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Genetic polymorphisms in HIFIA are associated with prostate cancer risk in a Chinese population

Asian Journal of Andrology 2012年第6期14卷 864-869页

作者： pu Li Qiang Cao Peng-fei Shao Hong-Zhou Cai Hai Zhou Jia-Wei Chen Chao Qin Zheng-Dong Zhang Xiao-Bing Ju Chang-Jun Yin State Key Laboratory of Reproductive Medicine Department of Urology The First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China Department of Molecular and Genetic Toxicology School of Public Health Nanjing Medical University Nanjing 210029 China

The hypoxia-inducible factor-1α（HIF-1α） plays an important role in regulating angiogenesis, which is essential for tumor growth and metastasis. Genetic variations of HIFIA （coding HIF-1α） have been shown to influence an individual＇s susceptibility to many human tumors; however, evidence on associations between HIFIA single-nucleotide polymorphisms （SNPs） and prostate cancer （PCa） risk is conflicting. We genotyped three potentially functional polymorphisms in HIFIA （rs11549465, rs11549467 and rs2057482） using the TaqMan method and assessed their associations with PCa risk in a case-control study of 662 PCa patients and 716 controls in a Chinese Hart population. Compared with rs 11549467 GG genotype, the variant genotypes GA ＋AA had a significantly increased PCa risk （adjusted odds ratio （OR）= 1.70; 95% confidence interval （C1）= 1.06-2.72）, particularly among older patients （0R=2.01; 95%C1 = 1.05-3.86）, smokers （0R=2.06; 95%C1 = 1.07-3.99）, never drinkers （OR=2.16; 95%C1 = 1.20-3.86） and patients without a family history of cancer （OR= 1.71; 95%C1= 1.02-2.89）. Furthermore, patients with rs11549467 variant genotypes were associated with a higher Gleason score （OR=2.14; 95%CI = 1.22-3.75）. No altered PCa risk was associated with the rs 11549465 and rs2057482 polymorphism. However, the combined variant genotypes of rs2057482 and rs 11549467 were associated with increased PCa risk （0R=2.10; 95%C1= 1.23-3.57 among subjects carrying three or more risk alleles）. These results suggest that HIFIA polymorphisms may impact PCa susceptibility and progression in the Chinese Han population.

关键词： genetic association HIF-1α HIFIA polymorphism prostate cancer

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Quantum information processing and metrology with color centers in diamonds

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Frontiers of physics 2014年第5期9卷 587-597页

作者： Jing-Wei Zhou Peng-fei Wang Fa-Zhan Shi pu Huang Xi Kong Xiang-Kun Xu Qi Zhang Zi-Xiang Wang Xing Rong Jiang-Feng Du Hefei National Laboratory for Physics Sciences at the Microscale and Department of Modern Physics University of Science and Technology of China Hefei 230026 China

The Nitrogen Vacancy （NV） center is becoming a promising qubit for quantum information processing. The defect has a long coherence time at room temperature and it allows spin state initialized and read out by laser and manipulated by microwave pulses. It has been utilized as a ultra sensi- tive probe for magnetic fields and remote spins as well. Here, we review the recent progresses in experimental demonstrations based on NV centers. We first introduce our work on implementation of the Deutsch- Jozsa algorithm with a single electronic spin in diamond. Then the quantum nature of the bath around the center spin is revealed and continuous wave dynamical decoupling has been demonstrated. By applying dynamical decoupling, a multi-pass quantum metrology protocol is realized to enhance phase estimation. In the final, we demonstrated NV center can be regarded as a ultra-sensitive sensor spin to implement nuclear magnetic resonance （NMR） imaging at nanoscale.

关键词： quantum information processing and metrology Nitrogen Vacancy center phase estimation dynamical deeoupling single spin detection

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Short- and long-term effect of complete versus culprit-only revascularization in patients undergoing primary PCI for multivessel disease： a meta-analysis

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Journal of Geriatric Cardiology 2017年第6期14卷 416-422页

作者： Hong LI Shuai MENG Duo yang Hua-Gang ZHU Xiang LI Lian-Mei pu Ruo-fei JIA Wei-Guang CHEN Chao QU Ze-Ning JIN The 33^rd Ward Department of Emergency Cardiology Beijing An Zhen Hospital Capital Medical University Beijing China

Objective The optimal strategy during primary percutaneous coronary intervention （PCI） in patients with acute myocardial infarction and multivessel disease is still controversial. Therefore, the aim of our study is to evaluate the short- and long-term effect of complete revas- cularization （CR） versus infarct-related artery revascularization （IR） following primary PCI. Methods We identified randomized controlled studies （RCTs） by systematic search of pubMed, EMBASE, Web of Science, *** Website, Cochrane Library and Google scholar Database. Primary outcome was major adverse cardiac events （MACE）. Result Nine RCTs （2198 patients） with mean follow-up of 21.1 months were retrieved. Overall, CR was associated with significantly lower risk of MACE compared with IR therapy when followed by long-term duration （≥ 12 months）（RR： 0.56; 95% Ch 0.47-0.68; I^2 = 58.5%）. Additionally, CR was associated with equivalent rates of all-cause mortality （RR： 0.76; 95% CI： 0.53-1.08; I^2= 0.0%） and myocardial infarction （RR： 0.81; 95% CI： 0.57-1.16; I^2= 26.4%） compared with control. Meanwhile, risk of stroke was similar between groups （RR： 0.73; 95% CI： 0.24-2.19; I^2= 0.0%）. However, rates of cardiac death and target vessel revascularization were significantly decreased in the CR group （RR： 0.41; 95% CI： 0.23-0.72; I^2 = 0.0% and RR： 0.46; 95% CI： 0.37-0.57; I^2= 47.4%）. Conclusion Complete revascularization appears to have long-term clinical benefit with regard to adverse cardiac events following primary PCI. However, more studies are needed to confirm these findings.

关键词： Adverse cardiac events Complete revascularization Culprit-related artery Meta-analysis Multivessel disease

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Band alignment between NiO_(x) and nonpolar/semipolar GaN planes for selective-area-doped termination structure

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Chinese Physics B 2021年第6期30卷 583-587页

作者： Ji-Yao Du Ji-Yu Zhou Xiao-Bo Li Tao-fei pu Liu-An Li Xin-Zhi Liu Jin-Ping Ao School of Automation and Electrical Engineering Shenyang Ligong UniversityShenyang 110159China Institute of Technology and Science Tokushima UniversityTokushimaJapan School of Physics Sun Yat-Sen UniversityGuangzhou 510275China

Band alignment between NiO_(x) and nonpolar GaN plane and between NiO_(x) and semipolar GaN plane are measured by x-ray photoelectron spectroscopy. They demonstrate that the maximum value of the valence band in the unintentional-doped a-plane, m-plane, and r-plane GaN are comparable to each other, which means that all the substrates are of n-type with similar background carrier concentrations. However, the band offset at the NiO_(x)/GaN interface presents obvious crystalline plane dependency although they are coated with the same NiO_(x) films. By fitting the Ga 3 d spectrum obtained from the NiO_(x)/GaN interface, we find that relatively high Ga–O content at the interface corresponds to a small band offset. On the one hand, the high Ga–O content on the GaN surface will change the growth mode of NiO_(x). On the other hand, the affinity difference between Ga and O forms a dipole which will introduce an extra energy band bending.

关键词： GaN NiO_(x) band alignment vertical diode

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An improved method for image denoising based on fractional-order integration

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Frontiers of Information Technology & Electronic Engineering 2020年第10期21卷 1485-1493页

作者： Li XU Guo HUANG Qing-li CHEN Hong-yin QIN Tao MEN Yi-fei pu College of Electronics and Materials Engineering Leshan Normal UniversityLeshan 614000China College of Computer Science Sichuan UniversityChengdu 610064China Key Lab of Internet Natural Language Processing of Sichuan Provincial Education Department Leshan Normal UniversityLeshan 614000China

Given that the existing image denoising methods damage the texture details of an image,a new method based on fractional integration is ***,the fractional-order integral formula is deduced by generalizing the Cauchy integral,and then the approximate value of the fractional-order integral operator is estimated by a numerical ***,a fractional-order integral mask operator of any order is constructed in eight pixel directions of the *** results show that the proposed image denoising method can protect the edge texture information of the image while removing the ***,this method can obtain higher image feature values and better image vision after denoising than the existing denoising methods,because a texture protection mechanism is adopted during the iterative processing.

关键词： Fractional-order integral Cauchy integral Image denoising Fractional gradient Texture protection

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基于数据挖掘探究中医古籍中腰痹膏摩处方药物选用规律

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新中医 2024年第10期56卷 7-13页

作者：李飞董航高天蕾杨留映王爽张星贺云南中医药大学第二临床医学院云南昆明650500

目的:通过数据挖掘技术分析中医古籍中治疗腰痹的膏摩处方的药物选用规律。方法:查阅并分析中医古籍中用于治疗腰痹的膏摩处方,提取古籍出处、方名、处方药物,采用SATI软件分析处方药物及其四气、五味、归经的频次、支持度,采用UCINET、... 详细信息

目的:通过数据挖掘技术分析中医古籍中治疗腰痹的膏摩处方的药物选用规律。方法:查阅并分析中医古籍中用于治疗腰痹的膏摩处方,提取古籍出处、方名、处方药物,采用SATI软件分析处方药物及其四气、五味、归经的频次、支持度,采用UCINET、NetDraw软件分析药物的中心度。结果:通过查阅37本含有腰痹膏摩方的古籍,共检索出81首治疗腰痹的膏摩处方,涉及217味中药,药物使用总频次为958次。《圣济总录》《普济方》《太平圣惠方》是记载膏摩处方较多的古籍。方名“摩腰膏”出现次数最多(方名相同,但部分药物不同),频次为9次,其次是摩腰丹,频次为7次。附子使用频次最多,达37次,其余使用频次≥20次的药物,按使用频次由高到低依次是花椒、当归、吴茱萸、干姜、川芎、丁香、朱砂、雄黄、白芷、肉桂、生姜、麝香、细辛。醋、猪脂是使用最多的制膏辅料。选用的药物以温、热性药为主,其次是寒、平性药和凉性药;选用的药物多为辛味药,其次是苦、甘味药;选用的药物多为归肝、脾经的药物。结论:采用膏摩疗法治疗腰痹应以温、通、补法为主,重视肝脾、肝肾同治。利用现代技术提取中药有效成分,结合最新的制膏工艺,可制作出性质更稳定、功效更显著、更适用于临床的膏摩剂型,是膏摩疗法发展的重要部分。

关键词：腰痹膏摩疗法数据挖掘中医古籍用药规律

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Symmetry breaking of photonic spin-orbit interactions in metasurfaces

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光电工程 2017年第3期44卷 319-325页

作者： fei Zhang Mingbo pu Jun Luo Honglin Yu Xiangang Luo State Key Laboratory of Optical Technologies on Nano-Fabrication and Micro-Engineering Institute of Optics and Electronics Chinese Academy of Sciences Key Laboratory of Optoelectronic Technology and System Ministry of Education Chongqing University

Spin-orbit optical phenomena pertain to the wider class of electromagnetic effects originating from the interaction of the photon spin with the spatial structure and propagation characteristics of an optical wave,mediated by suitable optical *** are many emerging photonic applications of spin-orbit interactions(SOI)of light,such as control of the optical wave propagation via the spin,enhanced optical manipulation,and generation of structured optical ***,current applications are based on symmetric SOI,that is,the behaviours of polarized photons with two opposite spins are opposite,leading to the limit of spin-based *** symmetry of SOI can be broken in our proposed metasurfaces,consisting of spatially varying birefringence,which can arbitrarily and independently build SOI for two opposite spins without reduction of optical energy *** obtain three kinds of dual-functional metasurfaces at visible and infrared wavelengths with high *** concept of generation of asymmetric SOI for two spins,using anisotropic metasurfaces,will open new degrees of freedoms for building new types of spin-controlled multifunctional shared-aperture devices for the generation of complex structured optical fields.

关键词： metasurfaces metamaterials spin-orbit interactions

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核电厂钨基屏蔽材料制备工艺及性能研究

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热处理 2024年第4期39卷 14-19,24页

作者：张泽群陆海峰宋沅泽郭飞蒲立星洪彬龙谭强福建宁德核电有限公司福建宁德355200 苏州热工研究院有限公司江苏苏州215000 国家核电厂安全及可靠性工程技术研究中心江苏苏州215004

为满足对核电站新的防辐射要求,采用高能等离子喷涂技术在45钢板上制备了W、W-Ni和W-Ni-Cr涂层,检测了涂层的显微组织、硬度、结合强度和成分分布,并采用实验室放射源测试研究了涂层和铅的屏蔽性能。结果表明:与W和W-Ni-Cr涂层相比,W-N... 详细信息

为满足对核电站新的防辐射要求,采用高能等离子喷涂技术在45钢板上制备了W、W-Ni和W-Ni-Cr涂层,检测了涂层的显微组织、硬度、结合强度和成分分布,并采用实验室放射源测试研究了涂层和铅的屏蔽性能。结果表明:与W和W-Ni-Cr涂层相比,W-Ni涂层较均匀致密,孔隙率较小,为4.7%,硬度高达500~550 HV0.3,结合强度高于67.5 MPa;W-Ni涂层的屏蔽性能最佳,4 mm厚W-Ni涂层的屏蔽效果是相同厚度Pb涂层的1.16倍。

关键词：屏蔽涂层等离子喷涂孔隙率屏蔽性能

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The primary dolostone in the Meso-Neoproterozoic:Cases study on platforms in China

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Journal of Palaeogeography 2022年第2期11卷 151-172页

作者： Zhi-Dong Bao Han-Cheng Ji Yuan Wang Zong-Feng Li Ting Liang Bo Niu Ming-yang Wei Kai Lu Yan-Qing Shi Hua Zhang pu Wan Zhuo-Lun Li Zhi-Bo yang Rui Liu Can-Xing Liu Xu-Lin Zhong Xiao-Qi Guo Peng-fei Xiang Zhong-Xian Cai Shui-Chang Zhang China University of Petroleum(Beijing) Beijing 102249China State Key Laboratory of Petroleum Resources and Prospecting Ministry of EducationBeijing 102249China China University of Geosciences(Wuhan) Wuhan 430074China Petro China Research Institute of Petroleum Exploration and Development Beijing 100083China

Meso-Neoproterozoic dolostone is abnormally well-developed in the platform areas in China,detailly,in the Mesoproterozoic Calymmian Wumishan Formation of North China Basin,Neoproterozoic Ediacaran Qigbulak Formation of Tarim Basin,and the Neoproterozoic Ediacaran Dengying Formation of Sichuan *** outcrops and drilling cores from these basins show that these dolostones are mostly thick-bedded to massive,with mud-sized to silt-sized crystalline dolostone reaching 86%-97%of the total dolostone *** dolostones basically suffered no secondary metasomatism,regardless of containing microorganisms(such as algae and bacteria)or *** analyses of sedimentary palaeogeographic features indicate that:(1)the Meso-Neoproterozoic dolostone nearly covered the entire area basins,and was widely deposited in supratidal to intertidal zones,as well as in open platform environments;(2)the dolostone was subdivided according to the crystalline size,with the distribution controlled by geomorphology,i.e.,the pure mud-sized crystalline dolostone developing in depression areas,whereas the grainy mud-sized crystalline dolostone or the mound stromatolitic mud-sized crystalline dolostone developing in uplift areas;(3)deep-water basins developed between the carbonate platforms,and the seismic profiles show that these basins were formed by syngenetic deep faults in the Meso-Neoproterozoic *** syngenetic faults increased Mg^(2+)concentration in the seawater by injecting rich-Mg2+-bearing hydrothermal fluids into the carbonate *** analyses of geochemical and paleoclimatic indexes reveal that there is no obvious difference in carbon and oxygen isotope ratios between dolostones having different textures,with the ratios similar to those of the global seawater of the Meso-Neoproterozoic,indicating that the silt-sized crystalline dolostone has the same sedimentary origin as the mud-sized crystalline dolostone,i.e.,the former is from authigenic recrystallization of the

关键词： Thick-bedded to massive dolostone C-O isotopes Meso-Neoproterozoic Tarim basin Sichuan basin North China Basin

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资产管理公司:问题与建议

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财经问题研究 2001年第4期 36-41页

作者：蒲宇飞国务院体改办国际体制比较司北京100017

我国资产管理公司成立以来 ,在不良资产的收购、管理与处置方面取得了一定的成绩 ,但同时也面临着诸多困难与障碍。为解决这些问题 ,目前应尽快设立、修订有关法律法规 ,明确相关主体的关系并规范其行为。其次 ,把养老金改革与不良资产... 详细信息

我国资产管理公司成立以来 ,在不良资产的收购、管理与处置方面取得了一定的成绩 ,但同时也面临着诸多困难与障碍。为解决这些问题 ,目前应尽快设立、修订有关法律法规 ,明确相关主体的关系并规范其行为。其次 ,把养老金改革与不良资产处置相结合。再次 ,在具体处置活动中探索采用EVA方法。

关键词：资产管理不良资产养老基金资产管理公司中国

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