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Emergence of antibiotic resistance Pseudomonas aeruginosa in intensive care unit;a critical review

Genes & Diseases 2019年第2期6卷 109-119页

作者： Preeti Pachori Ragini Gothalwal puneet Gandhi Department of Biotechnology Barkatullah UniversityBhopal 462026Madhya PradeshIndia Department of Research Bhopal Memorial Hospital and Research Centre(BMHRC)Bhopal 462037Madhya PradeshIndia

The emergence of antibiotic resistant bacteria in the healthcare is a serious *** the Healthcare premises precisely intensive care unit are major sources of microbial *** findings have demonstrated not only microbial diversity but also drug resistant microbes largely habitat in *** aeruginosa found as a part of normal intestinal flora and a significant pathogen responsible for wide range of ICU acquired infection in critically ill *** infection associated with this organism including gastrointestinal infection,urinary tract infections and blood stream *** caused by this organism are difficult to treat because of the presence of its innate resistance to many antibiotics(b-lactam and penem group of antibiotics),and its ability to acquire further resistance mechanism to multiple class of antibiotics,including Beta-lactams,aminoglycosides and *** the molecular evolution microbes adopted several mechanism to maintain genomic *** tool microbe use for its survival is mainly biofilm formation,quorum sensing,and horizontal gene transfer and enzyme *** genomic plasticity provide an ideal habitat to grow and survive in hearse environment mainly antibiotics *** review focus on infection caused by Pseudomonas aeruginosa,its mechanisms of resistance and available treatment *** present study provides a systemic review on major source of Pseudomonas aeruginosa in ***,study also emphasizes virulence gene/s associated with Pseudomonas aeruginosa genome for extended drug *** gives detailed overview of antibiotic drug resistance mechanism.

关键词： Antibiotics Blood stream infections Infection Pathogen Resistance Urinary tract infections

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Pretreatment of caffeine leads to partial neuroprotection in MPTP model of Parkinson＇s disease

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Neural Regeneration Research 2016年第11期11卷 1750-1751页

作者： puneet Bagga Anant B. Patel Center for Magnetic Resonance and Optical Imaging Department of Radiology University of Pennsylvania Philadelphia PA USA CSIR-Centre for Cellular and Molecular Biology Habsiguda Hyderabad India

Parkinson＇s disease （PD） is disorder affecting more than a common neurodegenerative 1% people above 60 years of age worldwide, manifesting as the impaired motor function such as tremors, rigidity, akinesia/bradykinesia and postural inefficiency with a reduced life expectancy （Dorsey et al., 2007）. PD is believed to be the end result of the progressive death of dopaminergic neurons in the substantia nigra pars compacta （SNc）.

关键词： MPTP Pretreatment of caffeine leads to partial neuroprotection in MPTP model of Parkinson’s disease

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A Markov regenerative process with recurrence time and its application

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Financial Innovation 2021年第1期7卷 777-798页

作者： puneet Pasricha Dharmaraja Selvamuthu Department of Mathematics Indian Institute of Technology DelhiNew Delhi 110016India

This study proposes a non-homogeneous continuous-time Markov regenerative process with recurrence times,in particular,forward and backward recurrence *** obtain the transient solution of the process in the form of a generalized Markov renewal equation.A distinguishing feature is that Markov and semi-Markov processes result as special cases of the proposed *** model the credit rating dynamics to demonstrate its applicability,we apply the proposed stochastic process to Standard and Poor’s rating agency’s ***,statistical tests confirm that the proposed model captures the rating dynamics better than the existing models,and the inclusion of recurrence times significantly impacts the transition probabilities.

关键词： Non-homogeneous Markov regenerative process Recurrence times Markov renewal equation Credit ratings Default distribution

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Dynamic behavior of sandwich beams with different compositions of magnetorheological fluid core

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International Journal of Smart and Nano Materials 2021年第1期12卷 88-106页

作者： Subash Acharya Vipin J Allien puneet N P Hemantha Kumar Department of Mechanical Engineering NITK SurathkalMangaloreKarnatakaIndia

Magnetorheological fluid(MRF)sandwich beams belong to a class of adaptive beams that consists of MRF sandwiched between two or more face layers and have a great prospective for use in semi-active control of beam vibrations due to their superior vibration suppression *** composition of MRF has a strong influence on the MRF properties and hence affects the vibration characteristics of the *** this work,six MRF samples(MRFs)composed of combination of two particle sizes and three weight fractions of carbonyl iron pow-der(CIP)were prepared and their viscoelastic properties were *** MRFs were used to fabricate different MRF core sandwich ***,a sandwich beam with commer-cially available MRF 132DG fluid as core was *** modal parameters of the cantilever MRF sandwich beams were determined at different magnetic ***,sinusoidal sweep excitation tests were performed on these beams at different magnetic fields to investigate their vibration suppres-sion *** having larger particle size and higher weight fraction of CIP resulted in higher damping ratio and vibration ***,optimal particle size and weight fraction of CIP were determined based on the maximization of damping ratio and minimization of weight of MRF.

关键词： Smart materials adaptive sandwich beam damping ratio vibration suppression complex shear modulus

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Effect of Elevated CO_2 and Drought on Soil Microbial Communities Associated with Andropogon gerardii

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Journal of Integrative Plant Biology 2008年第11期50卷 1406-1415页

作者： Issmat I. Kassem puneet Joshi Yon Sigler Scott Heckathorn Qi Wang Department of Environmental Sciences University of Toledo Ohio 43606 USA Department of Civil Engineering University of Toledo Ohio 43606 USA

Our understanding of the effects of elevated atmospheric CO2, singly and in combination with other environmental changes, on plant-soil interactions is incomplete. Elevated CO2 effects on C4 plants, though smaller than on C3 species, are mediated mostly via decreased stomatal conductance and thus water loss. Therefore, we characterized the interactive effect of elevated CO2 and drought on soil microbial communities associated with a dominant C4 prairie grass, Andropogon gerardii Vitman. Elevated CO2 and drought both affected resources available to the soil microbial community. For example, elevated CO2 increased the soil C：N ratio and water content during drought, whereas drought alone decreased both. Drought significantly decreased soil microbial biomass. In contrast, elevated CO2 increased biomass while ameliorating biomass decreases that were induced under drought. Total and active direct bacterial counts and carbon substrate use （overall use and number of used sources） increased significantly under elevated CO2. Denaturing gradient gel electrophoresis analysis revealed that drought and elevated CO2, singly and combined, did not affect the soil bacteria community structure. We conclude that elevated CO2 alone increased bacterial abundance and microbial activity and carbon use, probably in response to increased root exudation. Elevated CO2 also limited drought-related impacts on microbial activity and biomass, which likely resulted from decreased plant water use under elevated CO2. These are among the first results showing that elevated CO2 and drought work in opposition to modulate plant-associated soil-bacteria responses, which should then influence soil resources and plant and ecosystem function.

关键词： denaturing gradient gel electrophoresis drought elevated CO2 soil microbial communities.

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Bone Elimination Technique of Cerebral Vessels with 64 Slice CT: Comparision of Volume CT DSA ＆ Conventional CTA

Bone Elimination Technique of Cerebral Vessels with 64 Slice...

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作者： Kumar puneet Gupta 重庆医科大学

学位级别：硕士

OBJECTIVE: The aim of this study was to investigate the differences in the time and image quality of reconstructed cerebral angiograms between volume CT digital subtraction angiography （VCTDSA） and conventional CT angiography（CTA） with bone elimination technique. MATERIALS AND METHODS: Thirty-two patients with cerebrovascular diseases, who underwent VCTDSA in our department, were further remodeled cerebral vessels with both VCTDSA and conventional CTA. Cerebral vessels were displayed with 3D volume rendering （3D VR） and 3D maximum intensity projection （3D MIP）, respectively. The post-processing time and the image quality were then compared. RESULTS: The image quality with VCTDSA vessel reconstruction was excellent. Compared with conventional CTA, VCTDSA had an advantage in displaying the integrity of vessels, the range of intracranial arteries and veins, and also in lessening the remained high density shadows （ p＜0.001）. The time of post-processing by VCTDSA （mean: 6.87±2.96 min） was much shorter than that of conventional CTA （mean: 14.37±1.66 min）（ p＜0.001）. There was a significant positive correlation between the post-processing time and the subtraction image quality with VCTDSA （ r=0.79, p＜0.001）. CONCLUSION: VCTDSA is a fast, accurate and feasible method for the sensitive assessment of cerebrovascular structures and can be used as a powerful tool in the diagnosis of cerebrovascular diseases. Compared with conventional CTA, VCTDSA has an advantage in displaying the integrity of vessels, the range of intracranial arteries and veins, and also in lessening the remained high density shadow. The post-processing time of VCTDSA is significant shorter than that of conventional CTA.

关键词： Slice DSA CTA conventional image quality The and high density significant time volume rendering the differences

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Assessing forest understory biomass in northwest Florida (USA) and its potential to meet the state energy needs

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Forestry Studies in China 2011年第4期13卷 303-310页

作者： Marian MARINESCU puneet DWIVEDI Jarek NOWAK FPInnovations Vancouver British Columbia V6T 1Z4 Canada School of Forest Resources and Conservation University of Florida Gainesville 32601 USA Florida Division of Forestry Tallahassee 32399 USA

A stratified random sampling approach was employed to quantify total biomass across prevalent non-commercial forest understory species found in six counties of northwest Florida, USA. The moisture content （wet basis） and calorific values of these species were also measured. Total green biomass from forest understory species was estimated to be around 12 million metric tons, mostly comprised of Cliftonia monophylla （titi, buckwheat tree） and Cyrilla racemiflora （white titi, swamp titi）. This understory forest biomass would be sufficient to generate about 28.8 million GJ of electricity or 1589.25 million liters of ethanol. A need was identified to determine the inventory of forest understory biomass at the state level and assess the overall sustainability of utilizing forest understory biomass for bioenergy.

关键词： bioenergy biomass Florida United States forest understory moisture content

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Homotopy study of magnetohydrodynamic mixed convection nanofluid multiple slip flow and heat transfer from a vertical cylinder with entropy generation

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Propulsion and Power Research 2019年第2期8卷 147-162页

作者： Nisha Shukla puneet Rana OAnwar Bég Bani Singh AKadir Department of Mathematics Jaypee Institute of Information TechnologyA-10Sector-62Noida 201307Uttar PradeshIndia Fluid Mechanics Propulsion and NanosystemsAeronautical and Mechanical EngineeringSchool of ComputingScience&EngineeringUniversity of SalfordNewton BuildingM54WTUK Materials and Corrosion Petroleum and Gas EngineeringSchool of ComputingScience&EngineeringUniversity of SalfordNewton BuildingM54WTUK

Stimulated by thermal optimization in magnetic materials process engineering,the present investigation investigates theoretically the entropy generation in mixed convection magnetohydrodynamic(MHD)flow of an electrically-conducting nanofluid from a vertical *** mathematical model includes the effects of viscous dissipation,second order velocity slip and thermal slip,has been *** cylindrical partial differential form of the two-component non-homogenous nanofluid model has been transformed into a system of coupled ordinary differential equations by applying similarity *** effects of governing parameters with no-flux nanoparticle concentration have been examined on important quantities of ***,the dimensionless form of the entropy generation number has also been evaluated using homotopy analysis method(HAM).The present analytical results achieve good correlation with numerical results(shooting method).Entropy is found to be an increasing function of second order velocity slip,magnetic field and curvature *** is elevated with increasing curvature parameter and magnetic parameter whereas it is reduced with mixed convection *** flow is accelerated with curvature parameter but decelerated with magnetic *** transfer rate(Nusselt number)is enhanced with greater mixed convection parameter,curvature parameter and first order velocity slip parameter but reduced with increasing second order velocity slip *** generation is also increased with magnetic parameter,second order slip velocity parameter,curvature parameter,thermophoresis parameter,buoyancy parameter and Reynolds number whereas it is suppressed with first order velocity slip parameter,Brownian motion parameter and thermal slip parameter.

关键词： Magnetohydrodynamic(MHD) Nanofluid Vertical cylinder Homotopy analysis method(HAM) Second order slip Entropy Curvature

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Simultaneous breast and ovarian metastasis from gallbladder carcinoma

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Hepatobiliary & Pancreatic Diseases International 2010年第5期9卷 553-554页

作者： Sanjay Singh puneet Gupta Rahul Khanna Ajay K Khanna Department of General Surgery Institute of Medical SciencesBanaras Hindu University

BACKGROUND:Gallbladder carcinoma is a common malignancy in the Indian *** commonly metastasizes through lymphatics,direct invasion,and hematogenous spread.A common extra-abdominal site of metastasis is the *** metastasis to breast and ovary is extremely ***:This report describes an unusual case of carcinoma gallbladder metastasizing to the breast and ovary at the same ***:A 45-year-old woman came to us with complaints of flatulent dyspepsia associated with weight loss and *** of the abdomen revealed hepatomegaly with thick-walled gallbladder with multiple stones and a mass at the fundus,but normal uterus and ***-enhanced computer tomography of the abdomen showed a gallbladder mass infiltrating the liver *** patient underwent radical *** examination revealed a poorly-differentiated adenocarcinoma with margins free from tumor *** month after surgery she developed a breast *** of the abdomen for metastatic workup revealed an ovary *** mastectomy and salphingo-opherectomy were performed,and histopathological examination revealed a metastatic *** patient is now on chemotherapy with ***:This is an unusual case of carcinoma of the gallbladder with metastasis to the breast and ovary,which has not been documented before.

关键词： gallbladder carcinoma breast metastasis ovary metastasis

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Immunophenotypic signature of primary glioblastoma multiforme: A case of extended progression free survival

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World Journal of Clinical Cases 2017年第6期5卷 247-253页

作者： puneet Gandhi Richa Khare Nitin Garg Sandeep Sorte Department of Research Bhopal Memorial Hospital and Research Centre Department of Neurosurgery Bhopal Memorial Hospital and Research Centre Bansal Hospital

Glioblastoma-multiforme(GBM), the most aggressive glial tumor, has a worldwide age-adjusted incidence ranging from 0.59-3.69/100000 persons. Despite current multimodal-treatment approach, median-survival time and progression-free survival(PFS) remains short. Glioblastomas display a variety of molecular alterations, which necessitates determining which of these have a prognostic significance. This is a case of a 45-yearold patient who presented with progressive slurring of speech and features of raised intracranial pressure. Computed tomography(CT) scan revealed a large heterogeneously enhancing lesion in the left front-temporalperisylvian region with solid, cystic areas, suggestive of malignant glioma. Partial tumor-excision was followed by concurrent chemo-radiotherapy. Histopathologically, the tumor was astrocytoma grade-IV. Patient had an extended PFS of 12 mo, with an overall survival of 26 mo. Primary-GBM was confirmed using molecular markers and the immunophenotypic signature was defined by evaluating systemic expression of human telomerase reverse transcriptase, interleukin-6, neutrophil-lymphocyte ratio, tissue inhibitor of metalloproteinases-1, human chitinase-3-like-protein-1(YKL-40) and high mobility group-A1. Current findings suggest that this signature can identify worst outcomes, independent of clinical criteria.

关键词： Glioblastoma multiforme Immunophenotypic signature Progression free survival Molecular markers Human telomerase reverse transcriptase Interleukin-6 Tissue inhibitor of metalloproteinases-1 YKL-40 High mobility group-A1

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