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Complete oral rehabilitation in a case with severe dental fluorosis

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World Journal of Clinical Cases 2014年第12期2卷 938-942页

作者： Nikhil joshi Jayant Palaskar Mahasweta joshi Rahul Kathariya Department of Prosthodontics Crown Bridge and Implantology Sinhgad Dental College and Hospital STES campus Vadgaon (Budruk) Pune 411041 Maharastra India Department of Public Health Dentistry Sinhgad Dental College and Hospital STES Campus Vadgaon (Budruk) Pune 411041 Maharastra India Dr. D.Y Patil Dental College and Hospital Dr. D.Y Vidyapeeth (Deemed University) Pune 411018 Maharashtra India

the authors have presented a technique of full occlusal rehabilitation in a case of severe dental fluorosis. In this technique, maxillary and mandibular anterior teeth were simultaneously prepared and restored first. this was followed by simultaneous preparation of maxillary and mandibular posterior teeth that were restored in canine guided occlusion. the technique and sequence followed here is unique and is not available in dental literature. this technique reduces number of appointments while fulfilling all objectives. Periodontal followup over 3 years was satisfactory. A restorative treatment protocol has been devised for fluorosis which will act as a guide for the dental practitioners.

关键词： Occlusal rehabilitation Dental fluorosis treatment protocol Restorative management Occlusal plane

Assigning conservation value and identifying hotspots of endemic rattan diversity in the Western Ghats, India

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Plant Diversity 2017年第5期39卷 263-272页

作者： Mukta joshi Bipin Charles G. Ravikanth N.A. Aravind Ashoka trust for Research in Ecology and the Environment (AtREE) Royal Enclave Srirampura Jakkur PO Bangalore 560064 India Indian Institute of Sdence Education and Research Dr. Homi Bhabha Road Pashan Pune 411008 India

Rattans, or canes, are one of the most important non-timber forest products supporting the livelihood of many forest-dwelling communities in South and North-eastern India. Due to increased demand for rattan products, rattans have been extracted indiscriminately from the Western Ghats, a 1600-km mountain chain running parallel to the west coast of India. Extensive harvesting, loss of habitat and poor regeneration has resulted in dwindling rattan populations, necessitating an urgent attempt to conserve existing rattan resources. In this study, using niche-modelling tools, an attempt has been made to identify areas of high species richness of rattans in the Western Ghats, one of the mega-diversity regions of the world. We have also developed conservation values for 21 economically important and endemic rattans of the Western Ghats. We identified at least two to three sites of extremely high species richness outside the existing protected area network that should be prioritized for in situ *** study emphasizes the need to develop strategies for the long-term conservation of rattans in the Western Ghats, India.

关键词： Calamus NtFP Distribution Protected areas Gap analysis Species distribution models

Stem cell secretome restore the adipo-osteo differentiation imbalance in diabetic dental pulp-derived mesenchymal stem cells

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Chronic Diseases and translational Medicine 2024年第4期10卷 340-349页

作者： Avinash Sanap Kalpana joshi Supriya Kheur Ramesh Bhonde Regenerative Medicine Laboratory Dr.D.Y.Patil Dental College and HospitalDr.D.Y.Patil VidyapeethPimpriPuneIndia Department of Biotechnology Sinhgad College of Engineering affiliated to Savitribai Phule Pune UniversityPuneIndia

Background:Mesenchymal stem cells(MSCs)from type 2 diabetes mellitus(t2DM)individuals exhibit increased adipogenesis and decreased *** investigated the potential of adipose tissue-derived MSCs(ADMSCs)secretome obtained from healthy individuals in restoring the tumor necrosis factor-α(tNF-α)mediated imbalance in the adipo/osteogenic differentiation in the dental pulp-derived MSCs obtained from t2DM individuals(dDPMSCs).Methods:dDPMSCs were differentiated into adipocytes and osteocytes using a standard cocktail in the presence of(a)induction cocktail,(b)induction cocktail+tNF-α,and(c)induction cocktail+tNF-α+ADMSCs-secretome(50%)for 15 and 21 days *** adipocytes and osteocytes were stained by oil red O and alizarin red and analyzed by using ImageJ *** expression of the key genes involved was analyzed by using reverse-transcription polymerase chain reaction(Rt-PCR).Results:treatment of tNF-αaugmented the adipogenesis(9571±765 vs.19,815±1585 pixel,pthe osteogenesis(15,603±1248 vs.11,894±951 pixel,pthe oil red O and alizarin red staining ***,dDPMSCs differentiated along with tNF-αand 50%ADMSCs secretome exhibited enhanced osteogenesis(11,894±951 vs.41,808±3344 pixel,ptionally,dDPMSCs differentiated along with ADMSCs secretome exhibited decreased expression of PPARg(pterix(pted as revealed by the Rt-PCR ***:ADMSCs secretome from healthy individuals restore the tNF-αinfluenced differentiation fate of dDPMSCs and therefore can be explored for t2DM clinical management in the future.

关键词： differentiation mesenchymal stem cells microenvironment secretome type 2 diabetes mellitus

toluene Alkylation to Selective Formation of p-Xylene over Co-Crystalline ZSM-12/ZSM-5 Catalyst

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Journal of Natural Gas Chemistry 2007年第1期16卷 37-41页

作者： P.N.joshi P.S.Niphadkar P.A.Desai R.Patil V.V.Bokade Catalysis Division National Chemical LaboratoryPune-411008India

the alkylation of toluene with methanol to selective formation of p-xylene has been systematically studied. ZSM-12 （MtW）/ZSM-5 co-crystalline zeolite in 40：60 proportions have been synthesized by the same molar gel composition, but at different temperatures and periods than that of ZSM-12 and ZSM-5, separately. All the prepared samples are characterized by XRD, SEM, BEt, and XRF. the activity of toluene alkylation was investigated with a mixture of toluene and methanol as a feed over the ZSM-12, ZSM-12/ZSM-5 co-crystalline, ZSM-5, and physical mixture of ZSM-12/ZSM-5. From characterization, it is observed that the ZSM-12/ZSM-5 co-crystalline material is different from that of ZSM-12, ZSM-5, and their physical mixture. Further, the ZSM-12/ZSM-5 co-crystalline zeolite produces the highest content of xylene and has better selectivity for p-xylene than ZSM-12, ZSM-5, and their physical mixture.

关键词： ZSM-12 ZSM-5 co-crystalline toluene alkylation p-xylene

Silicone Rubber Composites with Improved Electrical Conductivity/Hardness Using Hybrid Fillers： Carbon Black-Expanded GraphitelPolyaniline

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材料科学与工程（中英文B版） 2013年第4期3卷 226-234页

作者： Apama joshi Anjali Athawale Department of Chemistry University of Pune Pune 411007 India

Dispersion sensitivity analysis&consistency im provement of APFSDS

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Defence technology（防务技术） 2017年第4期13卷 316-322页

作者： Sangeeta Sharma Panda L.K. Gite A. Anandaraj R.S. Deodhar D.K. joshi K.M. Rajan Armament Research Development Establishment (ARDE) Defence Research Development Organization Ministry of Defence Government of India Pashan Pune Maharashtra 411 021 India

the purpose of this study is to investigate and quantify some possible sources of dispersion of 120 mm APFSDS tank ammunition both experimentally and *** paper aims to point out the most influential source during In-Bore Balloting Motion phase as well as in External Ballistics phase of the ammunition and quantifies its effect on *** obtained from flight trials is critically analysed and parameters affecting dispersion such as initial yaw/pitch rates,yaw/pitch dampening,plane start angle,launch spin,clearance,centre of gravity shift,dynamic imbalance angle,cross wind,*** observed and,later on,studied in detail by extensive External Ballistics Monte Carlo(EBMC)simulation and Six Degree of Freedom(6-DOF)trajectory *** Bore Balloting Motion simulation shows that reduction in residual spin by about 5%results in drastic56%reduction in first maximum yaw.A correlation between first maximum yaw and residual spin is *** of data analysis are used in design modification for existing *** of designs are evaluated numerically before freezing five designs for further *** designs are critically assessed in terms of their comparative performance during In-bore travel&external ballistics *** are validated by free flight trials for the finalised design.

关键词： APFSDS Dispersion Consistency Accuracy Yaw rate Spin Muzzle jump factor In-bore dynamics Monte Carlo simulation

Mesenchymal stem cell conditioned medium ameliorates diabetic serum-induced insulin resistance in 3t3-L1 cells

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Chronic Diseases and translational Medicine 2021年第1期7卷 47-56页

作者： Avinash Sanap Ramesh Bhonde Kalpana joshi Interdisciplinary School of Health Sciences Savitribai Phule Pune UniversityPune 411007India Dr.D.Y.Palil Vidyapeeth PimpriPune 411018India Department of Biotechnology Sinhgad College of Engineering affiliated to Savitribai Phule Pune UniversityPune 411041India Regenerative Medicine Laboratory Dr.D.Y.Patil VidyapeethPimpriPune 411018India

Background: Pharmacological factors used to induce insulin resistance (IR) inin vitro models may not mimic the fullin vivo features of type 2 diabetes mellitus (t2DM). this study aimed to examine the ability of diabetic serum (DS) to induce IR and investigate whether adipose-derived mesenchymal stem cell conditioned medium (ADMSC-CM) reverses DS-induced ***: DS was obtained from newly diagnosed t2DM patients. IR was induced in differentiated 3t3-L1 cells by employing dexamethasone, tumor necrosis factor alpha (tNF-α), palmitate and DS. Glucose uptake (2-[N-[7-nitrobenz-2-oxa-1,3-diazol-4-yl] amino]-2-deoxyglucose(2-NBDG) uptake assay), intracellular levels of reactive oxygen species (ROS), and superoxide radicals (O2-) (fluorescence microscopy and fluorometry) were analyzed in control and experimental samples. mRNA expression of key genes involved in glucose transport and inflammation were analyzed by using reverse transcription polymerase chain reaction (Rt-PCR). Pro-inflammatory cytokines and phospho-insulin receptor substrate (IRS) (Ser-307) protein expression were analyzed by fluorescence activated cell sorter analysis. Statistical significance was determined by using one-way ANOVA followed by tukey’s multiple comparison ***: ADMSC-CM significantly increased the DS-mediated decrease in 2-NBDG uptake (11.01 ± 0.50vs. 7.20 ± 0.30,P t, 6.35 ± 0.46vs. 9.80 ± 0.10,P t, 3.00 ± 0.10vs. 4.60 ± 0.09,P tion. Further, the ADMSC-CM restored DS-induced down regulation GLUt4 (1.52- fold,P the up-regulation of PPARγ (0.35-fold,P tein expression compared to the baseline (median fluorescence intensity, 88,192 ± 2720vs. 65,450 ± 3111,P to the traditionally used pharmacological factors, namely dexamethasone, tNF-α, and palmitate, which can be

关键词： Insulin resistance Inflammation Mesenchymal stem cells Oxidative stress type 2 diabetes mellitus

Acinetobacter baumannii:An emerging pathogenic threat to public health

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World Journal of Clinical Infectious Diseases 2013年第3期3卷 25-36页

作者： Suresh G joshi Geetanjali M Litake Surgical and Nosocomial Infections Research Program Drexel University College of Medicine PhiladelphiaPA 19102 United States Department of Biotechnology Modern College University of Pune affiliate Pune 411007 India

Over the last three decades, Acinetobacter has gained importance as a leading nosocomial pathogen, partly due to its impressive genetic capabilities to acquire resistance and partly due to high selective pressure, especially in critical care units. this low-virulence organism has turned into a multidrug resistant pathogen and now alarming healthcare providers worldwide. Acinetobacter baumanni(A. baumannii) is a major species, contributing about 80% of all Acinetobacter hospital-acquired infections. It disseminates antibiotic resistance by virtue of its extraordinary ability to accept or donate resistance plasmids. the procedures for breaking the route of transmission are still proper hand washing and personal hygiene(both the patient and the healthcare professional), reducing patient's biofilm burden from skin, and judicious use of antimicrobial agents. the increasing incidence of extended-spectrum beta-lactamases and carbapenemases in A. baumannii leaves almost no cure for these "bad bugs".to control hospital outbreaks of multidrug resistantAcinetobacter infection, we need to contain their dissemination or require new drugs or a rational combination therapy. the optimal treatment for multidrug-resistant A. baumannii infection has not been clearly established, and empirical therapy continues to require knowledge of susceptibility patterns of isolates from one's own institution. this review mainly focused on general features and introduction to A. baumannii and its epidemiological status, potential sources of infection, risk factors, and strategies to control infection to minimize spread.

关键词： Acinetobacter Acinetobacter baumannii Biofilm Combination therapy Hospital-acquired infection Intensive care unit Multidrug resistance Nosocomial Pathogen Risk factor

Experimental Investigation of Mechanical Properties of Impact Modified Polyvinyl Chloride-Fly Ash Composites

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Journal of Minerals and Materials Characterization and Engineering 2019年第1期7卷 34-47页

作者： Pramod Shriniwas joshi Deepti Sanjiv Marathe Gharda Institute of technology Ratnagiri India Department of Polymer Engineering Maharashtra Institute of Technology Pune India

the mechanical properties like tensile, pin bearing and impact properties have been studied for composites containing Fly Ash (FA) and Impact modifier (IM) in Polyvinyl Chloride (PVC) for furniture and pipe applications. Pin-bearing test is an important tool to evaluate the ability of the material to retain fasteners and the ability of the material to sustain load during the service life. the present paper evaluates the effect of variation of FA and IM on the pin bearing strength, tensile strength, modulus elongation at break and impact strength. Scanning electron microtopography indicates that the impact modifier forms a co-continuous phase at 10% of IM in PVC. Increase in void content decreases impact strength and tensile strength. As void content increases moisture absorption also increases. the results of pin bearing tests were analogous to tensile test and correlate well. Results were in accordance with impact modification theory. Moisture absorption was studied keeping in view outdoor applications.

关键词： Flyash-PVC Composites Impact Modifier Pin Bearing Properties tensile Strength