnosis in Resource Constrained Setting: How Good Is the Current Algorithm?

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World Journal of AIDS 2014年第1期4卷 45-51页

作者： Nayana Ingole purva Sarkate Supriya Paranjpe Rahul Sarode Sameer Shinde Preeti Mehta Department of Microbiology Seth G S Medical College and KEM Hospital Parel Mumbai India

Background: The conventional HIV testing algorithm in most of the developed countries consists of two tests: an HIV enzyme immunoassay capable of identifying HIV-1 and HIV-2 antibodies and a confirmatory HIV-1 Western blot or immunofluorescence assay. However, the current algorithm for HIV diagnosis in India uses three sequential antibody assays. There has always been doubt regarding the benefits of this algorithm. Objective: To determine the utility of the current diagnostic algorithm and to find out the proportion of indeterminate or discrepant results. Methods: Retrospective analysis of HIV antibody testing data was carried out over a period of five years after institutional ethics committee approval. The specimens positive with the screening test and negative with both the supplemental tests were labeled as discrepant. Specimens positive with any of the two tests (screening and one of the supplemental tests) and negative with the remaining supplemental test were labeled as indeterminate. These indeterminate specimens were confirmed by immunoblotting. Results: A total of 141,296 samples were tested. Of these, 71 (0.05%) samples were indeterminate and 292 (0.21%) were discrepant. Western blot was done on 60 indeterminate samples of which 10 (16.67%) were positive for HIV 1 antibodies, 14 (23.33%) were negative for HIV antibodies and 36 (60%) had indeterminate result. Conclusion: In view of the low numbers of indeterminate and discrepant results, the current algorithm appears to be appropriate in our resource constrained setting. However, the algorithm for HIV testing should also include DNA PCR testing facility to resolve western blot indeterminate results.

关键词： HIV Indeterminate Discrepant Rapid Tests Western Blot Algorithm

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Congenital Laryngeal Web: A Laryngology Rarity

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International Journal of Otolaryngology and Head & Neck Surgery 2018年第4期7卷 143-147页

作者： Markandeya Tiwari Vinson Louis Gonzaga Fernandes Sarah George Vibhav B. Sanzgiri purva Khandolkar Department of Otorhinolaryngology and Head & Neck Surgery Goa Medical College and Hospital Bambolim Goa India

Congenital laryngeal web is an otolaryngology rarity, which occurs due to incomplete recanalization of the larynx. We report a case of a 22 year-old patient who presented with a congenital anterior laryngeal web. We s... 详细信息

关键词： Laryngeal Web Larynx Keel Silastic Sheet

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Squamous Inclusion Cyst in the Palatine Tonsil Mimicking a Tumor

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International Journal of Otolaryngology and Head & Neck Surgery 2018年第5期7卷 249-253页

作者： Vinson Louis Gonzaga Fernandes purva Khandolkar Vivek G. Pillai Isha Rajendra Sukhthankar Aditi Ashok Chari Department of Otorhinolaryngology and Head & Neck Surgery Goa Medical College and Hospital Bambolim Goa India

Squamous inclusion cyst is a rare benign cystic lesion most commonly affecting the floor of mouth in the oral cavity. Its presence in the palatine tonsil of the oropharynx is an extremely rare occurrence. We highlight a case of an elderly female who was histopathologically diagnosed as squamous inclusion cyst of the palatine tonsil. We shall discuss the presentation, diagnosis, management and postoperative follow-up of the case.

关键词： Squamous Inclusion Cyst Palatine Tonsil Benign

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A Rare Case Report of Pyogenic Granuloma of Tongue

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International Journal of Otolaryngology and Head & Neck Surgery 2018年第3期7卷 75-79页

作者： Vinson Louis Gonzaga Fernandes Nina Margarida De Gouveia Pinto Vibhav B. Sanzgiri purva Khandolkar Isha Rajendra Sukhthankar Department of Otorhinolaryngology and Head & Neck Surgery Goa Medical College Goa India

Pyogenic granuloma is an inflammatory hyperplasia secondary to chronic irritation. We report a case of a 24-year-old male patient who presented with a pyogenic granuloma on the right lateral border of the tongue. We s... 详细信息

关键词： Pyogenic Granuloma Tongue Lateral Border

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蓝青蛙酒廊与录音棚

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城市环境设计 2009年第8期 66-67页

作者： Chris Lee Kapil Gupta Tomas Ruis Osborne Santosh Thorat purva Jamdade Suril Patel Dharmesh Thakker Niti Gourisaria Vrinda Seksaria Udayan Mazumdar Fram Petit 宋刚

Serie建筑师事务所Serie建筑师事务所是一个国际化事务所,涉及的领域包括建筑、城市的设计,事务所关注于当代城市中建筑类型的进化和变异以及这些智慧形式在空间解决方案上的应用。类型学式的研究,或者用他们的名词,"连续"(SERIES)的思... 详细信息

Serie建筑师事务所Serie建筑师事务所是一个国际化事务所,涉及的领域包括建筑、城市的设计,事务所关注于当代城市中建筑类型的进化和变异以及这些智慧形式在空间解决方案上的应用。类型学式的研究,或者用他们的名词,"连续"(SERIES)的思考和探索(利用建筑类型的累积智慧)是Serie作品的关键。事务所已经完成一系列获奖的作品:宝石技术工厂、蓝青蛙酒廊和录音棚、Thanks精品店,以及印度孟买的李奥贝纳总部。事务所的主持是Chris Lee和KapilGupta。

关键词：录音棚青蛙建筑类型

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