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Study on prevention effect of Zishen Yutai pill combined with progesterone for threatened abortion in rats

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Asian Pacific Journal of Tropical Medicine 2016年第6期9卷 559-563页

作者： Yi Zhang Wei Yan pu-Feng ge Yan Li Qian Ye Department of Obstetrics and Gynecology the First Affiliated Hospital of Zhejiang Chinese Medical University

Objective:To observe preventive and therapeutic effects and the mechanism of actions on Zishen Yutai pill combined with progesterone on threatened abortion in ***:After pregnancy,50 SPF female SD rats were selected and divided into control group,model group,progesterone group,Zishen Yutai pill group,and progesterone plus Zishen Yutai pill group(combination group),with 10 rats in each *** rats of control group and abortion model group were lavaged with 2 mL/kg normal saline on pregnancy day 1 for continuous 10 *** in Zishen Yutai pill group were given 1.575 g/kg/d of Zishen Yutai pill for intragastric administration for continuous 10 *** in progesterone group were given intramuscular injection treatment of 0.1 mL/d progestin,continuous for 10 *** in combination group were given injection therapy of aqueous solution of Zishen Yutai pill for continuous 10 days,and other treatments were the same as previous two *** model were established then and live births,numbers of abortion and average rate of abortion were compared between the five *** blood was collected to detect the estradiol(E2) and progestational hormone(P),and obtain ratio of Th1/Th2 cytokines(IL-2,INF-γ,IL-4,IL-10).Results:Significant more live births of rats were found in the control group compared with other four groups(Pgesterone group,Zishen Yutai pill group and joint group(Pgesterone group and Zishen Yutai pill *** serum E2 level of P of rats in the control group,progesterone group,Zishen Yutai pill group and joint group were significant higher than that of abortion model group(Pgesterone group,Zishen Yutai pill group and joint group were not significant different(P>0.05) but

关键词： Zishen Yutai pill Progesterone Threatened abortion Aromatizing enzyme Th1/Th2 balance SOCS3

基于支持向量机与因子分析的电容器状态识别研究

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铁道车辆 2024年第4期62卷 86-91页

作者：谭静侯涛杜小渊戈璞李继伟中车永济电机有限公司陕西西安710016

电容器作为牵引系统故障率较高的关键部件,影响列车的稳定运行,且在运行过程中其状态不易直接测量,所以研究电容器状态识别是十分必要的。首先,分析牵引系统中适用性较广的金属薄膜电容物理结构和失效机理,确定影响电容状态的直观计算... 详细信息

电容器作为牵引系统故障率较高的关键部件,影响列车的稳定运行,且在运行过程中其状态不易直接测量,所以研究电容器状态识别是十分必要的。首先,分析牵引系统中适用性较广的金属薄膜电容物理结构和失效机理,确定影响电容状态的直观计算指标为电压、电流。其次,根据电容器设计余量,将其寿命等级分为以1%为步长的11个等级,搭建半实物仿真平台采集预充电过程中电压电流多组实时数据。再次,为降低高采样频率数据复杂度,对数据进行特征指标计算,选择均方根、方差、标准差、峭度、偏度作为特征指标,采用SVM机器学习对特征数据进行训练,对电容器状态等级进行识别,准确率达到95%;为再次提升模型准确率,引入因子分析模型,因子分析模型可以降低数据维度,剔除重叠信息,对指标进行因子得分计算,对电容器状态等级进行判定。最后,提出SVM与因子分析综合权重判定方法,实现电容器的状态识别。根据电容器的状态可计算电容剩余寿命,该方法为电容器的监测、更换、维护提供了可靠依据。

关键词：变流器电容器状态识别支持向量机因子分析

阿帕替尼联合SOX方案治疗晚期胃癌的有效性和安全性的荟萃分析

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山东第一医科大学（山东省医学科学院）学报 2024年第5期45卷 269-277页

作者：热依拉·阿布都肉苏力李胜葛蒲韩笑张清霜空军军医大学附属西京医院陕西西安710000 临沂市人民医院医用气体供应中心山东临沂276000 澳门大学中华医药研究院中国澳门特别行政区999078 中山大学附属第五医院药学部广东广州519000 临沂市人民医院药学部山东临沂276000

目的系统评价阿帕替尼联合SOX方案(替吉奥+奥沙利铂)治疗晚期胃癌的有效性和安全性。方法检索pubMed、Embase、Cochranelibrary、***、万方、中国知网,查找研究阿帕替尼联合SOX方案治疗晚期胃癌患者的有效性与安全性的随机对照试验。对... 详细信息

目的系统评价阿帕替尼联合SOX方案(替吉奥+奥沙利铂)治疗晚期胃癌的有效性和安全性。方法检索pubMed、Embase、Cochranelibrary、***、万方、中国知网,查找研究阿帕替尼联合SOX方案治疗晚期胃癌患者的有效性与安全性的随机对照试验。对纳入的文献进行数据提取,主要结局指标为客观缓解率(objective response rate,ORR)、疾病控制率(disease control rate,DCR);次要结局指标为部分缓解率(partial response rate,PRR)、安全性相关指标(高血压、蛋白尿、手足综合征、腹泻、口腔黏膜炎、疲劳、白细胞减少症、血小板减少症等不良反应的发生人数)。应用R 4.0.3进行统计分析,应用RevMan 5.3进行质量评价图的制作。结果共检索到1699篇文献,最终纳入28项研究,包含2110例患者。相较于SOX方案,阿帕替尼联合SOX方案能够提高患者DCR(OR=3.90,95%CI:3.15~4.83,P<0.001)、ORR(OR=2.73,95%CI:2.26~3.31,P<0.001)、PRR(OR=2.33,95%CI:1.94~2.81,P<0.001),差异有统计学意义。该治疗方案的药品不良反应:高血压(OR=2.47,95%CI:1.26~4.83,P=0.008)、蛋白尿(OR=2.16,95%CI:1.46~3.21,P<0.001)、手足综合征(OR=2.19,95%CI:1.44~3.32,P<0.001)的发生率增加,差异有统计学意义。结论本荟萃分析结果表明,阿帕替尼联合SOX方案治疗晚期胃癌有效性显著,不良反应相对轻微,有望在临床上得到应用。

关键词：晚期胃癌阿帕替尼 SOX方案荟萃分析

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苹果霉心病不同光谱检测方式对比研究

光谱学与光谱分析 2024年第3期44卷 883-890页

作者：张仲雄刘昊灵魏子朝浦育歌张佐经赵娟胡瑾西北农林科技大学机械与电子工程学院陕西杨凌712100 农业农村部农业物联网重点实验室陕西杨凌712100 陕西省农业信息感知与智能服务重点实验室陕西杨凌712100

苹果霉心病是一种对消费者健康产生威胁的水果内部病害,在苹果进入消费市场前实现霉心病的快速无损检测有助于提升苹果品质和保障消费者安全。近年来,可见/近红外光谱技术凭借其快速无损、操作简单、成本低和批量在线检测等优势,被广泛... 详细信息

苹果霉心病是一种对消费者健康产生威胁的水果内部病害,在苹果进入消费市场前实现霉心病的快速无损检测有助于提升苹果品质和保障消费者安全。近年来,可见/近红外光谱技术凭借其快速无损、操作简单、成本低和批量在线检测等优势,被广泛用于水果品质无损检测研究中,而根据实际检测需求进行光谱检测方式选择是开展水果光谱无损检测的关键步骤,为探寻苹果霉心病光谱无损检测中最佳的检测方式,首先基于实验室自主搭建的苹果漫反射、漫透射和透射光谱采集系统分别获取了243个苹果样本的三种光谱数据,然后采用一阶导数(FD)、归一化(NOR)、 S-G平滑(S-G)、多元散射校正(MSC)和标准正态变量变化(SNV)五种方法对光谱数据进行预处理,其次将局部线性嵌入(LLE)、多尺度分析(MDS)、分布邻域嵌入(SNE)和t分布邻域嵌入(t-SNE)四种流形学习方法用于光谱数据降维,并与传统的主成分分析(PCA)降维方法比较,最后基于降维后数据建立了最小二乘支持向量机(LS-SVM)算法的苹果霉心病分类模型。结果表明:在三种不同的光谱检测方式中,透射检测方式优于漫透射检测方式,漫透射检测优于漫反射检测方式。在五种不同的光谱降维方法中,基于SNE的降维方法在三种不同的光谱数据中都优于其他降维方法,最终以透射检测方式结合SNE降维方法构建了最优的苹果霉心病判别模型,其校正集和测试集的准确率分别为99.52%和97.14%。该研究对苹果霉心病光谱无损检测研究中的实验平台搭建和检测装备研发提供了指导。

关键词：苹果霉心病可见/近红外光谱检测方式光谱降维流行学习

Performance improvement of magneto-acousto-electrical tomography for biological tissues with sinusoid-Barker coded excitation

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Chinese Physics B 2018年第9期27卷 346-353页

作者： Zheng-Feng Yu Yan Zhou Yu-Zhi Li Qing-Yu Ma ge-pu Guol Juan Tu Dong Zhang Jiangsu Provincial Engineering Laboratory of Audio Technology School of Physics and TechnologyNanjing Normal UniversityNanjing 210023China Institute of Acoustics Nanjing UniversityNanjing 210093China

By combining magnetics, acoustics and electrics, the magneto-acoustic-electrical tomography（MAET） proves to possess the capability of differentiating electrical impedance variation and thus improving the spatial resolution. However,the signal-to-noise ratio（SNR） of the collected MAET signal is still unsatisfactory for biological tissues with low-level electrical conductivity. In this study, the formula of MAET measurement with sinusoid-Barker coded excitation is derived and simplified for a planar piston transducer. Numerical simulations are conducted for a four-layered gel phantom with the 13-bit sinusoid-Barker coded excitation, and the performances of wave packet recovery with side-lobe suppression are improved by using the mismatched compression filter, which is also demonstrated by experimentally measuring a three-layered gel phantom. It is demonstrated that comparing with the single-cycle sinusoidal excitation, the amplitude of the driving signal can be reduced greatly with an SNR enhancement of 10 dB using the 13-bit sinusoid-Barker coded excitation. The amplitude and polarity of the wave packet filtered from the collected MAET signal can be used to achieve the conductivity derivative at the tissue boundary. In this study, we apply the sinusoid-Barker coded modulation method and the mismatched suppression scheme to MAET measurement to ensure the safety for biological tissues with improved SNR and spatial resolution, and suggest the potential applications in biomedical imaging.

关键词： magneto-acousto-electrical tomography sinusoid-Barker coded excitation mismatched compression filter side lobe suppression

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石灰浆液喷嘴雾化特性

工程热物理学报 2008年第9期29卷 1515-1517页

作者：蒲舸张力重庆大学动力工程学院重庆400044

石灰浆液雾化喷嘴是烟气喷雾干燥净化系统的关键设备。利用Win212-2型激光粒度分析仪,对外混及内-外混相结合双流体石灰浆液喷嘴的雾化特性进行了试验研究,分析了气液质量比、石灰浆液浓度等参数对雾化粒径分布和雾化角的影响规律。结... 详细信息

石灰浆液雾化喷嘴是烟气喷雾干燥净化系统的关键设备。利用Win212-2型激光粒度分析仪,对外混及内-外混相结合双流体石灰浆液喷嘴的雾化特性进行了试验研究,分析了气液质量比、石灰浆液浓度等参数对雾化粒径分布和雾化角的影响规律。结果表明,气液质量比增大,浆液液滴平均直径减小,但当气液比增大到一定值后,粒径变化趋于平缓;浆液浓度增加,液滴平均直径增加;气液质量比增加,雾化角减小。

关键词：石灰浆液喷嘴雾化特性

Variation of microbiological and small molecule metabolite profiles of Nuodeng ham during ripening by high-throughput sequencing and GC-TOF-MS

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Food Science and Human Wellness 2024年第4期13卷 2187-2196页

作者： Cong Li Yingling Zou Guozhou Liao Zijiang Yang Dahai Gu Yuehong pu Changrong ge Guiying Wang Livestock Product Processing and Engineering Technology Research Center of Yunnan Province Yunnan Agricultural UniversityKunming 650201China College of Food Science and Technology Yunnan Agricultural UniversityKunming 650201China

The internal microbial diversity and small molecular metabolites of Nuodeng ham in different processing years(the first,second and third year sample)were analyzed by high-throughput sequencing technology and gas chromatography-time of flight mass spectrography(GC-TOF-MS)to study the effects of microorganisms and small molecular metabolites on the quality of ham in different processing *** results showed that the dominant bacteria phyla of Nuodeng ham in different processing years were Proteobacteria and Firmicutes,the dominant fungi phyla were Ascomycota and Basidiomycota,while Staphylococcus and Aspergillus were the dominant bacteria and fungi of Nuodeng ham,***,252 kinds of small molecular metabolites were identified from Nuodeng ham in different processing years,and 12 different metabolites were screened through multivariate statistical *** metabolic pathway analysis showed that 23 metabolic pathways were related to ham fermentation,of which 8 metabolic pathways had significant effects on ham fermentation(Impact>0.01,P<0.05).The content of L-proline,phenyllactic acid,L-lysine,carnosine,taurine,D-proline,betaine and creatine were significantly positively correlated with the relative abundance of Staphylococcus and Serratia,but negatively correlated with the relative abundance of Halomonas,Aspergillus and Yamadazyma.

关键词： Nuodeng ham Microbial diversity Small molecule metabolites High-throughput sequencing Gas chromatography-time of flight mass spectrography

Magnetic Fields Reduce Apoptosis by Suppressing Phase Separation of Tau-441

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Research 2024年第1期2023卷 181-197页

作者： Wen-Juan Lin Wen-pu Shi Wan-Yi ge Liang-Liang Chen Wei-Hong Guo Peng Shang Da-Chuan Yin Key Laboratory for Space Bioscience and Biotechnology School of Life SciencesNorthwestern Polytechnical University127 Youyixi RoadXi'an 710072ShaanxiPR China

The biological effects of magnetic fields(MFs)have been a controversial ***,in recent years,there has been increasing evidence that MFs do affect biological ***,the physical mechanism remains ***,we show that MFs(16 T)reduce apoptosis in cell lines by inhibiting liquid–liquid phase separation(LLPS)of Tau-441,suggesting that the MF effect on LLPS may be one of the mechanisms for understanding the“mysterious”magnetobiological *** LLPS of Tau-441 occurred in the cytoplasm after induction with *** phase-separated droplets of Tau-441 recruited hexokinase(HK),resulting in a decrease in the amount of free HK in the *** cells,HK and Bax compete to bind to the voltage-dependent anion channel(VDAC I)on the mitochondrial membrane.A decrease in the number of free HK molecules increased the chance of Bax binding to VDAC I,leading to increased Bax-mediated *** the presence of a static MF,LLPS was marked inhibited and HK recruitment was reduced,resulting in an increased probability of HK binding to VDAC I and a decreased probability of Bax binding to VDAC I,thus reducing Bax-mediated *** findings revealed a new physical mechanism for understanding magnetobiological effects from the perspective of *** addition,these results show the potential applications of physical environments,such as MFs in this study,in the treatment of LLPS-related diseases.

关键词： inhibited Apoptosis finding

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城市生活垃圾可燃成分燃烧特性热重分析

重庆大学学报（自然科学版） 2009年第5期32卷 598-603页

作者：蒲舸王炯张力重庆大学动力工程学院重庆400030

通过热重分析仪研究城市生活垃圾单组分试样以及混合试样的燃烧特性,分别确定各试样的着火温度、燃尽温度及综合燃烧特性指数,并通过燃烧动力学分析得到各试样的活化能。垃圾在燃烧过程中表现为热解小分子气体的燃烧过程和剩余的固定碳... 详细信息

通过热重分析仪研究城市生活垃圾单组分试样以及混合试样的燃烧特性,分别确定各试样的着火温度、燃尽温度及综合燃烧特性指数,并通过燃烧动力学分析得到各试样的活化能。垃圾在燃烧过程中表现为热解小分子气体的燃烧过程和剩余的固定碳燃烧过程。纸、织物燃烧猛烈,但持续时间短,塑料燃烧持续时间最长,最耐烧。尽管峰值有一些改变,各单一成分的燃烧特性在混合试样的燃烧特性曲线上均有所体现。

关键词：城市生活垃圾燃烧特性热重分析