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A Robust N-Terminal Pro-Brain Natriuretic Peptide Assay for Clinical Diagnosis of Heart Failure in Elderly Patients

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Journal of Analysis and Testing 2024年第1期8卷 74-82页

作者： Xue Gong Jiangling Wu Jiajia zhang Zhongwei Jiang Yi Wang pu zhang Engineering Research Center for Biotechnology of Active Substances(Ministry of Education) Chongqing Key Laboratory of Green Synthesis and ApplicationsCollege of ChemistryChongqing Normal UniversityChongqing 401331China Chongqing Research Center for Pharmaceutical Engineering College of PharmacyChongqing Medical UniversityChongqing 400016China Department of Clinical Laboratory University Town Hospital of Chongqing Medical UniversityChongqing 401331China

Heart failure(HF)is a clinical hallmark of cardiovascular syndrome leading to substantial morbidity,repeated hospitalization,and enormous healthcare *** elderly populations continue to increase,biomarker-guided diagnosis and treatment for age-related cardiac decline have become *** evidence demonstrates that N-terminal proBNP(NT-proBNP)can provide a unique window into the diagnosis and risk stratification with ***,a simple yet robust aptasensor is developed for on-site recognizing the NT-proBNP by its targeting aptamer,thus achieving the accurate diagnosis of *** aptasensing system is prepared by absorbing the fluorophore-labeled aptamer strand onto the graphene oxide(GO),leading to efficient quenching without possible off-site signal *** aptamer strand can specifically identify target NT-proBNP molecules via a versatile conformational transformation,resulting in the desorption of the aptamer-NTproBNP complexes from GO and re-generation fluorescence signal,thus allowing sensitive detection of NT-proBNP in 37 clinical blood *** advantage of the high specificity of aptamer-guaranteed recognitions of NT-proBNP,this aptasensor system readily achieves better diagnostic performance for HF than commercially adopted chemiluminescence immunoassay(Siemens,CLIA)in hospitals in terms of accuracy(89.2%vs 83.8%),specificity(89.5%vs 84.2%),and positive predictive value(88.9%vs 83.3%).This work provides a stable option for the diagnosis and treatment of elderly HF-related diseases inclinics.

关键词： NT-proBNP Graphene oxide Aptamer Heart failure Clinical diagnosis

Integrated bulk and single-cell transcriptome data identify clinically relevant cell populations in clear cell renal cell carcinoma

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Genes & Diseases 2024年第1期11卷 42-45页

作者： Pingbao zhang pu zhang Jun Gao Xiaosong Li Chengcheng Wei Weihui Liu QingLiu He Yuan zhang Department of Urology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Urology Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghai 200032China Clinical Molecular Medicine Testing Center The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Urology The Second Affiliated Hospital of Fujian Medical UniversityQuanzhouFujian 362000China Department of Nephrology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China

Renal cell carcinoma,which consists of three main histological subtypes,namely,clear cell renal cell carcinoma(ccRCC),papillary RCC(pRCC),and chromophobe RCC(chRCC),accounts for most kidney cancer *** accounts for approximately 85%of all RcC cases,1 and it is a malignant tumor with multiple molecular features and a poor *** have shown that ccRCC is one of the most immune and vaso-invasive cancer types.2 Considering that ccRCC is not sensitive to either radiotherapy or chemotherapy,targeted therapies.

关键词： chemotherapy cancer cases

Experimental Study on Towing Characteristics of Composite Bucket Wellhead Platform

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China Ocean Engineering 2024年第3期38卷 531-542页

作者： zhang pu-yang LIU Ying-fei LE Cong-huan DING Hong-yan BAI Yu State Key Laboratory of Hydraulic Engineering Intelligent Construction and Operation Tianjin UniversityTianjin 300072China

With the rapid development of large-scale development of marginal oilfields in China,simple wellhead platforms that are simple in structure and easy to install have become an inevitable choice in the process of oilfield ***,traditional simple wellhead platforms are often discarded after a single *** pursuit of a more costeffective approach to developing marginal oilfields,this paper proposes a new offshore oil field development facility—an integrated bucket foundation for wellhead *** verify the safety of its towing behavior and obtain the dynamic response characteristics of the structure,this paper takes a bucket integrated bucket foundation for wellhead platform with a diameter of 40 m as the research *** combining physical model tests and numerical simulations,it analyzes the static stability and dynamic response characteristics of the structure during towing,complete with the effects of the draft,wave height,wave period,and towing point height,which produce the dynamic responses of the structure under different influence factors,such as roll angle,pitch angle,heave acceleration and towing force as well as the sensibility to transport *** results show that the integrated bucket foundation for wellhead platform is capable of self-floating towing,and its movement is affected by the local environment,which will provide a reference for actual projects.

关键词： composite bucket foundation wellhead platform air flotation towing model test

Highly selective photocatalytic reduction of CO_(2) to CH_(4) on electron-rich Fe species cocatalyst under visible light irradiation

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Carbon Energy 2024年第1期6卷 255-266页

作者： Qianying Lin Jiwu Zhao pu zhang Shuo Wang Ying Wang Zizhong zhang Na Wen Zhengxin Ding Rusheng Yuan Xuxu Wang Jinlin Long State Key Laboratory of Photocatalysis on Energy and Environment College of ChemistryFuzhou UniversityFuzhouChina

Efficient photocatalytic reduction of CO_(2) to high-calorific-value CH4,an ideal target product,is a blueprint for C_(1)industry relevance and carbon neutrality,but it also faces great ***,we demonstrate unprecedented hybrid SiC photocatalysts modified by Fe-based cocatalyst,which are prepared via a facile impregnation-reduction method,featuring an optimized local electronic *** exhibits a superior photocatalytic carbon-based products yield of 30.0μmol g^(−1) h^(−1) and achieves a record CH_(4) selectivity of up to 94.3%,which highlights the effectiveness of electron-rich Fe cocatalyst for boosting photocatalytic performance and ***,the synergistic effects of directional migration of photogenerated electrons and strongπ-back bonding on low-valence Fe effectively strengthen the adsorption and activation of reactants and intermediates in the CO_(2)→CH_(4) *** study inspires an effective strategy for enhancing the multielectron reduction capacity of semiconductor photocatalysts with low-cost Fe instead of noble metals as cocatalysts.

关键词： artificial synthesis of CH_(4) electronic structure optimization Fe species cocatalyst photocatalytic CO_(2) reduction SiC

Research on Sleeve Grouting Density Detection Based on the Impact Echo Method

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Structural Durability & Health Monitoring 2024年第2期18卷 143-159页

作者： pu zhang Yingjun Li Xinyu Zhu Shizhan Xu Pinwu Guan Wei Liu Yanwei Guo Haibo Wang School of Civil Engineering Zhengzhou UniversityZhengzhou450000China Xixi Expressway Construction Co. Ltd.Nanyang474450China

Grouting defects are an inherent challenge in construction practices,exerting a considerable impact on the operational structural integrity of *** investigation employed the impact-echo technique for the detection of grouting anomalies within connections,enhancing its precision through the integration of wavelet packet energy principles for damage identification purposes.A series of grouting completeness assessments were meticulously conducted,taking into account variables such as the divergent material properties of the sleeves and the configuration of adjacent *** findings revealed that:(i)the energy distribution for the highstrength concrete cohort predominantly occupied the frequency bands 42,44,45,and 47,whereas for other groups,it was concentrated within the 37 to 40 frequency band;(ii)the delineation of empty sleeves was effectively discernible by examining the wavelet packet energy ratios across the spectrum of frequencies,albeit distinguishing between sleeves with 50%and full grouting density proved challenging;and(iii)the wavelet packet energy analysis yielded variable detection outcomes contingent on the material attributes of the sleeves,demonstrating heightened sensitivity when applied to ultrahigh-performance concrete matrices and GFRP-reinforced steel bars.

关键词： Prefabricated building steel grouting sleeve impact echo method wavelet packet energy grouted defect

1,6-Conjugate addition of para-quinone methides using gem-diborylcarbanions: Practical access to gem-diborylalkanes bearing vicinal tertiary/quaternary stereocenters

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Green Synthesis and Catalysis 2024年第1期5卷 68-72页

作者： pu-zhang Zi Xing-Bang Liu Quan-Hong Zhao Min He Yuan Huang Department of Medicinal Chemistry School of PharmacyXi'an Jiaotong UniversityXi'an710061China

A novel,efficient and pragmatic method to prepare gem-diboron products with vicinal tertiary/quaternary stereocenters using LiTMP-mediated 1,6-conjugate addition of gem-diborylalkanes to para-quinone methides was described for the first *** results showed that various gem-diboron products with vicinal tertiary and quaternary stereocenters could be formed within 15 min at ambient *** simple protocol has also been applied for the efficient synthesis of the analogue of Bedaquiline.

关键词： gem-Diborylalkanes Quaternary stereocenter Conjugate addition para-Quinone methides Organoboron compounds

面向高水平社会主义市场经济体制的财税金融政策协同

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现代经济探讨 2024年第4期 22-28页

作者：姜旭张普常州大学吴敬琏经济学院常州213159

中共二十大报告将构建高水平社会主义市场经济体制作为着力推动高质量发展的重要抓手。增强财税金融政策的协同水平,既是全面深化改革的系统性、整体性、协同性要求在提升宏观经济治理能力上的具体体现,也内生于高水平社会主义市场经济... 详细信息

中共二十大报告将构建高水平社会主义市场经济体制作为着力推动高质量发展的重要抓手。增强财税金融政策的协同水平,既是全面深化改革的系统性、整体性、协同性要求在提升宏观经济治理能力上的具体体现,也内生于高水平社会主义市场经济体制对于金融高质量发展的实际要求。精准支持实体经济、持续优化多方结构、统筹监管各类风险,既是衡量财税金融政策协同效率、协同能力和协同质量的重要标准,也是进一步提升政策协同水平的关键策略。未来,应基于风险防范责任前置、政策主导角色后置、疏通经济循环阻滞、完善综合评价机制的推进原则,实现财税金融政策更高水平的协同,为构建新发展格局、推动高质量发展创造良好的金融经济环境和宏观治理保障。

关键词：现代财税金融体制政策协同高水平社会主义市场经济体制协同治理

醒面对面团水分状态、微观形态和物性的影响研究

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食品工业科技 2024年第6期45卷 42-48页

作者：张艳艳张捷张菁张普刘兴丽张华郑州轻工业大学食品与生物工程学院中原食品实验室冷链食品加工与安全控制教育部重点实验室河南郑州450002

为研究醒面对冷冻面团品质的影响,本文研究了醒面过程中(0、30、60、90、120 min),面团水分分布的变化规律以及面团冷冻后冰晶分布、微观结构和蠕变恢复特性的变化。结果表明:随着醒面时间的延长,面团中可冻结水含量降低了0.96%;微观结... 详细信息

为研究醒面对冷冻面团品质的影响,本文研究了醒面过程中(0、30、60、90、120 min),面团水分分布的变化规律以及面团冷冻后冰晶分布、微观结构和蠕变恢复特性的变化。结果表明:随着醒面时间的延长,面团中可冻结水含量降低了0.96%;微观结构的结果表明,面团在冻结过程中形成的冰晶空隙和数量逐渐减小,冰晶分布越来越均匀;随着醒面时间从0 min延长至120 min,冷冻面团的平均空隙面积从22.65减小到11.80,空隙数目从10627.00减少到3346.00;随着醒面时间的延长,在蠕变阶段,冷冻面团的最大蠕变柔量Jmax显著增加(P<0.05),零剪切粘度η0显著降低(P<0.05);面团醒发120 min后,冷冻面团最大蠕变柔量Jmax降低了0.50×10^(-4)Pa^(-1),零剪切粘度η0降低了0.43×10^(5)Pa^(-1),这说明冷冻面团的硬度降低,面团的形状更容易保持;在恢复阶段,瞬时柔量J_(0)与黏弹性柔量J_(m)分别增加了1.26×10^(-4)和2.88×10^(-4)Pa^(-1),冷冻面团的恢复力增加。综上,醒面降低了面团中可冻结水的含量,提高了面团的持水力,减小了冷冻过程中冰晶对面团网络结构的破坏,从而提高了冷冻面团的品质。

关键词：醒面水分状态微观结构冷冻面团

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多功能光谱仪定标方法

兵器装备工程学报 2024年第5期45卷 106-111,179页

作者：李卓张朴 91404部队河北秦皇岛066000 中国船舶集团第七一〇研究所湖北宜昌443003

为了精确标定红外探测器的光谱响应函数,分别通过两点线性定标法、多点线性拟合定标法、非线性多项式拟合定标法以及远距离小面源定标法对多功能光谱辐射计进行标定,解算出辐射计的光谱响应系数和偏置系数,采用定标后的辐射计对不同温... 详细信息

为了精确标定红外探测器的光谱响应函数,分别通过两点线性定标法、多点线性拟合定标法、非线性多项式拟合定标法以及远距离小面源定标法对多功能光谱辐射计进行标定,解算出辐射计的光谱响应系数和偏置系数,采用定标后的辐射计对不同温度黑体标准源的辐射亮度进行测量,并与黑体理论辐射亮度进行对比。结果表明,多点定标可减小噪声引起的随机误差和非线性响应引起的系统误差;当被测目标温度变化范围较小时,宜采用多点线性拟合定标,以减少噪声引起的随机误差带来的影响;当被测目标温度变化范围较大时,宜采用多点非线性拟合定标,以减少非线性响应引起的系统误差带来的影响;当被测目标温度较高时,光谱辐射计入瞳处信号较大,宜采用远距离小面源法标定,测量误差低于2%。定标后的测试精度优于国内外同类仪器。

关键词：多功能光谱辐射计定标光谱响应系数偏置系数线性拟合多项式拟合